This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein ma... See more...

Aliases for PTP4A3 Gene

Aliases for PTP4A3 Gene

  • Protein Tyrosine Phosphatase 4A3 2 3 5
  • PRL-3 2 3 4
  • PRL-R 2 3 4
  • PRL3 2 3 4
  • Protein-Tyrosine Phosphatase Of Regenerating Liver 3 3 4
  • Protein Tyrosine Phosphatase Type IVA, Member 3 2 3
  • Protein Tyrosine Phosphatase Type IVA 3 3 4
  • Phosphatase Of Regenerating Liver 3 2 3
  • EC 3.1.3.48 4 50
  • Potentially Prenylated Protein Tyrosine Phosphatase 3
  • Protein-Tyrosine Phosphatase 4a3 4
  • PTP4A3 5

External Ids for PTP4A3 Gene

Previous GeneCards Identifiers for PTP4A3 Gene

  • GC00U990504
  • GC08U900031
  • GC08P142111
  • GC08P142403
  • GC08P142501
  • GC08P142432
  • GC08P137749

Summaries for PTP4A3 Gene

Entrez Gene Summary for PTP4A3 Gene

  • This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

CIViC Summary for PTP4A3 Gene

GeneCards Summary for PTP4A3 Gene

PTP4A3 (Protein Tyrosine Phosphatase 4A3) is a Protein Coding gene. Diseases associated with PTP4A3 include Functioning Pituitary Adenoma and Ocular Melanoma. Among its related pathways are Signaling events mediated by PRL and PAK Pathway. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is PTP4A1.

UniProtKB/Swiss-Prot Summary for PTP4A3 Gene

  • Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.

Gene Wiki entry for PTP4A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTP4A3 Gene

Genomics for PTP4A3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTP4A3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTP4A3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTP4A3

Top Transcription factor binding sites by QIAGEN in the PTP4A3 gene promoter:
  • STAT5A

Genomic Locations for PTP4A3 Gene

Latest Assembly
chr8:141,391,995-141,432,454
(GRCh38/hg38)
Size:
40,460 bases
Orientation:
Plus strand

Previous Assembly
chr8:142,402,121-142,442,554
(GRCh37/hg19 by Entrez Gene)
Size:
40,434 bases
Orientation:
Plus strand

chr8:142,402,093-142,441,620
(GRCh37/hg19 by Ensembl)
Size:
39,528 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr8(ALT_REF_LOCI_1):58,573-104,910 (+)

Genomic View for PTP4A3 Gene

Genes around PTP4A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTP4A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTP4A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTP4A3 Gene

Proteins for PTP4A3 Gene

  • Protein details for PTP4A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75365-TP4A3_HUMAN
    Recommended name:
    Protein tyrosine phosphatase type IVA 3
    Protein Accession:
    O75365
    Secondary Accessions:
    • Q8IVN5
    • Q99849
    • Q9BTW5

    Protein attributes for PTP4A3 Gene

    Size:
    173 amino acids
    Molecular mass:
    19535 Da
    Quaternary structure:
    • Interacts with tubulin.
    Miscellaneous:
    • [Isoform 2]: Unstructured and inactive.

    Three dimensional structures from OCA and Proteopedia for PTP4A3 Gene

    Alternative splice isoforms for PTP4A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTP4A3 Gene

Selected DME Specific Peptides for PTP4A3 Gene

O75365:
  • DWPFDDGAPP
  • QFIRQKRRGA
  • GMKYEDA
  • HCVAGLGRAPVLVA
  • YLEKYRPK
  • MRFLITHNP

Post-translational modifications for PTP4A3 Gene

  • Farnesylated. Farnesylation is required for membrane targeting (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PTP4A3 Gene

Gene Families for PTP4A3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PTP4A3 Gene

GenScript: Design optimal peptide antigens:
  • Protein-tyrosine phosphatase of regenerating liver 3 (TP4A3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75365

UniProtKB/Swiss-Prot:

TP4A3_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with PTP4A3: view

Function for PTP4A3 Gene

Molecular function for PTP4A3 Gene

UniProtKB/Swiss-Prot Function:
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine.

Enzyme Numbers (IUBMB) for PTP4A3 Gene

Phenotypes From GWAS Catalog for PTP4A3 Gene

Gene Ontology (GO) - Molecular Function for PTP4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IBA 21873635
GO:0004727 prenylated protein tyrosine phosphatase activity TAS 9514946
GO:0005515 protein binding IPI 23178297
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with PTP4A3: view
genes like me logo Genes that share phenotypes with PTP4A3: view

Animal Models for PTP4A3 Gene

MGI Knock Outs for PTP4A3:

Animal Models for research

  • Taconic Biosciences Mouse Models for PTP4A3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTP4A3

Clone products for research

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTP4A3 Gene

Localization for PTP4A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTP4A3 Gene

Cell membrane. Early endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTP4A3 gene
Compartment Confidence
plasma membrane 4
nucleus 4
endosome 4
cytoskeleton 2
mitochondrion 2
cytosol 2
extracellular 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for PTP4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 23178297
GO:0005737 cytoplasm IMP 23178297
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PTP4A3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTP4A3 Gene

Pathways & Interactions for PTP4A3 Gene

PathCards logo

SuperPathways for PTP4A3 Gene

SuperPathway Contained pathways
1 PAK Pathway
.36
2 Signaling events mediated by PRL
genes like me logo Genes that share pathways with PTP4A3: view

Pathways by source for PTP4A3 Gene

1 BioSystems pathway for PTP4A3 Gene
1 Qiagen pathway for PTP4A3 Gene
  • Epithelial Adherens Junctions

SIGNOR curated interactions for PTP4A3 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for PTP4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 23178297
GO:0006470 protein dephosphorylation IEA --
GO:0007219 Notch signaling pathway IDA --
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with PTP4A3: view

Drugs & Compounds for PTP4A3 Gene

(3) Drugs for PTP4A3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0
Calcium Nutra 6959

(1) Additional Compounds for PTP4A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Na(+)
  • Na+
  • SODIUM ion
  • Sodium(1+)
7440-23-5
genes like me logo Genes that share compounds with PTP4A3: view

Transcripts for PTP4A3 Gene

mRNA/cDNA for PTP4A3 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTP4A3

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for PTP4A3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -
SP3: - -
SP4:

Relevant External Links for PTP4A3 Gene

GeneLoc Exon Structure for
PTP4A3

Expression for PTP4A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTP4A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTP4A3 Gene

This gene is overexpressed in Muscle - Skeletal (x7.8), Heart - Left Ventricle (x7.7), and Heart - Atrial Appendage (x4.2).

Protein differential expression in normal tissues from HIPED for PTP4A3 Gene

This gene is overexpressed in Retina (36.0), Heart (24.2), and Monocytes (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTP4A3 Gene



Protein tissue co-expression partners for PTP4A3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTP4A3

SOURCE GeneReport for Unigene cluster for PTP4A3 Gene:

Hs.744870

mRNA Expression by UniProt/SwissProt for PTP4A3 Gene:

O75365-TP4A3_HUMAN
Tissue specificity: Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.

Evidence on tissue expression from TISSUES for PTP4A3 Gene

  • Muscle(4.5)
  • Lung(4.4)
  • Eye(4.2)
  • Heart(2.6)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with PTP4A3: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTP4A3 Gene

