PTK2B Gene (Protein Coding)

Protein Tyrosine Kinase 2 Beta

GC08P027311
GIFtS:
50
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal... See more...

Aliases for PTK2B Gene

Aliases for PTK2B Gene

  • Protein Tyrosine Kinase 2 Beta 2 3 5
  • CADTK 2 3 4
  • RAFTK 2 3 4
  • FAK2 2 3 4
  • CAKB 2 3 4
  • PYK2 2 3 4
  • Calcium-Regulated Non-Receptor Proline-Rich Tyrosine Kinase 3 4
  • Related Adhesion Focal Tyrosine Kinase 3 4
  • Calcium-Dependent Tyrosine Kinase 3 4
  • Protein-Tyrosine Kinase 2-Beta 3 4
  • Proline-Rich Tyrosine Kinase 2 3 4
  • Cell Adhesion Kinase Beta 3 4
  • Focal Adhesion Kinase 2 3 4
  • EC 2.7.10.2 4 50
  • CAK-Beta 3 4
  • FADK 2 3 4
  • PTK 2 3
  • PTK2B Protein Tyrosine Kinase 2 Beta 3
  • Protein Kinase B 3
  • EC 2.7.10 50
  • FADK2 3
  • PTK2B 5
  • PKB 3

External Ids for PTK2B Gene

Previous HGNC Symbols for PTK2B Gene

  • FAK2

Previous GeneCards Identifiers for PTK2B Gene

  • GC08P027003
  • GC08P027685
  • GC08P027190
  • GC08P027224
  • GC08P025714

Summaries for PTK2B Gene

Entrez Gene Summary for PTK2B Gene

  • This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CIViC Summary for PTK2B Gene

GeneCards Summary for PTK2B Gene

PTK2B (Protein Tyrosine Kinase 2 Beta) is a Protein Coding gene. Diseases associated with PTK2B include Osteoporosis and Osteopetrosis. Among its related pathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PTK2.

UniProtKB/Swiss-Prot Summary for PTK2B Gene

  • Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2.

Gene Wiki entry for PTK2B Gene

Additional gene information for PTK2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTK2B Gene

Genomics for PTK2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PTK2B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTK2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTK2B

Top Transcription factor binding sites by QIAGEN in the PTK2B gene promoter:
  • NRSF form 1
  • STAT1
  • STAT3

Genomic Locations for PTK2B Gene

Latest Assembly
chr8:27,311,478-27,459,391
(GRCh38/hg38)
Size:
147,914 bases
Orientation:
Plus strand

Previous Assembly
chr8:27,168,995-27,316,908
(GRCh37/hg19 by Entrez Gene)
Size:
147,914 bases
Orientation:
Plus strand

chr8:27,168,999-27,316,903
(GRCh37/hg19 by Ensembl)
Size:
147,905 bases
Orientation:
Plus strand

Genomic View for PTK2B Gene

Genes around PTK2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTK2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTK2B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PTK2B Gene

Proteins for PTK2B Gene

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  • Protein details for PTK2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14289-FAK2_HUMAN
    Recommended name:
    Protein-tyrosine kinase 2-beta
    Protein Accession:
    Q14289
    Secondary Accessions:
    • D3DST0
    • Q13475
    • Q14290
    • Q16709
    • Q6PID4

    Protein attributes for PTK2B Gene

    Size:
    1009 amino acids
    Molecular mass:
    115875 Da
    Quaternary structure:
    • Homodimer, or homooligomer. Interacts with SIRPA and SH2D3C. Interacts with ARHGAP10. Interacts with DLG4 (By similarity). Interacts with KCNA2 (By similarity). Interacts with NPHP1, ASAP1, ASAP2, ARHGAP26, SKAP2 and TGFB1I1. The Tyr-402 phosphorylated form interacts with SRC (via SH2 domain) and SRC family members. Forms a signaling complex with EPHA1, LCK and phosphatidylinositol 3-kinase; upon activation by EFNA1. Interacts with GRB2 (via SH2 domain). Interacts with P53/TP53 and MDM2. Interacts with MYLK. Interacts with BCAR1. Interacts with PDPK1. Interacts (hypophosphorylated) with PXN. Interacts with RB1CC1. Interacts with RHOU. Interacts with VAV1. Interacts with LPXN and PTPN12.
    Miscellaneous:
    • Promotes bone resorption, and thus PTK2B/PYK2 inhibitors might be used to treat osteoporosis.

