This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moon... See more...

Aliases for PTGS1 Gene

Aliases for PTGS1 Gene

  • Prostaglandin-Endoperoxide Synthase 1 2 3 4 5
  • Cyclooxygenase-1 2 3 4
  • PGHS-1 2 3 4
  • COX1 2 3 4
  • Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase And Cyclooxygenase) 2 3
  • Prostaglandin G/H Synthase 1 3 4
  • Prostaglandin H2 Synthase 1 3 4
  • PGH Synthase 1 3 4
  • EC 1.14.99.1 4 50
  • PTGHS 2 3
  • EC 1.14.99 50
  • PGG/HS 3
  • PCOX1 3
  • PES-1 3
  • PGHS1 3
  • PTGS1 5
  • COX-1 4
  • PHS 1 4
  • COX3 3
  • PHS1 3

External Ids for PTGS1 Gene

Previous GeneCards Identifiers for PTGS1 Gene

  • GC09P116237
  • GC09P116779
  • GC09P118586
  • GC09P120509
  • GC09P122212
  • GC09P124173
  • GC09P125133
  • GC09P094748

Summaries for PTGS1 Gene

Entrez Gene Summary for PTGS1 Gene

  • This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for PTGS1 Gene

PTGS1 (Prostaglandin-Endoperoxide Synthase 1) is a Protein Coding gene. Diseases associated with PTGS1 include Gastric Ulcer and Aspirin Resistance. Among its related pathways are Overview of nanoparticle effects and HETE and HPETE biosynthesis and metabolism. Gene Ontology (GO) annotations related to this gene include heme binding and dioxygenase activity. An important paralog of this gene is PTGS2.

UniProtKB/Swiss-Prot Summary for PTGS1 Gene

  • Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons (PubMed:7947975). Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (Probable).

Tocris Summary for PTGS1 Gene

  • Cyclooxygenase (also known as COX, Prostaglandin-endoperoxide synthase, Prostaglandin G/H synthase) is expressed in cells in three isoforms. COX-1 (constitutive) and COX-2 (inducible) isoforms catalyze the rate-limiting step of prostaglandin production.

Gene Wiki entry for PTGS1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTGS1 Gene

Genomics for PTGS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTGS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J122370 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 256.7 +1.4 1395 2.6 SIN3A EBF1 SPI1 EGR1 NRF1 HDGF ZMYM3 IKZF1 ARID2 KDM1A PTGS1 ENSG00000269970 OR1J2
GH09J122369 Enhancer 0.2 Ensembl 250.7 -0.8 -805 0.2 PTGS1 HSALNG0074236 RBM18
GH09J122368 Enhancer 0.2 Ensembl 250.7 -1.6 -1605 0.2 PTGS1 HSALNG0074236 RBM18
GH09J122346 Enhancer 1.2 FANTOM5 ENCODE CraniofacialAtlas 12 -22.3 -22311 2.3 EZH2 ZMYM3 MXD4 SIN3A THAP11 ELF1 SMAD4 SAP130 DMAP1 GABPB1 PTGS1 TTLL11 MRRF RBM18 ENSG00000233616 piR-38344-140 RF00017-7272
GH09J122389 Enhancer 0.8 Ensembl ENCODE 18.3 +22.2 22194 7.4 JUND CEBPB BHLHE40 SPI1 PKNOX1 ATF4 ARID1B IKZF1 ATF3 EP300 PTGS1 ENSG00000234156 OR1K1 OR1Q1 OR1N2 ENSG00000233616 lnc-OR1J1-2 OR1J2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTGS1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTGS1

Top Transcription factor binding sites by QIAGEN in the PTGS1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • Sp1

Genomic Locations for PTGS1 Gene

Latest Assembly
chr9:122,369,906-122,395,703
(GRCh38/hg38)
Size:
25,798 bases
Orientation:
Plus strand

Previous Assembly
chr9:125,132,812-125,157,982
(GRCh37/hg19 by Entrez Gene)
Size:
25,171 bases
Orientation:
Plus strand

chr9:125,132,824-125,157,982
(GRCh37/hg19 by Ensembl)
Size:
25,159 bases
Orientation:
Plus strand