Orthologs for PTP4A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTP4A3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PTP4A3 29 30
  • 99.04 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PTP4A3 29 30
  • 89.98 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PTP4A3 29 30
  • 89.4 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ptp4a3 29 16 30
  • 88.63 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ptp4a3 29
  • 88.44 (n)
Oppossum
(Monodelphis domestica)
Mammalia PTP4A3 30
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PTP4A3 30
  • 42 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PTP4A3 29 30
  • 82.85 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PTP4A3 30
  • 90 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ptp4a3 29
  • 77.65 (n)
Zebrafish
(Danio rerio)
Actinopterygii ptp4a3 29
  • 77.65 (n)
PTP4A3 30
  • 75 (a)
OneToOne
wufc54b05 29
Fruit Fly
(Drosophila melanogaster)
Insecta PRL-1 30
  • 54 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea T19D2.2 30
  • 47 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10622 30
  • 66 (a)
OneToMany
Species where no ortholog for PTP4A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PTP4A3 Gene

ENSEMBL:
Gene Tree for PTP4A3 (if available)
TreeFam:
Gene Tree for PTP4A3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTP4A3: view image
Alliance of Genome Resources:
Additional Orthologs for PTP4A3

Paralogs for PTP4A3 Gene

Paralogs for PTP4A3 Gene

(2) SIMAP similar genes for PTP4A3 Gene using alignment to 3 proteins:

  • TP4A3_HUMAN
  • E5RFQ4_HUMAN
  • E5RGR3_HUMAN
genes like me logo Genes that share paralogs with PTP4A3: view

Variants for PTP4A3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTP4A3 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs74648509 Benign: not provided 141,426,934(+) C/T
NM_032611.3(PTP4A3):c.199-5C>T
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PTP4A3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PTP4A3 Gene

Variant ID Type Subtype PubMed ID
dgv12368n54 CNV loss 21841781
dgv7330n100 CNV gain 25217958
dgv7331n100 CNV gain 25217958
dgv902n27 CNV loss 19166990
esv1011203 CNV insertion 20482838
esv1229387 CNV insertion 17803354
esv1265503 CNV insertion 17803354
esv1420349 CNV insertion 17803354
esv22902 CNV loss 19812545
esv2737756 CNV deletion 23290073
esv2737782 CNV deletion 23290073
esv3433413 CNV duplication 20981092
esv3891495 CNV gain 25118596
nsv1023036 CNV loss 25217958
nsv1126125 CNV deletion 24896259
nsv465956 CNV gain 19166990
nsv465958 CNV loss 19166990
nsv465959 CNV loss 19166990
nsv470240 CNV loss 18288195
nsv509285 CNV insertion 20534489
nsv612575 CNV gain 21841781
nsv612577 CNV loss 21841781
nsv612578 CNV loss 21841781
nsv6431 CNV insertion 18451855
nsv824751 CNV gain 20364138
nsv949996 CNV deletion 24416366

Variation tolerance for PTP4A3 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTP4A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTP4A3
Leiden Open Variation Database (LOVD)
PTP4A3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTP4A3 Gene

Disorders for PTP4A3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PTP4A3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
functioning pituitary adenoma
  • secretory adenoma of the pituitary gland
ocular melanoma
  • eye melanoma
pharynx squamous cell carcinoma
colorectal cancer
  • crc
melanoma, uveal
  • uveal melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PTP4A3

genes like me logo Genes that share disorders with PTP4A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTP4A3 Gene

Publications for PTP4A3 Gene

  1. Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling. (PMID: 11355880) Matter WF … Vlahos CJ (Biochemical and biophysical research communications 2001) 3 4 22
  2. Down-regulation of the human PRL-3 gene is associated with the metastasis of primary non-small cell lung cancer. (PMID: 17717498) Yamashita S … Kawahara K (Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 2007) 3 22
  3. Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases. (PMID: 15788667) Li J … Zeng Q (Clinical cancer research : an official journal of the American Association for Cancer Research 2005) 3 22
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Structural insights into molecular function of the metastasis-associated phosphatase PRL-3. (PMID: 14704153) Kozlov G … Ekiel I (The Journal of biological chemistry 2004) 3 4

Products for PTP4A3 Gene

Sources for PTP4A3 Gene