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Aliases for PTPN20 Gene

Aliases for PTPN20 Gene

  • Protein Tyrosine Phosphatase, Non-Receptor Type 20 2 3 5
  • Protein Tyrosine Phosphatase, Non-Receptor Type 20A 2 3
  • Protein Tyrosine Phosphatase, Non-Receptor Type 20B 2 3
  • EC 4 56
  • PTPN20A 3 4
  • PTPN20B 3 4
  • Tyrosine-Protein Phosphatase Non-Receptor Type 20 3
  • BA142I17.1 3
  • BA42B19.1 3
  • HPTPN20 4
  • CT126 3

External Ids for PTPN20 Gene

Previous HGNC Symbols for PTPN20 Gene

  • PTPN20A
  • PTPN20B

Previous GeneCards Identifiers for PTPN20 Gene

  • GC10M048358

Summaries for PTPN20 Gene

Entrez Gene Summary for PTPN20 Gene

  • The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes. The encoded protein appears to be targeted to sites of actin polymerization. A pseudogene of this gene has been defined on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for PTPN20 Gene

PTPN20 (Protein Tyrosine Phosphatase, Non-Receptor Type 20) is a Protein Coding gene. Among its related pathways are PAK Pathway. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is PTPN13.

UniProtKB/Swiss-Prot for PTPN20 Gene

  • Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates.

Additional gene information for PTPN20 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPN20 Gene

Genomics for PTPN20 Gene

GeneHancer (GH) Regulatory Elements for PTPN20 Gene

Promoters and enhancers for PTPN20 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I046911 Promoter 1 EPDnew Ensembl 550.8 +0.2 194 0.4 PTPN20 PIR60586
GH10I047401 Enhancer 1.2 Ensembl ENCODE 5.6 +493.9 493890 8.4 PKNOX1 CLOCK ATF1 ARNT ZNF133 SIN3A GLI4 ZNF2 ZBTB7B BRCA1 AGAP9 BMS1P2 LOC105378289 BMS1P1 MAPK8 PTPN20 LOC105378292 ZNF488
GH10I046522 Enhancer 1.3 Ensembl ENCODE 3.9 -386.7 -386698 3.6 HDGF ARNT SIN3A YBX1 ZNF2 ZBTB7B ZNF766 ZNF143 ZNF207 FOS PARGP1 AGAP4 BMS1P1 AGAP9 WASHC2C LOC105378289 AGAP10P FAM21FP ZFAND4 FAM35BP
GH10I047104 Enhancer 0.4 ENCODE 4.4 +193.4 193362 1.2 MAX MYC GDF10 RBP3 PTPN20 PIR48231 LOC105378291
GH10I046987 Enhancer 0.2 Ensembl 0.2 +76.1 76123 0.6 PIR61149 PTPN20 PIR41333
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PTPN20 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PTPN20 Gene

Genomic Locations for PTPN20 Gene
120,435 bases
Plus strand

Genomic View for PTPN20 Gene

Genes around PTPN20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPN20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPN20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN20 Gene

Proteins for PTPN20 Gene

  • Protein details for PTPN20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 20
    Protein Accession:
    Secondary Accessions:
    • A6NNH8
    • B7ZKV3
    • Q4JDG6
    • Q4JDK1
    • Q4JDK5
    • Q4JDK6
    • Q4JDK8
    • Q4JDK9
    • Q4JDL0
    • Q4JDL1
    • Q4JDL4
    • Q4JDL5
    • Q4JDL6
    • Q4JDL7
    • Q4JDL8
    • Q5RJ33
    • Q5T1G3

    Protein attributes for PTPN20 Gene

    420 amino acids
    Molecular mass:
    48423 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAW28797.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

neXtProt entry for PTPN20 Gene

Selected DME Specific Peptides for PTPN20 Gene


Post-translational modifications for PTPN20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTPN20 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PTPN20 Gene

Gene Families for PTPN20 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with PTPN20: view

Function for PTPN20 Gene

Molecular function for PTPN20 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates.

Enzyme Numbers (IUBMB) for PTPN20 Gene

Gene Ontology (GO) - Molecular Function for PTPN20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with PTPN20: view
genes like me logo Genes that share phenotypes with PTPN20: view

Animal Models for PTPN20 Gene

MGI Knock Outs for PTPN20:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPN20

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PTPN20 Gene

Localization for PTPN20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN20 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the microtubule-organizing center and intracellular membrane compartments.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPN20 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PTPN20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA,IDA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with PTPN20: view

Pathways & Interactions for PTPN20 Gene

SuperPathways for PTPN20 Gene

SuperPathway Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with PTPN20: view

Pathways by source for PTPN20 Gene

1 Qiagen pathway for PTPN20 Gene

Gene Ontology (GO) - Biological Process for PTPN20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with PTPN20: view

No data available for SIGNOR curated interactions for PTPN20 Gene

Drugs & Compounds for PTPN20 Gene

(2) Drugs for PTPN20 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with PTPN20: view

Transcripts for PTPN20 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN20 Gene

No ASD Table

Relevant External Links for PTPN20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTPN20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTPN20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPN20 Gene

This gene is overexpressed in Esophagus (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTPN20 Gene

Protein tissue co-expression partners for PTPN20 Gene

NURSA nuclear receptor signaling pathways regulating expression of PTPN20 Gene:


mRNA Expression by UniProt/SwissProt for PTPN20 Gene:

Tissue specificity: Present in many cell lines (at protein level). Widely expressed.

