Aliases for PTPA Gene
Aliases for PTPA Gene
- Protein Phosphatase 2 Phosphatase Activator 2 3 5
- Phosphotyrosyl Phosphatase Activator 2 3 4
- Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B 3 4
- Protein Phosphatase 2A Activator, Regulatory Subunit 4 2 3
- Protein Phosphatase 2A, Regulatory Subunit B (PR 53) 2 3
- Protein Phosphatase 2 Regulatory Subunit 4 2 3
- PP2A Phosphatase Activator 2 3
- PPP2R4 3 4
- Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit 4 4
External Ids for PTPA Gene
- HGNC: 9308
- Entrez Gene: 5524
- Ensembl: ENSG00000119383
- OMIM: 600756
- UniProtKB: Q15257
Previous HGNC Symbols for PTPA Gene
- PPP2R4
Summaries for PTPA Gene
-
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTPA Gene
PTPA (Protein Phosphatase 2 Phosphatase Activator) is a Protein Coding gene. Diseases associated with PTPA include Apical Myocardial Infarction and Spinocerebellar Ataxia 12. Among its related pathways are ERK Signaling and Akt Signaling.
UniProtKB/Swiss-Prot for PTPA Gene
-
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.
Additional gene information for PTPA Gene
- Monarch Initiative
- Search for PTPA at DataMed
- Search for PTPA at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTPA Gene
Genomics for PTPA Gene
GeneHancer (GH) Regulatory Elements for PTPA Gene
Promoters and enhancers for PTPA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PTPA on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PTPA Gene
Genomic Locations for PTPA Gene
- chr9:129,110,945-129,148,946
- (GRCh38/hg38)
- Size:
- 38,002 bases
- Orientation:
- Plus strand
- chr9:131,873,228-131,911,225
- (GRCh37/hg19)
- Size:
- 37,998 bases
- Orientation:
- Plus strand
Genomic View for PTPA Gene
Genes around PTPA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q34.11 by Entrez Gene
- 9q34.11 by HGNC
- 9q34.11 by Ensembl
PTPA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTPA Gene
Proteins for PTPA Gene
-
Protein details for PTPA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15257-PTPA_HUMAN
- Recommended name:
- Serine/threonine-protein phosphatase 2A activator
- Protein Accession:
- Q15257
- A2A347
- A9IZU4
- B4DXM4
- Q15258
- Q53GZ3
- Q5TZQ2
- Q9BUK1
- Q9NNZ7
- Q9NNZ8
- Q9NNZ9
Protein attributes for PTPA Gene
- Size:
- 358 amino acids
- Molecular mass:
- 40668 Da
- Quaternary structure:
-
- Associates with PP2A heterodimeric core enzyme PP2A(D), composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A) (PubMed:16916641). Interacts with PPP2CB (By similarity).
Three dimensional structures from OCA and Proteopedia for PTPA Gene
Post-translational modifications for PTPA Gene
Other Protein References for PTPA Gene
- ENSEMBL proteins:
-
- ENSP00000335200
- ENSP00000351885
- ENSP00000377036
- ENSP00000406997
- ENSP00000349726
- ENSP00000416522
- ENSP00000395499
- ENSP00000387726
- ENSP00000394001
- ENSP00000403542
- ENSP00000337412
- ENSP00000405100
- ENSP00000393196
- ENSP00000393092
- ENSP00000393796
- ENSP00000389312
- ENSP00000400314
- ENSP00000347109
- ENSP00000408726
- ENSP00000411604
- ENSP00000408316
- ENSP00000416661
- ENSP00000337448
- ENSP00000394338
- ENSP00000396660
- ENSP00000399069
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PTPA (PPP2R4)
-
Custom Antibody ServicesOriGene Antibodies for PTPA
- Novus Biologicals Antibodies for PTPA
-
Abcam antibodies for PTPA
- Invitrogen Antibodies for PTPA
- GeneTex PTPA Antibody for PTPA
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PTPA
- Origene Custom Protein Services for PTPA
- Search GeneTex for Proteins for PTPA
Assay Products
No data available for DME Specific Peptides for PTPA Gene
Domains & Families for PTPA Gene
Gene Families for PTPA Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PTPA Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PTPA Gene
- GenScript: Design optimal peptide antigens:
-
- Protein phosphatase 2A activator, regulatory subunit 4 (A6PVP0_HUMAN)
- cDNA FLJ52532, weakly similar to Serine/threonine-protein phosphatase 2A regulatory subunit B' (B4DDQ6_HUMAN)
- cDNA FLJ54705, highly similar to Serine/threonine-protein phosphatase 2A regulatory subunit B' (B4DZF8_HUMAN)
- Protein phosphatase 2A activator, regulatory subunit 4 (B7ZBP6_HUMAN)
- Serine/threonine-protein phosphatase 2A regulatory subunit B' (PTPA_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15257- Family:
-
- Belongs to the PTPA-type PPIase family.