Genomic View for PTGS1 Gene

Genes around PTGS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGS1 Gene

Proteins for PTGS1 Gene

  • Protein details for PTGS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23219-PGH1_HUMAN
    Recommended name:
    Prostaglandin G/H synthase 1
    Protein Accession:
    P23219
    Secondary Accessions:
    • A8K1V7
    • B4DHQ2
    • B4E2S5
    • Q15122
    • Q3HY28
    • Q3HY29
    • Q5T7T6
    • Q5T7T7
    • Q5T7T8

    Protein attributes for PTGS1 Gene

    Size:
    599 amino acids
    Molecular mass:
    68686 Da
    Cofactor:
    Name=heme b; Xref=ChEBI:CHEBI:60344;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site.
    • Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PTGS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PTGS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.
    • PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.

    Three dimensional structures from OCA and Proteopedia for PTGS1 Gene

    Alternative splice isoforms for PTGS1 Gene

neXtProt entry for PTGS1 Gene

Selected DME Specific Peptides for PTGS1 Gene

P23219:
  • MFAFFAQHFTHQFFKT
  • WLREHNRVCD
  • FNEYRKRF
  • LYHWHPL
  • LGHGVDL
  • AGRIGGGRN
  • PVNPCCYYPCQ
  • CDCTRTG
  • LRLFKDGK
  • FSNVSYYTR
  • VGQEVFGL
  • GNPICSP
  • GPGFTKA
  • DCPTPMG
  • LYGDIDA
  • RLILIGETIKI
  • YWKPSTFGG
  • SWESFSN
  • YSYEQFLFNTSMLVDYGVEALVDAFSRQ
  • FIPDPQG
  • RLFKDGK
  • TVRSNLIPSPPTYN
  • LKFDPELLF
  • GAPFSLKGL

Post-translational modifications for PTGS1 Gene

  • Glycosylation at Asn143, Asn67, and Asn103
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Antibodies for research

Domains & Families for PTGS1 Gene

Gene Families for PTGS1 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for PTGS1 Gene

InterPro:
Blocks:
  • Type I EGF
  • Animal haem peroxidase signature
  • Haem peroxidase

Suggested Antigen Peptide Sequences for PTGS1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61263, highly similar to Prostaglandin G/H synthase 1 (EC 1.14.99.1) (B4DHQ2_HUMAN)
  • Prostaglandin-endoperoxide synthase 1 (PGH1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P23219

UniProtKB/Swiss-Prot:

PGH1_HUMAN :
  • Belongs to the prostaglandin G/H synthase family.
Family:
  • Belongs to the prostaglandin G/H synthase family.
genes like me logo Genes that share domains with PTGS1: view

Function for PTGS1 Gene

Molecular function for PTGS1 Gene

UniProtKB/Swiss-Prot Function:
Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons (PubMed:7947975). Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (Probable).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2; Xref=Rhea:RHEA:23728, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:32395, ChEBI:CHEBI:57405; EC=1.14.99.1; Evidence={ECO:0000269|PubMed:7947975};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2; Xref=Rhea:RHEA:42596, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:82629; Evidence={ECO:0000269|PubMed:7947975};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=AH2 + prostaglandin G2 = A + H2O + prostaglandin H2; Xref=Rhea:RHEA:42600, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:57405, ChEBI:CHEBI:82629; Evidence={ECO:0000269|PubMed:7947975};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=5.1 uM for arachidonate {ECO:0000269|PubMed:7947975};
UniProtKB/Swiss-Prot EnzymeRegulation:
The cyclooxygenase activity is inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen, flurbiprofen, ketoprofen, naproxen, flurbiprofen, anirolac, fenclofenac and diclofenac.
GENATLAS Biochemistry:
prostaglandin G/H synthase 1,constitutively expressed in a wide range of tissues,acting first as a dioxygenase,then as a peroxidase (lipocalin family,Kernel group),monomer,potent mediator of inflammation

Enzyme Numbers (IUBMB) for PTGS1 Gene

Phenotypes From GWAS Catalog for PTGS1 Gene

Gene Ontology (GO) - Molecular Function for PTGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IEA --
GO:0004666 prostaglandin-endoperoxide synthase activity IDA 1380156
GO:0005515 protein binding IPI 32814053
GO:0016491 oxidoreductase activity IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with PTGS1: view
genes like me logo Genes that share phenotypes with PTGS1: view

