The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, m... See more...

Aliases for PTPN21 Gene

Aliases for PTPN21 Gene

  • Protein Tyrosine Phosphatase Non-Receptor Type 21 2 3 5
  • PTPD1 2 3 4
  • Tyrosine-Protein Phosphatase Non-Receptor Type 21 3 4
  • Protein-Tyrosine Phosphatase D1 3 4
  • EC 3.1.3.48 4 50
  • PTPRL10 2 3
  • DJ1175B15.2 (Protein Tyrosine Phosphatase, Non-Receptor Type 21) 3
  • EC 3.1.3 50
  • PTPN21 5

External Ids for PTPN21 Gene

Previous GeneCards Identifiers for PTPN21 Gene

  • GC14M086439
  • GC14M082750
  • GC14M086924
  • GC14M088003
  • GC14M088932
  • GC14M069102

Summaries for PTPN21 Gene

Entrez Gene Summary for PTPN21 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTPN21 Gene

PTPN21 (Protein Tyrosine Phosphatase Non-Receptor Type 21) is a Protein Coding gene. Among its related pathways are Signaling events mediated by focal adhesion kinase and PAK Pathway. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is PTPN14.

Gene Wiki entry for PTPN21 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPN21 Gene

Genomics for PTPN21 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTPN21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J088550 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 255.3 +1.9 1875 5.3 MYC JUND POLR2A YY1 DEK ELK1 ETS1 TBP ZNF341 MNT PTPN21 ENSG00000258789 SPATA7 ENSG00000258983 EML5 HSALNG0103038
GH14J088487 Enhancer 0.6 Ensembl ENCODE 16 +66.4 66428 2.8 CUX1 TCF7L2 EGR2 ZFHX2 HSALNG0103034 lnc-SPATA7-2 SPATA7 RNU4-22P PTPN21 ENSG00000258983
GH14J089362 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 5.1 -812.2 -812208 8.8 BCLAF1 SP1 ZMYM3 POLR2A CEBPA ATF3 YY1 MXD4 BCL11A KLF11 FOXN3 PTPN21 HSALNG0103084 LOC101928817 ENSG00000258752 ENSG00000258380 TTC8
GH14J088594 Promoter 0.4 EPDnew 10.8 -39.4 -39394 0.1 USF1 ZC3H14 PTPN21 ENSG00000278576 HSALNG0103042 NONHSAG015659.2 EML5
GH14J088481 Enhancer 0.4 Ensembl ENCODE 10.7 +72.6 72571 2.3 KDM1A SPATA7 PTPN21 lnc-SPATA7-2 piR-52368-049
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTPN21 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTPN21

Top Transcription factor binding sites by QIAGEN in the PTPN21 gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • c-Jun
  • ITF-2
  • Lmo2
  • Max1
  • RP58
  • STAT5B
  • Tal-1beta

Genomic Locations for PTPN21 Gene

Latest Assembly
chr14:88,465,778-88,555,007
(GRCh38/hg38)
Size:
89,230 bases
Orientation:
Minus strand

Previous Assembly
chr14:88,932,122-89,021,351
(GRCh37/hg19 by Entrez Gene)
Size:
89,230 bases
Orientation:
Minus strand

chr14:88,932,122-89,021,077
(GRCh37/hg19 by Ensembl)
Size:
88,956 bases
Orientation:
Minus strand

Genomic View for PTPN21 Gene

Genes around PTPN21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPN21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPN21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN21 Gene

Proteins for PTPN21 Gene

  • Protein details for PTPN21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16825-PTN21_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 21
    Protein Accession:
    Q16825

    Protein attributes for PTPN21 Gene

    Size:
    1174 amino acids
    Molecular mass:
    133281 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PTPN21 Gene

Selected DME Specific Peptides for PTPN21 Gene

Q16825:
  • IAMVTAEEEGGR
  • YIATQGP
  • GQERTVWHLQYTDWP
  • SLQEVSEPLTA
  • TRYQYYLQ
  • EGLPPLG
  • RTQREGPE
  • TLSVESTGQE
  • VHCSAGVGRTG
  • GFLSYLEEIQSVRRHTNS
  • CYATTGLK
  • PTKENNTGYINASHIKV
  • LEAVAQRLELRE
  • LAGLAVQADFGD

Post-translational modifications for PTPN21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PTPN21 Gene

Gene Families for PTPN21 Gene

Suggested Antigen Peptide Sequences for PTPN21 Gene

GenScript: Design optimal peptide antigens:
  • Protein-tyrosine phosphatase D1 (PTN21_HUMAN)
  • DJ1175B15.2 (Protein tyrosine phosphatase, non-receptor type 21) (Q8WX29_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16825

UniProtKB/Swiss-Prot:

PTN21_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with PTPN21: view

Function for PTPN21 Gene

Molecular function for PTPN21 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
GENATLAS Biochemistry:
protein tyrosine phosphatase,non-receptor type 21,widely expressed

Enzyme Numbers (IUBMB) for PTPN21 Gene

Phenotypes From GWAS Catalog for PTPN21 Gene

Gene Ontology (GO) - Molecular Function for PTPN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity TAS,IBA 21873635
GO:0005515 protein binding IPI 15143158
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with PTPN21: view
genes like me logo Genes that share phenotypes with PTPN21: view

Animal Models for research

  • Taconic Biosciences Mouse Models for PTPN21

miRNA for PTPN21 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPN21

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTPN21 Gene

Localization for PTPN21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN21 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPN21 gene
Compartment Confidence
cytoskeleton 4
mitochondrion 3
cytosol 3
nucleus 2
plasma membrane 1
extracellular 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (2)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PTPN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005856 cytoskeleton TAS,IEA --
genes like me logo Genes that share ontologies with PTPN21: view

Pathways & Interactions for PTPN21 Gene

PathCards logo

SuperPathways for PTPN21 Gene

SuperPathway Contained pathways
1 PAK Pathway
.36
2 Signaling events mediated by focal adhesion kinase
genes like me logo Genes that share pathways with PTPN21: view

Pathways by source for PTPN21 Gene

1 BioSystems pathway for PTPN21 Gene
1 Qiagen pathway for PTPN21 Gene
  • Epithelial Adherens Junctions

SIGNOR curated interactions for PTPN21 Gene

Activates:

Gene Ontology (GO) - Biological Process for PTPN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 7519780
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with PTPN21: view

Drugs & Compounds for PTPN21 Gene

(2) Drugs for PTPN21 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0
genes like me logo Genes that share compounds with PTPN21: view

Transcripts for PTPN21 Gene

mRNA/cDNA for PTPN21 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPN21

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN21 Gene

No ASD Table

Relevant External Links for PTPN21 Gene

GeneLoc Exon Structure for
PTPN21

Expression for PTPN21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTPN21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPN21 Gene

This gene is overexpressed in Pancreatic juice (55.6) and Placenta (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPN21 Gene



Protein tissue co-expression partners for PTPN21 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTPN21

SOURCE GeneReport for Unigene cluster for PTPN21 Gene:

Hs.437040

Evidence on tissue expression from TISSUES for PTPN21 Gene

  • Muscle(4.4)
  • Liver(4.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with PTPN21: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPN21 Gene

Orthologs for PTPN21 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN21 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PTPN21 29 30
  • 99.23 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 90 (a)
OneToMany
-- 30
  • 83 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia PTPN21 29 30
  • 86.92 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 86 (a)
OneToMany
-- 30
  • 86 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia PTPN21 29 30
  • 83.75 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ptpn21 29 16 30
  • 83.73 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ptpn21 29
  • 82.48 (n)
Chicken
(Gallus gallus)
Aves PTPN21 29 30
  • 76.18 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PTPN21 30
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ptpn21 29
  • 71.69 (n)
Str.19434 29
Zebrafish
(Danio rerio)
Actinopterygii ptpn21 29 30
  • 70.62 (n)
OneToOne
Dr.19765 29
Fruit Fly
(Drosophila melanogaster)
Insecta Pez 30 31
  • 27 (a)
OneToMany
Species where no ortholog for PTPN21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PTPN21 Gene

ENSEMBL:
Gene Tree for PTPN21 (if available)
TreeFam:
Gene Tree for PTPN21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTPN21: view image
Alliance of Genome Resources:
Additional Orthologs for PTPN21

Paralogs for PTPN21 Gene

(16) SIMAP similar genes for PTPN21 Gene using alignment to 5 proteins:

  • PTN21_HUMAN
  • G3V1Q9_HUMAN
  • G3V3S6_HUMAN
  • H0YJ59_HUMAN
  • Q8WX29_HUMAN
genes like me logo Genes that share paralogs with PTPN21: view

Variants for PTPN21 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTPN21 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs140596899 Likely Benign: not provided 88,479,075(-) G/C
NM_007039.4(PTPN21):c.2356C>G (p.Pro786Ala)
MISSENSE
rs145819801 Benign: not provided 88,479,631(-) G/C
NM_007039.4(PTPN21):c.1800C>G (p.His600Gln)
MISSENSE
rs193920899 Uncertain Significance: Malignant tumor of prostate 88,550,324(-) T/G
NM_007039.4(PTPN21):c.94A>C (p.Asn32His)
MISSENSE
rs61746983 Benign: not provided 88,469,016(-) C/T
NM_007039.4(PTPN21):c.3296G>A (p.Ser1099Asn)
MISSENSE
rs61747078 Benign: not provided 88,479,169(-) G/A
NM_007039.4(PTPN21):c.2262C>T (p.Pro754=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PTPN21 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PTPN21 Gene

Variant ID Type Subtype PubMed ID
esv3426068 CNV insertion 20981092
esv3635277 CNV gain 21293372
nsv1049685 CNV gain 25217958
nsv1122923 CNV deletion 24896259
nsv456391 CNV gain 19166990
nsv516846 CNV gain 19592680
nsv565512 CNV gain 21841781

Variation tolerance for PTPN21 Gene

Residual Variation Intolerance Score: 5.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.85; 91.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTPN21 Gene

Human Gene Mutation Database (HGMD)
PTPN21
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPN21
Leiden Open Variation Database (LOVD)
PTPN21

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN21 Gene

Disorders for PTPN21 Gene

Additional Disease Information for PTPN21

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for PTPN21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPN21 Gene

Publications for PTPN21 Gene

  1. Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain. (PMID: 7519780) Møller NP … Ullrich A (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4
  2. Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability. (PMID: 19000305) Korff S … Gebert J (BMC cancer 2008) 3 40
  3. Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration. (PMID: 18223254) Carlucci A … Feliciello A (The Journal of biological chemistry 2008) 3 22
  4. Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. (PMID: 16918960) Zeitlin AA … Simmonds MJ (Clinical endocrinology 2006) 3 40
  5. Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling. (PMID: 15143158) Cardone L … Feliciello A (Molecular and cellular biology 2004) 3 22

Products for PTPN21 Gene

Sources for PTPN21 Gene