The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associat... See more...

Aliases for PTPN14 Gene

Aliases for PTPN14 Gene

  • Protein Tyrosine Phosphatase Non-Receptor Type 14 2 3 5
  • PEZ 2 3 4
  • Tyrosine-Protein Phosphatase Non-Receptor Type 14 3 4
  • Protein-Tyrosine Phosphatase Pez 3 4
  • EC 3.1.3.48 4 51
  • Cytoskeletal-Associated Protein Tyrosine Phosphatase 3
  • EC 3.1.3 51
  • CATLPH 3
  • PTPN14 5
  • PTP36 3
  • PTPD2 4

External Ids for PTPN14 Gene

Previous GeneCards Identifiers for PTPN14 Gene

  • GC01M213183
  • GC01M210351
  • GC01M211133
  • GC01M211587
  • GC01M210919
  • GC01M212597
  • GC01M214530
  • GC01M185197
  • GC01M214523
  • GC01M214336

Summaries for PTPN14 Gene

Entrez Gene Summary for PTPN14 Gene

  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]

GeneCards Summary for PTPN14 Gene

PTPN14 (Protein Tyrosine Phosphatase Non-Receptor Type 14) is a Protein Coding gene. Diseases associated with PTPN14 include Choanal Atresia And Lymphedema and Metatypical Basal Cell Carcinoma. Among its related pathways are Angiogenesis (CST) and Adhesion. Gene Ontology (GO) annotations related to this gene include phosphatase activity and transcription coregulator activity. An important paralog of this gene is PTPN21.

UniProtKB/Swiss-Prot Summary for PTPN14 Gene

  • Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.

Gene Wiki entry for PTPN14 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPN14 Gene

Genomics for PTPN14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTPN14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J214546 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 606.7 +2.2 2208 7.7 CREB1 TEAD4 PRDM10 ZNF629 KDM1A CTCF ZNF692 BACH1 FOXA1 PRDM1 PTPN14 lnc-PTPN14-4 MF281438-004 SMYD2
GH01J214482 Promoter/Enhancer 0.5 EPDnew dbSUPER 611.4 +69.7 69660 0.1 PTPN14 ENSG00000213036 LOC643454 lnc-USH2A-4 HE856199 lnc-PTPN14-4 SMYD2
GH01J214450 Enhancer 1 Ensembl ENCODE dbSUPER 16.6 +98.2 98159 7.4 CTCF ZNF600 PKNOX1 SMARCC1 JUND SMARCC2 CEBPB NR3C1 FOS OSR2 PTPN14 SMYD2 KCNK2 PROX1 HE856199 ENSG00000213036
GH01J214580 Enhancer 1.1 Ensembl ENCODE dbSUPER 12 -30.8 -30781 4.7 CTCF RFX1 ZNF692 ZNF174 FOXA1 PRDM1 REST RAD21 POLR2A TRIM22 PTPN14 CENPF lnc-PTPN14-4
GH01J214524 Enhancer 0.9 ENCODE dbSUPER 12.1 +26.4 26426 2.6 ZNF629 FOXA1 IKZF2 ZNF561 DPF2 GATAD2B TSHZ1 CEBPB SCRT1 KLF13 PTPN14 KRT18P12 RF00994-090 lnc-PTPN14-4 SMYD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTPN14 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTPN14

Top Transcription factor binding sites by QIAGEN in the PTPN14 gene promoter:
  • AhR
  • ATF6
  • c-Myc
  • FOXO3
  • FOXO3a
  • FOXO3b
  • FOXO4
  • Roaz
  • TBP
  • ZIC2

Genomic Locations for PTPN14 Gene

Genomic Locations for PTPN14 Gene
chr1:214,348,700-214,552,449
(GRCh38/hg38)
Size:
203,750 bases
Orientation:
Minus strand
chr1:214,522,039-214,725,792
(GRCh37/hg19)
Size:
203,754 bases
Orientation:
Minus strand

Genomic View for PTPN14 Gene

Genes around PTPN14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPN14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPN14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN14 Gene

Proteins for PTPN14 Gene

  • Protein details for PTPN14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15678-PTN14_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 14
    Protein Accession:
    Q15678
    Secondary Accessions:
    • Q5VSI0

    Protein attributes for PTPN14 Gene

    Size:
    1187 amino acids
    Molecular mass:
    135261 Da
    Quaternary structure:
    • Interacts with FLT4; the interaction is enhanced by stimulation with VEGFC. Interacts (via PPxY motifs) with YAP1 (via WW domains); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional co-activator activity.