Evidence on tissue expression from TISSUES for PTPN20 Gene

  • Lung(4.3)
  • Heart(4.1)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with PTPN20: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPN20 Gene

Orthologs for PTPN20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PTPN20 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
PTPN20A 33
  • 99.44 (n)
(Canis familiaris)
Mammalia PTPN20B 33
  • 84.5 (n)
-- 34
  • 67 (a)
(Bos Taurus)
Mammalia PTPN20B 33
  • 79.52 (n)
-- 34
  • 69 (a)
(Rattus norvegicus)
Mammalia Ptpn20b 33
  • 78.6 (n)
(Mus musculus)
Mammalia Ptpn20 33 16 34
  • 77.83 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 54 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 37 (a)
(Gallus gallus)
Aves -- 34
  • 15 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
(Danio rerio)
Actinopterygii ptpn11b 34
  • 20 (a)
(Caenorhabditis elegans)
Secernentea K07F5.8 34
  • 25 (a)
F47B3.7 34
  • 23 (a)
T27A3.5 34
  • 23 (a)
ZK484.7 34
  • 23 (a)
C55B7.3 34
  • 22 (a)
F47B3.6 34
  • 22 (a)
Y48G9A.9 34
  • 22 (a)
C17H12.3 34
  • 21 (a)
F10G8.1 34
  • 21 (a)
C02B10.6 34
  • 20 (a)
C33H5.16 34
  • 20 (a)
F20H11.4 34
  • 20 (a)
F36H12.10 34
  • 20 (a)
F47B3.1 34
  • 20 (a)
F55F8.7 34
  • 19 (a)
F25H5.7 34
  • 17 (a)
F36H1.3 34
  • 17 (a)
T28F4.3 34
  • 17 (a)
M04G7.2 34
  • 16 (a)
ZK354.8 34
  • 16 (a)
B0207.1 34
  • 14 (a)
T22C1.8 34
  • 13 (a)
ZK616.8 34
  • 13 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PTP1 33
  • 48.51 (n)
(Oryza sativa)
Liliopsida Os12g0174800 33
  • 46.58 (n)
Species where no ortholog for PTPN20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTPN20 Gene

Gene Tree for PTPN20 (if available)
Gene Tree for PTPN20 (if available)

Paralogs for PTPN20 Gene

Paralogs for PTPN20 Gene

(3) SIMAP similar genes for PTPN20 Gene using alignment to 1 proteins: Pseudogenes for PTPN20 Gene

genes like me logo Genes that share paralogs with PTPN20: view

Variants for PTPN20 Gene

Sequence variations from dbSNP and Humsavar for PTPN20 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000405237 -- 47,000,464(+) C/T intron_variant
rs1000666132 -- 46,999,158(+) A/G intron_variant
rs1000734035 -- 47,000,792(+) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1001142130 -- 46,998,859(+) C/T intron_variant
rs1001484054 -- 46,992,672(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PTPN20 Gene

Variant ID Type Subtype PubMed ID
dgv115e214 CNV gain 21293372
dgv124e214 CNV gain 21293372
dgv136e199 CNV deletion 23128226
dgv450n106 CNV deletion 24896259
dgv734n100 CNV gain 25217958
dgv737n100 CNV loss 25217958
dgv738n100 CNV loss 25217958
dgv739n100 CNV gain 25217958
dgv740n100 CNV gain+loss 25217958
nsv1068308 CNV deletion 25765185
nsv1068691 CNV deletion 25765185
nsv1069476 CNV deletion 25765185
nsv1143505 CNV deletion 24896259
nsv433259 CNV loss 18776910
nsv550716 CNV gain 21841781
nsv550717 CNV loss 21841781
nsv550718 CNV loss 21841781
nsv550719 CNV loss 21841781
nsv550720 CNV loss 21841781
nsv550803 CNV loss 21841781
nsv820767 CNV deletion 20802225
nsv820873 CNV deletion 20802225
nsv831849 CNV gain 17160897
nsv831850 CNV gain+loss 17160897
nsv831862 CNV gain 17160897
nsv8634 CNV gain+loss 18304495
nsv947921 CNV duplication 23825009
nsv947966 CNV duplication 23825009
nsv951589 CNV deletion 24416366
nsv951590 CNV deletion 24416366

Additional Variant Information for PTPN20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PTPN20 Gene

Disorders for PTPN20 Gene

Additional Disease Information for PTPN20

No disorders were found for PTPN20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPN20 Gene

Publications for PTPN20 Gene

  1. Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization. (PMID: 15790311) Fodero-Tavoletti MT … Tiganis T (The Biochemical journal 2005) 2 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for PTPN20 Gene

Sources for PTPN20 Gene

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