Aliases for PTPN7 Gene
External Ids for PTPN7 Gene
Previous GeneCards Identifiers for PTPN7 Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for PTPN7 Gene
PTPN7 (Protein Tyrosine Phosphatase Non-Receptor Type 7) is a Protein Coding gene. Diseases associated with PTPN7 include Lentigines. Among its related pathways are MAPK signaling pathway and Downstream signaling in naive CD8+ T cells. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is PTPRR.
UniProtKB/Swiss-Prot Summary for PTPN7 Gene
Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.