Aliases for PTPN5 Gene

Aliases for PTPN5 Gene

  • Protein Tyrosine Phosphatase Non-Receptor Type 5 2 3 5
  • STEP 2 3 4
  • Protein Tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) 2 3
  • Tyrosine-Protein Phosphatase Non-Receptor Type 5 3 4
  • Striatal-Enriched Protein Tyrosine Phosphatase 2 3
  • Striatum-Enriched Protein-Tyrosine Phosphatase 3 4
  • Neural-Specific Protein-Tyrosine Phosphatase 3 4
  • EC 4 50
  • PTPSTEP 2 3
  • STEP61 2 3
  • Protein-Tyrosine Phosphatase Striatum-Enriched 3
  • PTPN5 5

External Ids for PTPN5 Gene

Previous GeneCards Identifiers for PTPN5 Gene

  • GC11U990112
  • GC11M019694
  • GC11M018788
  • GC11M018713
  • GC11M018706
  • GC11M018434
  • GC11M018749

Summaries for PTPN5 Gene

GeneCards Summary for PTPN5 Gene

PTPN5 (Protein Tyrosine Phosphatase Non-Receptor Type 5) is a Protein Coding gene. Diseases associated with PTPN5 include Viral Gastritis and Phencyclidine Abuse. Among its related pathways are Signal transduction_Erk Interactions- Inhibition of Erk and MAPK signaling pathway. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphotyrosine residue binding. An important paralog of this gene is PTPRR.

UniProtKB/Swiss-Prot Summary for PTPN5 Gene

  • May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.

Gene Wiki entry for PTPN5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPN5 Gene

Genomics for PTPN5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTPN5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J018790 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 266.6 +1.0 993 1.7 POLR2A SP2 TAF1 CTCF SP3 ZBTB8A EZH2 ZBTB11 ZFHX2 KDM1A PTPN5 piR-57133-070 IGSF22
GH11J018010 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.1 +780.0 780016 3.8 BCLAF1 SP1 MYC NCOR1 ZNF600 ZNF592 KLF9 ATF3 POLR2A ZBTB10 SERGEF SAAL1 SNORD14A GTF2H1 SNORD14B SPTY2D1 ENSG00000256361 PTPN5 ENSG00000256282 TSG101
GH11J018802 Enhancer 0.9 Ensembl ENCODE 22.3 -10.3 -10280 1.2 ZNF654 ATF2 CEBPA ATF3 REST CEBPB TRIM22 CTCF CTBP1 MAFF PTPN5 RF00017-799 piR-32791-001 MRGPRX1
GH11J018768 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.7 +23.0 23020 3 BCLAF1 SP1 ZNF207 BCL11A ZNF592 SIN3A TRIM22 IRF4 EBF1 SMARCA5 piR-57133-070 PTPN5 IGSF22 IGSF22-AS1 LDHA SERGEF GTF2H1
GH11J018771 Enhancer 0.4 Ensembl dbSUPER 20.7 +19.7 19677 1.9 BATF PTPN5 piR-57133-070 IGSF22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTPN5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTPN5

Top Transcription factor binding sites by QIAGEN in the PTPN5 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • RP58
  • TBP

Genomic Locations for PTPN5 Gene

Latest Assembly
64,794 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
64,794 bases
Minus strand

(GRCh37/hg19 by Ensembl)
64,794 bases
Minus strand

Genomic View for PTPN5 Gene

Genes around PTPN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN5 Gene

Proteins for PTPN5 Gene

  • Protein details for PTPN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 5
    Protein Accession:
    Secondary Accessions:
    • B3KXG7
    • B7Z386
    • B7ZAF5
    • D3DQY7
    • Q6P1Z2
    • Q8N2A1
    • Q8NDP8

    Protein attributes for PTPN5 Gene

    565 amino acids
    Molecular mass:
    63538 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTPN5 Gene

