Aliases for PTP4A1 Gene
External Ids for PTP4A1 Gene
Previous GeneCards Identifiers for PTP4A1 Gene
This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]
GeneCards Summary for PTP4A1 Gene
PTP4A1 (Protein Tyrosine Phosphatase 4A1) is a Protein Coding gene. Diseases associated with PTP4A1 include Ovarian Lymphoma and Colorectal Cancer. Among its related pathways are PAK Pathway and Signaling events mediated by PRL. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is PTP4A2.
UniProtKB/Swiss-Prot Summary for PTP4A1 Gene
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.