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Aliases for PTP4A3 Gene

Aliases for PTP4A3 Gene

  • Protein Tyrosine Phosphatase Type IVA, Member 3 2 3 5
  • Protein-Tyrosine Phosphatase Of Regenerating Liver 3 3 4
  • Phosphatase Of Regenerating Liver 3 2 3
  • Protein-Tyrosine Phosphatase 4a3 3 4
  • EC 3.1.3.48 4 56
  • PRL-R 3 4
  • PRL-3 3 4
  • PRL3 3 4
  • Potentially Prenylated Protein Tyrosine Phosphatase 3
  • Protein Tyrosine Phosphatase Type IVA 3 3

External Ids for PTP4A3 Gene

Previous GeneCards Identifiers for PTP4A3 Gene

  • GC00U990504
  • GC08U900031
  • GC08P142111
  • GC08P142403
  • GC08P142501
  • GC08P142432
  • GC08P137749

Summaries for PTP4A3 Gene

Entrez Gene Summary for PTP4A3 Gene

  • This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

CIViC summary for PTP4A3 Gene

GeneCards Summary for PTP4A3 Gene

PTP4A3 (Protein Tyrosine Phosphatase Type IVA, Member 3) is a Protein Coding gene. Diseases associated with PTP4A3 include Melanoma, Uveal. Among its related pathways are Signaling events mediated by PRL and PAK Pathway. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is PTP4A2.

UniProtKB/Swiss-Prot for PTP4A3 Gene

  • Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.

Gene Wiki entry for PTP4A3 Gene

Additional gene information for PTP4A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTP4A3 Gene

Genomics for PTP4A3 Gene

GeneHancer (GH) Regulatory Elements for PTP4A3 Gene

Promoters and enhancers for PTP4A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I141391 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 550.8 +0.4 354 1.9 HDGF CLOCK ARNT SIN3A ZNF766 E2F8 FOS ATF7 SP5 NCOA1 ENSG00000244998 LOC105375790 PTP4A3 GPR20 LINC01300
GH08I141393 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 552.5 +2.0 2000 1.1 BCOR ZMYM3 KDM1A ZNF112 PTP4A3 ENSG00000244998 PTK2 SLC45A4 LINC01300 PIR43419
GH08I141421 Promoter/Enhancer 0.9 EPDnew dbSUPER 550.3 +29.4 29435 0.1 ZIC2 NR2F2 PTP4A3 PIR43419 FP248
GH08I141424 Promoter/Enhancer 0.8 EPDnew dbSUPER 550.3 +30.0 29967 0.1 EGR2 PTP4A3 PIR43419 FP248
GH08I141400 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 3.8 +11.8 11771 7.2 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B DMAP1 YBX1 SLC30A9 ZNF207 SLC45A4 DENND3 LINC01300 ENSG00000244998 TRAPPC9 PTP4A3 PIR43419
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PTP4A3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTP4A3 gene promoter:

Genomic Locations for PTP4A3 Gene

Genomic Locations for PTP4A3 Gene
chr8:141,391,993-141,432,454
(GRCh38/hg38)
Size:
40,462 bases
Orientation:
Plus strand
chr8:142,402,093-142,441,620
(GRCh37/hg19)

Genomic View for PTP4A3 Gene

Genes around PTP4A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTP4A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTP4A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTP4A3 Gene

Proteins for PTP4A3 Gene

  • Protein details for PTP4A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75365-TP4A3_HUMAN
    Recommended name:
    Protein tyrosine phosphatase type IVA 3
    Protein Accession:
    O75365
    Secondary Accessions:
    • Q8IVN5
    • Q99849
    • Q9BTW5

    Protein attributes for PTP4A3 Gene

    Size:
    173 amino acids
    Molecular mass:
    19535 Da
    Quaternary structure:
    • Interacts with tubulin.

    Three dimensional structures from OCA and Proteopedia for PTP4A3 Gene

    Alternative splice isoforms for PTP4A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTP4A3 Gene

Selected DME Specific Peptides for PTP4A3 Gene

O75365:
  • DWPFDDGAPP
  • QFIRQKRRGA
  • GMKYEDA
  • HCVAGLGRAPVLVA
  • YLEKYRPK
  • MRFLITHNP

Post-translational modifications for PTP4A3 Gene

  • Farnesylated. Farnesylation is required for membrane targeting (By similarity).

Antibody Products

  • R&D Systems Antibodies for PTP4A3 (PRL-3/PTP4A3)
  • Cell Signaling Technology (CST) Antibodies for PTP4A3 (PTP4A3)
  • Abcam antibodies for PTP4A3

Domains & Families for PTP4A3 Gene

Gene Families for PTP4A3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PTP4A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75365

UniProtKB/Swiss-Prot:

TP4A3_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with PTP4A3: view

Function for PTP4A3 Gene

Molecular function for PTP4A3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine.
UniProtKB/Swiss-Prot Function:
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.

Enzyme Numbers (IUBMB) for PTP4A3 Gene

Phenotypes From GWAS Catalog for PTP4A3 Gene

Gene Ontology (GO) - Molecular Function for PTP4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0004727 prenylated protein tyrosine phosphatase activity TAS 9514946
GO:0005515 protein binding IPI 23178297
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PTP4A3: view
genes like me logo Genes that share phenotypes with PTP4A3: view

Animal Models for PTP4A3 Gene

MGI Knock Outs for PTP4A3:

Animal Model Products

miRNA for PTP4A3 Gene

miRTarBase miRNAs that target PTP4A3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTP4A3 Gene

Localization for PTP4A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTP4A3 Gene

Cell membrane. Early endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTP4A3 gene
Compartment Confidence
plasma membrane 4
nucleus 3
endosome 3
mitochondrion 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PTP4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 23178297
GO:0005737 cytoplasm IMP 23178297
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PTP4A3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTP4A3 Gene

Pathways & Interactions for PTP4A3 Gene

genes like me logo Genes that share pathways with PTP4A3: view

Pathways by source for PTP4A3 Gene

1 BioSystems pathway for PTP4A3 Gene
1 Qiagen pathway for PTP4A3 Gene

Gene Ontology (GO) - Biological Process for PTP4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 23178297
GO:0006470 protein dephosphorylation IEA --
GO:0007219 Notch signaling pathway IEA --
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with PTP4A3: view

No data available for SIGNOR curated interactions for PTP4A3 Gene

Drugs & Compounds for PTP4A3 Gene

(3) Drugs for PTP4A3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0

(2) Additional Compounds for PTP4A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with PTP4A3: view

Transcripts for PTP4A3 Gene

Unigene Clusters for PTP4A3 Gene

Protein tyrosine phosphatase type IVA, member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTP4A3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -
SP3: - -
SP4:

Relevant External Links for PTP4A3 Gene

GeneLoc Exon Structure for
PTP4A3
ECgene alternative splicing isoforms for
PTP4A3

Expression for PTP4A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTP4A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTP4A3 Gene

This gene is overexpressed in Muscle - Skeletal (x7.8), Heart - Left Ventricle (x7.7), and Heart - Atrial Appendage (x4.2).

Protein differential expression in normal tissues from HIPED for PTP4A3 Gene

This gene is overexpressed in Retina (36.0), Heart (24.2), and Monocytes (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTP4A3 Gene



Protein tissue co-expression partners for PTP4A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PTP4A3 Gene:

PTP4A3

SOURCE GeneReport for Unigene cluster for PTP4A3 Gene:

Hs.744870

mRNA Expression by UniProt/SwissProt for PTP4A3 Gene:

O75365-TP4A3_HUMAN
Tissue specificity: Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.

