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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of ... See more...
Aliases for PTPN3 Gene
Aliases for PTPN3 Gene
External Ids for PTPN3 Gene
- HGNC: 9655
- NCBI Entrez Gene: 5774
- Ensembl: ENSG00000070159
- OMIM®: 176877
- UniProtKB/Swiss-Prot: P26045
Previous GeneCards Identifiers for PTPN3 Gene
- GC09M102938
- GC09M103872
- GC09M105597
- GC09M107520
- GC09M109220
- GC09M111177
- GC09M112138
- GC09M081738
Summaries for PTPN3 Gene
-
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
GeneCards Summary for PTPN3 Gene
PTPN3 (Protein Tyrosine Phosphatase Non-Receptor Type 3) is a Protein Coding gene. Diseases associated with PTPN3 include Cholangiocarcinoma and Type 1 Diabetes Mellitus. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include phosphatase activity and cytoskeletal protein binding. An important paralog of this gene is PTPN4.
UniProtKB/Swiss-Prot Summary for PTPN3 Gene
-
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
Additional gene information for PTPN3 Gene
- HGNC (9655)
- NCBI Entrez Gene (5774)
- Ensembl (ENSG00000070159)
- OMIM® (176877)
- UniProtKB/Swiss-Prot (P26045)
- Open Targets Platform(ENSG00000070159)
- Monarch Initiative
- Search for PTPN3 at DataMed
- Search for PTPN3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPN3 Gene
Genomics for PTPN3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PTPN3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PTPN3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTPN3
- Top Transcription factor binding sites by QIAGEN in the PTPN3 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- Nkx2-5
- POU6F1 (c2)
- USF-1
- USF1
Genomic Locations for PTPN3 Gene
Latest Assembly
- chr9:109,375,466-109,538,395
- (GRCh38/hg38)
- Size:
- 162,930 bases
- Orientation:
- Minus strand
Previous Assembly
- chr9:112,137,974-112,260,587
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 122,614 bases
- Orientation:
- Minus strand
- chr9:112,137,746-112,260,590
- (GRCh37/hg19 by Ensembl)
- Size:
- 122,845 bases
- Orientation:
- Minus strand
Genomic View for PTPN3 Gene
Genes around PTPN3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q31 by HGNC
- 9q31.3 by Entrez Gene
- 9q31.3 by Ensembl
PTPN3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTPN3 Gene
Proteins for PTPN3 Gene
-
Protein details for PTPN3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P26045-PTN3_HUMAN
- Recommended name:
- Tyrosine-protein phosphatase non-receptor type 3
- Protein Accession:
- P26045
- A0AUW9
- E7EN99
- E9PGU7
Protein attributes for PTPN3 Gene
- Size:
- 913 amino acids
- Molecular mass:
- 103990 Da
- Quaternary structure:
- No Data Available
Three dimensional structures from OCA and Proteopedia for PTPN3 Gene
Protein Expression for PTPN3 Gene
Selected DME Specific Peptides for PTPN3 Gene
- P26045:
-
- YIATQGP
- YPLDIVR
- KCHQYWP
- WPDHGVP
- HCSAGIGR
Post-translational modifications for PTPN3 Gene
Other Protein References for PTPN3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for PTPN3
- Novus Biologicals Antibodies for PTPN3
- Invitrogen Antibodies for PTPN3 (AFLGC-PTPN3)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PTPN3
Protein products for research
-
OriGene Purified Proteins for PTPN3
- Search Origene for MassSpec and Protein Over-expression Lysates for PTPN3
- Origene Custom Protein Services for PTPN3
- antibodies-online: Show 6 available PTPN3 Proteins ranked by validation data
- Compare Top PTPN3 Proteins
-
Quality Products:
-
Abcam proteins for PTPN3
Assay products for research
Domains & Families for PTPN3 Gene
Gene Families for PTPN3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PTPN3 Gene
- InterPro:
- Blocks:
-
- PDZ/DHR/GLGF domain
- Band 4.1 domain
- ERM family signature
- Protein tyrosine phosphatase signature
- ProtoNet:
Suggested Antigen Peptide Sequences for PTPN3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ52384, highly similar to Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (B7Z8K9_HUMAN)
