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The protein encoded by this gene contains a characteristic motif of protein tyrosine phosphatases (PTPs). PTPs regulate activities of phosphoproteins through dephosphorylation. They are signaling molecules involved in the regulation of a wide variety of biological processes. The specific function of this protein has not yet been determined. Alternatively spliced transcript vari... See more...
Aliases for PTPDC1 Gene
Aliases for PTPDC1 Gene
External Ids for PTPDC1 Gene
- HGNC: 30184
- NCBI Entrez Gene: 138639
- Ensembl: ENSG00000158079
- UniProtKB/Swiss-Prot: A2A3K4
Previous GeneCards Identifiers for PTPDC1 Gene
- GC09P092135
- GC09P093872
- GC09P095832
- GC09P096793
- GC09P066469
Summaries for PTPDC1 Gene
-
The protein encoded by this gene contains a characteristic motif of protein tyrosine phosphatases (PTPs). PTPs regulate activities of phosphoproteins through dephosphorylation. They are signaling molecules involved in the regulation of a wide variety of biological processes. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTPDC1 Gene
PTPDC1 (Protein Tyrosine Phosphatase Domain Containing 1) is a Protein Coding gene. Among its related pathways are PAK Pathway. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is CDC14A.
UniProtKB/Swiss-Prot Summary for PTPDC1 Gene
-
May play roles in cilia formation and/or maintenance.
Additional gene information for PTPDC1 Gene
- HGNC (30184)
- NCBI Entrez Gene (138639)
- Ensembl (ENSG00000158079)
- UniProtKB/Swiss-Prot (A2A3K4)
- Open Targets Platform(ENSG00000158079)
- Monarch Initiative
- Search for PTPDC1 at DataMed
- Search for PTPDC1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPDC1 Gene
Genomics for PTPDC1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PTPDC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PTPDC1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTPDC1
- Top Transcription factor binding sites by QIAGEN in the PTPDC1 gene promoter:
-
- COMP1
- NF-AT
- NF-AT1
- NF-AT2
- NF-AT3
- NF-AT4
- NF-kappaB1
- POU2F1
- RelA
- XBP-1
Genomic Locations for PTPDC1 Gene
Latest Assembly
- chr9:94,029,031-94,109,856
- (GRCh38/hg38)
- Size:
- 80,826 bases
- Orientation:
- Plus strand
Previous Assembly
- chr9:96,793,095-96,872,138
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 79,044 bases
- Orientation:
- Plus strand
- chr9:96,793,076-96,872,138
- (GRCh37/hg19 by Ensembl)
- Size:
- 79,063 bases
- Orientation:
- Plus strand
Genomic View for PTPDC1 Gene
Genes around PTPDC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q22.32 by HGNC
- 9q22.32 by Entrez Gene
- 9q22.32 by Ensembl
PTPDC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTPDC1 Gene
Proteins for PTPDC1 Gene
-
Protein details for PTPDC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A2A3K4-PTPC1_HUMAN
- Recommended name:
- Protein tyrosine phosphatase domain-containing protein 1
- Protein Accession:
- A2A3K4
- Q5T3M4
- Q6NXE8
- Q8IWM1
- Q8N1X4
- Q8N9F5
Protein attributes for PTPDC1 Gene
- Size:
- 754 amino acids
- Molecular mass:
- 84457 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAC04391.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04421.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for PTPDC1 Gene
Selected DME Specific Peptides for PTPDC1 Gene
- A2A3K4:
-
- EQLKEPVITK
- FVRAKRPNSIQTRGQLLCVREF
- KYTKVGE
- RQRHLLHGYEAR
- TDNILAM
Post-translational modifications for PTPDC1 Gene
Other Protein References for PTPDC1 Gene
Antibodies for research
- Novus Biologicals Antibodies for PTPDC1
- Invitrogen Antibodies for PTPDC1 (AFLGC-PTPDC1)
- antibodies-online: Show 4 available PTPDC1 Antibodies ranked by validation data
- Compare Top PTPDC1 Antibodies
-
Quality Products:
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for PTPDC1
- Origene Custom Protein Services for PTPDC1
- antibodies-online: Show 5 available PTPDC1 Proteins ranked by validation data
- Compare Top PTPDC1 Proteins
-
Quality Products:
-
Abcam proteins for PTPDC1
Assay products for research
Domains & Families for PTPDC1 Gene
Gene Families for PTPDC1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PTPDC1 Gene
Suggested Antigen Peptide Sequences for PTPDC1 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein tyrosine phosphatase domain-containing protein 1 (PTPC1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
A2A3K4UniProtKB/Swiss-Prot:
PTPC1_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Non-receptor class PTPDC1 subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Non-receptor class PTPDC1 subfamily.
