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This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]
PTP4A1 (Protein Tyrosine Phosphatase 4A1) is a Protein Coding gene. Diseases associated with PTP4A1 include Ovarian Lymphoma and Colorectal Cancer. Among its related pathways are PAK Pathway and Signaling events mediated by PRL. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is PTP4A2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
GO:0004725 | protein tyrosine phosphatase activity | IBA,NAS | 10569806 |
GO:0005515 | protein binding | IPI | 28330616 |
GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA,IDA | 10940933 |
GO:0005768 | endosome | IEA | -- |
GO:0005769 | early endosome | IEA | -- |
GO:0005783 | endoplasmic reticulum | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PAK Pathway |
Epithelial Adherens Junctions
.36
|
|
2 | Signaling events mediated by PRL |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006470 | protein dephosphorylation | IEA | -- |
GO:0007049 | cell cycle | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0016311 | dephosphorylation | IEA | -- |
GO:0030335 | positive regulation of cell migration | IBA | 21873635 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Phosphate |
|
14066-19-4, 14265-44-2 |
|
|||
sodium |
|
7440-23-5 |
|
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||
SP2: | |||||||||||||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PTP4A1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PTP4A1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PTP4A1 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ptp4a1 30 |
|
||
Cow (Bos Taurus) |
Mammalia | PTP4A1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ptp4a1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PTP4A1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PTP4A1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PTP4A1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ptp4a1 30 |
|
||
Str.6243 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.7522 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ptp4a1 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.678 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | PRL-1 30 31 32 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008708 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | prl-1 30 |
|
||
T19D2.2 31 |
|
OneToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10622 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
ovarian lymphoma |
|
|
colorectal cancer |
|
|
breast cancer |
|