Aliases for PTPN7 Gene
External Ids for PTPN7 Gene
Previous GeneCards Identifiers for PTPN7 Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for PTPN7 Gene
PTPN7 (Protein Tyrosine Phosphatase Non-Receptor Type 7) is a Protein Coding gene. Diseases associated with PTPN7 include Rasopathy. Among its related pathways are Signal transduction_Erk Interactions- Inhibition of Erk and MAPK signaling pathway. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRR.
UniProtKB/Swiss-Prot Summary for PTPN7 Gene
Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.