Evidence on tissue expression from TISSUES for PTP4A3 Gene

  • Muscle(4.4)
  • Lung(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with PTP4A3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTP4A3 Gene

Orthologs for PTP4A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTP4A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTP4A3 33 34
  • 99.04 (n)
cow
(Bos Taurus)
Mammalia PTP4A3 33 34
  • 89.98 (n)
dog
(Canis familiaris)
Mammalia PTP4A3 33 34
  • 89.4 (n)
mouse
(Mus musculus)
Mammalia Ptp4a3 33 16 34
  • 88.63 (n)
rat
(Rattus norvegicus)
Mammalia Ptp4a3 33
  • 88.44 (n)
oppossum
(Monodelphis domestica)
Mammalia PTP4A3 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTP4A3 34
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTP4A3 33 34
  • 82.85 (n)
lizard
(Anolis carolinensis)
Reptilia PTP4A3 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptp4a3 33
  • 77.65 (n)
zebrafish
(Danio rerio)
Actinopterygii ptp4a3 33
  • 77.65 (n)
PTP4A3 34
  • 75 (a)
OneToOne
wufc54b05 33
fruit fly
(Drosophila melanogaster)
Insecta PRL-1 34
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T19D2.2 34
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10622 34
  • 66 (a)
OneToMany
Species where no ortholog for PTP4A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTP4A3 Gene

ENSEMBL:
Gene Tree for PTP4A3 (if available)
TreeFam:
Gene Tree for PTP4A3 (if available)

Paralogs for PTP4A3 Gene

Paralogs for PTP4A3 Gene

(2) SIMAP similar genes for PTP4A3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PTP4A3: view

Variants for PTP4A3 Gene

Sequence variations from dbSNP and Humsavar for PTP4A3 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000017268 -- 141,411,391(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000137641 -- 141,396,772(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000202971 -- 141,428,990(+) G/C intron_variant
rs1000300764 -- 141,406,315(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000338825 -- 141,401,432(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PTP4A3 Gene

Variant ID Type Subtype PubMed ID
nsv949996 CNV deletion 24416366
nsv824751 CNV gain 20364138
nsv6431 CNV insertion 18451855
nsv612578 CNV loss 21841781
nsv612577 CNV loss 21841781
nsv612575 CNV gain 21841781
nsv509285 CNV insertion 20534489
nsv470240 CNV loss 18288195
nsv465959 CNV loss 19166990
nsv465958 CNV loss 19166990
nsv465956 CNV gain 19166990
nsv1126125 CNV deletion 24896259
nsv1023036 CNV loss 25217958
esv3891495 CNV gain 25118596
esv3433413 CNV duplication 20981092
esv2737782 CNV deletion 23290073
esv2737756 CNV deletion 23290073
esv22902 CNV loss 19812545
esv1420349 CNV insertion 17803354
esv1265503 CNV insertion 17803354
esv1229387 CNV insertion 17803354
esv1011203 CNV insertion 20482838
dgv902n27 CNV loss 19166990
dgv7331n100 CNV gain 25217958
dgv7330n100 CNV gain 25217958
dgv12368n54 CNV loss 21841781

Variation tolerance for PTP4A3 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTP4A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTP4A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTP4A3 Gene

Disorders for PTP4A3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PTP4A3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
melanoma, uveal
  • uveal melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PTP4A3

genes like me logo Genes that share disorders with PTP4A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTP4A3 Gene

Publications for PTP4A3 Gene

  1. Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling. (PMID: 11355880) Matter WF … Vlahos CJ (Biochemical and biophysical research communications 2001) 3 4 22 58
  2. Down-regulation of the human PRL-3 gene is associated with the metastasis of primary non-small cell lung cancer. (PMID: 17717498) Yamashita S … Kawahara K (Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 2007) 3 22 58
  3. Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases. (PMID: 15788667) Li J … Zeng Q (Clinical cancer research : an official journal of the American Association for Cancer Research 2005) 3 22 58
  4. Structural insights into molecular function of the metastasis-associated phosphatase PRL-3. (PMID: 14704153) Kozlov G … Ekiel I (The Journal of biological chemistry 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PTP4A3 Gene

Sources for PTP4A3 Gene

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