This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer develo... See more...

Aliases for PTP4A1 Gene

Aliases for PTP4A1 Gene

  • Protein Tyrosine Phosphatase 4A1 2 3 5
  • PTPCAAX1 2 3 4
  • PRL-1 2 3 4
  • PRL1 2 3 4
  • Protein-Tyrosine Phosphatase Of Regenerating Liver 1 3 4
  • Protein Tyrosine Phosphatase Type IVA, Member 1 2 3
  • Protein Tyrosine Phosphatase Type IVA 1 3 4
  • Phosphatase Of Regenerating Liver 1 2 3
  • EC 3.1.3.48 4 50
  • Protein Tyrosine Phosphatase Type IVA Protein 1 3
  • Protein-Tyrosine Phosphatase 4a1 4
  • PVT1/PTP4A1 Fusion 3
  • PTP(CAAX1) 3
  • PTP(CAAXI) 4
  • PTP4A1 5
  • HH72 3

External Ids for PTP4A1 Gene

Previous GeneCards Identifiers for PTP4A1 Gene

  • GC06P064264
  • GC06P064279
  • GC06P064340
  • GC06P061461

Summaries for PTP4A1 Gene

Entrez Gene Summary for PTP4A1 Gene

  • This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]

GeneCards Summary for PTP4A1 Gene

PTP4A1 (Protein Tyrosine Phosphatase 4A1) is a Protein Coding gene. Diseases associated with PTP4A1 include Ovarian Lymphoma and Bronchus Cancer. Among its related pathways are Signaling events mediated by PRL and PAK Pathway. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is PTP4A2.

UniProtKB/Swiss-Prot Summary for PTP4A1 Gene

  • Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.

Gene Wiki entry for PTP4A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTP4A1 Gene

Genomics for PTP4A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTP4A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J063569 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.2 +56.8 56817 7.6 SP1 ZNF207 ZNF600 MYC IKZF1 SSRP1 ZNF580 ZNF592 KLF9 POLR2A ENSG00000266680 ENSG00000285976 HSALNG0050968 PTP4A1 PHF3 LGSN SCAT8 HSALNG0050966 RF00017-5115
GH06J063521 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 250.4 +6.1 6060 1.8 SSRP1 KLF9 CEBPA MXD4 FOXA1 THAP11 FOXA2 SAP130 MIER3 RARA HSALNG0050965 PTP4A1 LGSN piR-56341-197 RF00017-5115
GH06J063515 Enhancer 1.1 Ensembl ENCODE 250.7 -0.7 -677 4 SSRP1 CEBPA ATF3 ZIC2 CHD4 YY1 MXD4 CEBPB FOXA1 KLF11 PTP4A1 LGSN HSALNG0050962 RF00017-5115
GH06J063456 Enhancer 1.3 FANTOM5 Ensembl ENCODE 3.1 -57.6 -57638 4.8 SSRP1 CEBPA ATF3 YY1 MXD4 CEBPB FOXA1 KLF11 HOMEZ KMT2B LGSN PTP4A1 lnc-PTP4A1-6 lnc-PTP4A1-5
GH06J063509 Enhancer 1.3 FANTOM5 Ensembl ENCODE 1.6 -6.0 -6016 2.7 SSRP1 ZMYM3 CEBPA ATF3 CHD4 YY1 MXD4 FOXA1 KLF11 HOMEZ LGSN SCAT8 PTP4A1 HSALNG0050962 lnc-PTP4A1-2 RF00017-5115
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTP4A1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTP4A1

Top Transcription factor binding sites by QIAGEN in the PTP4A1 gene promoter:
  • AML1a
  • CBF(2)
  • E4BP4
  • FOXJ2
  • FOXJ2 (long isoform)
  • HNF-1
  • HNF-1A
  • HNF-3beta
  • MRF-2
  • NF-Y

Genomic Locations for PTP4A1 Gene

Latest Assembly
chr6:63,516,440-63,583,588
(GRCh38/hg38)
Size:
67,149 bases
Orientation:
Plus strand

Previous Assembly
chr6:64,226,345-64,293,493
(GRCh37/hg19 by Entrez Gene)
Size:
67,149 bases
Orientation:
Plus strand

chr6:64,231,666-64,293,492
(GRCh37/hg19 by Ensembl)
Size:
61,827 bases
Orientation:
Plus strand

Genomic View for PTP4A1 Gene

Genes around PTP4A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTP4A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTP4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTP4A1 Gene

Proteins for PTP4A1 Gene

  • Protein details for PTP4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93096-TP4A1_HUMAN
    Recommended name:
    Protein tyrosine phosphatase type IVA 1
    Protein Accession:
    Q93096
    Secondary Accessions:
    • B2R6C8
    • O00648
    • Q49A54

    Protein attributes for PTP4A1 Gene

    Size:
    173 amino acids
    Molecular mass:
    19815 Da
    Quaternary structure:
    • Homotrimer. Interacts with ATF5 (By similarity). Interacts with tubulin.

    Three dimensional structures from OCA and Proteopedia for PTP4A1 Gene

neXtProt entry for PTP4A1 Gene

Selected DME Specific Peptides for PTP4A1 Gene

Q93096:
  • DWPFDDGAPP
  • EELKKYGVTT
  • KFREEPGCC
  • HCVAGLGRAPVLVA
  • YLEKYRPK
  • MRFLITHNP
  • NQIVDDWL
  • QFIRQKRRGA
  • GMKYEDA

Post-translational modifications for PTP4A1 Gene

  • Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.
  • Ubiquitination at Lys15 and Lys32
  • Modification sites at PhosphoSitePlus

Domains & Families for PTP4A1 Gene

Gene Families for PTP4A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PTP4A1 Gene

GenScript: Design optimal peptide antigens:
  • Protein tyrosine phosphatase type IVA protein 1 (B5BU78_HUMAN)
  • Protein-tyrosine phosphatase of regenerating liver 1 (TP4A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q93096

UniProtKB/Swiss-Prot:

TP4A1_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with PTP4A1: view

Function for PTP4A1 Gene

Molecular function for PTP4A1 Gene

UniProtKB/Swiss-Prot Function:
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000269|PubMed:9018080};.
UniProtKB/Swiss-Prot Induction:
Strongly down-regulated upon tetrodotoxin treatment.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sodium orthovanadate and pentamidine.
GENATLAS Biochemistry:
rat nuclear protein tyrosine phosphatase homolog,involved in cellular growth of the liver in differentiation of intestine and other tissues

Enzyme Numbers (IUBMB) for PTP4A1 Gene

Phenotypes From GWAS Catalog for PTP4A1 Gene

Gene Ontology (GO) - Molecular Function for PTP4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IBA,NAS 10569806
GO:0005515 protein binding IPI 28330616
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PTP4A1: view
genes like me logo Genes that share phenotypes with PTP4A1: view

miRNA for PTP4A1 Gene

miRTarBase miRNAs that target PTP4A1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTP4A1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTP4A1 Gene

Localization for PTP4A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTP4A1 Gene

Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=And mitotic spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTP4A1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
endoplasmic reticulum 5
endosome 5
nucleus 4
cytosol 3
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PTP4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA,IDA 10940933
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with PTP4A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTP4A1 Gene

Pathways & Interactions for PTP4A1 Gene

PathCards logo

SuperPathways for PTP4A1 Gene

SuperPathway Contained pathways
1 PAK Pathway
.36
2 Signaling events mediated by PRL
genes like me logo Genes that share pathways with PTP4A1: view

Pathways by source for PTP4A1 Gene

1 BioSystems pathway for PTP4A1 Gene
1 Qiagen pathway for PTP4A1 Gene
  • Epithelial Adherens Junctions

Interacting Proteins for PTP4A1 Gene

SIGNOR curated interactions for PTP4A1 Gene

Activates:

Gene Ontology (GO) - Biological Process for PTP4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0007275 multicellular organism development IEA --
GO:0016311 dephosphorylation IEA --
GO:0030335 positive regulation of cell migration IBA 21873635
genes like me logo Genes that share ontologies with PTP4A1: view

Drugs & Compounds for PTP4A1 Gene

(11) Drugs for PTP4A1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0

(8) Additional Compounds for PTP4A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Na(+)
  • Na+
  • SODIUM ion
  • Sodium(1+)
7440-23-5
genes like me logo Genes that share compounds with PTP4A1: view

Transcripts for PTP4A1 Gene

mRNA/cDNA for PTP4A1 Gene

14 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTP4A1

Alternative Splicing Database (ASD) splice patterns (SP) for PTP4A1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2:
SP3:

Relevant External Links for PTP4A1 Gene

GeneLoc Exon Structure for
PTP4A1

Expression for PTP4A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTP4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTP4A1 Gene

This gene is overexpressed in Liver (x6.8) and Muscle - Skeletal (x6.2).

Protein differential expression in normal tissues from HIPED for PTP4A1 Gene

This gene is overexpressed in Brain (22.8), Heart (12.5), Pancreas (9.7), and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTP4A1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTP4A1

SOURCE GeneReport for Unigene cluster for PTP4A1 Gene:

Hs.227777

mRNA Expression by UniProt/SwissProt for PTP4A1 Gene:

Q93096-TP4A1_HUMAN
Tissue specificity: Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.

Evidence on tissue expression from TISSUES for PTP4A1 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Lung(4.7)
  • Muscle(4.6)
  • Kidney(3.1)
  • Skin(2.8)
  • Intestine(2.6)
  • Stomach(2.5)
  • Blood(2.3)
  • Bone marrow(2.2)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with PTP4A1: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTP4A1 Gene

Orthologs for PTP4A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTP4A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PTP4A1 29 30
  • 99.81 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PTP4A1 29 30
  • 97.11 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PTP4A1 30
  • 96 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ptp4a1 29
  • 95.57 (n)
Cow
(Bos Taurus)
Mammalia PTP4A1 29 30
  • 95.18 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ptp4a1 29 16 30
  • 94.99 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PTP4A1 30
  • 94 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PTP4A1 29 30
  • 86.13 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PTP4A1 30
  • 94 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ptp4a1 29
  • 82.66 (n)
Str.6243 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.7522 29
Zebrafish
(Danio rerio)
Actinopterygii ptp4a1 29 30
  • 77.46 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.678 29
Fruit Fly
(Drosophila melanogaster)
Insecta PRL-1 29 30 31
  • 58.63 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008708 29
  • 56.63 (n)
Worm
(Caenorhabditis elegans)
Secernentea prl-1 29
  • 58.13 (n)
T19D2.2 30
  • 48 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10622 30
  • 63 (a)
OneToMany
Species where no ortholog for PTP4A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PTP4A1 Gene

ENSEMBL:
Gene Tree for PTP4A1 (if available)
TreeFam:
Gene Tree for PTP4A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTP4A1: view image
Alliance of Genome Resources:
Additional Orthologs for PTP4A1

Paralogs for PTP4A1 Gene

Paralogs for PTP4A1 Gene

(2) SIMAP similar genes for PTP4A1 Gene using alignment to 4 proteins:

  • TP4A1_HUMAN
  • B5BU78_HUMAN
  • J3KSB4_HUMAN
  • Q5TCM7_HUMAN
genes like me logo Genes that share paralogs with PTP4A1: view

Variants for PTP4A1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTP4A1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs1618240 Benign: not provided 63,580,063(+) G/T
NM_003463.4(PTP4A1):c.411G>T (p.Arg137=)
SYNONYMOUS
rs1681943 Benign: not provided 63,580,091(+) C/T
NM_003463.4(PTP4A1):c.439C>T (p.Leu147=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PTP4A1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PTP4A1 Gene

Variant ID Type Subtype PubMed ID
nsv965739 CNV duplication 23825009
nsv965740 CNV duplication 23825009

Variation tolerance for PTP4A1 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTP4A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTP4A1
Leiden Open Variation Database (LOVD)
PTP4A1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTP4A1 Gene

Disorders for PTP4A1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PTP4A1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
ovarian lymphoma
bronchus cancer
  • malignant neoplasm of bronchus and lung
colorectal cancer
  • crc
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PTP4A1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PTP4A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTP4A1 Gene

Publications for PTP4A1 Gene

  1. The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer. (PMID: 9642300) Peng Y … Taub R (The Journal of biological chemistry 1998) 2 3 4 22
  2. Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms. (PMID: 15571731) Jeong DG … Ryu SE (Journal of molecular biology 2005) 3 4 22
  3. Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach. (PMID: 15501285) Raghavendra Prasad HS … Gopalakrishnakone P (Toxicon : official journal of the International Society on Toxinology 2004) 3 4 22
  4. The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis. (PMID: 12235145) Wang J … Herbst R (The Journal of biological chemistry 2002) 3 4 22
  5. Subcellular localization of intracellular protein tyrosine phosphatases in T cells. (PMID: 10940933) Gjörloff-Wingren A … Mustelin T (European journal of immunology 2000) 3 4 22

Products for PTP4A1 Gene

Sources for PTP4A1 Gene