PTPN3 Gene (Protein Coding)

Protein Tyrosine Phosphatase Non-Receptor Type 3

GC09M109375
GIFtS:
45
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of ... See more...

Aliases for PTPN3 Gene

Aliases for PTPN3 Gene

  • Protein Tyrosine Phosphatase Non-Receptor Type 3 2 3 5
  • PTPH1 2 3 4
  • Tyrosine-Protein Phosphatase Non-Receptor Type 3 3 4
  • Protein-Tyrosine Phosphatase H1 3 4
  • EC 3.1.3.48 4 50
  • PTP-H1 3 4
  • Cytoskeletal-Associated Protein Tyrosine Phosphatase 3
  • PTPN3 5

External Ids for PTPN3 Gene

Previous GeneCards Identifiers for PTPN3 Gene

  • GC09M102938
  • GC09M103872
  • GC09M105597
  • GC09M107520
  • GC09M109220
  • GC09M111177
  • GC09M112138
  • GC09M081738

Summaries for PTPN3 Gene

Entrez Gene Summary for PTPN3 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

GeneCards Summary for PTPN3 Gene

PTPN3 (Protein Tyrosine Phosphatase Non-Receptor Type 3) is a Protein Coding gene. Diseases associated with PTPN3 include Cholangiocarcinoma and Type 1 Diabetes Mellitus. Among its related pathways are Signaling by GPCR and RET signaling. Gene Ontology (GO) annotations related to this gene include phosphatase activity and cytoskeletal protein binding. An important paralog of this gene is PTPN4.

UniProtKB/Swiss-Prot Summary for PTPN3 Gene

  • May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

Gene Wiki entry for PTPN3 Gene

Additional gene information for PTPN3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPN3 Gene

Genomics for PTPN3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PTPN3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09J109494 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 258.2 +41.0 40994 6 ZMYM3 NFIC ZIC2 MXD4 KLF11 ZNF341 SIN3A THAP11 ELF1 ZNF623 PTPN3 PALM2AKAP2 lnc-PALM2-3 YBX1P6 HSALNG0073609 EPB41L4B
GH09J109536 Enhancer 0.7 Ensembl ENCODE dbSUPER 250.7 +0.7 714 2 CUX1 NFIA HSALNG0073613 PTPN3 YBX1P6 RF00017-7217 PALM2AKAP2
GH09J109472 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 22.6 +62.0 61959 7.5 ZNF600 SSRP1 ZNF580 ZMYM3 CEBPA ATF3 NFIC ZIC2 YY1 FEZF1 PTPN3 EPB41L4B YBX1P6 HSALNG0073609 PALM2AKAP2 lnc-EPB41L4B-1 HSALNG0073605
GH09J109518 Enhancer 0.8 Ensembl ENCODE 19.3 +20.1 20094 1 YY1 FOXA2 RXRA ZBTB33 JUND HNF4A FOXA1 RAD21 GLIS1 REST YBX1P6 PTPN3 EPB41L4B MIR3927 PALM2AKAP2
GH09J109467 Enhancer 0.8 FANTOM5 Ensembl dbSUPER 18.9 +70.3 70294 0.6 SPI1 MYC POLR2A MNT PTPN3 EPB41L4B HSALNG0073609 lnc-EPB41L4B-1 PALM2AKAP2 HSALNG0073605
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTPN3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTPN3

Top Transcription factor binding sites by QIAGEN in the PTPN3 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Nkx2-5
  • POU6F1 (c2)
  • USF-1
  • USF1

Genomic Locations for PTPN3 Gene

Latest Assembly
chr9:109,375,466-109,538,395
(GRCh38/hg38)
Size:
162,930 bases
Orientation:
Minus strand

Previous Assembly
chr9:112,137,974-112,260,587
(GRCh37/hg19 by Entrez Gene)
Size:
122,614 bases
Orientation:
Minus strand

chr9:112,137,746-112,260,590
(GRCh37/hg19 by Ensembl)
Size:
122,845 bases
Orientation:
Minus strand

Genomic View for PTPN3 Gene

Genes around PTPN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPN3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PTPN3 Gene