- cDNA, FLJ78965, highly similar to Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (B7Z9V1_HUMAN)
- Protein-tyrosine phosphatase H1 (PTN3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P26045UniProtKB/Swiss-Prot:
PTN3_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Function for PTPN3 Gene
Molecular function for PTPN3 Gene
- UniProtKB/Swiss-Prot Function:
- May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
- GENATLAS Biochemistry:
- protein tyrosine phosphatase,non receptor type 3,(ERM) family member,responding and participating in reorganization of membrane-cytoplasmic interactions
Enzyme Numbers (IUBMB) for PTPN3 Gene
Phenotypes From GWAS Catalog for PTPN3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001784 | phosphotyrosine residue binding | IPI | 10364224 |
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004725 | protein tyrosine phosphatase activity | IEA,TAS | -- |
| GO:0005515 | protein binding | IEA,IPI | 9341175 |
| GO:0008092 | cytoskeletal protein binding | IEA | -- |
Phenotypes for PTPN3 Gene
- MGI mutant phenotypes for PTPN3:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for PTPN3:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased viability
- Dynamic nuclei (hole, folded or small irregular)
- No cells
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Increased cell death in HCT116 cells
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Synthetic lethal with paclitaxel
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased cell spreading
Animal Models for research
-
Taconic Biosciences Mouse Models for PTPN3
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PTPN3 - Starting at $85 >
- * PTPN3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PTPN3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPN3
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTPN3
miRNA for PTPN3 Gene
- miRTarBase miRNAs that target PTPN3
-
- mmu-miR-425-5p (MIRT008571)
- hsa-miR-103a-3p (MIRT027192)
- hsa-miR-21-5p (MIRT031028)
- hsa-miR-16-5p (MIRT032073)
- hsa-miR-432-5p (MIRT439865)
- hsa-miR-377-5p (MIRT439867)
- mmu-miR-143-3p (MIRT589192)
- mmu-miR-5098 (MIRT589193)
- mmu-miR-466p-3p (MIRT589194)
- mmu-miR-466c-3p (MIRT589195)
- mmu-miR-466b-3p (MIRT589196)
- mmu-miR-421-3p (MIRT589197)
- mmu-miR-3082-5p (MIRT589198)
- mmu-miR-362-3p (MIRT589199)
- mmu-miR-329-3p (MIRT589200)
- mmu-miR-509-3p (MIRT604768)
- hsa-miR-125a-3p (MIRT612629)
- hsa-miR-8485 (MIRT612630)
- hsa-miR-4801 (MIRT612631)
- hsa-miR-4731-3p (MIRT612632)
- hsa-miR-6818-3p (MIRT622556)
- hsa-miR-4684-5p (MIRT622557)
- hsa-miR-3941 (MIRT622558)
- hsa-miR-593-3p (MIRT622559)
- hsa-miR-6895-3p (MIRT622560)
- hsa-miR-5699-3p (MIRT622561)
- hsa-miR-4421 (MIRT622562)
- hsa-miR-6748-3p (MIRT622563)
- hsa-miR-603 (MIRT622564)
- hsa-miR-362-3p (MIRT622565)
- hsa-miR-329-3p (MIRT622566)
- hsa-miR-4710 (MIRT627803)
- hsa-miR-1294 (MIRT671386)
- hsa-miR-6134 (MIRT672836)
- hsa-miR-7854-3p (MIRT672837)
- hsa-miR-6865-5p (MIRT674312)
- hsa-miR-6815-5p (MIRT674313)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPN3
- Browse OriGene Inhibitory RNA Products For PTPN3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPN3
Clone products for research
- Applied Biological Materials (abm): Clones for PTPN3 - Starting at $45 >
- * PTPN3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG220447
- MR220447
- MR220447L3
- MR220447L4
- RC215851
- RC215851L1
- RC215851L2
- RC215851L3
- RC215851L4
- RC226648
- RC226648L3
- RC226648L4
- RC226736
- RC226736L3
- RC226736L4
- RC226819
- RC226819L3
- RC226819L4
- RC226916
- RC226916L3
- RC226916L4
- RC226972
- RC226972L3
- RC226972L4
- RG215851
- RG226648
- RG226736
- RG226819
- RG226916
- RG226972
- MR220447L3V
- MR220447L4V
- RC215851L1V
- RC215851L2V
- RC215851L3V
- RC215851L4V
- RC226648L3V
- RC226648L4V
- RC226736L3V
- RC226736L4V
- RC226819L3V
- RC226819L4V
- RC226916L3V
- RC226916L4V
- RC226972L3V