Function for PTPA Gene
Molecular function for PTPA Gene
- UniProtKB/Swiss-Prot Function:
- PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme Numbers (IUBMB) for PTPA Gene
Phenotypes From GWAS Catalog for PTPA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | IBA | -- |
| GO:0005102 | signaling receptor binding | IPI | 10830164 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0005524 | ATP binding | IDA | 16916641 |
Phenotypes for PTPA Gene
- MGI mutant phenotypes for PTPA:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PTPA:
-
- Decreased shRNA abundance (Z-score < -2)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Increased cell death HMECs cells
- Negative genetic interaction between BLM-/- and BLM+/+
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Increased Akt phosphorylation after EGF stimulation
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Apoptosis resistance
- Increased viability
- Increased transferrin (TF) endocytosis
Animal Models for PTPA Gene
- MGI Knock Outs for PTPA:
-
- Ptpa Ptpa<tm1.1(KOMP)Vlcg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PTPA
-
CRISPR Products
-
OriGene CRISPR knockouts for PTPA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPA
- genomics-online: gRNA clones - Search results for 147 available PPP2R4 gene related products
- Overview of 147 available PPP2R4 gene related products
- Applied Biological Materials CRISPR for PTPA
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for PTPA
miRNA for PTPA Gene
- miRTarBase miRNAs that target PTPA
-
- hsa-mir-30a-5p (MIRT005188)
- hsa-mir-326 (MIRT043628)
- hsa-mir-183-5p (MIRT438392)
- hsa-mir-1231 (MIRT736203)
- hsa-mir-1236-5p (MIRT736291)
- hsa-mir-1253 (MIRT736548)
- hsa-mir-1275 (MIRT736932)
- hsa-mir-1321 (MIRT737357)
- hsa-mir-1343-5p (MIRT737484)
- hsa-mir-149-3p (MIRT737779)
- hsa-mir-184 (MIRT738195)
- hsa-mir-185-3p (MIRT738217)
- hsa-mir-185-5p (MIRT738260)
- hsa-mir-1911-3p (MIRT738481)
- hsa-mir-3120-5p (MIRT739965)
- hsa-mir-3150a-3p (MIRT740280)
- hsa-mir-3175 (MIRT740680)
- hsa-mir-3176 (MIRT740700)
- hsa-mir-3179 (MIRT740747)
- hsa-mir-3190-5p (MIRT740972)
- hsa-mir-3192-5p (MIRT741031)
- hsa-mir-3202 (MIRT741165)
- hsa-mir-3654 (MIRT741918)
- hsa-mir-3677-5p (MIRT742154)
- hsa-mir-3922-3p (MIRT742976)
- hsa-mir-4278 (MIRT743691)
- hsa-mir-4300 (MIRT743854)
- hsa-mir-4306 (MIRT743916)
- hsa-mir-4419a (MIRT744199)
- hsa-mir-4434 (MIRT744409)
- hsa-mir-4446-3p (MIRT744625)
- hsa-mir-4463 (MIRT744880)
- hsa-mir-4476 (MIRT745045)
- hsa-mir-4492 (MIRT745297)
- hsa-mir-4494 (MIRT745332)
- hsa-mir-4498 (MIRT745378)
- hsa-mir-4505 (MIRT745537)
- hsa-mir-4510 (MIRT745638)
- hsa-mir-4516 (MIRT745762)
- hsa-mir-4525 (MIRT745922)
- hsa-mir-4644 (MIRT746388)
- hsa-mir-4665-5p (MIRT746770)
- hsa-mir-4675 (MIRT746888)
- hsa-mir-4693-3p (MIRT747149)
- hsa-mir-4716-3p (MIRT747498)
- hsa-mir-4723-5p (MIRT747663)
- hsa-mir-4728-5p (MIRT747875)
- hsa-mir-4739 (MIRT748074)
- hsa-mir-4741 (MIRT748125)
- hsa-mir-4756-5p (MIRT748446)
- hsa-mir-4768-3p (MIRT748633)
- hsa-mir-4804-5p (MIRT749026)
- hsa-mir-5001-5p (MIRT749371)
- hsa-mir-5010-5p (MIRT749504)
- hsa-mir-505-5p (MIRT749588)
- hsa-mir-5197-3p (MIRT750091)
- hsa-mir-548aa (MIRT750478)
- hsa-mir-548ap-3p (MIRT750563)
- hsa-mir-548t-3p (MIRT750797)
- hsa-mir-5591-5p (MIRT751083)
- hsa-mir-5698 (MIRT751296)
- hsa-mir-5703 (MIRT751365)
- hsa-mir-5787 (MIRT751486)
- hsa-mir-6085 (MIRT751807)
- hsa-mir-6090 (MIRT752044)
- hsa-mir-6127 (MIRT752113)
- hsa-mir-6129 (MIRT752185)
- hsa-mir-6130 (MIRT752274)
- hsa-mir-6133 (MIRT752378)
- hsa-mir-625-5p (MIRT752602)
- hsa-mir-626 (MIRT752622)
- hsa-mir-6726-5p (MIRT753926)
- hsa-mir-6732-5p (MIRT754081)
- hsa-mir-6760-5p (MIRT754937)
- hsa-mir-6763-5p (MIRT755022)
- hsa-mir-6785-5p (MIRT755870)
- hsa-mir-6794-5p (MIRT756098)
- hsa-mir-6805-5p (MIRT756484)
- hsa-mir-6813-5p (MIRT756743)
- hsa-mir-6825-5p (MIRT757010)
- hsa-mir-6827-5p (MIRT757064)
- hsa-mir-6864-5p (MIRT757911)
- hsa-mir-6870-5p (MIRT757996)
- hsa-mir-6873-5p (MIRT758082)
- hsa-mir-6876-3p (MIRT758131)
- hsa-mir-6876-5p (MIRT758155)
- hsa-mir-6878-5p (MIRT758224)
- hsa-mir-6883-5p (MIRT758455)
- hsa-mir-7111-5p (MIRT759054)
- hsa-mir-7515 (MIRT759390)
- hsa-mir-762 (MIRT759513)
- hsa-mir-920 (MIRT760480)
- hsa-mir-939-5p (MIRT760775)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPA
- Browse OriGene Inhibitory RNA Products For PTPA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPA
- genomics-online: shRNA clones - Search results for 147 available PPP2R4 gene related products
- Overview of 147 available PPP2R4 gene related products
Clone Products
-
OriGene ORF clones in human for PTPA
- RC230794L1V
- RC230794L2V
- RC212144L1V
- RC212144L2V
- RC200671L1V
- RC200671L2V
- RC214340L1V
- RC214340L2V
- RC214397L1V
- RC214397L2V
- RC230794
- RC230794L1
- RC230794L2
- RG230794
- RC232395
- RG232395
- RC212144
- RC212144L1
- RC212144L2
- RG212144
- RC200671
- RC200671L1
- RC200671L2
- RG200671
- RC214340
- RC214340L1
- RC214340L2
- RG214340
- RC214397
- RC214397L1
- RC214397L2
- RG214397
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PTPA
- VectorBuilder custom plasmid, inducible vectors for PTPA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTPA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPA
- Applied Biological Materials Clones for PTPA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PTPA
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPA Gene
Localization for PTPA Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTPA Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 4 |
| cytoskeleton | 3 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
| endosome | 1 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000159 | protein phosphatase type 2A complex | IDA | 10318862 |
| GO:0005634 | nucleus | IDA,IEA | 17333320 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 17333320 |
| GO:0034704 | calcium channel complex | IDA | 10830164 |
Pathways & Interactions for PTPA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Beta-Adrenergic Signaling |
.36
|
|
| 2 | p70S6K Signaling |
.60
|
.54
|
| 3 | Cyclins and Cell Cycle Regulation | ||
| 4 | ERK Signaling |
.61
|
.49
|
| 5 | TGF-Beta Pathway |
.60
|
|
Pathways by source for PTPA Gene
7 BioSystems pathways for PTPA Gene
1 KEGG pathway for PTPA Gene
4 GeneGo (Thomson Reuters) pathways for PTPA Gene
25 Qiagen pathways for PTPA Gene
1 Cell Signaling Technology pathway for PTPA Gene
Interacting Proteins for PTPA Gene
Selected Interacting proteins:
Q15257-PTPA_HUMAN
ENSP00000351885
for PTPA Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PTPA
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000413 | protein peptidyl-prolyl isomerization | IEA | -- |
| GO:0032515 | negative regulation of phosphoprotein phosphatase activity | IDA | 16916641 |
| GO:0032516 | positive regulation of phosphoprotein phosphatase activity | IDA | 16916641 |
| GO:0035307 | positive regulation of protein dephosphorylation | IDA | 16916641 |
| GO:0035308 | negative regulation of protein dephosphorylation | IDA | 16916641 |
Drugs & Compounds for PTPA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cantharidin | Approved, Investigational | Pharma | Inhibitor of protein phosphatases 1/2A | 14 | ||
| Calyculin A | Experimental | Pharma | Protein phosphatase inhibitor | 0 | ||
| Okadaic acid | Experimental | Pharma | Protein phosphatase 1 inhibitor | 0 | ||
| GLYCYLALANYL-N-2-NAPHTHYL-L-PROLINEAMIDE | Experimental | Pharma | Target | 0 | ||
| Ceramide | Pharma | Protein phosphatase and CAPP modulator | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for PTPA Gene
mRNA/cDNA for PTPA Gene
- (13) REFSEQ mRNAs :
- (633) Selected AceView cDNA sequences:
- (26) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000358994 2664 bps (uc004bxl.3)
- ENST00000455292 949 bps (uc064wjo.1)
- ENST00000393370 2737 bps (uc004bxn.3)
- ENST00000348141 2737 bps (uc064wjp.1)
- ENST00000347048 1989 bps (uc010myr.3)
CRISPR Products
-
OriGene CRISPR knockouts for PTPA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPA
- genomics-online: gRNA clones - Search results for 147 available PPP2R4 gene related products
- Overview of 147 available PPP2R4 gene related products
- Applied Biological Materials CRISPR for PTPA
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for PTPA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPA
- Browse OriGene Inhibitory RNA Products For PTPA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPA
- genomics-online: shRNA clones - Search results for 147 available PPP2R4 gene related products
- Overview of 147 available PPP2R4 gene related products
Clone Products
-
OriGene ORF clones in human for PTPA
- RC230794L1V
- RC230794L2V
- RC212144L1V
- RC212144L2V
- RC200671L1V
- RC200671L2V
- RC214340L1V
- RC214340L2V
- RC214397L1V
- RC214397L2V
- RC230794
- RC230794L1
- RC230794L2
- RG230794
- RC232395
- RG232395
- RC212144
- RC212144L1
- RC212144L2
- RG212144
- RC200671
- RC200671L1
- RC200671L2
- RG200671
- RC214340
- RC214340L1
- RC214340L2
- RG214340
- RC214397
- RC214397L1
- RC214397L2
- RG214397
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PTPA
- VectorBuilder custom plasmid, inducible vectors for PTPA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTPA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPA
- Applied Biological Materials Clones for PTPA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PTPA Gene
NURSA nuclear receptor signaling pathways regulating expression of PTPA Gene:
PTPAmRNA Expression by UniProt/SwissProt for PTPA Gene:
Q15257-PTPA_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for PTPA Gene
- Nervous system(4.9)
- Heart(4.6)
- Blood(4.5)
- Liver(4.5)
- Lung(4.2)
- Kidney(3.5)
- Intestine(3.4)
- Skin(3.2)
- Muscle(3.1)
- Adrenal gland(2.5)
- Pancreas(2.3)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for PTPA
-
OriGene qPCR primer pairs for PTPA
- genomics-online: primer clones - Search results for 147 available PPP2R4 gene related products
- Overview of 147 available PPP2R4 gene related products
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPA Gene
Orthologs for PTPA Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PPP2R4 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PPP2R4 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PPP2R4 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PPP2R4 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PPP2R4 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ppp2r4 34 33 |
|
OneToOne | |
| Ptpa 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Ppp2r4 33 |
|
||
| chicken (Gallus gallus) |
Aves | PPP2R4 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PPP2R4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ppp2r4 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.8828 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ppp2r4 34 33 |
|
OneToOne | |
| wufc23d07 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8890 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Ptpa 34 33 |
|
OneToMany | |
| CG2104 34 |
|
OneToMany | |||
| CG8509 34 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008652 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | Y71H2AM.20 34 33 |
|
OneToOne | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ACR139C 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RRD2 36 33 |
|
||
| RRD1 34 |
|
OneToOne | |||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F11187g 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G08960 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.5058 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os06g0219800 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU03269 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC1782.05 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | Cin.6463 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.6463 33 |
|
- Species where no ortholog for PTPA was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for PTPA Gene
- ENSEMBL:
- Gene Tree for PTPA (if available)
- TreeFam:
- Gene Tree for PTPA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PTPA: view image
Paralogs for PTPA Gene
No data available for Paralogs for PTPA Gene
Variants for PTPA Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000015998 | -- | 129,110,231(+) | T/ | upstream_transcript_variant | |
| rs1000067347 | -- | 129,121,371(+) | A/G | intron_variant | |
| rs1000087902 | -- | 129,121,262(+) | G/A | intron_variant | |
| rs1000177380 | -- | 129,126,280(+) | G/A | intron_variant | |
| rs1000294266 | -- | 129,132,789(+) | C/G | intron_variant |
Residual Variation Intolerance Score:
42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.32;
26.18% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PTPA Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PTPA
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPA Gene
Disorders for PTPA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| apical myocardial infarction |
|
|
| spinocerebellar ataxia 12 |
|
|
| alzheimer disease |
|
|
| breast cancer |
|
|
| leukemia, acute myeloid |
|
Search PTPA in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PTPA
No data available for UniProtKB/Swiss-Prot and Genatlas for PTPA Gene
Publications for PTPA Gene
- Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A. (PMID: 8530035) Van Hoof C … Goris J (Genomics 1995) 2 3 4 22 58
- The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase. (PMID: 16380387) Jordens J … Van Hoof C (The Journal of biological chemistry 2006) 2 3 22 58
- The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions. (PMID: 16782712) Magnusdottir A … Nordlund P (The Journal of biological chemistry 2006) 3 4 22 58
- Structure and mechanism of the phosphotyrosyl phosphatase activator. (PMID: 16916641) Chao Y … Shi Y (Molecular cell 2006) 3 4 22 58
- Identification and characterization of alternative splice products encoded by the human phosphotyrosyl phosphatase activator gene. (PMID: 10880964) Janssens V … Goris J (European journal of biochemistry 2000) 3 4 22 58
Products for PTPA Gene
- R&D Systems Antibodies for PTPA (PPP2R4)
- Browse R&D Systems for Human Recombinant Proteins
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- Browse Human Proteins and Enzymes
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for PTPA
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PTPA
- Origene Custom Protein Services for PTPA
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- OriGene qPCR primer pairs and template standards for PTPA
- OriGene qPCR primer pairs for PTPA
- OriGene CRISPR knockouts for PTPA
- OriGene ORF clones in human for PTPA
- RC230794L1V
- RC230794L2V
- RC212144L1V
- RC212144L2V
- RC200671L1V
- RC200671L2V
- RC214340L1V
- RC214340L2V
- RC214397L1V
- RC214397L2V
- RC230794
- RC230794L1
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- RG230794
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- RC200671L1
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- RC214340
- RC214340L1
- RC214340L2
- RG214340
- RC214397
- RC214397L1
- RC214397L2
- RG214397
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PTPA
- GenScript: Next-day shipping of latest version cDNA ORF clones for PTPA in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PTPA
- GenScript Custom Assay Services for PTPA
- GenScript Custom overexpressing Cell Line Services for PTPA
- GenScript: Design CRISPR guide RNA sequences for PTPA
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PTPA
- Sino Biological Human cDNA Clone for PTPA
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PTPA
- Novus Biologicals lysates and proteins for PTPA
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PTPA
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder custom plasmid, inducible vectors for PTPA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTPA
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 85 available PPP2R4 Antibodies ranked by validation data
- Compare Top PPP2R4 Antibodies
- antibodies-online: Search results for 8 available PPP2R4 Elisa Kits ranked by validation data
- Compare Top PPP2R4 Elisa Kits
- antibodies-online: Search results for 9 available PPP2R4 Proteins ranked by validation data
- Compare Top PPP2R4 Proteins
- GeneTex PTPA Antibody for PTPA
- Search GeneTex for Proteins for PTPA
- Horizon Cell Lines for PTPA
- genomics-online: cdna clones - Search results for 147 available PPP2R4 gene related products
- Overview of 147 available PPP2R4 gene related products
- orf clones - Search results for 147 available PPP2R4 gene related products
- Overview of 147 available PPP2R4 gene related products
- genomics-online: gRNA clones - Search results for 147 available PPP2R4 gene related products
- Overview of 147 available PPP2R4 gene related products
- genomics-online: primer clones - Search results for 147 available PPP2R4 gene related products
- Overview of 147 available PPP2R4 gene related products
- genomics-online: shRNA clones - Search results for 147 available PPP2R4 gene related products
- Overview of 147 available PPP2R4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPA
- GeneCopoeia miRNA 3'UTR Target clone products for PTPA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPA
Sources for PTPA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD