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This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer develo... See more...
Aliases for PTP4A1 Gene
Aliases for PTP4A1 Gene
External Ids for PTP4A1 Gene
- HGNC: 9634
- NCBI Entrez Gene: 7803
- Ensembl: ENSG00000112245
- OMIM®: 601585
- UniProtKB/Swiss-Prot: Q93096
Previous GeneCards Identifiers for PTP4A1 Gene
- GC06P064264
- GC06P064279
- GC06P064340
- GC06P061461
Summaries for PTP4A1 Gene
-
This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]
GeneCards Summary for PTP4A1 Gene
PTP4A1 (Protein Tyrosine Phosphatase 4A1) is a Protein Coding gene. Diseases associated with PTP4A1 include Ovarian Lymphoma and Bronchus Cancer. Among its related pathways are Signaling events mediated by PRL and PAK Pathway. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is PTP4A2.
UniProtKB/Swiss-Prot Summary for PTP4A1 Gene
-
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
Additional gene information for PTP4A1 Gene
- HGNC (9634)
- NCBI Entrez Gene (7803)
- Ensembl (ENSG00000112245)
- OMIM® (601585)
- UniProtKB/Swiss-Prot (Q93096)
- Open Targets Platform(ENSG00000112245)
- Alliance of Genome Resources
- Search for PTP4A1 at DataMed
- Search for PTP4A1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTP4A1 Gene
Genomics for PTP4A1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PTP4A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PTP4A1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTP4A1
- Top Transcription factor binding sites by QIAGEN in the PTP4A1 gene promoter:
-
- AML1a
- CBF(2)
- E4BP4
- FOXJ2
- FOXJ2 (long isoform)
- HNF-1
- HNF-1A
- HNF-3beta
- MRF-2
- NF-Y
Genomic Locations for PTP4A1 Gene
Latest Assembly
- chr6:63,516,440-63,583,588
- (GRCh38/hg38)
- Size:
- 67,149 bases
- Orientation:
- Plus strand
Previous Assembly
- chr6:64,226,345-64,293,493
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 67,149 bases
- Orientation:
- Plus strand
Genomic View for PTP4A1 Gene
Genes around PTP4A1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q12 by HGNC
- 6q12 by Entrez Gene
- 6q12 by Ensembl
PTP4A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTP4A1 Gene
Proteins for PTP4A1 Gene
-
Protein details for PTP4A1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q93096-TP4A1_HUMAN
- Recommended name:
- Protein tyrosine phosphatase type IVA 1
- Protein Accession:
- Q93096
- B2R6C8
- O00648
- Q49A54
Protein attributes for PTP4A1 Gene
- Size:
- 173 amino acids
- Molecular mass:
- 19815 Da
- Quaternary structure:
-
- Homotrimer. Interacts with ATF5 (By similarity). Interacts with tubulin.
Protein Expression for PTP4A1 Gene
Selected DME Specific Peptides for PTP4A1 Gene
- Q93096:
-
- DWPFDDGAPP
- EELKKYGVTT
- KFREEPGCC
- HCVAGLGRAPVLVA
- YLEKYRPK
- MRFLITHNP
- NQIVDDWL
- QFIRQKRRGA
- GMKYEDA
Post-translational modifications for PTP4A1 Gene
- Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.
-
Ubiquitination at Lys15 and Lys32
- NX_Q93096 (NX_Q93096-1)
- Modification sites at PhosphoSitePlus
Other Protein References for PTP4A1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ PTP4A1/PRL1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for PTP4A1
- Novus Biologicals Antibodies for PTP4A1
- Invitrogen Antibodies for PTP4A1 (AFLGC-PTP4A1)
-
Boster Bio Antibodies for PTP4A1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PTP4A1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for PTP4A1
- Origene Custom Protein Services for PTP4A1
- ProSpec Recombinant Proteins for PTP4A1
- antibodies-online: Show 10 available PTP4A1 Proteins ranked by validation data
- Compare Top PTP4A1 Proteins
-
Quality Products:
-
Abcam proteins for PTP4A1
Assay products for research
- antibodies-online: Show 2 available PTP4A1 Elisa Kits ranked by validation data
- Compare Top PTP4A1 Elisa Kits
-
Quality Products:
Domains & Families for PTP4A1 Gene
Gene Families for PTP4A1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PTP4A1 Gene
Suggested Antigen Peptide Sequences for PTP4A1 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein tyrosine phosphatase type IVA protein 1 (B5BU78_HUMAN)
- Protein-tyrosine phosphatase of regenerating liver 1 (TP4A1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q93096- Family:
-
- Belongs to the protein-tyrosine phosphatase family.
Function for PTP4A1 Gene
Molecular function for PTP4A1 Gene
- UniProtKB/Swiss-Prot Function:
- Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000269|PubMed:9018080};.
- UniProtKB/Swiss-Prot Induction:
- Strongly down-regulated upon tetrodotoxin treatment.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by sodium orthovanadate and pentamidine.
- GENATLAS Biochemistry:
- rat nuclear protein tyrosine phosphatase homolog,involved in cellular growth of the liver in differentiation of intestine and other tissues
Enzyme Numbers (IUBMB) for PTP4A1 Gene
Phenotypes From GWAS Catalog for PTP4A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004725 | protein tyrosine phosphatase activity | IBA,NAS | 10569806 |
| GO:0005515 | protein binding | IPI | 28330616 |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PTP4A1 Gene
- MGI mutant phenotypes for PTP4A1:
-
inferred from 2 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- immune system phenotype
- mortality/aging
- renal/urinary system phenotype
- hematopoietic system phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- skeleton phenotype
- integument phenotype
- GenomeRNAi human phenotypes for PTP4A1:
-
- no effect
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Increased cell death HMECs cells
- Decreased viability (cell death)
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability in pancreas lineage
- Condensed medial Golgi
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PTP4A1 - Starting at $85 >
- * PTP4A1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PTP4A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTP4A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTP4A1
miRNA for PTP4A1 Gene
- miRTarBase miRNAs that target PTP4A1
-
- hsa-miR-130b-3p (MIRT020207)
- hsa-miR-124-3p (MIRT022499)
- hsa-miR-30a-5p (MIRT028544)
- hsa-miR-26b-5p (MIRT029304)
- hsa-miR-19b-3p (MIRT031146)
- hsa-miR-106b-3p (MIRT038554)
- hsa-miR-324-3p (MIRT042827)
- hsa-miR-186-5p (MIRT044985)
- hsa-miR-100-5p (MIRT048438)
- hsa-let-7a-5p (MIRT052393)
- hsa-miR-339-5p (MIRT053055)
- hsa-miR-218-5p (MIRT439869)
- hsa-miR-203b-3p (MIRT470026)
- hsa-miR-2355-5p (MIRT470027)
- hsa-miR-584-5p (MIRT470028)
- hsa-miR-466 (MIRT470029)
- hsa-miR-3143 (MIRT470030)
- hsa-miR-4645-3p (MIRT470031)
- hsa-miR-6729-3p (MIRT470032)
- hsa-miR-1324 (MIRT470033)
- hsa-miR-758-5p (MIRT470034)
- hsa-miR-218-2-3p (MIRT470035)
- hsa-miR-8076 (MIRT470036)
- hsa-miR-4643 (MIRT470037)
- hsa-miR-4789-3p (MIRT470038)
- hsa-miR-1277-5p (MIRT470039)
- hsa-miR-144-3p (MIRT470040)
- hsa-miR-543 (MIRT470041)
- hsa-miR-655-3p (MIRT470042)
- hsa-miR-374c-5p (MIRT470043)
- hsa-miR-6788-5p (MIRT485170)
- hsa-miR-30c-2-3p (MIRT485171)
- hsa-miR-30c-1-3p (MIRT485172)
- hsa-miR-4769-5p (MIRT485173)
- hsa-miR-4654 (MIRT485174)
- hsa-miR-6778-5p (MIRT485175)
- hsa-miR-1233-5p (MIRT485176)
- hsa-miR-4648 (MIRT485177)
- hsa-miR-8085 (MIRT485178)
- hsa-miR-6731-5p (MIRT485179)
- hsa-miR-6878-5p (MIRT485180)
- hsa-miR-4468 (MIRT485181)
- hsa-miR-4742-5p (MIRT485182)
- hsa-miR-4495 (MIRT485183)
- hsa-miR-5590-3p (MIRT485184)
- hsa-miR-142-5p (MIRT485185)
- hsa-miR-4690-5p (MIRT485186)
- hsa-miR-4803 (MIRT485187)
- hsa-miR-4796-3p (MIRT485188)
- hsa-miR-93-5p (MIRT485189)
- hsa-miR-526b-3p (MIRT485190)
- hsa-miR-519d-3p (MIRT485191)
- hsa-miR-20b-5p (MIRT485192)
- hsa-miR-20a-5p (MIRT485193)
- hsa-miR-17-5p (MIRT485194)
- hsa-miR-106b-5p (MIRT485195)
- hsa-miR-106a-5p (MIRT485196)
- hsa-miR-548ah-5p (MIRT485197)
- hsa-miR-3609 (MIRT485198)
- hsa-miR-299-3p (MIRT485199)
- hsa-miR-30b-5p (MIRT485200)
- hsa-miR-30c-5p (MIRT485201)
- hsa-miR-30d-5p (MIRT485202)
- hsa-miR-30e-5p (MIRT485203)
- hsa-miR-374b-3p (MIRT546898)
- hsa-let-7g-3p (MIRT546899)
- hsa-let-7a-2-3p (MIRT546900)
- hsa-miR-5682 (MIRT546901)
- hsa-miR-585-5p (MIRT546902)
- hsa-miR-4775 (MIRT546903)
- hsa-miR-767-5p (MIRT546904)
- hsa-miR-6871-3p (MIRT546905)
- hsa-miR-5683 (MIRT546906)
- hsa-miR-32-3p (MIRT546907)
- hsa-miR-548l (MIRT546908)
- hsa-miR-8054 (MIRT546909)
- hsa-miR-548k (MIRT546910)
- hsa-miR-548av-5p (MIRT546911)
- hsa-miR-559 (MIRT546912)
- hsa-miR-548y (MIRT546913)
- hsa-miR-548w (MIRT546914)
- hsa-miR-548o-5p (MIRT546915)
- hsa-miR-548j-5p (MIRT546916)
- hsa-miR-548i (MIRT546917)
- hsa-miR-548h-5p (MIRT546918)
- hsa-miR-548d-5p (MIRT546919)
- hsa-miR-548c-5p (MIRT546920)
- hsa-miR-548bb-5p (MIRT546921)
- hsa-miR-548b-5p (MIRT546922)
- hsa-miR-548ay-5p (MIRT546923)
- hsa-miR-548au-5p (MIRT546924)
- hsa-miR-548as-5p (MIRT546925)
- hsa-miR-548ar-5p (MIRT546926)
- hsa-miR-548aq-5p (MIRT546927)
- hsa-miR-548ap-5p (MIRT546928)
- hsa-miR-548am-5p (MIRT546929)
- hsa-miR-548ak (MIRT546930)
- hsa-miR-548ae-5p (MIRT546931)
- hsa-miR-548ad-5p (MIRT546932)
- hsa-miR-548ab (MIRT546933)
- hsa-miR-548a-5p (MIRT546934)
- hsa-miR-340-5p (MIRT546935)
- hsa-miR-29a-3p (MIRT546936)
- hsa-miR-29c-3p (MIRT546937)
- hsa-miR-29b-3p (MIRT546938)
- hsa-miR-4762-3p (MIRT561696)
- hsa-miR-3161 (MIRT561697)
- hsa-miR-3192-3p (MIRT561698)
- hsa-miR-6739-5p (MIRT561699)
- hsa-miR-6733-5p (MIRT561700)
- hsa-miR-3153 (MIRT561701)
- hsa-miR-4668-5p (MIRT561702)
- hsa-miR-3148 (MIRT561703)
- hsa-miR-6871-5p (MIRT561704)
- hsa-miR-1231 (MIRT561705)
- hsa-miR-632 (MIRT561706)
- hsa-miR-4288 (MIRT561707)
- hsa-miR-641 (MIRT561708)
- hsa-miR-3617-5p (MIRT561709)
- hsa-miR-7161-5p (MIRT561710)
- hsa-miR-548u (MIRT561711)
- hsa-miR-6885-3p (MIRT566191)
- hsa-miR-4639-5p (MIRT566192)
- hsa-miR-633 (MIRT566193)
- hsa-miR-4313 (MIRT566194)
- hsa-miR-6887-3p (MIRT566195)
- hsa-miR-2116-3p (MIRT566196)
- hsa-miR-3651 (MIRT566197)
- hsa-miR-6769a-3p (MIRT566198)
- hsa-miR-4323 (MIRT566199)
- hsa-miR-3943 (MIRT566200)
- hsa-miR-5692a (MIRT566201)
- mmu-miR-669f-3p (MIRT581528)
- hsa-miR-944 (MIRT732217)
- hsa-miR-4503 (MIRT769816)
- hsa-miR-6792-5p (MIRT779319)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTP4A1
- Browse OriGene Inhibitory RNA Products For PTP4A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTP4A1
Clone products for research
- Applied Biological Materials (abm): Clones for PTP4A1 - Starting at $45 >
- * PTP4A1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG201475
- MG201481
- MG201483
- MG218456
- MR201475
- MR201475L3
- MR201475L4
- MR201483
- MR201483L3
- MR201483L4
- MR218456
- MR218456L3
- MR218456L4
- RC200435
- RC200435L1
- RC200435L2
- RC200435L3
- RC200435L4
- RG200435
- RR201626
- RR201626L3
- RR201626L4
- MR201475L3V
- MR201475L4V
- MR201483L3V
- MR201483L4V
- MR218456L3V
- MR218456L4V
- RC200435L1V
- RC200435L2V
