This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015] See more...

Aliases for PTOV1 Gene

Aliases for PTOV1 Gene

  • PTOV1 Extended AT-Hook Containing Adaptor Protein 2 3 5
  • Activator Interaction Domain-Containing Protein 2 3 4
  • Prostate Tumor-Overexpressed Gene 1 Protein 3 4
  • Prostate Tumor Overexpressed 1 2 3
  • PTOV-1 3 4
  • ACID2 3 4
  • PTOV1 5

External Ids for PTOV1 Gene

Previous GeneCards Identifiers for PTOV1 Gene

  • GC19P051012
  • GC19P050722
  • GC19P055032
  • GC19P055046
  • GC19P050354
  • GC19P046730

Summaries for PTOV1 Gene

Entrez Gene Summary for PTOV1 Gene

  • This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for PTOV1 Gene

PTOV1 (PTOV1 Extended AT-Hook Containing Adaptor Protein) is a Protein Coding gene. Diseases associated with PTOV1 include Neuropathy, Hereditary, With Liability To Pressure Palsies. An important paralog of this gene is MED25.

UniProtKB/Swiss-Prot Summary for PTOV1 Gene

  • May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.

Gene Wiki entry for PTOV1 Gene

Additional gene information for PTOV1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTOV1 Gene

Genomics for PTOV1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTOV1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTOV1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTOV1

Top Transcription factor binding sites by QIAGEN in the PTOV1 gene promoter:
  • ATF6
  • c-Myb
  • CREB
  • deltaCREB
  • E47
  • GATA-2
  • IRF-7A
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2

Genomic Locations for PTOV1 Gene

Genomic Locations for PTOV1 Gene
chr19:49,848,554-49,860,744
(GRCh38/hg38)
Size:
12,191 bases
Orientation:
Plus strand
chr19:50,353,992-50,364,001
(GRCh37/hg19)
Size:
10,010 bases
Orientation:
Plus strand

Genomic View for PTOV1 Gene

Genes around PTOV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTOV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTOV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTOV1 Gene

Proteins for PTOV1 Gene

  • Protein details for PTOV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YD1-PTOV1_HUMAN
    Recommended name:
    Prostate tumor-overexpressed gene 1 protein
    Protein Accession:
    Q86YD1
    Secondary Accessions:
    • Q6UXX7
    • Q96BU3
    • Q9HBN4
    • Q9NYL1

    Protein attributes for PTOV1 Gene

    Size:
    416 amino acids
    Molecular mass:
    46869 Da
    Quaternary structure:
    • May interact with CREBBP. Interacts with FLOT1.
    SequenceCaution:
    • Sequence=AAF70635.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PTOV1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTOV1 Gene

Post-translational modifications for PTOV1 Gene

  • Ubiquitination at Lys212, Lys237, Lys91, Lys104, Lys301, Lys331, Lys176, Lys337, and Lys373
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PTOV1 Gene

Domains & Families for PTOV1 Gene

Gene Families for PTOV1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PTOV1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PTOV1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58135, highly similar to Homo sapiens prostate tumor overexpressed gene 1 (PTOV1), mRNA (B4DG17_HUMAN)
  • Activator interaction domain-containing protein 2 (PTOV1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86YD1

UniProtKB/Swiss-Prot:

PTOV1_HUMAN :
  • Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.
Family:
  • Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.
genes like me logo Genes that share domains with PTOV1: view

Function for PTOV1 Gene

Molecular function for PTOV1 Gene

UniProtKB/Swiss-Prot Function:
May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.
UniProtKB/Swiss-Prot Induction:
By testosterone.

Phenotypes From GWAS Catalog for PTOV1 Gene

genes like me logo Genes that share phenotypes with PTOV1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PTOV1

CRISPR Products

miRNA for PTOV1 Gene

miRTarBase miRNAs that target PTOV1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTOV1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTOV1 Gene

Localization for PTOV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTOV1 Gene

Cell membrane. Cytoplasm, perinuclear region. Nucleus. Note=Translocates from the cytoplasm to the nucleus at the onset of S-phase. Also localizes to lipid rafts.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTOV1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
extracellular 1
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PTOV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PTOV1: view

Pathways & Interactions for PTOV1 Gene

PathCards logo

SuperPathways for PTOV1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PTOV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with PTOV1: view

No data available for Pathways by source and SIGNOR curated interactions for PTOV1 Gene

Drugs & Compounds for PTOV1 Gene

No Compound Related Data Available

Transcripts for PTOV1 Gene

mRNA/cDNA for PTOV1 Gene

8 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTOV1

Alternative Splicing Database (ASD) splice patterns (SP) for PTOV1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a ·
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6: -
SP7: - -
SP8: -
SP9:
SP10:
SP11:
SP12: -
SP13:

ExUns: 15b ^ 16a · 16b ^ 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PTOV1 Gene

GeneLoc Exon Structure for
PTOV1

Expression for PTOV1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTOV1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTOV1 Gene

This gene is overexpressed in Placenta (30.5), Adrenal (16.8), Ovary (10.3), and Fetal ovary (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTOV1 Gene



Protein tissue co-expression partners for PTOV1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTOV1

SOURCE GeneReport for Unigene cluster for PTOV1 Gene:

Hs.587979

mRNA Expression by UniProt/SwissProt for PTOV1 Gene:

Q86YD1-PTOV1_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, placenta, skeletal muscle and small intestine.

Evidence on tissue expression from TISSUES for PTOV1 Gene

  • Nervous system(4.9)
  • Pancreas(4.5)
  • Lung(4)
  • Eye(3.1)
  • Muscle(3.1)
  • Skin(2.8)
  • Liver(2.8)
  • Kidney(2.7)
  • Intestine(2.6)
  • Heart(2.5)
  • Stomach(2.3)
  • Adrenal gland(2.2)
  • Spleen(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with PTOV1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTOV1 Gene

Orthologs for PTOV1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTOV1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PTOV1 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia PTOV1 30 31
  • 92.69 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PTOV1 30 31
  • 91.41 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ptov1 30
  • 89.5 (n)
Mouse
(Mus musculus)
Mammalia Ptov1 30 17 31
  • 89.1 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PTOV1 31
  • 37 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 21 (a)
OneToMany
-- 31
  • 14 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii med25 31
  • 21 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG13609 30
  • 47.29 (n)
MED25 31
  • 8 (a)
OneToMany
Species where no ortholog for PTOV1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PTOV1 Gene

ENSEMBL:
Gene Tree for PTOV1 (if available)
TreeFam:
Gene Tree for PTOV1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTOV1: view image

Paralogs for PTOV1 Gene

Paralogs for PTOV1 Gene

(1) SIMAP similar genes for PTOV1 Gene using alignment to 8 proteins:

  • PTOV1_HUMAN
  • B4DG17_HUMAN
  • M0QX53_HUMAN
  • M0QY25_HUMAN
  • M0QYH6_HUMAN
  • M0QYH7_HUMAN
  • M0QYQ4_HUMAN
  • M0QZB9_HUMAN

Pseudogenes.org Pseudogenes for PTOV1 Gene

genes like me logo Genes that share paralogs with PTOV1: view

Variants for PTOV1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTOV1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs755715265 Likely Benign: Long QT syndrome 49,857,051(+) A/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for PTOV1 Gene

Structural Variations from Database of Genomic Variants (DGV) for PTOV1 Gene

Variant ID Type Subtype PubMed ID
dgv53n68 CNV loss 17160897
dgv54n68 CNV loss 17160897
nsv1072361 CNV deletion 25765185
nsv1118833 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv470150 CNV gain 18288195
nsv524068 CNV loss 19592680
nsv524534 CNV loss 19592680
nsv526372 CNV loss 19592680
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for PTOV1 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.67; 72.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTOV1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTOV1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTOV1 Gene

Disorders for PTOV1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PTOV1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search PTOV1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with PTOV1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTOV1 Gene

Publications for PTOV1 Gene

  1. PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts. (PMID: 15713644) Santamaría A … Paciucci R (Molecular and cellular biology 2005) 2 3 4 23
  2. PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle. (PMID: 12598323) Santamaría A … Thomson TM (The American journal of pathology 2003) 2 3 4
  3. The extended AT-hook is a novel RNA binding motif. (PMID: 26156556) Filarsky M … Németh A (RNA biology 2015) 2 3
  4. MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation. (PMID: 17641689) Lee HK … Um SJ (The EMBO journal 2007) 3 4
  5. Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. (PMID: 15778465) Benzinger A … Hermeking H (Molecular & cellular proteomics : MCP 2005) 3 4

Products for PTOV1 Gene

  • Signalway ELISA kits for PTOV1

Sources for PTOV1 Gene