Aliases for PTPN3 Gene
Aliases for PTPN3 Gene
External Ids for PTPN3 Gene
- HGNC: 9655
- Entrez Gene: 5774
- Ensembl: ENSG00000070159
- OMIM: 176877
- UniProtKB: P26045
Previous GeneCards Identifiers for PTPN3 Gene
- GC09M102938
- GC09M103872
- GC09M105597
- GC09M107520
- GC09M109220
- GC09M111177
- GC09M112138
- GC09M081738
Summaries for PTPN3 Gene
-
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
GeneCards Summary for PTPN3 Gene
PTPN3 (Protein Tyrosine Phosphatase, Non-Receptor Type 3) is a Protein Coding gene. Diseases associated with PTPN3 include Cholangiocarcinoma and Non-Functioning Pituitary Adenoma. Among its related pathways are TNFR1 Pathway and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include phosphatase activity and cytoskeletal protein binding. An important paralog of this gene is PTPN4.
UniProtKB/Swiss-Prot for PTPN3 Gene
-
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
Additional gene information for PTPN3 Gene
- Monarch Initiative
- Search for PTPN3 at DataMed
- Search for PTPN3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN3 Gene
Genomics for PTPN3 Gene
GeneHancer (GH) Regulatory Elements for PTPN3 Gene
Promoters and enhancers for PTPN3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH09J109494 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 658.2 | +40.8 | 40757 | 5.6 | PKNOX1 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ELK1 KLF13 SP3 SP5 | PTPN3 GC09P109498 PALM2 YBX1P6 ENSG00000207329 | |
| GH09J109536 | Enhancer | 0.6 | ENCODE dbSUPER | 650.7 | +0.7 | 672 | 2 | GATA3 NFIA CUX1 | PTPN3 YBX1P6 | |
| GH09J109472 | Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 22.6 | +61.9 | 61917 | 7.5 | PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF48 YY1 | PTPN3 EPB41L4B PALM2 YBX1P6 GC09P109498 ENSG00000207329 | |
| GH09J109469 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 12 | +68.4 | 68412 | 1.6 | ELF3 CTCF RAD21 YY1 TEAD3 ZFHX2 GATA3 EGR1 SMC3 ZNF143 | PTPN3 EPB41L4B GC09P109498 ENSG00000207329 | |
| GH09J109440 | Enhancer | 1.3 | Ensembl ENCODE dbSUPER | 7.6 | +97.5 | 97527 | 1.7 | ATF1 FOXA2 SIN3A IRF4 ZNF143 ZFP91 FOS ATF7 RUNX3 RXRA | EPB41L4B RNU6-984P PTPN3 GC09P109498 ENSG00000207329 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PTPN3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PTPN3 gene promoter:
-
- E2F
- POU6F1 (c2)
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- USF-1
- USF1
- Nkx2-5
Regulatory Element Products
Genomic Locations for PTPN3 Gene
Genomic Locations for PTPN3 Gene
- chr9:109,375,466-109,538,353
- (GRCh38/hg38)
- Size:
- 162,888 bases
- Orientation:
- Minus strand
- chr9:112,137,746-112,260,593
- (GRCh37/hg19)
- Size:
- 122,848 bases
- Orientation:
- Minus strand
Genomic View for PTPN3 Gene
Genes around PTPN3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q31.3 by Entrez Gene
- 9q31 by HGNC
- 9q31.3 by Ensembl
PTPN3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTPN3 Gene
Proteins for PTPN3 Gene
-
Protein details for PTPN3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P26045-PTN3_HUMAN
- Recommended name:
- Tyrosine-protein phosphatase non-receptor type 3
- Protein Accession:
- P26045
- A0AUW9
- E7EN99
- E9PGU7
Protein attributes for PTPN3 Gene
- Size:
- 913 amino acids
- Molecular mass:
- 103990 Da
- Quaternary structure:
- No Data Available
Three dimensional structures from OCA and Proteopedia for PTPN3 Gene
Protein Expression for PTPN3 Gene
Post-translational modifications for PTPN3 Gene
Other Protein References for PTPN3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PTPN3
- Novus Biologicals Antibodies for PTPN3
- Invitrogen Antibodies for PTPN3 (AFLGC-PTPN3)
- GeneTex PTPN3 Antibody for PTPN3
-
Boster Bio Antibodies for PTPN3
-
Santa Cruz Biotechnology (SCBT) Antibodies for PTPN3
Protein Products
-
OriGene Purified Proteins for PTPN3
- Search Origene for MassSpec and Protein Over-expression Lysates for PTPN3
- Origene Custom Protein Services for PTPN3
- antibodies-online: Search results for 4 available PTPN3 Proteins ranked by validation data
- Compare Top PTPN3 Proteins
-
Quality Products:
- Search GeneTex for Proteins for PTPN3
-
Abcam proteins for PTPN3
Assay Products
