Aliases for PTMS Gene

Aliases for PTMS Gene

  • Parathymosin 2 3 4 5
  • ParaT 3

External Ids for PTMS Gene

Previous GeneCards Identifiers for PTMS Gene

  • GC12M006676
  • GC12M006801
  • GC12P006753
  • GC12P006745
  • GC12P006746
  • GC12P006875

Summaries for PTMS Gene

GeneCards Summary for PTMS Gene

PTMS (Parathymosin) is a Protein Coding gene. Diseases associated with PTMS include Macular Dystrophy, Patterned, 3 and Noonan Syndrome 1.

UniProtKB/Swiss-Prot Summary for PTMS Gene

  • Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.

Gene Wiki entry for PTMS Gene

Additional gene information for PTMS Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTMS Gene

Genomics for PTMS Gene

GeneHancer (GH) Regulatory Elements for PTMS Gene

Promoters and enhancers for PTMS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTMS on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTMS

Top Transcription factor binding sites by QIAGEN in the PTMS gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • AREB6
  • deltaCREB
  • FOXO4
  • p53
  • TBP

Genomic Locations for PTMS Gene

Genomic Locations for PTMS Gene
chr12:6,765,516-6,770,952
(GRCh38/hg38)
Size:
5,437 bases
Orientation:
Plus strand
chr12:6,874,682-6,880,118
(GRCh37/hg19)
Size:
5,437 bases
Orientation:
Plus strand

Genomic View for PTMS Gene

Genes around PTMS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTMS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTMS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTMS Gene

Proteins for PTMS Gene

  • Protein details for PTMS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20962-PTMS_HUMAN
    Recommended name:
    Parathymosin
    Protein Accession:
    P20962

    Protein attributes for PTMS Gene

    Size:
    102 amino acids
    Molecular mass:
    11530 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PTMS Gene

Post-translational modifications for PTMS Gene

  • Ubiquitination at Lys15
  • Modification sites at PhosphoSitePlus

Other Protein References for PTMS Gene

No data available for DME Specific Peptides for PTMS Gene

Domains & Families for PTMS Gene

Gene Families for PTMS Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PTMS Gene

Blocks:
  • Prothymosin/parathymosin
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PTMS Gene

GenScript: Design optimal peptide antigens:
  • PTMS protein (A2VCM6_HUMAN)
  • Parathymosin (O15256_HUMAN)
  • Parathymosin (PTMS_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P20962

UniProtKB/Swiss-Prot:

PTMS_HUMAN :
  • Belongs to the pro/parathymosin family.
Family:
  • Belongs to the pro/parathymosin family.
genes like me logo Genes that share domains with PTMS: view

Function for PTMS Gene

Molecular function for PTMS Gene

UniProtKB/Swiss-Prot Function:
Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.
GENATLAS Biochemistry:
parathymosin,highly homolog to prothymosin,mainly expressed in liver,kidney,brain,formerly assigned to 17q12-q22

Phenotypes From GWAS Catalog for PTMS Gene

genes like me logo Genes that share phenotypes with PTMS: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTMS

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTMS Gene

Localization for PTMS Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTMS gene
Compartment Confidence
nucleus 5
extracellular 3
cytoskeleton 3
mitochondrion 3
cytosol 3
plasma membrane 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PTMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10854063
genes like me logo Genes that share ontologies with PTMS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PTMS Gene

Pathways & Interactions for PTMS Gene

PathCards logo

SuperPathways for PTMS Gene

No Data Available

Gene Ontology (GO) - Biological Process for PTMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006260 DNA replication TAS 10854063
genes like me logo Genes that share ontologies with PTMS: view

No data available for Pathways by source and SIGNOR curated interactions for PTMS Gene

Drugs & Compounds for PTMS Gene

(1) Drugs for PTMS Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PTMS: view

Transcripts for PTMS Gene

mRNA/cDNA for PTMS Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTMS

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTMS Gene

No ASD Table

Relevant External Links for PTMS Gene

GeneLoc Exon Structure for
PTMS

Expression for PTMS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTMS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PTMS Gene

This gene is overexpressed in Fetal Brain (15.2) and Uterus (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTMS Gene



Protein tissue co-expression partners for PTMS Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTMS

SOURCE GeneReport for Unigene cluster for PTMS Gene:

Hs.504613

Evidence on tissue expression from TISSUES for PTMS Gene

  • Liver(4.8)
  • Kidney(4.7)
  • Nervous system(3.4)
  • Spleen(2.8)
  • Intestine(2.6)
  • Muscle(2.6)
  • Eye(2.4)
  • Lung(2.4)
  • Heart(2.3)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with PTMS: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTMS Gene

Orthologs for PTMS Gene

This gene was present in the common ancestor of mammals.

Orthologs for PTMS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTMS 31
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTMS 31
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTMS 31 30
  • 93.04 (n)
OneToOne
Species where no ortholog for PTMS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PTMS Gene

ENSEMBL:
Gene Tree for PTMS (if available)
TreeFam:
Gene Tree for PTMS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTMS: view image

Paralogs for PTMS Gene

No data available for Paralogs for PTMS Gene

Variants for PTMS Gene

Additional dbSNP identifiers (rs#s) for PTMS Gene

Structural Variations from Database of Genomic Variants (DGV) for PTMS Gene

Variant ID Type Subtype PubMed ID
dgv2323n54 CNV loss 21841781
esv27720 CNV loss 19812545
esv3580394 CNV gain 25503493
nsv1071006 CNV deletion 25765185
nsv1126309 CNV deletion 24896259
nsv557257 CNV loss 21841781
nsv557258 CNV loss 21841781
nsv832323 CNV loss 17160897

Variation tolerance for PTMS Gene

Residual Variation Intolerance Score: 51.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTMS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTMS

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTMS Gene

Disorders for PTMS Gene

MalaCards: The human disease database

(2) MalaCards diseases for PTMS Gene - From: DISEASES

Disorder Aliases PubMed IDs
macular dystrophy, patterned, 3
  • mdpt3
noonan syndrome 1
  • ns1
- elite association - COSMIC cancer census association via MalaCards
Search PTMS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PTMS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PTMS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTMS Gene

Publications for PTMS Gene

  1. Parathymosin affects the binding of linker histone H1 to nucleosomes and remodels chromatin structure. (PMID: 15716277) Martic G … Papamarcaki T (The Journal of biological chemistry 2005) 2 3 23 54
  2. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J … Lambert JC (Molecular psychiatry 2009) 3 41 54
  3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 41 54
  4. The thymosins. Prothymosin alpha, parathymosin, and beta-thymosins: structure and function. (PMID: 12852257) Hannappel E … Huff T (Vitamins and hormones 2003) 3 23 54
  5. Nuclear distribution of prothymosin alpha and parathymosin: evidence that prothymosin alpha is associated with RNA synthesis processing and parathymosin with early DNA replication. (PMID: 10854063) Vareli K … van Driel R (Experimental cell research 2000) 3 23 54

Products for PTMS Gene

Sources for PTMS Gene