Function for PTPDC1 Gene
Molecular function for PTPDC1 Gene
- UniProtKB/Swiss-Prot Function:
- May play roles in cilia formation and/or maintenance.
Enzyme Numbers (IUBMB) for PTPDC1 Gene
Phenotypes From GWAS Catalog for PTPDC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004725 | protein tyrosine phosphatase activity | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 32296183 |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PTPDC1 Gene
- MGI mutant phenotypes for PTPDC1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PTPDC1:
-
- no effect
- Decreased viability
- shRNA abundance <= 25%
- Decreased cell migration
- Synthetic lethal with vaccinia virus (VACV) infection
- Increased nuclear migration speed
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased epidermal growth factor (EGF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
Animal Models for PTPDC1 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for PTPDC1
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PTPDC1 - Starting at $85 >
- * PTPDC1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PTPDC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPDC1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTPDC1
miRNA for PTPDC1 Gene
- miRTarBase miRNAs that target PTPDC1
-
- hsa-miR-340-5p (MIRT019589)
- hsa-miR-21-5p (MIRT031061)
- hsa-miR-16-5p (MIRT032059)
- hsa-miR-17-5p (MIRT325509)
- hsa-miR-20a-5p (MIRT325510)
- hsa-miR-93-5p (MIRT325511)
- hsa-miR-106a-5p (MIRT325512)
- hsa-miR-142-5p (MIRT325513)
- hsa-miR-106b-5p (MIRT325514)
- hsa-miR-302a-3p (MIRT325515)
- hsa-miR-302b-3p (MIRT325516)
- hsa-miR-302c-3p (MIRT325517)
- hsa-miR-302d-3p (MIRT325518)
- hsa-miR-372-3p (MIRT325519)
- hsa-miR-373-3p (MIRT325520)
- hsa-miR-20b-5p (MIRT325521)
- hsa-miR-520e (MIRT325522)
- hsa-miR-520a-3p (MIRT325524)
- hsa-miR-526b-3p (MIRT325525)
- hsa-miR-520b (MIRT325527)
- hsa-miR-520c-3p (MIRT325528)
- hsa-miR-519d-3p (MIRT325529)
- hsa-miR-520d-3p (MIRT325530)
- hsa-miR-548n (MIRT325532)
- hsa-miR-302e (MIRT325533)
- hsa-miR-5590-3p (MIRT325534)
- hsa-miR-31-3p (MIRT555149)
- hsa-miR-4758-3p (MIRT555150)
- hsa-miR-539-5p (MIRT555151)
- hsa-miR-4698 (MIRT555152)
- hsa-miR-4712-3p (MIRT555153)
- hsa-miR-8063 (MIRT555154)
- hsa-miR-6769a-3p (MIRT555155)
- hsa-miR-3943 (MIRT555156)
- hsa-miR-4323 (MIRT555157)
- hsa-miR-4262 (MIRT555158)
- hsa-miR-181d-5p (MIRT555159)
- hsa-miR-181c-5p (MIRT555160)
- hsa-miR-181b-5p (MIRT555161)
- hsa-miR-181a-5p (MIRT555162)
- hsa-miR-562 (MIRT555163)
- hsa-miR-543 (MIRT555164)
- hsa-miR-4796-3p (MIRT555165)
- hsa-miR-548ah-5p (MIRT555166)
- hsa-miR-3609 (MIRT555167)
- hsa-miR-6509-5p (MIRT687148)
- hsa-miR-5706 (MIRT687149)
- hsa-miR-4782-5p (MIRT687150)
- hsa-miR-23c (MIRT687151)
- hsa-miR-23b-3p (MIRT687152)
- hsa-miR-23a-3p (MIRT687153)
- hsa-miR-130a-5p (MIRT687154)
- hsa-miR-6839-5p (MIRT687155)
- hsa-miR-378j (MIRT687156)
- hsa-miR-4766-5p (MIRT687157)
- hsa-miR-4756-3p (MIRT687158)
- hsa-miR-1298-3p (MIRT687159)
- hsa-miR-3126-3p (MIRT687160)
- hsa-miR-5580-3p (MIRT687161)
- hsa-miR-1304-5p (MIRT700533)
- hsa-miR-6765-5p (MIRT700534)
- hsa-miR-193a-5p (MIRT700535)
- hsa-miR-122-5p (MIRT700536)
- hsa-miR-504-3p (MIRT700537)
- hsa-miR-1827 (MIRT700538)
- hsa-miR-6514-5p (MIRT700539)
- hsa-miR-4802-5p (MIRT700540)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPDC1
