Aliases for PTP4A3 Gene
External Ids for PTP4A3 Gene
Previous GeneCards Identifiers for PTP4A3 Gene
This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for PTP4A3 Gene
PTP4A3 (Protein Tyrosine Phosphatase 4A3) is a Protein Coding gene. Diseases associated with PTP4A3 include Functioning Pituitary Adenoma and Ocular Melanoma. Among its related pathways are Signaling events mediated by PRL and PAK Pathway. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is PTP4A1.
UniProtKB/Swiss-Prot Summary for PTP4A3 Gene
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.