No data available for DME Specific Peptides for PTPN3 Gene
Domains & Families for PTPN3 Gene
Gene Families for PTPN3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PTPN3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PTPN3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P26045UniProtKB/Swiss-Prot:
PTN3_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Function for PTPN3 Gene
Molecular function for PTPN3 Gene
- UniProtKB/Swiss-Prot Function:
- May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
- GENATLAS Biochemistry:
- protein tyrosine phosphatase,non receptor type 3,(ERM) family member,responding and participating in reorganization of membrane-cytoplasmic interactions
Enzyme Numbers (IUBMB) for PTPN3 Gene
Phenotypes From GWAS Catalog for PTPN3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001784 | phosphotyrosine residue binding | IPI | 10364224 |
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004725 | protein tyrosine phosphatase activity | IEA,TAS | -- |
| GO:0005515 | protein binding | IEA,IPI | 9341175 |
| GO:0008092 | cytoskeletal protein binding | IEA | -- |
Phenotypes for PTPN3 Gene
- MGI mutant phenotypes for PTPN3:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for PTPN3:
-
- Synthetic lethal with paclitaxel
- Dynamic nuclei (hole, folded or small irregular)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Increased cell death HMECs cells
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Mildly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
Animal Model Products
-
Taconic Biosciences Mouse Models for PTPN3
- Cyagen custom Knockout/knockin (KOKI) mouse models for PTPN3
-
CRISPR Products
-
OriGene CRISPR knockouts for PTPN3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPN3
- genomics-online: gRNA clones - Search results for 99 available PTPN3 gene related products
- Overview of 99 available PTPN3 gene related products
- Applied Biological Materials CRISPR for PTPN3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTPN3
- GenScript: Design CRISPR guide RNA sequences for PTPN3
miRNA for PTPN3 Gene
- miRTarBase miRNAs that target PTPN3
-
- hsa-mir-103a-3p (MIRT027192)
- hsa-mir-21-5p (MIRT031028)
- hsa-mir-16-5p (MIRT032073)
- hsa-mir-432-5p (MIRT439865)
- hsa-mir-377-5p (MIRT439867)
- hsa-mir-125a-3p (MIRT612629)
- hsa-mir-8485 (MIRT612630)
- hsa-mir-4801 (MIRT612631)
- hsa-mir-4731-3p (MIRT612632)
- hsa-mir-6818-3p (MIRT622556)
- hsa-mir-4684-5p (MIRT622557)
- hsa-mir-3941 (MIRT622558)
- hsa-mir-593-3p (MIRT622559)
- hsa-mir-6895-3p (MIRT622560)
- hsa-mir-5699-3p (MIRT622561)
- hsa-mir-4421 (MIRT622562)
- hsa-mir-6748-3p (MIRT622563)
- hsa-mir-603 (MIRT622564)
- hsa-mir-362-3p (MIRT622565)
- hsa-mir-329-3p (MIRT622566)
- hsa-mir-4710 (MIRT627803)
- hsa-mir-1294 (MIRT671386)
- hsa-mir-6134 (MIRT672836)
- hsa-mir-7854-3p (MIRT672837)
- hsa-mir-6865-5p (MIRT674312)
- hsa-mir-6815-5p (MIRT674313)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPN3
- Browse OriGene Inhibitory RNA Products For PTPN3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPN3
- genomics-online: shRNA clones - Search results for 99 available PTPN3 gene related products
- Overview of 99 available PTPN3 gene related products
Clone Products
-
OriGene ORF clones in human for PTPN3
- RC215851
- RC215851L1
- RC215851L2
- RC215851L3
- RC215851L4
- RC226648
- RC226648L1
- RC226648L2
- RC226648L3
- RC226648L4
- RC226736
- RC226736L1
- RC226736L2
- RC226736L3
- RC226736L4
- RC226819
- RC226819L1
- RC226819L2
- RC226819L3
- RC226819L4
- RC226916
- RC226916L1
- RC226916L2
- RC226916L3
- RC226916L4
- RC226972
- RC226972L1
- RC226972L2
- RC226972L3
- RC226972L4
- RC515851
- RG215851
- RG226648
- RG226736
- RG226819
- RG226916
- RG226972
- RC215851L1V
- RC215851L2V
- RC215851L3V
- RC215851L4V
- RC226648L1V
- RC226648L2V
- RC226648L3V
- RC226648L4V
- RC226736L1V
- RC226736L2V
- RC226736L3V
- RC226736L4V
- RC226819L1V
- RC226819L2V
- RC226819L3V
- RC226819L4V
- RC226916L1V
- RC226916L2V
- RC226916L3V
- RC226916L4V
- RC226972L1V
- RC226972L2V
- RC226972L3V
- RC226972L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PTPN3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPN3
- Applied Biological Materials Clones for PTPN3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PTPN3
No data available for Transcription Factor Targets and HOMER Transcription for PTPN3 Gene
Localization for PTPN3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTPN3 Gene
- Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| cytosol | 3 |
| nucleus | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 10940933 |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0009898 | cytoplasmic side of plasma membrane | IDA | 10940933 |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTPN3 Gene
Pathways & Interactions for PTPN3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 2 | TNFR1 Pathway | ||
| 3 | PAK Pathway | ||
| 4 | Listeria monocytogenes entry into host cells | ||
| 5 | Signaling by GPCR | ||
Pathways by source for PTPN3 Gene
3 Reactome pathways for PTPN3 Gene
6 Qiagen pathways for PTPN3 Gene
Interacting Proteins for PTPN3 Gene
Selected Interacting proteins:
P26045-PTN3_HUMAN
ENSP00000363667
for PTPN3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PTPN3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | IDA,IEA | 10364224 |
| GO:0016311 | dephosphorylation | IEA | -- |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IEA | -- |
| GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway | TAS | -- |
| GO:0045930 | negative regulation of mitotic cell cycle | IDA | 10364224 |
Drugs & Compounds for PTPN3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14265-44-2 |
|
Drug Products
Transcripts for PTPN3 Gene
mRNA/cDNA for PTPN3 Gene
- (17) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (180) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000447271 587 bps (uc064uzp.1)
- ENST00000374541 6703 bps (uc004bed.3)
- ENST00000497739 781 bps (uc064uzq.1)
- ENST00000412145 8765 bps (uc004beb.2)
- ENST00000446349 8630 bps (uc004bec.2)
Unigene Clusters for PTPN3 Gene
- Protein tyrosine phosphatase, non-receptor type 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PTPN3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPN3
- genomics-online: gRNA clones - Search results for 99 available PTPN3 gene related products
- Overview of 99 available PTPN3 gene related products
- Applied Biological Materials CRISPR for PTPN3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTPN3
- GenScript: Design CRISPR guide RNA sequences for PTPN3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPN3
- Browse OriGene Inhibitory RNA Products For PTPN3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPN3
- genomics-online: shRNA clones - Search results for 99 available PTPN3 gene related products
- Overview of 99 available PTPN3 gene related products
Clone Products
-
OriGene ORF clones in human for PTPN3
- RC215851
- RC215851L1
- RC215851L2
- RC215851L3
- RC215851L4
- RC226648
- RC226648L1
- RC226648L2
- RC226648L3
- RC226648L4
- RC226736
- RC226736L1
- RC226736L2
- RC226736L3
- RC226736L4
- RC226819
- RC226819L1
- RC226819L2
- RC226819L3
- RC226819L4
- RC226916
- RC226916L1
- RC226916L2
- RC226916L3
- RC226916L4
- RC226972
- RC226972L1
- RC226972L2
- RC226972L3
- RC226972L4
- RC515851
- RG215851
- RG226648
- RG226736
- RG226819
- RG226916
- RG226972
- RC215851L1V
- RC215851L2V
- RC215851L3V
- RC215851L4V
- RC226648L1V
- RC226648L2V
- RC226648L3V
- RC226648L4V
- RC226736L1V
- RC226736L2V
- RC226736L3V
- RC226736L4V
- RC226819L1V
- RC226819L2V
- RC226819L3V
- RC226819L4V
- RC226916L1V
- RC226916L2V
- RC226916L3V
- RC226916L4V
- RC226972L1V
- RC226972L2V
- RC226972L3V
- RC226972L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PTPN3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPN3
- Applied Biological Materials Clones for PTPN3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | · | 27c | · | 27d | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30a | · | 30b | · | 30c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||||||||||||
| SP14: |
Expression for PTPN3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Ureteric Bud Tip Cells Ureteric Bud
- Metanephros
mRNA differential expression in normal tissues according to GTEx for PTPN3 Gene
This gene is overexpressed in Muscle - Skeletal (x9.4), Liver (x4.9), and Heart - Left Ventricle (x4.1).
This gene is overexpressed in Placenta (52.9) and Liver (11.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPN3 Gene
NURSA nuclear receptor signaling pathways regulating expression of PTPN3 Gene:
PTPN3SOURCE GeneReport for Unigene cluster for PTPN3 Gene:
Hs.436429Evidence on tissue expression from TISSUES for PTPN3 Gene
- Nervous system(4.8)
- Intestine(4.3)
- Liver(4.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPN3 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- integumentary
- urinary
Regions:
Abdomen:
- biliary tract
- gallbladder
- kidney
- liver
General:
- skin
Primer Products
-
OriGene qPCR primer pairs for PTPN3
-
OriGene qPCR primer pairs and template standards for PTPN3
- genomics-online: primer clones - Search results for 99 available PTPN3 gene related products
- Overview of 99 available PTPN3 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for PTPN3 Gene
Orthologs for PTPN3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PTPN3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PTPN3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PTPN3 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ptpn3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ptpn3 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PTPN3 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PTPN3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PTPN3 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PTPN3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ptpn3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ptpn3 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Ptpmeg 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | F36H1.3 35 |
|
|
|
| ptp-1 34 35 |
|
OneToMany | |||
| F25H5.7 35 |
|
|
|||
| K07F5.8 35 |
|
|
|||
| F55F8.7 35 |
|
|
|||
| T22C1.8 35 |
|
|
|||
| C02B10.6 35 |
|
|
|||
| F36H12.10 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for PTPN3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for PTPN3 Gene
- ENSEMBL:
- Gene Tree for PTPN3 (if available)
- TreeFam:
- Gene Tree for PTPN3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PTPN3: view image
Paralogs for PTPN3 Gene
Paralogs for PTPN3 Gene
(35) SIMAP similar genes for PTPN3 Gene using alignment to 4 proteins:
- PTN3_HUMAN
- B7Z8K9_HUMAN
- B7Z9V1_HUMAN
- J3KN34_HUMAN
Variants for PTPN3 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193920798 | uncertain-significance, Malignant tumor of prostate | 109,436,926(-) | G/A | coding_sequence_variant, genic_upstream_transcript_variant, missense_variant | |
| rs1000067520 | -- | 109,399,262(-) | A/T | intron_variant | |
| rs1000070057 | -- | 109,424,100(-) | G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000125312 | -- | 109,428,555(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000126508 | -- | 109,467,796(-) | G/A | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759709 | CNV | loss | 17122850 |
| nsv1077172 | CNV | deletion | 25765185 |
| nsv1126917 | CNV | deletion | 24896259 |
| nsv831685 | CNV | gain | 17160897 |
| nsv8557 | CNV | loss | 18304495 |
Residual Variation Intolerance Score:
17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.57;
93.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PTPN3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN3 Gene
Disorders for PTPN3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cholangiocarcinoma |
|
|
| non-functioning pituitary adenoma |
|
|
| scott syndrome |
|
|
| functioning pituitary adenoma |
|
|
| diabetes mellitus, insulin-dependent |
|
Search PTPN3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PTPN3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PTPN3 Gene
Publications for PTPN3 Gene
- Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin. (PMID: 1648725) Yang Q … Tonks NK (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 22 58
- Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma. (PMID: 7874267) Ikuta S … Yachi A (Journal of gastroenterology 1994) 3 4 22 58
- Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PMID: 19167335) Barr AJ … Knapp S (Cell 2009) 3 4 58
- Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 44 58
- Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins. (PMID: 17166906) Jing M … Vande Pol SB (Journal of virology 2007) 3 22 58
Products for PTPN3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for PTPN3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PTPN3
- Search Origene for MassSpec and Protein Over-expression Lysates for PTPN3
- Origene Custom Protein Services for PTPN3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPN3
- Browse OriGene Inhibitory RNA Products For PTPN3
- OriGene qPCR primer pairs for PTPN3
- OriGene qPCR primer pairs and template standards for PTPN3
- OriGene CRISPR knockouts for PTPN3
- OriGene ORF clones in human for PTPN3
- RC215851
- RC215851L1
- RC215851L2
- RC215851L3
- RC215851L4
- RC226648
- RC226648L1
- RC226648L2
- RC226648L3
- RC226648L4
- RC226736
- RC226736L1
- RC226736L2
- RC226736L3
- RC226736L4
- RC226819
- RC226819L1
- RC226819L2
- RC226819L3
- RC226819L4
- RC226916
- RC226916L1
- RC226916L2
- RC226916L3
- RC226916L4
- RC226972
- RC226972L1
- RC226972L2
- RC226972L3
- RC226972L4
- RC515851
- RG215851
- RG226648
- RG226736
- RG226819
- RG226916
- RG226972
- RC215851L1V
- RC215851L2V
- RC215851L3V
- RC215851L4V
- RC226648L1V
- RC226648L2V
- RC226648L3V
- RC226648L4V
- RC226736L1V
- RC226736L2V
- RC226736L3V
- RC226736L4V
- RC226819L1V
- RC226819L2V
- RC226819L3V
- RC226819L4V
- RC226916L1V
- RC226916L2V
- RC226916L3V
- RC226916L4V
- RC226972L1V
- RC226972L2V
- RC226972L3V
- RC226972L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PTPN3
- GenScript: Next-day shipping of latest version cDNA ORF clones for PTPN3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PTPN3
- GenScript Custom Assay Services for PTPN3
- GenScript Custom overexpressing Cell Line Services for PTPN3
- GenScript: Design CRISPR guide RNA sequences for PTPN3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PTPN3
- Sino Biological Human cDNA Clone for PTPN3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PTPN3
- Novus Biologicals proteins and lysates for PTPN3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for PTPN3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for PTPN3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PTPN3 (AFLGC-PTPN3)
- Cyagen custom Knockout/knockin (KOKI) mouse models for PTPN3
- antibodies-online: Search results for 52 available PTPN3 Antibodies ranked by validation data
- Compare Top PTPN3 Antibodies
- antibodies-online: Search results for available PTPN3 related products ranked by validation data
- antibodies-online: Search results for 4 available PTPN3 Proteins ranked by validation data
- Compare Top PTPN3 Proteins
- Quality Products:
- GeneTex PTPN3 Antibody for PTPN3
- Search GeneTex for Proteins for PTPN3
- Santa Cruz Biotechnology (SCBT) Antibodies for PTPN3
- Search Santa Cruz Biotechnology (SCBT) for PTPN3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PTPN3
- Horizon Cell Lines for PTPN3
- genomics-online: cdna clones - Search results for 99 available PTPN3 gene related products
- Overview of 99 available PTPN3 gene related products
- orf clones - Search results for 99 available PTPN3 gene related products
- Overview of 99 available PTPN3 gene related products
- genomics-online: gRNA clones - Search results for 99 available PTPN3 gene related products
- Overview of 99 available PTPN3 gene related products
- genomics-online: primer clones - Search results for 99 available PTPN3 gene related products
- Overview of 99 available PTPN3 gene related products
- genomics-online: shRNA clones - Search results for 99 available PTPN3 gene related products
- Overview of 99 available PTPN3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPN3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPN3
- GeneCopoeia miRNA 3'UTR Target clone products for PTPN3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPN3
- Boster Bio Antibodies for PTPN3
- Browse Boster Bio ELISA Kits
Sources for PTPN3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt