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Aliases for PTP4A2 Gene

Aliases for PTP4A2 Gene

  • Protein Tyrosine Phosphatase Type IVA, Member 2 2 3 5
  • Protein-Tyrosine Phosphatase Of Regenerating Liver 2 3 4
  • Phosphatase Of Regenerating Liver 2 2 3
  • Protein-Tyrosine Phosphatase 4a2 3 4
  • PTP(CAAXII) 3 4
  • EC 3.1.3.48 4 56
  • PTPCAAX2 3 4
  • HU-PP-1 3 4
  • PRL-2 3 4
  • OV-1 3 4
  • PRL2 3 4
  • Protein Tyrosine Phosphatase Type IVA 2 3
  • Protein Tyrosine Phosphatase IVA2 3
  • Protein Tyrosine Phosphatase IVA 3
  • Ptp-IV1a 3
  • Ptp-IV1b 3
  • HH7-2 3
  • PTP4A 3
  • HH13 3

External Ids for PTP4A2 Gene

Previous HGNC Symbols for PTP4A2 Gene

  • PTP4A

Previous GeneCards Identifiers for PTP4A2 Gene

  • GC01M032182
  • GC01M031359
  • GC01M031798
  • GC01M032041
  • GC01M032372
  • GC01M030488

Summaries for PTP4A2 Gene

Entrez Gene Summary for PTP4A2 Gene

  • The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]

GeneCards Summary for PTP4A2 Gene

PTP4A2 (Protein Tyrosine Phosphatase Type IVA, Member 2) is a Protein Coding gene. Among its related pathways are Signaling events mediated by PRL and PAK Pathway. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is PTP4A1.

UniProtKB/Swiss-Prot for PTP4A2 Gene

  • Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.

Gene Wiki entry for PTP4A2 Gene

Additional gene information for PTP4A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTP4A2 Gene

Genomics for PTP4A2 Gene

GeneHancer (GH) Regulatory Elements for PTP4A2 Gene

Promoters and enhancers for PTP4A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I031924 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.4 +9.0 9023 22.1 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 GC01P031934 PTP4A2 TXLNA SNRNP40 KHDRBS1 RBBP4 ENSG00000229447 TSSK3 ZBTB8A TMEM39B
GH01I031921 Promoter/Enhancer 0.8 EPDnew dbSUPER 562.1 +25.5 25544 0.1 PRDM1 PTP4A2 ENSG00000269967 GC01M031906
GH01I031919 Promoter/Enhancer 0.8 EPDnew dbSUPER 561.3 +25.7 25722 0.1 PRDM1 PTP4A2 ENSG00000269967 GC01M031906
GH01I031845 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +97.0 96983 5 BCOR BHLHE40 ZMYM3 MNT CHAMP1 MITF ZFHX2 ADNP IKZF1 KDM1A PTP4A2 MTMR9LP SPOCD1 LCK SYNC ENSG00000203620
GH01I032331 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.6 -391.3 -391281 8.6 HDGF ARID4B SIN3A ZBTB7B IRF4 SLC30A9 POLR2B ZNF766 ZNF207 ZNF143 MARCKSL1 TMEM39B KHDRBS1 TXLNA MTMR9LP PTP4A2 HDAC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PTP4A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTP4A2 gene promoter:

Genomic Locations for PTP4A2 Gene

Genomic Locations for PTP4A2 Gene
chr1:31,906,421-31,944,856
(GRCh38/hg38)
Size:
38,436 bases
Orientation:
Minus strand
chr1:32,372,022-32,410,457
(GRCh37/hg19)

Genomic View for PTP4A2 Gene

Genes around PTP4A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTP4A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTP4A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTP4A2 Gene

Proteins for PTP4A2 Gene

  • Protein details for PTP4A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12974-TP4A2_HUMAN
    Recommended name:
    Protein tyrosine phosphatase type IVA 2
    Protein Accession:
    Q12974
    Secondary Accessions:
    • A8K9I8
    • B4DM39
    • D3DPP0
    • E9PGJ6
    • O00649
    • Q15197
    • Q15259
    • Q15260
    • Q15261
    • R4GN50

    Protein attributes for PTP4A2 Gene

    Size:
    167 amino acids
    Molecular mass:
    19127 Da
    Quaternary structure:
    • In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB.
    Miscellaneous:
    • A processed pseudogene with 96% sequence identity was found in the BRCA1 (113705) region of 17q21.

    Three dimensional structures from OCA and Proteopedia for PTP4A2 Gene

    Alternative splice isoforms for PTP4A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTP4A2 Gene

Selected DME Specific Peptides for PTP4A2 Gene

Q12974:
  • DWPFDDGAPP
  • EELKKYGVTT
  • KFREEPGCC
  • HCVAGLGRAPVLVA
  • YLEKYRPK
  • MRFLITHNP
  • NQIVDDWL
  • QFIRQKRRGA
  • GMKYEDA

Post-translational modifications for PTP4A2 Gene

  • Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB. Unfarnesylated forms are redirected to the nucleus and cytosol.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PTP4A2 Gene

Gene Families for PTP4A2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PTP4A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12974

UniProtKB/Swiss-Prot:

TP4A2_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with PTP4A2: view

Function for PTP4A2 Gene

Molecular function for PTP4A2 Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase 4A,member 2,homolog to rat PRL1 (regenerating liver protein tyrosine phosphatase 1),mainly expressed in nucleus
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sodium orthovanadate and pentamidine.
UniProtKB/Swiss-Prot Function:
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.

Enzyme Numbers (IUBMB) for PTP4A2 Gene

Phenotypes From GWAS Catalog for PTP4A2 Gene

Gene Ontology (GO) - Molecular Function for PTP4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0004727 prenylated protein tyrosine phosphatase activity TAS 9514946
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with PTP4A2: view
genes like me logo Genes that share phenotypes with PTP4A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PTP4A2

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTP4A2 Gene

Localization for PTP4A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTP4A2 Gene

Cell membrane. Early endosome. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTP4A2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
endosome 5
nucleus 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PTP4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA,IDA 10940933
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PTP4A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTP4A2 Gene

Pathways & Interactions for PTP4A2 Gene

genes like me logo Genes that share pathways with PTP4A2: view

Pathways by source for PTP4A2 Gene

1 BioSystems pathway for PTP4A2 Gene
1 Qiagen pathway for PTP4A2 Gene

Interacting Proteins for PTP4A2 Gene

SIGNOR curated interactions for PTP4A2 Gene

Activates:

Gene Ontology (GO) - Biological Process for PTP4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with PTP4A2: view

Drugs & Compounds for PTP4A2 Gene

(13) Drugs for PTP4A2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(6) Additional Compounds for PTP4A2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with PTP4A2: view

Transcripts for PTP4A2 Gene

Unigene Clusters for PTP4A2 Gene

Protein tyrosine phosphatase type IVA, member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTP4A2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:
SP6: -

Relevant External Links for PTP4A2 Gene

GeneLoc Exon Structure for
PTP4A2
ECgene alternative splicing isoforms for
PTP4A2

Expression for PTP4A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTP4A2 Gene

Protein differential expression in normal tissues from HIPED for PTP4A2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1), Frontal cortex (6.7), and Platelet (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTP4A2 Gene



Protein tissue co-expression partners for PTP4A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTP4A2 Gene:

PTP4A2

SOURCE GeneReport for Unigene cluster for PTP4A2 Gene:

Hs.470477

mRNA Expression by UniProt/SwissProt for PTP4A2 Gene:

Q12974-TP4A2_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue.

Evidence on tissue expression from TISSUES for PTP4A2 Gene

  • Nervous system(4.9)
  • Bone marrow(4.4)
  • Lung(3.6)
  • Liver(3)
  • Blood(2.8)
  • Eye(2.6)
  • Heart(2.5)
  • Intestine(2.5)
  • Spleen(2.4)
  • Muscle(2.3)
  • Kidney(2.1)
  • Lymph node(2.1)
  • Pancreas(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with PTP4A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTP4A2 Gene

Orthologs for PTP4A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTP4A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTP4A2 33 34
  • 99 (n)
oppossum
(Monodelphis domestica)
Mammalia PTP4A2 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTP4A2 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTP4A2 33 34
  • 96.81 (n)
cow
(Bos Taurus)
Mammalia PTP4A2 33 34
  • 96.21 (n)
mouse
(Mus musculus)
Mammalia Ptp4a2 33 16 34
  • 95.41 (n)
rat
(Rattus norvegicus)
Mammalia Ptp4a2 33
  • 92.81 (n)
chicken
(Gallus gallus)
Aves PTP4A2 33 34
  • 85.63 (n)
lizard
(Anolis carolinensis)
Reptilia PTP4A2 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptp4a2 33
  • 80.44 (n)
zebrafish
(Danio rerio)
Actinopterygii ptp4a2b 33 34
  • 75.25 (n)
ptp4a2a 34
  • 60 (a)
OneToMany
Dr.3996 33
fruit fly
(Drosophila melanogaster)
Insecta PRL-1 35 34
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea T19D2.2 34
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10622 34
  • 63 (a)
OneToMany
Species where no ortholog for PTP4A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTP4A2 Gene

ENSEMBL:
Gene Tree for PTP4A2 (if available)
TreeFam:
Gene Tree for PTP4A2 (if available)

Paralogs for PTP4A2 Gene

Paralogs for PTP4A2 Gene

(2) SIMAP similar genes for PTP4A2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for PTP4A2 Gene

genes like me logo Genes that share paralogs with PTP4A2: view

Variants for PTP4A2 Gene

Sequence variations from dbSNP and Humsavar for PTP4A2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000021497 -- 31,939,283(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000116051 -- 31,938,323(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000197062 -- 31,914,945(-) A/G intron_variant
rs1000233146 -- 31,914,620(-) G/T intron_variant
rs1000282597 -- 31,926,807(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PTP4A2 Gene

Variant ID Type Subtype PubMed ID
dgv71n106 CNV deletion 24896259
esv2127776 CNV deletion 18987734
esv2746463 CNV deletion 23290073
esv2746475 CNV deletion 23290073
esv2758930 CNV loss 17122850
esv33582 CNV loss 17666407
esv3560360 CNV deletion 23714750
nsv1009817 CNV gain 25217958
nsv1076345 CNV deletion 25765185
nsv1144366 CNV deletion 24896259
nsv834591 CNV loss 17160897
nsv945868 CNV duplication 23825009
nsv947424 CNV duplication 23825009
nsv950583 CNV duplication 24416366

Variation tolerance for PTP4A2 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTP4A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTP4A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTP4A2 Gene

Disorders for PTP4A2 Gene

Additional Disease Information for PTP4A2

No disorders were found for PTP4A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTP4A2 Gene

Publications for PTP4A2 Gene

  1. Characterization and genomic mapping of genes and pseudogenes of a new human protein tyrosine phosphatase. (PMID: 8661118) Zhao Z … Caskey CT (Genomics 1996) 2 3 4 22 58
  2. Analysis of stromal-epithelial interactions in prostate cancer identifies PTPCAAX2 as a potential oncogene. (PMID: 11734337) Wang Q … Waxman J (Cancer letters 2002) 3 4 22 58
  3. Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases. (PMID: 9018080) Cates CA … Crowell DN (Cancer letters 1996) 3 4 22 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PTP4A2 Gene

Sources for PTP4A2 Gene

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