    Three dimensional structures from OCA and Proteopedia for PTPN14 Gene

neXtProt entry for PTPN14 Gene

Selected DME Specific Peptides for PTPN14 Gene

Q15678:
  • IAMVTAEEEGGR
  • YIATQGP
  • GQERTVWHLQYTDWP
  • SLQEVSEPLTA
  • QVIRLAG
  • VVHCSAG
  • TRYQYYLQ
  • TLSVESTGQE
  • VHCSAGVGRTG
  • GFLSYLEEIQSVRRHTNS
  • CYATTGLK
  • PTKENNTGYINASHIKV
  • LEAVAQRLELRE
  • PIVVHCS
  • LAGLAVQADFGD

Post-translational modifications for PTPN14 Gene

  • Ubiquitinated by the ECS (Elongin BC-CUL2/5-SOCS-box protein)/LRR1 E3 ligase complex and subsequently targeted to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTPN14 Gene

Domains & Families for PTPN14 Gene

Gene Families for PTPN14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PTPN14 Gene

GenScript: Design optimal peptide antigens:
  • Protein-tyrosine phosphatase pez (PTN14_HUMAN)
  • PTPN14 protein (Q6PJC3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15678

UniProtKB/Swiss-Prot:

PTN14_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with PTPN14: view

Function for PTPN14 Gene

Molecular function for PTPN14 Gene

UniProtKB/Swiss-Prot Function:
Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
UniProtKB/Swiss-Prot Induction:
Up-regulated at protein level by cell density. However, at the mRNA level remains the same regardless of the status of cell density.
GENATLAS Biochemistry:
protein tyrosine phosphatase,non receptor type 14

Enzyme Numbers (IUBMB) for PTPN14 Gene

Phenotypes From GWAS Catalog for PTPN14 Gene

Gene Ontology (GO) - Molecular Function for PTPN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription coregulator activity IMP 22525271
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA,IMP 22525271
GO:0005515 protein binding IPI 22525271
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PTPN14: view
genes like me logo Genes that share phenotypes with PTPN14: view

Human Phenotype Ontology for PTPN14 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PTPN14 Gene

MGI Knock Outs for PTPN14:
  • Ptpn14 Ptpn14<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPN14

CRISPR Products

miRNA for PTPN14 Gene

miRTarBase miRNAs that target PTPN14

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPN14

No data available for Transcription Factor Targets and HOMER Transcription for PTPN14 Gene

Localization for PTPN14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN14 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPN14 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PTPN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10934049
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA,IDA 10934049
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with PTPN14: view

Pathways & Interactions for PTPN14 Gene

PathCards logo

SuperPathways for PTPN14 Gene

SuperPathway Contained pathways
1 Adhesion
2 Angiogenesis (CST)
3 Wnt / Hedgehog / Notch
4 PAK Pathway
.36
genes like me logo Genes that share pathways with PTPN14: view

Pathways by source for PTPN14 Gene

1 Qiagen pathway for PTPN14 Gene
  • Epithelial Adherens Junctions
3 Cell Signaling Technology pathways for PTPN14 Gene

SIGNOR curated interactions for PTPN14 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for PTPN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001946 lymphangiogenesis IEA,IMP 20826270
GO:0006470 protein dephosphorylation TAS 7733990
GO:0008285 negative regulation of cell proliferation IMP 22948661
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with PTPN14: view

Drugs & Compounds for PTPN14 Gene

(2) Drugs for PTPN14 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for PTPN14 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with PTPN14: view

Transcripts for PTPN14 Gene

mRNA/cDNA for PTPN14 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPN14

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN14 Gene

No ASD Table

Relevant External Links for PTPN14 Gene

GeneLoc Exon Structure for
PTPN14

Expression for PTPN14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTPN14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTPN14 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for PTPN14 Gene

This gene is overexpressed in Breast (42.0) and Placenta (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPN14 Gene



Protein tissue co-expression partners for PTPN14 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTPN14

SOURCE GeneReport for Unigene cluster for PTPN14 Gene:

Hs.193557

mRNA Expression by UniProt/SwissProt for PTPN14 Gene:

Q15678-PTN14_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PTPN14 Gene

  • Heart(4.5)
  • Lung(4.4)
  • Kidney(2.7)
  • Skin(2.4)
  • Muscle(2.4)
  • Intestine(2.2)
  • Nervous system(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPN14 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • respiratory
  • skeleton
Regions:
Head and neck:
  • ear
  • head
  • mouth
  • nose
  • pharynx
  • skull
Thorax:
  • heart
  • heart valve
genes like me logo Genes that share expression patterns with PTPN14: view

Orthologs for PTPN14 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN14 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PTPN14 30 31
  • 99.41 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 95 (a)
OneToMany
-- 31
  • 87 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia PTPN14 30 31
  • 91.21 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PTPN14 30 31
  • 89.95 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PTPN14 31
  • 88 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Ptpn14 30 17 31
  • 85.94 (n)
OneToOne
Chicken
(Gallus gallus)
Aves PTPN14 30 31
  • 78.2 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PTPN14 31
  • 82 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ptpn14 30
  • 69.02 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Pez 31 32
  • 27 (a)
OneToMany
Species where no ortholog for PTPN14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PTPN14 Gene

ENSEMBL:
Gene Tree for PTPN14 (if available)
TreeFam:
Gene Tree for PTPN14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTPN14: view image

Paralogs for PTPN14 Gene

(17) SIMAP similar genes for PTPN14 Gene using alignment to 3 proteins:

  • PTN14_HUMAN
  • E2J9M0_HUMAN
  • Q6PJC3_HUMAN
genes like me logo Genes that share paralogs with PTPN14: view

Variants for PTPN14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTPN14 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
709021 Benign: not provided 214,384,776(-) T/G MISSENSE_VARIANT
715858 Benign: not provided 214,384,472(-) G/A SYNONYMOUS_VARIANT
717438 Benign: not provided 214,364,603(-) G/A MISSENSE_VARIANT
717676 Benign: not provided 214,384,602(-) C/T MISSENSE_VARIANT
718490 Likely Benign: not provided 214,451,897(-) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PTPN14 Gene

Structural Variations from Database of Genomic Variants (DGV) for PTPN14 Gene

Variant ID Type Subtype PubMed ID
dgv145e212 CNV loss 25503493
dgv146e212 CNV loss 25503493
esv2669067 CNV deletion 23128226
esv275028 CNV loss 21479260
esv3578414 CNV loss 25503493
esv3578421 CNV loss 25503493
esv3588787 CNV loss 21293372
esv3588788 CNV loss 21293372
nsv468094 CNV loss 19166990
nsv516687 CNV loss 19592680
nsv549180 CNV loss 21841781
nsv945284 CNV duplication 23825009
nsv945285 CNV duplication 23825009

Variation tolerance for PTPN14 Gene

Residual Variation Intolerance Score: 8.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.75; 73.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTPN14 Gene

Human Gene Mutation Database (HGMD)
PTPN14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTPN14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPN14 Gene

Disorders for PTPN14 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PTPN14 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
choanal atresia and lymphedema
  • catlph
metatypical basal cell carcinoma
  • basosquamous carcinoma of skin
pectus excavatum
  • funnel chest
hennekam syndrome
  • hennekam lymphangiectasia-lymphedema syndrome
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

PTN14_HUMAN
  • Choanal atresia and lymphedema (CATLPH) [MIM:613611]: A disease characterized by posterior choanal atresia and lymphedema. Additional features are a high-arched palate, hypoplastic nipples, and mild pectus excavatum. {ECO:0000269 PubMed:20826270}. Note=The disease is caused by mutations affecting the gene represented in this entry. A homozygous deletion in PTPN14 predicted to result in frameshift and premature truncation, has been shown to be the cause of choanal atresia and lymphedema in one family.
  • Note=Influence clinical severity of hereditary haemorragic telagiectasia (HHT). {ECO:0000269 PubMed:22233626}.

Additional Disease Information for PTPN14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PTPN14: view

No data available for Genatlas for PTPN14 Gene

Publications for PTPN14 Gene

  1. The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin. (PMID: 12808048) Wadham C … Khew-Goodall Y (Molecular biology of the cell 2003) 3 4 23
  2. Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains. (PMID: 7733990) Smith AL … Crompton MR (Biochemical and biophysical research communications 1995) 2 3 4
  3. PTPN14 interacts with and negatively regulates the oncogenic function of YAP. (PMID: 22525271) Liu X … Zhang J (Oncogene 2013) 3 4
  4. PTPN14 is required for the density-dependent control of YAP1. (PMID: 22948661) Wang W … Chen J (Genes & development 2012) 3 4
  5. Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia. (PMID: 22233626) Benzinou M … Akhurst RJ (Nature communications 2012) 3 4

Products for PTPN14 Gene

  • Signalway ELISA kits for PTPN14

Sources for PTPN14 Gene