Aliases for PTH2R Gene
External Ids for PTH2R Gene
Previous HGNC Symbols for PTH2R Gene
Previous GeneCards Identifiers for PTH2R Gene
The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
GeneCards Summary for PTH2R Gene
PTH2R (Parathyroid Hormone 2 Receptor) is a Protein Coding gene. Among its related pathways are Presynaptic function of Kainate receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and parathyroid hormone receptor activity. An important paralog of this gene is PTH1R.
UniProtKB/Swiss-Prot for PTH2R Gene
This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).