The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for ... See more...

Aliases for PTPN1 Gene

Aliases for PTPN1 Gene

  • Protein Tyrosine Phosphatase Non-Receptor Type 1 2 3 5
  • Tyrosine-Protein Phosphatase Non-Receptor Type 1 3 4
  • Protein-Tyrosine Phosphatase 1B 3 4
  • EC 3.1.3.48 4 52
  • PTP1B 3 4
  • Protein Tyrosine Phosphatase, Placental 3
  • PTP-1B 4

External Ids for PTPN1 Gene

Previous HGNC Symbols for PTPN1 Gene

  • PTP1B

Previous GeneCards Identifiers for PTPN1 Gene

  • GC20P048855
  • GC20P049765
  • GC20P049812
  • GC20P048560
  • GC20P049126
  • GC20P045875

Summaries for PTPN1 Gene

Entrez Gene Summary for PTPN1 Gene

  • The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for PTPN1 Gene

PTPN1 (Protein Tyrosine Phosphatase Non-Receptor Type 1) is a Protein Coding gene. Diseases associated with PTPN1 include Diabetes Mellitus, Noninsulin-Dependent and Bubonic Plague. Among its related pathways are Development_Leptin signaling via JAK/STAT and MAPK cascades and Jak/STAT Signaling Pathway Intracellular Regulation. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is PTPN2.

UniProtKB/Swiss-Prot Summary for PTPN1 Gene

  • Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

Tocris Summary for PTPN1 Gene

  • Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinase and phosphorylase enzymes.

Gene Wiki entry for PTPN1 Gene

Additional gene information for PTPN1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPN1 Gene

Genomics for PTPN1 Gene

GeneHancer (GH) Regulatory Elements for PTPN1 Gene

Promoters and enhancers for PTPN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTPN1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTPN1

Top Transcription factor binding sites by QIAGEN in the PTPN1 gene promoter:
  • CREB
  • deltaCREB
  • Elk-1
  • Nkx3-1
  • Nkx3-1 v1
  • PPAR-alpha
  • Sp1
  • STAT3

Genomic Locations for PTPN1 Gene

Genomic Locations for PTPN1 Gene
chr20:50,510,321-50,585,241
(GRCh38/hg38)
Size:
74,921 bases
Orientation:
Plus strand
chr20:49,126,891-49,201,299
(GRCh37/hg19)
Size:
74,409 bases
Orientation:
Plus strand

Genomic View for PTPN1 Gene

Genes around PTPN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTPN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTPN1 Gene

Proteins for PTPN1 Gene

  • Protein details for PTPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18031-PTN1_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 1
    Protein Accession:
    P18031
    Secondary Accessions:
    • Q5TGD8
    • Q9BQV9
    • Q9NQQ4

    Protein attributes for PTPN1 Gene

    Size:
    435 amino acids
    Molecular mass:
    49967 Da
    Quaternary structure:
    • Interacts with EPHA3 (phosphorylated); dephosphorylates EPHA3 and may regulate its trafficking and function. Interacts with MET.

    Three dimensional structures from OCA and Proteopedia for PTPN1 Gene

neXtProt entry for PTPN1 Gene

Selected DME Specific Peptides for PTPN1 Gene

P18031:
  • DTCLLLMDKRKDPSSVD
  • YILTQGPL
  • DQLRFSY
  • VVHCSAG
  • RMGLIQT
  • FHYTTWPDFG
  • NRNRYRDVSP
  • GPVVVHCS
  • HCSAGIGR

Post-translational modifications for PTPN1 Gene

  • Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a sulfenamide cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.
  • Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50.
  • S-nitrosylation of Cys-215 inactivates the enzyme activity.
  • Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTPN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PTPN1

Domains & Families for PTPN1 Gene

Gene Families for PTPN1 Gene

Protein Domains for PTPN1 Gene

Blocks:
  • Protein tyrosine phosphatase signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PTPN1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92897, Homo sapiens protein tyrosine phosphatase, non-receptor type 1 (PTPN1), mRNA (A8K3M3_HUMAN)
  • cDNA FLJ50851, highly similar to Tyrosine-protein phosphatase non-receptor type1 (EC 3.1.3.48) (B4DSN5_HUMAN)
  • Protein-tyrosine phosphatase 1B (PTN1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P18031

UniProtKB/Swiss-Prot:

PTN1_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
genes like me logo Genes that share domains with PTPN1: view

Function for PTPN1 Gene

Molecular function for PTPN1 Gene

UniProtKB/Swiss-Prot Function:
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=. ;.
GENATLAS Biochemistry:
protein tyrosine phosphatase,non receptor type 1

Enzyme Numbers (IUBMB) for PTPN1 Gene

Phenotypes From GWAS Catalog for PTPN1 Gene

Gene Ontology (GO) - Molecular Function for PTPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA,TAS --
GO:0005158 insulin receptor binding IEA --
GO:0005515 protein binding IPI 8702689
genes like me logo Genes that share ontologies with PTPN1: view
genes like me logo Genes that share phenotypes with PTPN1: view

Human Phenotype Ontology for PTPN1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PTPN1 Gene

MGI Knock Outs for PTPN1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTPN1

CRISPR Products

Clone Products

  • Addgene plasmids for PTPN1

No data available for Transcription Factor Targets and HOMER Transcription for PTPN1 Gene

Localization for PTPN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTPN1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Interacts with EPHA3 at the cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTPN1 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
cytosol 5
plasma membrane 3
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
lysosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PTPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005769 early endosome IEA,IDA 21135139
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol TAS,IEA --
genes like me logo Genes that share ontologies with PTPN1: view

Pathways & Interactions for PTPN1 Gene

genes like me logo Genes that share pathways with PTPN1: view

Pathways by source for PTPN1 Gene

3 GeneGo (Thomson Reuters) pathways for PTPN1 Gene
  • Development_Leptin signaling via JAK/STAT and MAPK cascades
  • Development_Leptin signaling via PI3K-dependent pathway
  • Immune response IFN alpha/beta signaling pathway
1 R&D Systems pathway for PTPN1 Gene
6 Qiagen pathways for PTPN1 Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Apoptotic Pathways Triggered By HIV1
  • cAMP Pathway
  • Epithelial Adherens Junctions
2 Cell Signaling Technology pathways for PTPN1 Gene

SIGNOR curated interactions for PTPN1 Gene

Gene Ontology (GO) - Biological Process for PTPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IMP,IEA 22045810
GO:0007257 activation of JUN kinase activity IEA --
GO:0008286 insulin receptor signaling pathway IEA --
GO:0009966 regulation of signal transduction IMP 21135139
GO:0009968 negative regulation of signal transduction TAS --
genes like me logo Genes that share ontologies with PTPN1: view

Drugs & Compounds for PTPN1 Gene

(100) Drugs for PTPN1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
tiludronate Approved, Investigational, Vet_approved Pharma Target, inhibitor 2
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
2-(Oxalyl-Amino)-Benzoic Acid Experimental Pharma Target 0
(3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER Experimental Pharma Target 0

(38) Additional Compounds for PTPN1 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
VO-OHpic
675848-25-6

(5) Tocris Compounds for PTPN1 Gene

Compound Action Cas Number
BVT 948 Non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signaling 39674-97-0
NSC 87877 Potent inhibitor of shp2 and shp1 PTP 56990-57-9
Sodium orthovanadate Protein tyrosine phosphatase inhibitor 13721-39-6
TCS 401 Selective inhibitor of PTP1B 243966-09-8
VO-OHpic Potent PTEN inhibitor 675848-25-6

(5) ApexBio Compounds for PTPN1 Gene

Compound Action Cas Number
BVT 948 PTPs inhibitor,cell-permeable and non-competitve 39674-97-0
Etidronate 2809-21-4
NSC 87877 Shp2 /shp1 PTP inhibitor 56990-57-9
Sodium Orthovanadate PTP inhibitor 13721-39-6
TCS 401 Selective PTP1B inhibitor 243967-42-2
genes like me logo Genes that share compounds with PTPN1: view

Transcripts for PTPN1 Gene

mRNA/cDNA for PTPN1 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for PTPN1

Alternative Splicing Database (ASD) splice patterns (SP) for PTPN1 Gene

No ASD Table

Relevant External Links for PTPN1 Gene

GeneLoc Exon Structure for
PTPN1

Expression for PTPN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTPN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTPN1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.2), Bone (9.0), and Breast (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTPN1 Gene



Protein tissue co-expression partners for PTPN1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTPN1

SOURCE GeneReport for Unigene cluster for PTPN1 Gene:

Hs.417549

mRNA Expression by UniProt/SwissProt for PTPN1 Gene:

P18031-PTN1_HUMAN
Tissue specificity: Expressed in keratinocytes (at protein level).

Evidence on tissue expression from TISSUES for PTPN1 Gene

  • Nervous system(4.4)
  • Eye(4.3)
  • Kidney(3)
  • Muscle(2.8)
  • Blood(2.7)
  • Liver(2.7)
  • Intestine(2.4)
  • Heart(2.2)
  • Lung(2.2)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with PTPN1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPN1 Gene

Orthologs for PTPN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTPN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPN1 31 30
  • 99.77 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PTPN1 31 30
  • 89.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PTPN1 31 30
  • 87 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPN1 31
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptpn1 30
  • 81.59 (n)
mouse
(Mus musculus)
Mammalia Ptpn1 17 31 30
  • 81.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PTPN1 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPN1 31 30
  • 73.4 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPN1 31
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptpn1 30
  • 69.56 (n)
Str.7557 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15249 30
zebrafish
(Danio rerio)
Actinopterygii ptpn1 31 30
  • 63.53 (n)
OneToOne
-- 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10706 30
fruit fly
(Drosophila melanogaster)
Insecta Ptp61F 31 32
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10G8.1 32
  • 32 (a)
T22C1.8 32
  • 32 (a)
C55B7.3 32
  • 31 (a)
ZK484.7 32
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 40 (a)
OneToMany
Species where no ortholog for PTPN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTPN1 Gene

ENSEMBL:
Gene Tree for PTPN1 (if available)
TreeFam:
Gene Tree for PTPN1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTPN1: view image

Paralogs for PTPN1 Gene

Paralogs for PTPN1 Gene