- RC226972L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PTPN3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPN3
Cell Lines for research
-
Horizon Cell Lines for PTPN3
No data available for Transcription Factor Targets and HOMER Transcription for PTPN3 Gene
Localization for PTPN3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTPN3 Gene
- Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasm, cytoskeleton.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| nucleus | 3 |
| cytosol | 3 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 10940933 |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0009898 | cytoplasmic side of plasma membrane | IBA,IDA | 10940933 |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTPN3 Gene
Pathways & Interactions for PTPN3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
| 2 | TNFR1 Pathway |
Apoptotic Pathways Triggered By HIV1
.42
|
|
| 3 | PAK Pathway |
Epithelial Adherens Junctions
.36
|
|
| 4 | Listeria monocytogenes entry into host cells | ||
| 5 | Signaling by GPCR | ||
Pathways by source for PTPN3 Gene
3 Reactome pathways for PTPN3 Gene
6 Qiagen pathways for PTPN3 Gene
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Apoptotic Pathways Triggered By HIV1
- cAMP Pathway
- Epithelial Adherens Junctions
Interacting Proteins for PTPN3 Gene
Selected Interacting proteins:
P26045-PTN3_HUMAN
ENSP00000363667
for PTPN3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PTPN3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | IEA,IDA | 10364224 |
| GO:0016311 | dephosphorylation | IEA | -- |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IEA | -- |
| GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway | TAS | -- |
| GO:0045930 | negative regulation of mitotic cell cycle | IDA | 10364224 |
Transcripts for PTPN3 Gene
mRNA/cDNA for PTPN3 Gene
- 6 REFSEQ mRNAs :
- 26 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262539 6832 nts (view in UCSC)
- ENST00000374541 6704 nts (view in UCSC)
- ENST00000412145 8765 nts (view in UCSC)
- ENST00000446349 8630 nts (view in UCSC)
- ENST00000447271 587 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PTPN3 - Starting at $85 >
- * PTPN3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PTPN3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPN3
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTPN3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPN3
- Browse OriGene Inhibitory RNA Products For PTPN3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPN3
Clone products for research
- Applied Biological Materials (abm): Clones for PTPN3 - Starting at $45 >
- * PTPN3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG220447
- MR220447
- MR220447L3
- MR220447L4
- RC215851
- RC215851L1
- RC215851L2
- RC215851L3
- RC215851L4
- RC226648
- RC226648L3
- RC226648L4
- RC226736
- RC226736L3
- RC226736L4
- RC226819
- RC226819L3
- RC226819L4
- RC226916
- RC226916L3
- RC226916L4
- RC226972
- RC226972L3
- RC226972L4
- RG215851
- RG226648
- RG226736
- RG226819
- RG226916
- RG226972
- MR220447L3V
- MR220447L4V
- RC215851L1V
- RC215851L2V
- RC215851L3V
- RC215851L4V
- RC226648L3V
- RC226648L4V
- RC226736L3V
- RC226736L4V
- RC226819L3V
- RC226819L4V
- RC226916L3V
- RC226916L4V
- RC226972L3V
- RC226972L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PTPN3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPN3
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | · | 27c | · | 27d | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30a | · | 30b | · | 30c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||||||||||||
| SP14: |
Relevant External Links for PTPN3 Gene
- GeneLoc Exon Structure for
- PTPN3
Expression for PTPN3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Ureteric Bud Tip Cells Ureteric Bud
- Metanephros
mRNA differential expression in normal tissues according to GTEx for PTPN3 Gene
This gene is overexpressed in Muscle - Skeletal (x9.4), Liver (x4.9), and Heart - Left Ventricle (x4.1).
This gene is overexpressed in Placenta (52.9) and Liver (11.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPN3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTPN3
SOURCE GeneReport for Unigene cluster for PTPN3 Gene:
Hs.436429Evidence on tissue expression from TISSUES for PTPN3 Gene
- Nervous system(4.9)
- Intestine(4.5)
- Liver(4.5)
- Skin(2.3)
- Kidney(2.2)
- Muscle(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPN3 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- integumentary
- urinary
Regions:
Abdomen:
- biliary tract
- gallbladder
- kidney
- liver
General:
- skin
Primer products for research
-
OriGene qPCR primer pairs for PTPN3
-
OriGene qPCR primer pairs and template standards for PTPN3
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt for PTPN3 Gene
Orthologs for PTPN3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PTPN3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PTPN3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PTPN3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ptpn3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ptpn3 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PTPN3 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PTPN3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PTPN3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PTPN3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ptpn3 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ptpn3 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Ptpmeg 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | F36H1.3 32 |
|
|
|
| ptp-1 31 32 |
|
OneToMany | |||
| T22C1.8 32 |
|
|
|||
| K07F5.8 32 |
|
|
|||
| F55F8.7 32 |
|
|
|||
| F25H5.7 32 |
|
|
|||
| C02B10.6 32 |
|
|
|||
| F36H12.10 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for PTPN3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PTPN3 Gene
- ENSEMBL:
- Gene Tree for PTPN3 (if available)
- TreeFam:
- Gene Tree for PTPN3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PTPN3: view image
Paralogs for PTPN3 Gene
Paralogs for PTPN3 Gene
(35) SIMAP similar genes for PTPN3 Gene using alignment to 4 proteins:
- PTN3_HUMAN
- B7Z8K9_HUMAN
- B7Z9V1_HUMAN
- J3KN34_HUMAN
Variants for PTPN3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTPN3 Gene
| SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs140802922 | Benign: not provided | 109,389,341(-) |
G/A NM_002829.4(PTPN3):c.2145C>T (p.Ile715=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs193920798 | Uncertain Significance: Malignant tumor of prostate | 109,436,926(-) |
G/A NM_002829.4(PTPN3):c.632C>T (p.Ala211Val) |
MISSENSE | |
| rs10116806 | - |
p.Asp763Asn |
|||
| rs10979858 | - |
p.Thr409Ala |
|||
| rs35285139 | - |
p.Asp77Asn |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759709 | CNV | loss | 17122850 |
| nsv1077172 | CNV | deletion | 25765185 |
| nsv1126917 | CNV | deletion | 24896259 |
| nsv831685 | CNV | gain | 17160897 |
| nsv8557 | CNV | loss | 18304495 |
Residual Variation Intolerance Score:
17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.57;
93.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PTPN3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN3 Gene
Disorders for PTPN3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cholangiocarcinoma |
|
|
| type 1 diabetes mellitus |
|
|
| hyperinsulinemic hypoglycemia, familial, 5 |
|
|
| non-functioning pituitary adenoma |
|
|
| scott syndrome |
|
|
Search PTPN3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PTPN3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PTPN3 Gene
Publications for PTPN3 Gene
- Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin. (PMID: 1648725) Yang Q … Tonks NK (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 23
- Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma. (PMID: 7874267) Ikuta S … Yachi A (Journal of gastroenterology 1994) 3 4 23
- Large-scale structural analysis of the classical human protein tyrosine phosphatome. (PMID: 19167335) Barr AJ … Knapp S (Cell 2009) 3 4
- Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 41
- Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. (PMID: 17947517) Töpffer S … Steger G (The Journal of general virology 2007) 3 23
ExternalLinks
Products for PTPN3 Gene
- Custom Antibody ServicesOriGene Antibodies for PTPN3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PTPN3
- Search Origene for MassSpec and Protein Over-expression Lysates for PTPN3
- Origene Custom Protein Services for PTPN3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPN3
- Browse OriGene Inhibitory RNA Products For PTPN3
- OriGene qPCR primer pairs for PTPN3
- OriGene qPCR primer pairs and template standards for PTPN3
- OriGene CRISPR knockouts for PTPN3
- MG220447
- MR220447
- MR220447L3
- MR220447L4
- RC215851
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- RC226736
- RC226736L3
- RC226736L4
- RC226819
- RC226819L3
- RC226819L4
- RC226916
- RC226916L3
- RC226916L4
- RC226972
- RC226972L3
- RC226972L4
- RG215851
- RG226648
- RG226736
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- RG226916
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- MR220447L3V
- MR220447L4V
- RC215851L1V
- RC215851L2V
- RC215851L3V
- RC215851L4V
- RC226648L3V
- RC226648L4V
- RC226736L3V
- RC226736L4V
- RC226819L3V
- RC226819L4V
- RC226916L3V
- RC226916L4V
- RC226972L3V
- RC226972L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PTPN3
- Sino Biological Human cDNA Clone for PTPN3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PTPN3
- Novus Biologicals proteins and lysates for PTPN3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for PTPN3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for PTPN3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PTPN3 (AFLGC-PTPN3)
- VectorBuilder Custom and pre-made DNA vectors for PTPN3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PTPN3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PTPN3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PTPN3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PTPN3
- antibodies-online: Show 14 available PTPN3 Antibodies ranked by validation data
- Compare Top PTPN3 Antibodies
- antibodies-online: Search results for available PTPN3 related products ranked by validation data
- antibodies-online: Show 6 available PTPN3 Proteins ranked by validation data
- Compare Top PTPN3 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for PTPN3
- Search Santa Cruz Biotechnology (SCBT) for PTPN3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PTPN3
- Horizon Cell Lines for PTPN3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPN3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPN3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PTPN3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPN3
Sources for PTPN3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB