Aliases for PTPMT1 Gene
External Ids for PTPMT1 Gene
Previous GeneCards Identifiers for PTPMT1 Gene
GeneCards Summary for PTPMT1 Gene
PTPMT1 (Protein Tyrosine Phosphatase Mitochondrial 1) is a Protein Coding gene. Diseases associated with PTPMT1 include Mitochondrial Complex Ii Deficiency, Nuclear Type 1 and Optic Atrophy 11. Among its related pathways are Glycerophospholipid biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP16.
UniProtKB/Swiss-Prot Summary for PTPMT1 Gene
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity (PubMed:24709986).