- Browse OriGene Inhibitory RNA Products For PTPDC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPDC1
Clone products for research
- Applied Biological Materials (abm): Clones for PTPDC1 - Starting at $45 >
- * PTPDC1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG210441
- MR210441
- MR210441L3
- MR210441L4
- MR231190
- RC208971
- RC208971L1
- RC208971L2
- RC208971L3
- RC208971L4
- RC222339
- RC222339L3
- RC222339L4
- RC234825
- RC234912
- RG208971
- RG222339
- RG234825
- RG234912
- RR212558
- RR212558L3
- RR212558L4
- MR210441L3V
- MR210441L4V
- RC208971L1V
- RC208971L2V
- RC208971L3V
- RC208971L4V
- RC222339L3V
- RC222339L4V
- RR212558L3V
- RR212558L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PTPDC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPDC1
Cell Lines for research
-
Horizon Cell Lines for PTPDC1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPDC1 Gene
Localization for PTPDC1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PTPDC1 Gene
Pathways & Interactions for PTPDC1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PAK Pathway |
Epithelial Adherens Junctions
.36
|
|
Pathways by source for PTPDC1 Gene
1 Qiagen pathway for PTPDC1 Gene
- Epithelial Adherens Junctions
Interacting Proteins for PTPDC1 Gene
Selected Interacting proteins:
ENSP00000477817
A2A3K4-PTPC1_HUMAN
for PTPDC1 Gene via
STRING
UniProtKB
IID
GPS-Prot Interaction Network for PTPDC1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | IEA | -- |
| GO:0007224 | smoothened signaling pathway | IEA | -- |
| GO:0016311 | dephosphorylation | IEA | -- |
| GO:0030030 | cell projection organization | IEA | -- |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IEA | -- |
No data available for SIGNOR curated interactions for PTPDC1 Gene
Transcripts for PTPDC1 Gene
mRNA/cDNA for PTPDC1 Gene
- 4 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000288976 4398 nts (view in UCSC)
- ENST00000375360 4517 nts (view in UCSC)
- ENST00000467049 1861 nts (view in UCSC)
- ENST00000620992 4403 nts (view in UCSC)
- ENST00000650567 4332 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PTPDC1 - Starting at $85 >
- * PTPDC1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PTPDC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPDC1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTPDC1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPDC1
- Browse OriGene Inhibitory RNA Products For PTPDC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPDC1
Clone products for research
- Applied Biological Materials (abm): Clones for PTPDC1 - Starting at $45 >
- * PTPDC1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG210441
- MR210441
- MR210441L3
- MR210441L4
- MR231190
- RC208971
- RC208971L1
- RC208971L2
- RC208971L3
- RC208971L4
- RC222339
- RC222339L3
- RC222339L4
- RC234825
- RC234912
- RG208971
- RG222339
- RG234825
- RG234912
- RR212558
- RR212558L3
- RR212558L4
- MR210441L3V
- MR210441L4V
- RC208971L1V
- RC208971L2V
- RC208971L3V
- RC208971L4V
- RC222339L3V
- RC222339L4V
- RR212558L3V
- RR212558L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PTPDC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPDC1
Relevant External Links for PTPDC1 Gene
- GeneLoc Exon Structure for
- PTPDC1
Expression for PTPDC1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for PTPDC1 Gene
This gene is overexpressed in Nerve - Tibial (x4.3).