- RC200435L3V
- RC200435L4V
- RR201626L3V
- RR201626L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PTP4A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTP4A1
Cell Lines for research
-
Horizon Cell Lines for PTP4A1
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTP4A1 Gene
Localization for PTP4A1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTP4A1 Gene
- Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=And mitotic spindle.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| endoplasmic reticulum | 5 |
| endosome | 5 |
| nucleus | 4 |
| cytosol | 3 |
| mitochondrion | 2 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005737 | cytoplasm | IBA,IDA | 10940933 |
| GO:0005768 | endosome | IEA | -- |
| GO:0005769 | early endosome | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTP4A1 Gene
Pathways & Interactions for PTP4A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PAK Pathway |
Epithelial Adherens Junctions
.36
|
|
| 2 | Signaling events mediated by PRL | ||
Pathways by source for PTP4A1 Gene
1 BioSystems pathway for PTP4A1 Gene
1 Qiagen pathway for PTP4A1 Gene
- Epithelial Adherens Junctions
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0016311 | dephosphorylation | IEA | -- |
| GO:0030335 | positive regulation of cell migration | IBA | 21873635 |
Transcripts for PTP4A1 Gene
mRNA/cDNA for PTP4A1 Gene
- 14 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000470661 479 nts (view in UCSC)
- ENST00000473334 638 nts (view in UCSC)
- ENST00000626021 2203 nts (view in UCSC)
- ENST00000627002 447 nts (view in UCSC)
- ENST00000639568 1089 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PTP4A1 - Starting at $85 >
- * PTP4A1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PTP4A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTP4A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTP4A1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTP4A1
- Browse OriGene Inhibitory RNA Products For PTP4A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTP4A1
Clone products for research
- Applied Biological Materials (abm): Clones for PTP4A1 - Starting at $45 >
- * PTP4A1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG201475
- MG201481
- MG201483
- MG218456
- MR201475
- MR201475L3
- MR201475L4
- MR201483
- MR201483L3
- MR201483L4
- MR218456
- MR218456L3
- MR218456L4
- RC200435
- RC200435L1
- RC200435L2
- RC200435L3
- RC200435L4
- RG200435
- RR201626
- RR201626L3
- RR201626L4
- MR201475L3V
- MR201475L4V
- MR201483L3V
- MR201483L4V
- MR218456L3V
- MR218456L4V
- RC200435L1V
- RC200435L2V
- RC200435L3V
- RC200435L4V
- RR201626L3V
- RR201626L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PTP4A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTP4A1
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: |
Relevant External Links for PTP4A1 Gene
- GeneLoc Exon Structure for
- PTP4A1
Expression for PTP4A1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Blood (Hematopoietic System)
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Gall Bladder (Hepatobiliary System)
-
Adrenal Gland (Endocrine System)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for PTP4A1 Gene
This gene is overexpressed in Liver (x6.8) and Muscle - Skeletal (x6.2).
This gene is overexpressed in Brain (22.8), Heart (12.5), Pancreas (9.7), and Fetal Brain (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTP4A1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTP4A1
SOURCE GeneReport for Unigene cluster for PTP4A1 Gene:
Hs.227777mRNA Expression by UniProt/SwissProt for PTP4A1 Gene:
Q93096-TP4A1_HUMAN
Tissue specificity:
Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.
Evidence on tissue expression from TISSUES for PTP4A1 Gene
- Nervous system(5)
- Liver(4.8)
- Lung(4.7)
- Muscle(4.6)
- Kidney(3.1)
- Skin(2.8)
- Intestine(2.6)
- Stomach(2.5)
- Blood(2.3)
- Bone marrow(2.2)
- Heart(2.2)
Primer products for research
-
OriGene qPCR primer pairs for PTP4A1
-
OriGene qPCR primer pairs and template standards for PTP4A1
Gene Expression Assays for research
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTP4A1 Gene
Orthologs for PTP4A1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PTP4A1 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PTP4A1 29 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PTP4A1 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ptp4a1 29 |
|
||
| Cow (Bos Taurus) |
Mammalia | PTP4A1 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ptp4a1 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PTP4A1 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PTP4A1 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PTP4A1 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ptp4a1 29 |
|
||
| Str.6243 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7522 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ptp4a1 29 30 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.678 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | PRL-1 29 30 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008708 29 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | prl-1 29 |
|
||
| T19D2.2 30 |
|
OneToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10622 30 |
|
OneToMany |
- Species where no ortholog for PTP4A1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PTP4A1 Gene
- ENSEMBL:
- Gene Tree for PTP4A1 (if available)
- TreeFam:
- Gene Tree for PTP4A1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PTP4A1: view image
- Alliance of Genome Resources:
- Additional Orthologs for PTP4A1
Paralogs for PTP4A1 Gene
(2) SIMAP similar genes for PTP4A1 Gene using alignment to 4 proteins:
- TP4A1_HUMAN
- B5BU78_HUMAN
- J3KSB4_HUMAN
- Q5TCM7_HUMAN
Pseudogenes.org Pseudogenes for PTP4A1 Gene
Variants for PTP4A1 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.23;
5.11% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PTP4A1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTP4A1 Gene
Disorders for PTP4A1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ovarian lymphoma |
|
|
| bronchus cancer |
|
|
| colorectal cancer |
|
|
| breast cancer |
|
|
Search PTP4A1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PTP4A1
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PTP4A1 Gene
Publications for PTP4A1 Gene
- The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer. (PMID: 9642300) Peng Y … Taub R (The Journal of biological chemistry 1998) 2 3 4 22
- Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms. (PMID: 15571731) Jeong DG … Ryu SE (Journal of molecular biology 2005) 3 4 22
- Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach. (PMID: 15501285) Raghavendra Prasad HS … Gopalakrishnakone P (Toxicon : official journal of the International Society on Toxinology 2004) 3 4 22
- The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis. (PMID: 12235145) Wang J … Herbst R (The Journal of biological chemistry 2002) 3 4 22
- Subcellular localization of intracellular protein tyrosine phosphatases in T cells. (PMID: 10940933) Gjörloff-Wingren A … Mustelin T (European journal of immunology 2000) 3 4 22
ExternalLinks
Products for PTP4A1 Gene
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- Search for PTP4A1 Proteins at ProSci
- Horizon Cell Lines for PTP4A1
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- Boster Bio Antibodies for PTP4A1
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Sources for PTP4A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources