Aliases for PTPN18 Gene
External Ids for PTPN18 Gene
Previous GeneCards Identifiers for PTPN18 Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
GeneCards Summary for PTPN18 Gene
PTPN18 (Protein Tyrosine Phosphatase Non-Receptor Type 18) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and B cell receptor signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include phosphatase activity and non-membrane spanning protein tyrosine phosphatase activity. An important paralog of this gene is PTPN22.
UniProtKB/Swiss-Prot Summary for PTPN18 Gene
Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.