This gene is overexpressed in Heart (52.3) and Testis (11.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTPDC1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTPDC1
SOURCE GeneReport for Unigene cluster for PTPDC1 Gene:
Hs.437943Evidence on tissue expression from TISSUES for PTPDC1 Gene
- Nervous system(4.6)
- Skin(4.2)
Primer products for research
-
OriGene qPCR primer pairs for PTPDC1
-
OriGene qPCR primer pairs and template standards for PTPDC1
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPDC1 Gene
Orthologs for PTPDC1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PTPDC1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PTPDC1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ptpdc1 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PTPDC1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ptpdc1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PTPDC1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PTPDC1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PTPDC1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PTPDC1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100490857 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ptpdc1 30 31 |
|
OneToMany | |
| PTPDC1 (2 of 3) 31 |
|
OneToMany | |||
| PTPDC1 (1 of 3) 31 |
|
OneToMany | |||
| Dr.12870 30 |
|
||||
| Worm (Caenorhabditis elegans) |
Secernentea | T12B3.1 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for PTPDC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PTPDC1 Gene
- ENSEMBL:
- Gene Tree for PTPDC1 (if available)
- TreeFam:
- Gene Tree for PTPDC1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PTPDC1: view image
Paralogs for PTPDC1 Gene
Variants for PTPDC1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTPDC1 Gene
| SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs16909677 | - |
p.Leu571Gln |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2761543 | CNV | gain | 21179565 |
| esv3621110 | CNV | gain | 21293372 |
| esv3621111 | CNV | gain | 21293372 |
| nsv476461 | CNV | novel sequence insertion | 20440878 |
| nsv507521 | OTHER | sequence alteration | 20534489 |
| nsv831655 | CNV | gain | 17160897 |
| nsv982322 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.76;
47.02% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PTPDC1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PTPDC1
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPDC1 Gene
Disorders for PTPDC1 Gene
Additional Disease Information for PTPDC1
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for PTPDC1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTPDC1 Gene
Publications for PTPDC1 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling. (PMID: 28675297) Kumar P … Maddika S (Journal of proteome research 2017) 3
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
- Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
ExternalLinks
Products for PTPDC1 Gene
- Browse OriGene Antibodies
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- Custom Assay Services
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- Origene Custom Protein Services for PTPDC1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPDC1
- Browse OriGene Inhibitory RNA Products For PTPDC1
- OriGene qPCR primer pairs for PTPDC1
- OriGene qPCR primer pairs and template standards for PTPDC1
- OriGene CRISPR knockouts for PTPDC1
- MG210441
- MR210441
- MR210441L3
- MR210441L4
- MR231190
- RC208971
- RC208971L1
- RC208971L2
- RC208971L3
- RC208971L4
- RC222339
- RC222339L3
- RC222339L4
- RC234825
- RC234912
- RG208971
- RG222339
- RG234825
- RG234912
- RR212558
- RR212558L3
- RR212558L4
- MR210441L3V
- MR210441L4V
- RC208971L1V
- RC208971L2V
- RC208971L3V
- RC208971L4V
- RC222339L3V
- RC222339L4V
- RR212558L3V
- RR212558L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PTPDC1
- Sino Biological Human cDNA Clone for PTPDC1
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- Novus Biologicals Antibodies for PTPDC1
- Novus Biologicals proteins and lysates for PTPDC1
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- Taconic Biosciences Mouse Models for PTPDC1
- Find your next knockout model in the Taconic Knockout Repository
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- Invitrogen Antibodies for PTPDC1 (AFLGC-PTPDC1)
- VectorBuilder Custom and pre-made DNA vectors for PTPDC1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PTPDC1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PTPDC1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PTPDC1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PTPDC1
- antibodies-online: Show 4 available PTPDC1 Antibodies ranked by validation data
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- antibodies-online: Search results for available PTPDC1 related products ranked by validation data
- antibodies-online: Show 5 available PTPDC1 Proteins ranked by validation data
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- Horizon Cell Lines for PTPDC1
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPDC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPDC1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PTPDC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPDC1
Sources for PTPDC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB