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Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into th... See more...
Aliases for PTPA Gene
Aliases for PTPA Gene
- Protein Phosphatase 2 Phosphatase Activator 2 3 5
- Phosphotyrosyl Phosphatase Activator 2 3 4
- Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B' 3 4
- Protein Phosphatase 2A Activator, Regulatory Subunit 4 2 3
- Protein Phosphatase 2A, Regulatory Subunit B' (PR 53) 2 3
- Serine/Threonine-Protein Phosphatase 2A Activator 3 4
- Protein Phosphatase 2 Regulatory Subunit 4 2 3
- PP2A Phosphatase Activator 2 3
External Ids for PTPA Gene
- HGNC: 9308
- NCBI Entrez Gene: 5524
- Ensembl: ENSG00000119383
- OMIM®: 600756
- UniProtKB/Swiss-Prot: Q15257
Previous HGNC Symbols for PTPA Gene
- PPP2R4
Summaries for PTPA Gene
-
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTPA Gene
PTPA (Protein Phosphatase 2 Phosphatase Activator) is a Protein Coding gene. Diseases associated with PTPA include Leukodystrophy, Hypomyelinating, 12 and Breast Disease. Among its related pathways are Beta-Adrenergic Signaling and ERK Signaling.
UniProtKB/Swiss-Prot Summary for PTPA Gene
-
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.
Additional gene information for PTPA Gene
- HGNC (9308)
- NCBI Entrez Gene (5524)
- Ensembl (ENSG00000119383)
- OMIM® (600756)
- UniProtKB/Swiss-Prot (Q15257)
- Open Targets Platform(ENSG00000119383)
- Monarch Initiative
- Search for PTPA at DataMed
- Search for PTPA at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTPA Gene
Genomics for PTPA Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PTPA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PTPA on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTPA
Genomic Locations for PTPA Gene
Latest Assembly
- chr9:129,110,949-129,148,946
- (GRCh38/hg38)
- Size:
- 37,998 bases
- Orientation:
- Plus strand
Previous Assembly
- chr9:131,873,229-131,911,225
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 37,997 bases
- Orientation:
- Plus strand
- chr9:131,873,229-131,911,225
- (GRCh37/hg19 by Ensembl)
- Size:
- 37,997 bases
- Orientation:
- Plus strand
Genomic View for PTPA Gene
Genes around PTPA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q34.11 by HGNC
- 9q34.11 by Entrez Gene
- 9q34.11 by Ensembl
PTPA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTPA Gene
Proteins for PTPA Gene
-
Protein details for PTPA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15257-PTPA_HUMAN
- Recommended name:
- Serine/threonine-protein phosphatase 2A activator
- Protein Accession:
- Q15257
- A2A347
- A9IZU4
- B4DXM4
- Q15258
- Q53GZ3
- Q5TZQ2
- Q9BUK1
- Q9NNZ7
- Q9NNZ8
- Q9NNZ9
Protein attributes for PTPA Gene
- Size:
- 358 amino acids
- Molecular mass:
- 40668 Da
- Quaternary structure:
-
- Associates with PP2A heterodimeric core enzyme PP2A(D), composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A) (PubMed:16916641). Interacts with PPP2CB (By similarity).
