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Aliases for PTP4A1 Gene

Aliases for PTP4A1 Gene

  • Protein Tyrosine Phosphatase Type IVA, Member 1 2 3 5
  • Protein-Tyrosine Phosphatase Of Regenerating Liver 1 3 4
  • Phosphatase Of Regenerating Liver 1 2 3
  • Protein-Tyrosine Phosphatase 4a1 3 4
  • EC 3.1.3.48 4 56
  • PTPCAAX1 3 4
  • PRL-1 3 4
  • PRL1 3 4
  • Protein Tyrosine Phosphatase Type IVA Protein 1 3
  • Protein Tyrosine Phosphatase Type IVA 1 3
  • PVT1/PTP4A1 Fusion 3
  • PTP(CAAX1) 3
  • PTP(CAAXI) 4
  • HH72 3

External Ids for PTP4A1 Gene

Previous GeneCards Identifiers for PTP4A1 Gene

  • GC06P064264
  • GC06P064279
  • GC06P064340
  • GC06P061461

Summaries for PTP4A1 Gene

Entrez Gene Summary for PTP4A1 Gene

  • This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]

GeneCards Summary for PTP4A1 Gene

PTP4A1 (Protein Tyrosine Phosphatase Type IVA, Member 1) is a Protein Coding gene. Among its related pathways are Signaling events mediated by PRL and PAK Pathway. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is PTP4A2.

UniProtKB/Swiss-Prot for PTP4A1 Gene

  • Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.

Gene Wiki entry for PTP4A1 Gene

Additional gene information for PTP4A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTP4A1 Gene

Genomics for PTP4A1 Gene

GeneHancer (GH) Regulatory Elements for PTP4A1 Gene

Promoters and enhancers for PTP4A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I063569 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.2 +51.4 51392 7.3 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC SSRP1 ENSG00000266680 PTP4A1 PHF3 LGSN ENSG00000236345 GC06M063587
GH06I063522 Enhancer 0.8 ENCODE 550.8 +1.0 1043 0.2 DRAP1 SOX13 TFAP4 FOXA2 SAP130 ARID4B SIN3A ZNF384 CEBPG DNMT3B PTP4A1 LGSN GC06M063529
GH06I063456 Enhancer 1.2 FANTOM5 ENCODE 3.1 -62.9 -62946 4.8 FOXA2 MLX ARID4B DMAP1 ETS1 YY1 SLC30A9 ATF7 RXRA SP5 LGSN PTP4A1 GC06M063463 GC06M063421 GC06M063427 GC06M063428 GC06M063429
GH06I063509 Enhancer 1.2 FANTOM5 ENCODE 1.6 -11.3 -11324 2.7 PKNOX1 FOXA2 MLX ARID4B DMAP1 ETS1 YY1 ATF7 RXRA SP5 LGSN ENSG00000236345 PTP4A1 GC06P063496
GH06I063518 Enhancer 0.9 ENCODE 0.8 -2.6 -2579 1.7 HDGF PKNOX1 SMAD1 MLX IRF4 ZNF207 ATF7 RUNX3 RXRA JUNB PTP4A1 GC06P063496 LGSN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PTP4A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTP4A1 gene promoter:

Genomic Locations for PTP4A1 Gene

Genomic Locations for PTP4A1 Gene
chr6:63,521,748-63,583,588
(GRCh38/hg38)
Size:
61,841 bases
Orientation:
Plus strand
chr6:64,231,666-64,293,492
(GRCh37/hg19)

Genomic View for PTP4A1 Gene

Genes around PTP4A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTP4A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTP4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTP4A1 Gene

Proteins for PTP4A1 Gene

  • Protein details for PTP4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93096-TP4A1_HUMAN
    Recommended name:
    Protein tyrosine phosphatase type IVA 1
    Protein Accession:
    Q93096
    Secondary Accessions:
    • B2R6C8
    • O00648
    • Q49A54

    Protein attributes for PTP4A1 Gene

    Size:
    173 amino acids
    Molecular mass:
    19815 Da
    Quaternary structure:
    • Homotrimer. Interacts with ATF5 (By similarity). Interacts with tubulin.

    Three dimensional structures from OCA and Proteopedia for PTP4A1 Gene

neXtProt entry for PTP4A1 Gene

Selected DME Specific Peptides for PTP4A1 Gene

Q93096:
  • DWPFDDGAPP
  • EELKKYGVTT
  • KFREEPGCC
  • HCVAGLGRAPVLVA
  • YLEKYRPK
  • MRFLITHNP
  • NQIVDDWL
  • QFIRQKRRGA
  • GMKYEDA

Post-translational modifications for PTP4A1 Gene

  • Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.
  • Ubiquitination at isoforms=15 and Lys32
  • Modification sites at PhosphoSitePlus

Domains & Families for PTP4A1 Gene

Gene Families for PTP4A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PTP4A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q93096

UniProtKB/Swiss-Prot:

TP4A1_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with PTP4A1: view

Function for PTP4A1 Gene

Molecular function for PTP4A1 Gene

GENATLAS Biochemistry:
rat nuclear protein tyrosine phosphatase homolog,involved in cellular growth of the liver in differentiation of intestine and other tissues
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sodium orthovanadate and pentamidine.
UniProtKB/Swiss-Prot Function:
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
UniProtKB/Swiss-Prot Induction:
Strongly down-regulated upon tetrodotoxin treatment.

Enzyme Numbers (IUBMB) for PTP4A1 Gene

Gene Ontology (GO) - Molecular Function for PTP4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity NAS,IBA 10569806
GO:0005515 protein binding IPI 28330616
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with PTP4A1: view
genes like me logo Genes that share phenotypes with PTP4A1: view

Animal Model Products

miRNA for PTP4A1 Gene

miRTarBase miRNAs that target PTP4A1

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTP4A1 Gene

Localization for PTP4A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTP4A1 Gene

Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=And mitotic spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTP4A1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
endoplasmic reticulum 5
endosome 5
nucleus 3
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PTP4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IDA,IEA 10940933
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with PTP4A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTP4A1 Gene

Pathways & Interactions for PTP4A1 Gene

genes like me logo Genes that share pathways with PTP4A1: view

Pathways by source for PTP4A1 Gene

1 BioSystems pathway for PTP4A1 Gene
1 Qiagen pathway for PTP4A1 Gene

SIGNOR curated interactions for PTP4A1 Gene

Activates:

Gene Ontology (GO) - Biological Process for PTP4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0007275 multicellular organism development IEA --
GO:0016311 dephosphorylation IEA --
GO:0030335 positive regulation of cell migration IBA --
genes like me logo Genes that share ontologies with PTP4A1: view

Drugs & Compounds for PTP4A1 Gene

(9) Drugs for PTP4A1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(11) Additional Compounds for PTP4A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with PTP4A1: view

Transcripts for PTP4A1 Gene

Unigene Clusters for PTP4A1 Gene

Protein tyrosine phosphatase type IVA, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTP4A1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2:
SP3:

Relevant External Links for PTP4A1 Gene

GeneLoc Exon Structure for
PTP4A1
ECgene alternative splicing isoforms for
PTP4A1

Expression for PTP4A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTP4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTP4A1 Gene

This gene is overexpressed in Liver (x6.8) and Muscle - Skeletal (x6.2).

Protein differential expression in normal tissues from HIPED for PTP4A1 Gene

This gene is overexpressed in Brain (22.8), Heart (12.5), Pancreas (9.7), and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTP4A1 Gene



NURSA nuclear receptor signaling pathways regulating expression of PTP4A1 Gene:

PTP4A1

SOURCE GeneReport for Unigene cluster for PTP4A1 Gene:

Hs.227777

mRNA Expression by UniProt/SwissProt for PTP4A1 Gene:

Q93096-TP4A1_HUMAN
Tissue specificity: Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.

Evidence on tissue expression from TISSUES for PTP4A1 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Lung(4.7)
  • Muscle(4.5)
  • Heart(2.7)
  • Skin(2.6)
  • Blood(2.5)
  • Kidney(2.5)
  • Intestine(2.3)
  • Stomach(2.2)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with PTP4A1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTP4A1 Gene

Orthologs for PTP4A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTP4A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTP4A1 33 34
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia PTP4A1 33 34
  • 97.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PTP4A1 34
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptp4a1 33
  • 95.57 (n)
cow
(Bos Taurus)
Mammalia PTP4A1 33 34
  • 95.18 (n)
mouse
(Mus musculus)
Mammalia Ptp4a1 33 16 34
  • 94.99 (n)
oppossum
(Monodelphis domestica)
Mammalia PTP4A1 34
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTP4A1 33 34
  • 86.13 (n)
lizard
(Anolis carolinensis)
Reptilia PTP4A1 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptp4a1 33
  • 82.66 (n)
Str.6243 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7522 33
zebrafish
(Danio rerio)
Actinopterygii ptp4a1 33 34
  • 77.46 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.678 33
fruit fly
(Drosophila melanogaster)
Insecta PRL-1 33 34 35
  • 58.63 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008708 33
  • 56.63 (n)
worm
(Caenorhabditis elegans)
Secernentea prl-1 33
  • 58.13 (n)
T19D2.2 34
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10622 34
  • 63 (a)
OneToMany
Species where no ortholog for PTP4A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PTP4A1 Gene

ENSEMBL:
Gene Tree for PTP4A1 (if available)
TreeFam:
Gene Tree for PTP4A1 (if available)

Paralogs for PTP4A1 Gene

Paralogs for PTP4A1 Gene

(2) SIMAP similar genes for PTP4A1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PTP4A1: view

Variants for PTP4A1 Gene

Sequence variations from dbSNP and Humsavar for PTP4A1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000100161 -- 63,532,841(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000130102 -- 63,557,357(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000154491 -- 63,582,637(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000156309 -- 63,538,641(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000185087 -- 63,582,266(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PTP4A1 Gene

Variant ID Type Subtype PubMed ID
nsv965739 CNV duplication 23825009
nsv965740 CNV duplication 23825009

Variation tolerance for PTP4A1 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTP4A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTP4A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTP4A1 Gene

Disorders for PTP4A1 Gene

Additional Disease Information for PTP4A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PTP4A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTP4A1 Gene

Publications for PTP4A1 Gene

  1. The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer. (PMID: 9642300) Peng Y … Taub R (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms. (PMID: 15571731) Jeong DG … Ryu SE (Journal of molecular biology 2005) 3 4 22 58
  3. Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach. (PMID: 15501285) Raghavendra Prasad HS … Gopalakrishnakone P (Toxicon : official journal of the International Society on Toxinology 2004) 3 4 22 58
  4. The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis. (PMID: 12235145) Wang J … Herbst R (The Journal of biological chemistry 2002) 3 4 22 58
  5. Subcellular localization of intracellular protein tyrosine phosphatases in T cells. (PMID: 10940933) Gjörloff-Wingren A … Mustelin T (European journal of immunology 2000) 3 4 22 58

Products for PTP4A1 Gene

Sources for PTP4A1 Gene

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