Proteins for PTPN3 Gene

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  • Protein details for PTPN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26045-PTN3_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 3
    Protein Accession:
    P26045
    Secondary Accessions:
    • A0AUW9
    • E7EN99
    • E9PGU7

    Protein attributes for PTPN3 Gene

    Size:
    913 amino acids
    Molecular mass:
    103990 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PTPN3 Gene

    Alternative splice isoforms for PTPN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTPN3 Gene

Protein Expression for PTPN3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PTPN3 Gene

P26045:
  • YIATQGP
  • YPLDIVR
  • KCHQYWP
  • WPDHGVP
  • HCSAGIGR

Post-translational modifications for PTPN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTPN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PTPN3 Gene

Gene Families for PTPN3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PTPN3 Gene

InterPro:
Blocks:
  • PDZ/DHR/GLGF domain
  • Band 4.1 domain
  • ERM family signature
  • Protein tyrosine phosphatase signature

Suggested Antigen Peptide Sequences for PTPN3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52384, highly similar to Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (B7Z8K9_HUMAN)
  • cDNA, FLJ78965, highly similar to Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (B7Z9V1_HUMAN)
  • Protein-tyrosine phosphatase H1 (PTN3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P26045

UniProtKB/Swiss-Prot:

PTN3_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with PTPN3: view

Function for PTPN3 Gene

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Molecular function for PTPN3 Gene

UniProtKB/Swiss-Prot Function:
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
GENATLAS Biochemistry:
protein tyrosine phosphatase,non receptor type 3,(ERM) family member,responding and participating in reorganization of membrane-cytoplasmic interactions

Enzyme Numbers (IUBMB) for PTPN3 Gene

Phenotypes From GWAS Catalog for PTPN3 Gene

Gene Ontology (GO) - Molecular Function for PTPN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine residue binding IPI 10364224
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA,TAS --
GO:0005515 protein binding IEA,IPI 9341175
GO:0008092 cytoskeletal protein binding IEA --
genes like me logo Genes that share ontologies with PTPN3: view
genes like me logo Genes that share phenotypes with PTPN3: view

Human Phenotype Ontology for PTPN3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PTPN3 Gene

MGI Knock Outs for PTPN3:

Animal Models for research

  • Taconic Biosciences Mouse Models for PTPN3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPN3

Clone products for research

No data available for Transcription Factor Targets and HOMER Transcription for PTPN3 Gene

Localization for PTPN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN3 Gene

Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPN3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 3
cytosol 3
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PTPN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 10940933
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane TAS --
GO:0009898 cytoplasmic side of plasma membrane IBA,IDA 10940933
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PTPN3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTPN3 Gene

Pathways & Interactions for PTPN3 Gene

PathCards logo

SuperPathways for PTPN3 Gene

SuperPathway Contained pathways
1 Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
Activation of PKA through GPCR
.71
PKA Signaling
.56
2 TNFR1 Pathway
Apoptotic Pathways Triggered By HIV1
.42
3 PAK Pathway
Epithelial Adherens Junctions
.36
4 Listeria monocytogenes entry into host cells
EGFR downregulation
.45
5 Signaling by GPCR
Signal Transduction
.52
genes like me logo Genes that share pathways with PTPN3: view

Pathways by source for PTPN3 Gene

3 Reactome pathways for PTPN3 Gene
6 Qiagen pathways for PTPN3 Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Apoptotic Pathways Triggered By HIV1
  • cAMP Pathway
  • Epithelial Adherens Junctions

SIGNOR curated interactions for PTPN3 Gene

Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for PTPN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,IDA 10364224
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS --
GO:0045930 negative regulation of mitotic cell cycle IDA 10364224
genes like me logo Genes that share ontologies with PTPN3: view

Drugs & Compounds for PTPN3 Gene

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(58) Drugs for PTPN3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0

(37) Additional Compounds for PTPN3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PTPN3: view

Transcripts for PTPN3 Gene

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mRNA/cDNA for PTPN3 Gene

6 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPN3

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - -
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b · 30c
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9: - - - - - - - - - - - - -
SP10:
SP11:
SP12: -
SP13:
SP14:

Relevant External Links for PTPN3 Gene

GeneLoc Exon Structure for
PTPN3

Expression for PTPN3 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTPN3 Gene

mRNA expression in normal human tissues for PTPN3 Gene
mRNA expression by BioGPS for PTPN3 GenemRNA expression by GTEx for PTPN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPN3 Gene