Three dimensional structures from OCA and Proteopedia for PTPA Gene
Post-translational modifications for PTPA Gene
Other Protein References for PTPA Gene
- ENSEMBL proteins:
-
- ENSP00000351885
- ENSP00000395499
- ENSP00000349726
- ENSP00000335200
- ENSP00000337412
- ENSP00000337448
- ENSP00000347109
- ENSP00000377036
- ENSP00000399069
- ENSP00000394338
- ENSP00000393092
- ENSP00000400314
- ENSP00000393796
- ENSP00000396660
- ENSP00000405100
- ENSP00000408316
- ENSP00000389312
- ENSP00000408726
- ENSP00000416522
- ENSP00000393196
- ENSP00000394001
- ENSP00000416661
- ENSP00000387726
- ENSP00000411604
- Q15257.185
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences PPP2R4 Antibody
- G Biosciences Immunotagā¢ PPP2R4 Antibody
- GeneTex Anti-PPP2R4 antibody [N2C3] and Anti-PPP2R4 antibody
- BioLegend Purified anti-PPP2R4 (PTPA)
-
Custom Antibody ServicesOriGene Antibodies for PTPA
- Novus Biologicals Antibodies for PTPA
-
Abcam antibodies for PTPA
- Invitrogen Antibodies for PTPA (AFLGC-PTPA)
-
Custom Antibody ServicesProSci Antibodies for PTPA
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for PTPA
- Origene Custom Protein Services for PTPA
Assay products for research
No data available for DME Specific Peptides for PTPA Gene
Domains & Families for PTPA Gene
Gene Families for PTPA Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PTPA Gene
- InterPro:
- Blocks:
-
- Phosphotyrosyl phosphatase activator, PTPA
- ProtoNet:
Suggested Antigen Peptide Sequences for PTPA Gene
- GenScript: Design optimal peptide antigens:
-
- Protein phosphatase 2A activator, regulatory subunit 4 (A6PVP0_HUMAN)
- cDNA FLJ52532, weakly similar to Serine/threonine-protein phosphatase 2A regulatory subunit B' (B4DDQ6_HUMAN)
- cDNA FLJ54705, highly similar to Serine/threonine-protein phosphatase 2A regulatory subunit B' (B4DZF8_HUMAN)
- Protein phosphatase 2A activator, regulatory subunit 4 (B7ZBP6_HUMAN)
- Serine/threonine-protein phosphatase 2A regulatory subunit B' (PTPA_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15257- Family:
-
- Belongs to the PTPA-type PPIase family.
Function for PTPA Gene
Molecular function for PTPA Gene
- UniProtKB/Swiss-Prot Function:
- PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8;.
Enzyme Numbers (IUBMB) for PTPA Gene
Phenotypes From GWAS Catalog for PTPA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | IEA,IBA | 21873635 |
| GO:0005102 | signaling receptor binding | IPI | 10830164 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0005524 | ATP binding | IDA | 16916641 |
Phenotypes for PTPA Gene
- MGI mutant phenotypes for PTPA:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PTPA:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased viability
- Increased transferrin (TF) endocytosis
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Increased cell death HMECs cells
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in colon lineage
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased shRNA abundance (Z-score < -2)
- Apoptosis resistance
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, decreased FA abundance, decreased cell spreading
- Increased Akt phosphorylation after EGF stimulation
Animal Models for PTPA Gene
- MGI Knock Outs for PTPA:
-
- Ptpa Ptpa<tm1.1(KOMP)Vlcg>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PTPA - Starting at $85 >
- * PTPA CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PTPA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPA
miRNA for PTPA Gene
- miRTarBase miRNAs that target PTPA
-
- hsa-miR-30a-5p (MIRT005188)
- hsa-miR-326 (MIRT043628)
- hsa-miR-183-5p (MIRT438392)
- hsa-miR-1231 (MIRT736203)
- hsa-miR-1236-5p (MIRT736291)
- hsa-miR-1253 (MIRT736548)
- hsa-miR-1275 (MIRT736932)
- hsa-miR-1321 (MIRT737357)
- hsa-miR-1343-5p (MIRT737484)
- hsa-miR-149-3p (MIRT737779)
- hsa-miR-184 (MIRT738195)
- hsa-miR-185-3p (MIRT738217)
- hsa-miR-185-5p (MIRT738260)
- hsa-miR-1911-3p (MIRT738481)
- hsa-miR-3120-5p (MIRT739965)
- hsa-miR-3150a-3p (MIRT740280)
- hsa-miR-3175 (MIRT740680)
- hsa-miR-3176 (MIRT740700)
- hsa-miR-3179 (MIRT740747)
- hsa-miR-3190-5p (MIRT740972)
- hsa-miR-3192-5p (MIRT741031)
- hsa-miR-3202 (MIRT741165)
- hsa-miR-3654 (MIRT741918)
- hsa-miR-3677-5p (MIRT742154)
- hsa-miR-3922-3p (MIRT742976)
- hsa-miR-4278 (MIRT743691)
- hsa-miR-4300 (MIRT743854)
- hsa-miR-4306 (MIRT743916)
- hsa-miR-4419a (MIRT744199)
- hsa-miR-4434 (MIRT744409)
- hsa-miR-4446-3p (MIRT744625)
- hsa-miR-4463 (MIRT744880)
- hsa-miR-4476 (MIRT745045)
- hsa-miR-4492 (MIRT745297)
- hsa-miR-4494 (MIRT745332)
- hsa-miR-4498 (MIRT745378)
- hsa-miR-4505 (MIRT745537)
- hsa-miR-4510 (MIRT745638)
- hsa-miR-4516 (MIRT745762)
- hsa-miR-4525 (MIRT745922)
- hsa-miR-4644 (MIRT746388)
- hsa-miR-4665-5p (MIRT746770)
- hsa-miR-4675 (MIRT746888)
- hsa-miR-4693-3p (MIRT747149)
- hsa-miR-4716-3p (MIRT747498)
- hsa-miR-4723-5p (MIRT747663)
- hsa-miR-4728-5p (MIRT747875)
- hsa-miR-4739 (MIRT748074)
- hsa-miR-4741 (MIRT748125)
- hsa-miR-4756-5p (MIRT748446)
- hsa-miR-4768-3p (MIRT748633)
- hsa-miR-4804-5p (MIRT749026)
- hsa-miR-5001-5p (MIRT749371)
- hsa-miR-5010-5p (MIRT749504)
- hsa-miR-505-5p (MIRT749588)
- hsa-miR-5197-3p (MIRT750091)
- hsa-miR-548aa (MIRT750478)
- hsa-miR-548ap-3p (MIRT750563)
- hsa-miR-548t-3p (MIRT750797)
- hsa-miR-5591-5p (MIRT751083)
- hsa-miR-5698 (MIRT751296)
- hsa-miR-5703 (MIRT751365)
- hsa-miR-5787 (MIRT751486)
- hsa-miR-6085 (MIRT751807)
- hsa-miR-6090 (MIRT752044)
- hsa-miR-6127 (MIRT752113)
- hsa-miR-6129 (MIRT752185)
- hsa-miR-6130 (MIRT752274)
- hsa-miR-6133 (MIRT752378)
- hsa-miR-625-5p (MIRT752602)
- hsa-miR-626 (MIRT752622)
- hsa-miR-6726-5p (MIRT753926)
- hsa-miR-6732-5p (MIRT754081)
- hsa-miR-6760-5p (MIRT754937)
- hsa-miR-6763-5p (MIRT755022)
- hsa-miR-6785-5p (MIRT755870)
- hsa-miR-6794-5p (MIRT756098)
- hsa-miR-6805-5p (MIRT756484)
- hsa-miR-6813-5p (MIRT756743)
- hsa-miR-6825-5p (MIRT757010)
- hsa-miR-6827-5p (MIRT757064)
- hsa-miR-6864-5p (MIRT757911)
- hsa-miR-6870-5p (MIRT757996)
- hsa-miR-6873-5p (MIRT758082)
- hsa-miR-6876-3p (MIRT758131)
- hsa-miR-6876-5p (MIRT758155)
- hsa-miR-6878-5p (MIRT758224)
- hsa-miR-6883-5p (MIRT758455)
- hsa-miR-7111-5p (MIRT759054)
- hsa-miR-7515 (MIRT759390)
- hsa-miR-762 (MIRT759513)
- hsa-miR-920 (MIRT760480)
- hsa-miR-939-5p (MIRT760775)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPA
- Browse OriGene Inhibitory RNA Products For PTPA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPA
Clone products for research
- Applied Biological Materials (abm): Clones for PTPA - Starting at $45 >
- * PTPA as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG219967
- MR219967
- MR219967L3
- MR219967L4
- RC200671
- RC200671L3
- RC200671L4
- RC212144
- RC212144L1
- RC212144L2
- RC212144L3
- RC212144L4
- RC214340
- RC214340L3
- RC214340L4
- RC214397
- RC214397L3
- RC214397L4
- RC230794
- RC230794L3
- RC230794L4
- RC232395
- RG200671
- RG212144
- RG214340
- RG214397
- RG230794
- RG232395
- RR214140
- RR214140L3
- RR214140L4
- MR219967L3V
- MR219967L4V
- RC200671L3V
- RC200671L4V
- RC212144L1V
- RC212144L2V
- RC212144L3V
- RC212144L4V
- RC214340L3V
- RC214340L4V
- RC214397L3V
- RC214397L4V
- RC230794L3V
- RC230794L4V
- RR214140L3V
- RR214140L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PTPA
- Addgene plasmids for PTPA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPA
Cell Lines for research
-
Horizon Cell Lines for PTPA
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTPA Gene
Localization for PTPA Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTPA Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| cytosol | 4 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000159 | protein phosphatase type 2A complex | IDA | 10318862 |
| GO:0005634 | nucleus | IBA,IDA | 17333320 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 17333320 |
| GO:0034704 | calcium channel complex | IDA | 10830164 |
Pathways & Interactions for PTPA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Beta-Adrenergic Signaling |
Beta-Adrenergic Signaling
.37
Erythropoietin Pathway
.37
|
CDK5 Pathway
.36
|
| 2 | p70S6K Signaling |
p70S6K Signaling
.60
Renin-Angiotensin Pathway
.60
|
mTOR Pathway
.54
|
| 3 | Cyclins and Cell Cycle Regulation |
Cyclins and Cell Cycle Regulation
.67
|
Cell Cycle Control by BTG Proteins
.36
|
| 4 | ERK Signaling |
ERK Signaling
.61
|
ILK Signaling
.49
|
| 5 | TGF-Beta Pathway |
TGF-Beta Pathway
.60
|
Regulation of eIF4 and p70S6K
.43
|
Pathways by source for PTPA Gene
7 BioSystems pathways for PTPA Gene
1 KEGG pathway for PTPA Gene
4 GeneGo (Thomson Reuters) pathways for PTPA Gene
- Cell cycle Regulation of G1/S transition (part 1)
- Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
- Regulation of CFTR activity (norm and CF)
- Signal transduction_PKA signaling
25 Qiagen pathways for PTPA Gene
- Akt Signaling
- BAD Phosphorylation
- Beta-Adrenergic Signaling
- Breast Cancer Regulation by Stathmin1
- CDK5 Pathway
1 Cell Signaling Technology pathway for PTPA Gene
Interacting Proteins for PTPA Gene
Selected Interacting proteins:
Q15257-PTPA_HUMAN
ENSP00000377036
for PTPA Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PTPA
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000413 | protein peptidyl-prolyl isomerization | IEA | -- |
| GO:0007052 | mitotic spindle organization | IBA | 21873635 |
| GO:0032515 | negative regulation of phosphoprotein phosphatase activity | IDA | 16916641 |
| GO:0032516 | positive regulation of phosphoprotein phosphatase activity | IDA | 16916641 |
| GO:0035307 | positive regulation of protein dephosphorylation | IDA | 16916641 |
Drugs & Compounds for PTPA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cantharidin | Approved, Investigational | Pharma | Inhibitor of protein phosphatases 1/2A | 16 | ||
| Calyculin A | Experimental | Pharma | Protein phosphatase inhibitor | 0 | ||
| Okadaic acid | Experimental | Pharma | Protein phosphatase 1 inhibitor | 0 | ||
| GLYCYLALANYL-N-2-NAPHTHYL-L-PROLINEAMIDE | Experimental | Pharma | Target | 0 | ||
| Ceramide | Pharma | Protein phosphatase and CAPP modulator | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(7) ApexBio Compounds for PTPA Gene
| Compound | Action | Cas Number |
|---|---|---|
| Calyculin A | Protein phosphatase inhibitor | 101932-71-2 |
| Cantharidin | Inhibitor of protein phosphatases 1/2A | 56-25-7 |
| Ceramide | Protein phosphatase and CAPP modulator | 3102-57-6 |
| Fostriecin sodium salt | Antitumor antibiotic | 87860-39-7 |
| Fumonisin B1 | PP5/PP2CĪ±/PP2A/PP1Ī³2/PP2B inhibitor | 116355-83-0 |
| Okadaic acid | Protein phosphatase 1 inhibitor | 78111-17-8 |
| Tautomycetin | 119757-73-2 |
Drug products for research
- ApexBio compounds for PTPA
Transcripts for PTPA Gene
mRNA/cDNA for PTPA Gene
- 7 REFSEQ mRNAs :
- 31 NCBI additional mRNA sequence :
- 24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000337738 2746 nts (view in UCSC)
- ENST00000347048 1989 nts (view in UCSC)
- ENST00000348141 2737 nts (view in UCSC)
- ENST00000355007 2515 nts (view in UCSC)
- ENST00000357197 2653 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PTPA - Starting at $85 >
- * PTPA CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PTPA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPA
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPA
- Browse OriGene Inhibitory RNA Products For PTPA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPA
Clone products for research
- Applied Biological Materials (abm): Clones for PTPA - Starting at $45 >
- * PTPA as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG219967
- MR219967
- MR219967L3
- MR219967L4
- RC200671
- RC200671L3
- RC200671L4
- RC212144
- RC212144L1
- RC212144L2
- RC212144L3
- RC212144L4
- RC214340
- RC214340L3
- RC214340L4
- RC214397
- RC214397L3
- RC214397L4
- RC230794
- RC230794L3
- RC230794L4
- RC232395
