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This gene encodes the precursor of a peptide hormone that shares sequence similarity with the parathyroid hormone. This gene is expressed in various regions of the brain where it plays a role in the release of pituitary hormones, anxiety and nociception. The encoded precursor protein is proteolytically processed to generate the biologically active neuropeptide. [provided by RefSeq, Jul 2015]
PTH2 (Parathyroid Hormone 2) is a Protein Coding gene. Diseases associated with PTH2 include Polyomavirus-Associated Nephropathy. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Peptide ligand-binding receptors | ||
3 | Presynaptic function of Kainate receptors | ||
4 | G alpha (s) signalling events |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007218 | neuropeptide signaling pathway | IEA | -- |
Compound | Action | Cas Number |
---|---|---|
Parathyroid Hormone (1-34), bovine | Enhancer of blood calcium level | 12583-68-5 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | PTH2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PTH2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Pth2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Pth2 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
polyomavirus-associated nephropathy |
|
|