This gene is overexpressed in Muscle - Skeletal (x9.4), Liver (x4.9), and Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for PTPN3 Gene

This gene is overexpressed in Placenta (52.9) and Liver (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPN3 Gene



Protein tissue co-expression partners for PTPN3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTPN3

SOURCE GeneReport for Unigene cluster for PTPN3 Gene:

Hs.436429

Evidence on tissue expression from TISSUES for PTPN3 Gene

  • Nervous system(4.9)
  • Intestine(4.5)
  • Liver(4.5)
  • Skin(2.3)
  • Kidney(2.2)
  • Muscle(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPN3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • urinary
Regions:
Abdomen:
  • biliary tract
  • gallbladder
  • kidney
  • liver
General:
  • skin
genes like me logo Genes that share expression patterns with PTPN3: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt for PTPN3 Gene

Orthologs for PTPN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PTPN3 29 30
  • 99.53 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia PTPN3 29 30
  • 91.68 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia PTPN3 29 30
  • 90.72 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ptpn3 29
  • 87.48 (n)
Mouse
(Mus musculus)
 Mammalia Ptpn3 29 16 30
  • 87.22 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia PTPN3 30
  • 82 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia PTPN3 30
  • 71 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves PTPN3 29 30
  • 75.56 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia PTPN3 30
  • 73 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia ptpn3 29
  • 69.26 (n)
Zebrafish
(Danio rerio)
 Actinopterygii ptpn3 29 30
  • 61.96 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta Ptpmeg 30 31
  • 35 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea F36H1.3 31
  • 37 (a)
ptp-1 30 31
  • 35 (a)
 OneToMany
T22C1.8 31
  • 35 (a)
K07F5.8 31
  • 35 (a)
F55F8.7 31
  • 35 (a)
F25H5.7 31
  • 35 (a)
C02B10.6 31
  • 33 (a)
F36H12.10 31
  • 33 (a)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 41 (a)
 OneToMany
Species where no ortholog for PTPN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PTPN3 Gene

ENSEMBL:
Gene Tree for PTPN3 (if available)
TreeFam:
Gene Tree for PTPN3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTPN3: view image
Alliance of Genome Resources:
Additional Orthologs for PTPN3

Paralogs for PTPN3 Gene

Variants for PTPN3 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTPN3 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs140802922 Benign: not provided 109,389,341(-) G/A
NM_002829.4(PTPN3):c.2145C>T (p.Ile715=) 		NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs193920798 Uncertain Significance: Malignant tumor of prostate 109,436,926(-) G/A
NM_002829.4(PTPN3):c.632C>T (p.Ala211Val) 		MISSENSE
rs10116806 -- p.Asp763Asn
rs10979858 -- p.Thr409Ala
rs35285139 -- p.Asp77Asn

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PTPN3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PTPN3 Gene

Variant ID Type Subtype PubMed ID
esv2759709 CNV loss 17122850
nsv1077172 CNV deletion 25765185
nsv1126917 CNV deletion 24896259
nsv831685 CNV gain 17160897
nsv8557 CNV loss 18304495

Variation tolerance for PTPN3 Gene

Residual Variation Intolerance Score: 17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.57; 93.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTPN3 Gene

Human Gene Mutation Database (HGMD)
PTPN3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPN3
Leiden Open Variation Database (LOVD)
PTPN3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN3 Gene

Disorders for PTPN3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for PTPN3 Gene - From: ORP, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search PTPN3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PTPN3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PTPN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTPN3 Gene

Publications for PTPN3 Gene

  1. Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin. (PMID: 1648725) Yang Q … Tonks NK (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 22
  2. Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma. (PMID: 7874267) Ikuta S … Yachi A (Journal of gastroenterology 1994) 3 4 22
  3. Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients. (PMID: 24503127) Gao Q … Fan J (Gastroenterology 2014) 3 72
  4. Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PMID: 19167335) Barr AJ … Knapp S (Cell 2009) 3 4
  5. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 40

ExternalLinks

View latest publications for PTPN3 gene in Mastermind

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