    Alternative splice isoforms for PTPN5 Gene


neXtProt entry for PTPN5 Gene

Selected DME Specific Peptides for PTPN5 Gene


Post-translational modifications for PTPN5 Gene

  • Phosphorylation at Ser-245 by PKA deactivates PTPN5. Phosphorylation at Thr-255 and Ser-268 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PTPN5 Gene

Gene Families for PTPN5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PTPN5 Gene

Suggested Antigen Peptide Sequences for PTPN5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ45381 fis, clone BRHIP3021019, highly similar to Homo sapiens protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) (PTPN5), transcript variant 3, mRNA (B3KXG7_HUMAN)
  • cDNA, FLJ79169, highly similar to Tyrosine-protein phosphatase non-receptor type5 (EC (B7ZAF5_HUMAN)
  • Striatum-enriched protein-tyrosine phosphatase (PTN5_HUMAN)
  • PTPN5 protein (Q86TL3_HUMAN)
  • PTPN5 protein (Q86TL6_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with PTPN5: view

Function for PTPN5 Gene

Molecular function for PTPN5 Gene

UniProtKB/Swiss-Prot Function:
May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
GENATLAS Biochemistry:
protein tyrosine phosphatase,non receptor type 5,homologous to murine striatum enriched phosphatase

Enzyme Numbers (IUBMB) for PTPN5 Gene

Phenotypes From GWAS Catalog for PTPN5 Gene

Gene Ontology (GO) - Molecular Function for PTPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine residue binding IDA 16441242
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity TAS 7490079
GO:0005515 protein binding IPI 21044950
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PTPN5: view
genes like me logo Genes that share phenotypes with PTPN5: view

Animal Models for PTPN5 Gene

MGI Knock Outs for PTPN5:
  • Ptpn5 Ptpn5<tm1b(KOMP)Wtsi>
  • Ptpn5 Ptpn5<tm1Pjlo>

Animal Models for research

  • Taconic Biosciences Mouse Models for PTPN5

miRNA for PTPN5 Gene

miRTarBase miRNAs that target PTPN5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPN5

Clone products for research

  • Addgene plasmids for PTPN5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPN5 Gene

Localization for PTPN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN5 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPN5 gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 3
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PTPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS --
genes like me logo Genes that share ontologies with PTPN5: view

Pathways & Interactions for PTPN5 Gene

PathCards logo

SuperPathways for PTPN5 Gene

SuperPathway Contained pathways
1 MAPK signaling pathway
2 Neuroscience
3 PAK Pathway
4 Signal transduction_Erk Interactions- Inhibition of Erk
5 EGF/EGFR Signaling Pathway
genes like me logo Genes that share pathways with PTPN5: view

Pathways by source for PTPN5 Gene

2 BioSystems pathways for PTPN5 Gene
1 KEGG pathway for PTPN5 Gene
1 GeneGo (Thomson Reuters) pathway for PTPN5 Gene
  • Signal transduction_Erk Interactions- Inhibition of Erk
1 Qiagen pathway for PTPN5 Gene
  • Epithelial Adherens Junctions
1 Cell Signaling Technology pathway for PTPN5 Gene

SIGNOR curated interactions for PTPN5 Gene


Gene Ontology (GO) - Biological Process for PTPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 7490079
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0071345 cellular response to cytokine stimulus TAS --
genes like me logo Genes that share ontologies with PTPN5: view

Drugs & Compounds for PTPN5 Gene

(2) Drugs for PTPN5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0
genes like me logo Genes that share compounds with PTPN5: view

Transcripts for PTPN5 Gene

mRNA/cDNA for PTPN5 Gene

12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPN5

Clone products for research

  • Addgene plasmids for PTPN5

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - -
SP2: - -
SP3: - - - -

Relevant External Links for PTPN5 Gene

GeneLoc Exon Structure for

Expression for PTPN5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTPN5 Gene

mRNA differential expression in normal tissues according to GTEx for PTPN5 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x13.2), Brain - Putamen (basal ganglia) (x12.4), and Brain - Caudate (basal ganglia) (x10.2).

Protein differential expression in normal tissues from HIPED for PTPN5 Gene

This gene is overexpressed in Fetal Brain (35.2), Monocytes (16.4), and Frontal cortex (16.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTPN5 Gene

Protein tissue co-expression partners for PTPN5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTPN5

SOURCE GeneReport for Unigene cluster for PTPN5 Gene:


Evidence on tissue expression from TISSUES for PTPN5 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with PTPN5: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPN5 Gene

Orthologs for PTPN5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTPN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTPN5 29 30
  • 99.59 (n)
(Bos Taurus)
Mammalia PTPN5 29 30
  • 90.54 (n)
(Rattus norvegicus)
Mammalia Ptpn5 29
  • 90.06 (n)
(Canis familiaris)
Mammalia PTPN5 29 30
  • 89.97 (n)
(Mus musculus)
Mammalia Ptpn5 29 16 30
  • 88.66 (n)
(Ornithorhynchus anatinus)
Mammalia PTPN5 30
  • 84 (a)
(Monodelphis domestica)
Mammalia PTPN5 30
  • 77 (a)
(Gallus gallus)
Aves PTPN5 29 30
  • 67.18 (n)
(Anolis carolinensis)
Reptilia PTPN5 30
  • 69 (a)
(Danio rerio)
Actinopterygii ptpn5 29 30
  • 62.85 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG42327 30
  • 10 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTP1 30
  • 27 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 31 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2178 29
Species where no ortholog for PTPN5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PTPN5 Gene

Gene Tree for PTPN5 (if available)
Gene Tree for PTPN5 (if available)
Evolutionary constrained regions (ECRs) for PTPN5: view image
Alliance of Genome Resources:
Additional Orthologs for PTPN5

Paralogs for PTPN5 Gene

(41) SIMAP similar genes for PTPN5 Gene using alignment to 7 proteins:

  • L8E916_HUMAN
  • Q86TL3_HUMAN
  • Q86TL6_HUMAN
genes like me logo Genes that share paralogs with PTPN5: view

Variants for PTPN5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTPN5 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs367543221 Not Provided: not provided 18,729,473(-) C/T
NM_006906.2(PTPN5):c.1584G>A (p.Thr528=)
rs367543222 Not Provided: not provided 18,729,810(-) A/T
NM_006906.2(PTPN5):c.1338T>A (p.Thr446=)
rs367543223 Not Provided: not provided 18,729,817(-) C/T
NM_006906.2(PTPN5):c.1331G>A (p.Ser444Asn)
rs367543224 Not Provided: not provided 18,732,668(-) G/A
NM_006906.2(PTPN5):c.1253C>T (p.Ala418Val)
rs367543225 Not Provided: not provided 18,733,250(-) G/A
NM_006906.2(PTPN5):c.1203C>T (p.Ile401=)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PTPN5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PTPN5 Gene

Variant ID Type Subtype PubMed ID
esv3374278 CNV duplication 20981092
nsv1047371 CNV gain 25217958
nsv476807 CNV novel sequence insertion 20440878
nsv525192 CNV loss 19592680
nsv525452 CNV gain 19592680
nsv553633 CNV gain 21841781
nsv951317 CNV deletion 24416366

Variation tolerance for PTPN5 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.85; 86.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTPN5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN5 Gene

Disorders for PTPN5 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PTPN5 Gene - From: COP

Disorder Aliases PubMed IDs
viral gastritis
phencyclidine abuse
  • pcp abuse
fragile x syndrome
  • fxs
kagami-ogata syndrome
  • uniparental disomy, paternal, chromosome 14
disease of mental health
  • mental health
- elite association - COSMIC cancer census association via MalaCards
Search PTPN5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PTPN5

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PTPN5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPN5 Gene

Publications for PTPN5 Gene

  1. Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci. (PMID: 7490079) Li X … Francke U (Genomics 1995) 3 4 22
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  3. Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability. (PMID: 19000305) Korff S … Gebert J (BMC cancer 2008) 3 40
  4. Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. (PMID: 16441242) Eswaran J … Barr AJ (The Biochemical journal 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for PTPN5 Gene

Sources for PTPN5 Gene