- RG200671
- RG212144
- RG214340
- RG214397
- RG230794
- RG232395
- RR214140
- RR214140L3
- RR214140L4
- MR219967L3V
- MR219967L4V
- RC200671L3V
- RC200671L4V
- RC212144L1V
- RC212144L2V
- RC212144L3V
- RC212144L4V
- RC214340L3V
- RC214340L4V
- RC214397L3V
- RC214397L4V
- RC230794L3V
- RC230794L4V
- RR214140L3V
- RR214140L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PTPA
- Addgene plasmids for PTPA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPA
Relevant External Links for PTPA Gene
- GeneLoc Exon Structure for
- PTPA
Expression for PTPA Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTPA
mRNA Expression by UniProt/SwissProt for PTPA Gene:
Q15257-PTPA_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for PTPA Gene
- Nervous system(4.9)
- Heart(4.6)
- Liver(4.6)
- Blood(4.6)
- Lung(4.2)
- Kidney(3.7)
- Skin(3.7)
- Intestine(3.6)
- Muscle(3.2)
- Adrenal gland(2.8)
- Pancreas(2.7)
- Spleen(2.6)
- Lymph node(2.6)
- Stomach(2.6)
- Bone marrow(2.5)
- Thyroid gland(2.5)
- Eye(2.3)
- Bone(2.2)
Primer products for research
-
OriGene qPCR primer pairs for PTPA
-
OriGene qPCR primer pairs and template standards for PTPA
Gene Expression Assays for research
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTPA Gene
Orthologs for PTPA Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PPP2R4 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PPP2R4 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PPP2R4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PPP2R4 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PPP2R4 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ppp2r4 30 31 |
|
OneToOne | |
| Ptpa 17 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | Ppp2r4 30 |
|
||
| Chicken (Gallus gallus) |
Aves | PPP2R4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PPP2R4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ppp2r4 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.8828 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ppp2r4 30 31 |
|
OneToOne | |
| wufc23d07 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8890 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Ptpa 30 31 |
|
OneToMany | |
| CG2104 31 |
|
OneToMany | |||
| CG8509 31 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008652 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | Y71H2AM.20 30 31 |
|
OneToOne | |
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ACR139C 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RRD2 30 33 33 |
|
||
| RRD1 31 |
|
OneToOne | |||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F11187g 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT4G08960 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.5058 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os06g0219800 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU03269 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC1782.05 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.6463 30 |
|
- Species where no ortholog for PTPA was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PTPA Gene
- ENSEMBL:
- Gene Tree for PTPA (if available)
- TreeFam:
- Gene Tree for PTPA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PTPA: view image
Paralogs for PTPA Gene
No data available for Paralogs for PTPA Gene
Variants for PTPA Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTPA Gene
| SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11554659 | Benign: not provided | 129,142,498(+) |
C/T NM_178000.3(PTPA):c.840C>T (p.Ala280=) |
SYNONYMOUS | |
| rs138155879 | Benign: not provided | 129,134,882(+) |
A/C NM_178000.3(PTPA):c.548A>C (p.Lys183Thr) |
MISSENSE | |
| rs146867459 | Likely Benign: not provided | 129,142,436(+) |
C/G NM_178000.3(PTPA):c.787-9C>G |
INTRON | |
| rs147044679 | Benign: not provided | 129,123,135(+) |
C/T NM_178000.3(PTPA):c.213C>T (p.Ser71=) |
SYNONYMOUS_VARIANT,INTRON | |
| rs17508881 | Benign: not provided | 129,136,522(+) |
C/T NM_178000.3(PTPA):c.612C>T (p.Ala204=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.32;
26.18% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PTPA Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PTPA
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTPA Gene
Disorders for PTPA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leukodystrophy, hypomyelinating, 12 |
|
|
| breast disease |
|
|
| fragile x syndrome |
|
|
| alzheimer disease |
|
|
| crouzon syndrome with acanthosis nigricans |
|
|
Search PTPA in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PTPA
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PTPA Gene
Publications for PTPA Gene
- Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A. (PMID: 8530035) Van Hoof C ā¦ Goris J (Genomics 1995) 2 3 4 23
- The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions. (PMID: 16782712) Magnusdottir A ā¦ Nordlund P (The Journal of biological chemistry 2006) 3 4 23
- Structure and mechanism of the phosphotyrosyl phosphatase activator. (PMID: 16916641) Chao Y ā¦ Shi Y (Molecular cell 2006) 3 4 23
- The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase. (PMID: 16380387) Jordens J ā¦ Van Hoof C (The Journal of biological chemistry 2006) 2 3 23
- Identification and characterization of alternative splice products encoded by the human phosphotyrosyl phosphatase activator gene. (PMID: 10880964) Janssens V ā¦ Goris J (European journal of biochemistry 2000) 3 4 23
ExternalLinks
Products for PTPA Gene
- Custom Antibody ServicesOriGene Antibodies for PTPA
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PTPA
- Origene Custom Protein Services for PTPA
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTPA
- Browse OriGene Inhibitory RNA Products For PTPA
- OriGene qPCR primer pairs for PTPA
- OriGene qPCR primer pairs and template standards for PTPA
- OriGene CRISPR knockouts for PTPA
- MG219967
- MR219967
- MR219967L3
- MR219967L4
- RC200671
- RC200671L3
- RC200671L4
- RC212144
- RC212144L1
- RC212144L2
- RC212144L3
- RC212144L4
- RC214340
- RC214340L3
- RC214340L4
- RC214397
- RC214397L3
- RC214397L4
- RC230794
- RC230794L3
- RC230794L4
- RC232395
- RG200671
- RG212144
- RG214340
- RG214397
- RG230794
- RG232395
- RR214140
- RR214140L3
- RR214140L4
- MR219967L3V
- MR219967L4V
- RC200671L3V
- RC200671L4V
- RC212144L1V
- RC212144L2V
- RC212144L3V
- RC212144L4V
- RC214340L3V
- RC214340L4V
- RC214397L3V
- RC214397L4V
- RC230794L3V
- RC230794L4V
- RR214140L3V
- RR214140L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PTPA
- Sino Biological Human cDNA Clone for PTPA
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PTPA
- Novus Biologicals proteins and lysates for PTPA
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PTPA
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for PTPA (AFLGC-PTPA)
- ApexBio compounds for PTPA
- VectorBuilder Custom and pre-made DNA vectors for PTPA (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PTPA (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PTPA (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PTPA CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PTPA
- Addgene plasmids for PTPA
- antibodies-online: Show 25 available PPP2R4 Antibodies ranked by validation data
- Compare Top PPP2R4 Antibodies
- antibodies-online: Show 13 available PPP2R4 Elisa Kits ranked by validation data
- Compare Top PPP2R4 Elisa Kits
- antibodies-online: Show 9 available PPP2R4 Proteins ranked by validation data
- Compare Top PPP2R4 Proteins
- Custom Antibody ServicesProSci Antibodies for PTPA
- Search for PTPA Proteins at ProSci
- Horizon Cell Lines for PTPA
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTPA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTPA
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PTPA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTPA
Sources for PTPA Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36)