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Aliases for PTOV1 Gene

Aliases for PTOV1 Gene

  • Prostate Tumor Overexpressed 1 2 3 5
  • Activator Interaction Domain-Containing Protein 2 3 4
  • PTOV-1 3 4
  • ACID2 3 4
  • Prostate Tumor-Overexpressed Gene 1 Protein 3

External Ids for PTOV1 Gene

Previous GeneCards Identifiers for PTOV1 Gene

  • GC19P051012
  • GC19P050722
  • GC19P055032
  • GC19P055046
  • GC19P050354
  • GC19P046730

Summaries for PTOV1 Gene

Entrez Gene Summary for PTOV1 Gene

  • This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for PTOV1 Gene

PTOV1 (Prostate Tumor Overexpressed 1) is a Protein Coding gene. An important paralog of this gene is MED25.

UniProtKB/Swiss-Prot for PTOV1 Gene

  • May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.

Gene Wiki entry for PTOV1 Gene

Additional gene information for PTOV1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTOV1 Gene

Genomics for PTOV1 Gene

GeneHancer (GH) Regulatory Elements for PTOV1 Gene

Promoters and enhancers for PTOV1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049849 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +2.3 2311 3.7 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 PTOV1-AS1 PTOV1 PIR35655 PIR43463 GC19M049851 PRR12 IRF3 SNRNP70 PIH1D1 SNORD35A
GH19J049848 Enhancer 1.1 Ensembl ENCODE 650.7 -0.3 -332 0.9 BATF IRF4 ZNF121 FOS ETV6 ATF7 IKZF2 RUNX3 SP3 ZBTB11 PTOV1 PIR35655 GC19M049851 PRR12 SNRNP70 MED25 FUZ ADM5 CPT1C PRMT1
GH19J049816 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.6 -30.1 -30099 5 HDGF PKNOX1 ARNT ARID4B NEUROD1 SIN3A DMAP1 YBX1 ZBTB7B YY1 FUZ MED25 PRR12 PTOV1-AS2 PNKP PTOV1 SNRNP70 PIH1D1 POLD1 NUP62
GH19J048958 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.6 -884.8 -884815 10.2 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 FTL GC19P048966 GC19P048967 ENSG00000267898 NUP62 PTOV1-AS2 IRF3 SNORD35A SNORD35B PRR12
GH19J048871 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 20.3 -972.8 -972829 8.8 FEZF1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MEF2D SSRP1 GC19M048876 PPP1R15A PRR12 SNRNP70 IRF3 GRWD1 SNORD35A PTOV1-AS2 SNORD35B PIH1D1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTOV1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTOV1 gene promoter:
  • deltaCREB
  • CREB
  • c-Myb
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • IRF-7A
  • GATA-2
  • ATF6
  • E47

Genomic Locations for PTOV1 Gene

Genomic Locations for PTOV1 Gene
chr19:49,848,844-49,860,744
(GRCh38/hg38)
Size:
11,901 bases
Orientation:
Plus strand
chr19:50,353,992-50,364,001
(GRCh37/hg19)
Size:
10,010 bases
Orientation:
Plus strand

Genomic View for PTOV1 Gene

Genes around PTOV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTOV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTOV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTOV1 Gene

Proteins for PTOV1 Gene

  • Protein details for PTOV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YD1-PTOV1_HUMAN
    Recommended name:
    Prostate tumor-overexpressed gene 1 protein
    Protein Accession:
    Q86YD1
    Secondary Accessions:
    • Q6UXX7
    • Q96BU3
    • Q9HBN4
    • Q9NYL1

    Protein attributes for PTOV1 Gene

    Size:
    416 amino acids
    Molecular mass:
    46869 Da
    Quaternary structure:
    • May interact with CREBBP. Interacts with FLOT1.
    SequenceCaution:
    • Sequence=AAF70635.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PTOV1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTOV1 Gene

Post-translational modifications for PTOV1 Gene

  • Ubiquitination at posLast=373373, Lys337, Lys331, Lys301, posLast=237237, posLast=212212, posLast=176176, Lys104, and posLast=9191
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PTOV1 Gene

Domains & Families for PTOV1 Gene

Gene Families for PTOV1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PTOV1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q86YD1

UniProtKB/Swiss-Prot:

PTOV1_HUMAN :
  • Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.
Family:
  • Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.
genes like me logo Genes that share domains with PTOV1: view

Function for PTOV1 Gene

Molecular function for PTOV1 Gene

UniProtKB/Swiss-Prot Function:
May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.
UniProtKB/Swiss-Prot Induction:
By testosterone.

Phenotypes From GWAS Catalog for PTOV1 Gene

genes like me logo Genes that share phenotypes with PTOV1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PTOV1

miRNA for PTOV1 Gene

miRTarBase miRNAs that target PTOV1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTOV1 Gene

Localization for PTOV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTOV1 Gene

Cell membrane. Cytoplasm, perinuclear region. Nucleus. Note=Translocates from the cytoplasm to the nucleus at the onset of S-phase. Also localizes to lipid rafts.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTOV1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
mitochondrion 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PTOV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with PTOV1: view

Pathways & Interactions for PTOV1 Gene

SuperPathways for PTOV1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PTOV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PTOV1: view

No data available for Pathways by source and SIGNOR curated interactions for PTOV1 Gene

Drugs & Compounds for PTOV1 Gene

No Compound Related Data Available

Transcripts for PTOV1 Gene

Unigene Clusters for PTOV1 Gene

Prostate tumor overexpressed 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTOV1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a ·
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6: -
SP7: - -
SP8: -
SP9:
SP10:
SP11:
SP12: -
SP13:

ExUns: 15b ^ 16a · 16b ^ 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PTOV1 Gene

GeneLoc Exon Structure for
PTOV1
ECgene alternative splicing isoforms for
PTOV1

Expression for PTOV1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTOV1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTOV1 Gene

This gene is overexpressed in Placenta (30.5), Adrenal (16.8), Ovary (10.3), and Fetal ovary (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTOV1 Gene



Protein tissue co-expression partners for PTOV1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PTOV1 Gene:

PTOV1

SOURCE GeneReport for Unigene cluster for PTOV1 Gene:

Hs.587979

mRNA Expression by UniProt/SwissProt for PTOV1 Gene:

Q86YD1-PTOV1_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, placenta, skeletal muscle and small intestine.

Evidence on tissue expression from TISSUES for PTOV1 Gene

  • Nervous system(4.9)
  • Pancreas(4.4)
  • Lung(3.7)
  • Eye(2.8)
  • Muscle(2.6)
  • Liver(2.4)
  • Intestine(2.2)
  • Kidney(2.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with PTOV1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTOV1 Gene

Orthologs for PTOV1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PTOV1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTOV1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTOV1 34 33
  • 92.69 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PTOV1 34 33
  • 91.41 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptov1 33
  • 89.5 (n)
mouse
(Mus musculus)
Mammalia Ptov1 16 34 33
  • 89.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PTOV1 34
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 21 (a)
OneToMany
-- 34
  • 14 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii med25 34
  • 21 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13609 33
  • 47.29 (n)
MED25 34
  • 8 (a)
OneToMany
Species where no ortholog for PTOV1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTOV1 Gene

ENSEMBL:
Gene Tree for PTOV1 (if available)
TreeFam:
Gene Tree for PTOV1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTOV1: view image

Paralogs for PTOV1 Gene

Paralogs for PTOV1 Gene

(1) SIMAP similar genes for PTOV1 Gene using alignment to 8 proteins:

  • PTOV1_HUMAN
  • B4DG17_HUMAN
  • M0QX53_HUMAN
  • M0QY25_HUMAN
  • M0QYH6_HUMAN
  • M0QYH7_HUMAN
  • M0QYQ4_HUMAN
  • M0QZB9_HUMAN

Pseudogenes.org Pseudogenes for PTOV1 Gene

genes like me logo Genes that share paralogs with PTOV1: view

Variants for PTOV1 Gene

Sequence variations from dbSNP and Humsavar for PTOV1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1050332 benign, uncertain-significance, not specified, Early infantile epileptic encephalopathy 10 49,861,233(+) G/A downstream_transcript_variant
rs201872477 uncertain-significance, Epileptic encephalopathy 49,861,227(+) T/A/G downstream_transcript_variant
rs755715265 likely-benign, Long QT syndrome 49,857,051(+) A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs886054582 uncertain-significance, Epileptic encephalopathy 49,861,225(+) T/G downstream_transcript_variant
rs374836478 likely-benign, not specified 49,861,231(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PTOV1 Gene

Variant ID Type Subtype PubMed ID
dgv53n68 CNV loss 17160897
dgv54n68 CNV loss 17160897
nsv1072361 CNV deletion 25765185
nsv1118833 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv470150 CNV gain 18288195
nsv524068 CNV loss 19592680
nsv524534 CNV loss 19592680
nsv526372 CNV loss 19592680
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for PTOV1 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.67; 72.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTOV1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTOV1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTOV1 Gene

Disorders for PTOV1 Gene

Additional Disease Information for PTOV1

No disorders were found for PTOV1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTOV1 Gene

Publications for PTOV1 Gene

  1. PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts. (PMID: 15713644) Santamaría A … Paciucci R (Molecular and cellular biology 2005) 2 3 4 22 58
  2. PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle. (PMID: 12598323) Santamaría A … Thomson TM (The American journal of pathology 2003) 2 3 4 58
  3. MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation. (PMID: 17641689) Lee HK … Um SJ (The EMBO journal 2007) 3 4 58
  4. Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. (PMID: 15778465) Benzinger A … Hermeking H (Molecular & cellular proteomics : MCP 2005) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for PTOV1 Gene

Sources for PTOV1 Gene

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