    Three dimensional structures from OCA and Proteopedia for PTK2B Gene

    Alternative splice isoforms for PTK2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTK2B Gene

Protein Expression for PTK2B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PTK2B Gene

Q14289:
  • VCMWEIL
  • PESINFRRFT
  • CVKLGDFGLSRY
  • RLPIKWM
  • AENMADLIDGYCRL
  • PTANLDR

Post-translational modifications for PTK2B Gene

  • Phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration; this activation is indirect and may be mediated by production of reactive oxygen species (ROS). Tyr-402 is the major autophosphorylation site, but other kinases can also phosphorylate Tyr-402. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-402 promotes interaction with SRC and SRC family members, leading to phosphorylation at Tyr-579; Tyr-580 and Tyr-881. Phosphorylation at Tyr-881 is important for interaction with GRB2. Phosphorylated on tyrosine residues upon activation of FGR and PKC. Recruitment by NPHP1 to cell matrix adhesions initiates Tyr-402 phosphorylation. In monocytes, adherence to substrata is required for tyrosine phosphorylation and kinase activation. Angiotensin II, thapsigargin and L-alpha-lysophosphatidic acid (LPA) also induce autophosphorylation and increase kinase activity. Phosphorylation by MYLK promotes ITGB2 activation and is thus essential to trigger neutrophil transmigration during lung injury. Dephosphorylated by PTPN12.
  • Ubiquitination at Lys188 and Lys944
  • Modification sites at PhosphoSitePlus

Other Protein References for PTK2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for PTK2B

Domains & Families for PTK2B Gene

Gene Families for PTK2B Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PTK2B Gene

InterPro:
Blocks:
  • Tyrosine protein kinase, active site
  • Focal adhesion targeting region

Suggested Antigen Peptide Sequences for PTK2B Gene

GenScript: Design optimal peptide antigens:
  • Related adhesion focal tyrosine kinase (FAK2_HUMAN)
  • PTK2B protein tyrosine kinase 2 beta (Q6PID4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14289

UniProtKB/Swiss-Prot:

FAK2_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.
genes like me logo Genes that share domains with PTK2B: view

Function for PTK2B Gene

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Molecular function for PTK2B Gene

UniProtKB/Swiss-Prot Function:
Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18951788, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated in response to stimuli that lead to increased intracellular Ca(2+) levels; this activation is indirect and may be mediated by calcium-mediated production of reactive oxygen species (ROS). Activated by autophosphorylation at Tyr-402; this creates a binding site for SRC family kinases and leads to phosphorylation at additional tyrosine residues. Phosphorylation at Tyr-402, Tyr-579 and Tyr-580 is required for optimal kinase activity. Inhibited by PF-562,271, BIRB796, PF-4618433 and by PF-431396, PF-2318841 and their derivatives. Inhibited by sulfoximine-substituted trifluoromethylpyrimidines. Inhibited by 4-amino and 5-aryl substituted pyridinone compounds.
GENATLAS Biochemistry:
focal adhesion kinase 2

Enzyme Numbers (IUBMB) for PTK2B Gene

Phenotypes From GWAS Catalog for PTK2B Gene

Gene Ontology (GO) - Molecular Function for PTK2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004683 calmodulin-dependent protein kinase activity ISS --
GO:0004713 protein tyrosine kinase activity TAS 8939945
GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS,IDA 7544443
genes like me logo Genes that share ontologies with PTK2B: view
genes like me logo Genes that share phenotypes with PTK2B: view

Animal Models for PTK2B Gene

MGI Knock Outs for PTK2B:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTK2B

Clone products for research

  • Addgene plasmids for PTK2B

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTK2B Gene

Localization for PTK2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTK2B Gene

Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cell junction, focal adhesion. Cell projection, lamellipodium. Cytoplasm, cell cortex. Nucleus. Note=Interaction with NPHP1 induces the membrane-association of the kinase. Colocalizes with integrins at the cell periphery.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTK2B gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 4
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PTK2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 19880522
GO:0005737 cytoplasm TAS 7499242
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PTK2B: view

Pathways & Interactions for PTK2B Gene

PathCards logo

SuperPathways for PTK2B Gene

SuperPathway Contained pathways
1 ERK Signaling
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
2 Integrin Pathway
Integrin Pathway
.67
GnRH Signaling
.56
UPA-UPAR Pathway
.56
Transendothelial Migration of Leukocytes
.38
3 Development Angiotensin activation of ERK
Development ACM2 and ACM4 activation of ERK
.73
Development Angiotensin activation of ERK
.73
Development Angiotensin signaling via PYK2
.68
Development G-Proteins mediated regulation MARK-ERK signaling
.65
4 CCR5 Pathway in Macrophages
CCR5 Pathway in Macrophages
.52
Chemokine Signaling
.33
Chemokine signaling pathway
.32
5 Development Endothelin-1/EDNRA signaling
Development Endothelin-1/EDNRA signaling
.41
Development Endothelin-1/EDNRA transactivation of EGFR
.41
GnRH signaling pathway
.38
genes like me logo Genes that share pathways with PTK2B: view

Pathways by source for PTK2B Gene

18 GeneGo (Thomson Reuters) pathways for PTK2B Gene
  • Chemotaxis CXCR4 signaling pathway
  • Development A2B receptor- action via G-protein alpha s
  • Development A3 receptor signaling
  • Development ACM2 and ACM4 activation of ERK
  • Development Activation of ERK by Alpha-1 adrenergic receptors
44 Qiagen pathways for PTK2B Gene
  • Agrin Interactions at Neuromuscular Junction
  • Akt Signaling
  • Angiopoietin-TIE2 Signaling
  • Calpain Protease Regulates Cellular Mechanics
  • cAMP Pathway
2 Cell Signaling Technology pathways for PTK2B Gene

SIGNOR curated interactions for PTK2B Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PTK2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000302 response to reactive oxygen species IEA --
GO:0001525 angiogenesis IBA 21873635
GO:0001556 oocyte maturation IEA --
GO:0001666 response to hypoxia IEA --
genes like me logo Genes that share ontologies with PTK2B: view

Drugs & Compounds for PTK2B Gene

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(92) Drugs for PTK2B Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Leflunomide Approved, Investigational Pharma Target, antagonist AHR agonist,immunosuppressive agent 99
Baricitinib Approved, Investigational Pharma Target, inhibitor 0
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide Experimental Pharma Target 0
Genistein Investigational Pharma Target AR agonist, EGFR kinase inhibitor. Also estrogen and PPARgamma ligand 61

(76) Additional Compounds for PTK2B Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 58-64-0
LysoPA(0:0/16:0)
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • Lysophosphatidic acid(0:0/16:0)
  • LPA(16:0)
  • 2-Hexadecanoyl-phosphatidic acid
LysoPA(0:0/18:0)
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
  • Lysophosphatidic acid(18:0)
  • 2-Stearoyl-glycero-3-phosphate
LysoPA(0:0/18:1(9Z))
  • Lysophosphatidic acid(18:1)
  • LPA(0:0/18:1(9Z))
  • LPA(0:0/18:1)
  • Lysophosphatidic acid(0:0/18:1)
  • 2-Oleoyl-glycero-3-phosphate
LysoPA(0:0/18:2(9Z,12Z))
  • {3-hydroxy-2-[(9Z,12Z)-octadeca-9,12-dienoyloxy]propoxy}phosphonate
  • LPA(18:2)
  • LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • Lysophosphatidic acid(18:2)

(7) ApexBio Compounds for PTK2B Gene

Compound Action Cas Number
FAK Inhibitor 14 4506-66-5
PF-00562271 FAK/Pyk2 inhibitor,potent and ATP-competitive 939791-38-5
PF-431396 Pyk2 and FAK inhibitor 717906-29-1
PF-562271 ATP-competitive FAK inhibitor, reversible 717907-75-0
PF-562271 HCl FAK/Pyk2 inhibitor
TAE226 (NVP-TAE226) FAK inhibitor,potent and ATP-competitive 761437-28-9
Y 11 1086639-59-9
genes like me logo Genes that share compounds with PTK2B: view

Transcripts for PTK2B Gene

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mRNA/cDNA for PTK2B Gene

4 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTK2B

Clone products for research

  • Addgene plasmids for PTK2B

Alternative Splicing Database (ASD) splice patterns (SP) for PTK2B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - - - - -
SP2: - - - - -
SP3:
SP4: -
SP5: - - - - -
SP6: - -
SP7:
SP8:
SP9: -
SP10: - -

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PTK2B Gene

GeneLoc Exon Structure for
PTK2B

Expression for PTK2B Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTK2B Gene

mRNA expression in normal human tissues for PTK2B Gene
mRNA expression by BioGPS for PTK2B GenemRNA expression by GTEx for PTK2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTK2B Gene

This gene is overexpressed in Whole Blood (x7.3).

Protein differential expression in normal tissues from HIPED for PTK2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.1), Lymph node (9.5), Lung (7.7), and Cervix (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTK2B Gene



Protein tissue co-expression partners for PTK2B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTK2B

SOURCE GeneReport for Unigene cluster for PTK2B Gene:

Hs.491322

mRNA Expression by UniProt/SwissProt for PTK2B Gene:

Q14289-FAK2_HUMAN
Tissue specificity: Most abundant in the brain, with highest levels in amygdala and hippocampus. Low levels in kidney (at protein level). Also expressed in spleen and lymphocytes.

Evidence on tissue expression from TISSUES for PTK2B Gene

  • Nervous system(4.8)
  • Blood(4.6)
  • Stomach(3.2)
  • Lymph node(2.9)
  • Bone marrow(2.9)
  • Heart(2.8)
  • Intestine(2.8)
  • Spleen(2.8)
  • Skin(2.7)
  • Kidney(2.7)
  • Lung(2.4)
  • Muscle(2.4)
  • Liver(2.3)
  • Adrenal gland(2.1)
  • Bone(2)
  • Thyroid gland(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with PTK2B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTK2B Gene

Orthologs for PTK2B Gene

This gene was present in the common ancestor of animals.

Orthologs for PTK2B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PTK2B 29 30
  • 99.48 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia PTK2B 30
  • 91 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia PTK2B 29 30
  • 90.9 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia PTK2B 29 30
  • 90.69 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Ptk2b 29 16 30
  • 88.97 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ptk2b 29
  • 88.62 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia PTK2B 30
  • 84 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves PTK2B 29 30
  • 78.79 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia PTK2B 30
  • 72 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia ptk2b 29
  • 73.42 (n)
Zebrafish
(Danio rerio)
 Actinopterygii ptk2ba 30
  • 63 (a)
 OneToMany
ptk2bb 30
  • 59 (a)
 OneToMany
-- 29
Fruit Fly
(Drosophila melanogaster)
 Insecta Fak56D 30 31
  • 23 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea kin-23 31
  • 30 (a)
kin-32 30 31
  • 28 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.5720 30
  • 38 (a)
 OneToMany
Species where no ortholog for PTK2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PTK2B Gene

ENSEMBL:
Gene Tree for PTK2B (if available)
TreeFam:
Gene Tree for PTK2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTK2B: view image
Alliance of Genome Resources:
Additional Orthologs for PTK2B

Paralogs for PTK2B Gene

Paralogs for PTK2B Gene

(19) SIMAP similar genes for PTK2B Gene using alignment to 7 proteins:

  • FAK2_HUMAN
  • C9JHV9_HUMAN
  • E5RHL2_HUMAN
  • E5RJ77_HUMAN
  • E5RK84_HUMAN
  • E9PBI4_HUMAN
  • H0YB74_HUMAN
genes like me logo Genes that share paralogs with PTK2B: view

Variants for PTK2B Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTK2B Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs112665817 Benign: not provided 27,422,364(+) C/T
NM_173176.3(PTK2B):c.532C>T (p.Leu178=) 		SYNONYMOUS
rs116416838 Benign: not provided 27,440,228(+) A/G
NM_173176.3(PTK2B):c.1835-9A>G 		INTRON
rs11991368 Benign: not provided 27,422,366(+) G/A
NM_173176.3(PTK2B):c.534G>A (p.Leu178=) 		SYNONYMOUS
rs55853846 Benign: not provided 27,435,789(+) C/T
NM_173176.3(PTK2B):c.1239C>T (p.Pro413=) 		SYNONYMOUS
rs56175011 Likely Benign: not provided 27,433,522(+) C/Gp.Gln359Glu
NM_173176.3(PTK2B):c.1075C>G (p.Gln359Glu) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PTK2B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PTK2B Gene

Variant ID Type Subtype PubMed ID
dgv1390e214 CNV gain 21293372
esv2092173 CNV deletion 18987734
esv2430348 CNV insertion 19546169
esv2673904 CNV deletion 23128226
esv2676555 CNV deletion 23128226
esv3381982 CNV duplication 20981092
esv3441155 CNV insertion 20981092
esv3616717 CNV gain 21293372
esv3616719 CNV loss 21293372
esv3616721 CNV gain 21293372
esv3616722 CNV loss 21293372
esv3616723 CNV loss 21293372
nsv1020582 CNV gain 25217958
nsv1149289 CNV deletion 26484159
nsv471719 CNV loss 16327809

Variation tolerance for PTK2B Gene

Residual Variation Intolerance Score: 2.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.07; 87.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTK2B Gene

Human Gene Mutation Database (HGMD)
PTK2B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTK2B
Leiden Open Variation Database (LOVD)
PTK2B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTK2B Gene

Disorders for PTK2B Gene

MalaCards: The human disease database

(12) MalaCards diseases for PTK2B Gene - From: COP and GCD

Disorder Aliases PubMed IDs
osteoporosis
  • bone mineral density quantitative trait locus; bmnd
osteopetrosis
  • albers-schonberg disease
transient cerebral ischemia
  • tia
lung cancer
  • lung cancer, susceptibility to
ovarian cancer
  • ovarian cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search PTK2B in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FAK2_HUMAN
  • Note=Aberrant PTK2B/PYK2 expression may play a role in cancer cell proliferation, migration and invasion, in tumor formation and metastasis. Elevated PTK2B/PYK2 expression is seen in gliomas, hepatocellular carcinoma, lung cancer and breast cancer.

Additional Disease Information for PTK2B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PTK2B: view

No data available for Genatlas for PTK2B Gene

Publications for PTK2B Gene

  1. Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. (PMID: 7544443) Lev S … Schlessinger J (Nature 1995) 2 3 4 22
  2. Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. (PMID: 7499242) Avraham S … Groopman JE (The Journal of biological chemistry 1995) 2 3 4 22
  3. The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems. (PMID: 20028775) Collins M … Houtman JC (Journal of leukocyte biology 2010) 3 4 22
  4. T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells. (PMID: 20381867) Collins M … Houtman JC (Molecular immunology 2010) 3 4 22
  5. Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. (PMID: 19880522) Lim ST … Schlaepfer DD (The Journal of biological chemistry 2010) 3 4 22

ExternalLinks

View latest publications for PTK2B gene in Mastermind

Products for PTK2B Gene