Aliases for PTPN14 Gene
External Ids for PTPN14 Gene
Previous GeneCards Identifiers for PTPN14 Gene
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]
GeneCards Summary for PTPN14 Gene
PTPN14 (Protein Tyrosine Phosphatase Non-Receptor Type 14) is a Protein Coding gene. Diseases associated with PTPN14 include Choanal Atresia And Lymphedema and Metatypical Basal Cell Carcinoma. Among its related pathways are Adhesion and Wnt / Hedgehog / Notch. Gene Ontology (GO) annotations related to this gene include phosphatase activity and transcription coregulator activity. An important paralog of this gene is PTPN21.
UniProtKB/Swiss-Prot Summary for PTPN14 Gene
Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.