Animal Models for PTGS1 Gene

MGI Knock Outs for PTGS1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGS1

Clone products for research

  • Addgene plasmids for PTGS1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGS1 Gene

Localization for PTGS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGS1 Gene

Microsome membrane. Peripheral membrane protein. Endoplasmic reticulum membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGS1 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
mitochondrion 3
nucleus 3
endoplasmic reticulum 3
plasma membrane 2
cytoskeleton 2
peroxisome 2
cytosol 2
lysosome 2
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PTGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment IEA --
GO:0005737 cytoplasm IDA,ISS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with PTGS1: view

Pathways & Interactions for PTGS1 Gene

genes like me logo Genes that share pathways with PTGS1: view

Pathways by source for PTGS1 Gene

4 GeneGo (Thomson Reuters) pathways for PTGS1 Gene
  • Development VEGF signaling via VEGFR2 - generic cascades
  • HETE and HPETE biosynthesis and metabolism
  • Neurophysiological process PGE2-induced pain processing
  • Prostaglandin 2 biosynthesis and metabolism FM
1 Qiagen pathway for PTGS1 Gene
  • Endothelin-1 Signaling Pathway
2 Cell Signaling Technology pathways for PTGS1 Gene

UniProtKB/Swiss-Prot P23219-PGH1_HUMAN

  • Pathway: Lipid metabolism; prostaglandin biosynthesis.

Gene Ontology (GO) - Biological Process for PTGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process ISS --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006693 prostaglandin metabolic process IEA --
genes like me logo Genes that share ontologies with PTGS1: view

No data available for SIGNOR curated interactions for PTGS1 Gene

Drugs & Compounds for PTGS1 Gene

(207) Drugs for PTGS1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved, Vet_approved Pharma Target, inhibitor 1600
Acetaminophen Approved Pharma Target, inhibitor 1412
Ibuprofen Approved Pharma Target, inhibitor 758
Ketoprofen Approved, Vet_approved Pharma Target, inhibitor 102
Ketorolac Approved Pharma Target, inhibitor 485

(66) Additional Compounds for PTGS1 Gene - From: Novoseek, HMDB, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4'-Hydroxydiclofenac
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetate
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
64118-84-9
valerylsalicylate
Inhibitor, Inhibition
2-Hydroxychlorpropamide
  • N-(4-Chloro-2-hydroxybenzenesulfonyl)propane-1-carbamimidate
  • N-(4-Chloro-2-hydroxybenzenesulphonyl)propane-1-carbamimidate
  • N-(4-Chloro-2-hydroxybenzenesulphonyl)propane-1-carbamimidic acid
36892-36-1
3-Dechloroethylifosfamide
  • Dechloroethylcyclophosphamide
  • N-(2-Chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
  • N-(2-Chloroethyl)-2-oxo-1,3,2$l^{5}-oxazaphosphinan-2-amine
  • (+-)-Isomer OF dechloroethylcyclophosphamide
  • (R)-Isomer OF dechloroethylcyclophosphamide
36761-83-8
3'-Hydroxyhexobarbital
  • 3'-Hydroxyhexobarbital, (R-(r*,s*))-isomer
  • 3'-Hydroxyhexobarbital, (r*,s*)-(+-)-isomer
  • 3'-Hydroxyhexobarbital, (S-(r*,r*))-isomer
  • 3'-Hydroxyhexobarbital, (S-(r*,s*))-isomer
  • 3'-Hydroxyhexobarbitone
427-29-2

(4) Tocris Compounds for PTGS1 Gene

Compound Action Cas Number
NCX 4040 NO-donating aspirin; anti-inflammatory and antitumor 287118-97-2
NCX 466 Cyclooxygenase-inhibiting nitric oxide donor 1262956-64-8
Niflumic acid Cyclooxygenase-2 (COX-2) inhibitor; GPR35 agonist 4394-00-7
Resveratrol Cyclooxygenase inhibitor 501-36-0

(58) ApexBio Compounds for PTGS1 Gene

Compound Action Cas Number
(R)-(-)-Ibuprofen 51146-57-7
(S)-(+)-Ibuprofen 51146-56-6
Aceclofenac 89796-99-6
Acemetacin 53164-05-9
Acetaminophen 103-90-2
Amfenac Sodium Monohydrate 61618-27-7
Ampiroxicam 99464-64-9
Asaraldehyde 4460-86-0
Aspirin (Acetylsalicylic acid) Cyclooxygenase (COX) inhibitor 50-78-2
ATB-346 Non-steroidal anti-inflammatory drug 1226895-20-0
Bromfenac Sodium 91714-93-1
Bufexamac 2438-72-4
Celecoxib Selective cyclooxygenase-2 (COX-2) inhibitor 169590-42-5
Deracoxib 169590-41-4
Diclofenac 15307-86-5
Diclofenac Sodium COX inhibitor 15307-79-6
Diosgenin 512-04-9
DuP 697 88149-94-4
Etodolac COX-2 inhibitor 41340-25-4
Etoricoxib Specific COX-2 inhibitor 202409-33-4
Firocoxib 189954-96-9
FK 3311 Selective COX-2 inhibitor 116686-15-8
Flunixin Meglumin 42461-84-7
FR 122047 hydrochloride 130717-51-0
Ibuprofen 15687-27-1
Ibuprofen Lysine COX inhibitor 57469-77-9
Iguratimod COX-2 inhibitor,inhibits IL-1,IL-6,IL-8 and tumour necrosis factor. 123663-49-0
Indomethacin Cox inhibitor 53-86-1
Ketoprofen 22071-15-4
Ketorolac 74103-06-3
Ketorolac tromethamine salt 74103-07-4
Licofelone 156897-06-2
Loganin Cox-1 inhibitor 18524-94-2
Lornoxicam COX-1/COX-2 inhibitor 70374-39-9
Lumiracoxib 220991-20-8
Meclofenamate Sodium 6385-02-0
Mefenamic Acid Anti-inflammatory agent 61-68-7
Meloxicam (Mobic) Nonsteroidal anti-inflammatory drug 71125-38-7
Nabumetone 42924-53-8
Naproxen Sodium cyclooxygenase inhibitor 26159-34-2
NCX 4040 287118-97-2
NCX 466 1262956-64-8
Nepafenac Anti-inflammatory drug (NSAID) 78281-72-8
Nimesulide Non-steroidal anti-inflammatory drug 51803-78-2
Oxaprozin Anti-inflammatory drug 21256-18-8
Parecoxib Sodium 198470-85-8
Phenacetin Non-opioid analgesic 62-44-2
Piroxicam Prostaglandin synthesis/Coxinhibitor 36322-90-4
Rofecoxib COX-2 inhibitor 162011-90-7
Salicylic acid 69-72-7
SC 236 170569-86-5
SC 560 COX-1-selective inhibitor 188817-13-2
SC 58125 162054-19-5
Sulindac Anti-inflammatory agent;COX inhibitor 38194-50-2
Tolfenamic Acid Non-steroidal anti-inflammatory drug 13710-19-5
Triflusal 322-79-2
Valdecoxib COX-2 inhibitor 181695-72-7
Zaltoprofen Cyclooxygenase (COX) inhibitor 74711-43-6
genes like me logo Genes that share compounds with PTGS1: view

Drug products for research

Transcripts for PTGS1 Gene

mRNA/cDNA for PTGS1 Gene

7 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGS1

Clone products for research

  • Addgene plasmids for PTGS1

Alternative Splicing Database (ASD) splice patterns (SP) for PTGS1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d
SP1:
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: - - - - -
SP8: - - -

Relevant External Links for PTGS1 Gene

GeneLoc Exon Structure for
PTGS1

Expression for PTGS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTGS1 Gene

mRNA differential expression in normal tissues according to GTEx for PTGS1 Gene

This gene is overexpressed in Bladder (x10.9), Colon - Sigmoid (x6.6), and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for PTGS1 Gene

This gene is overexpressed in Urinary Bladder (25.0), Platelet (15.5), and Peripheral blood mononuclear cells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTGS1 Gene



Protein tissue co-expression partners for PTGS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTGS1

SOURCE GeneReport for Unigene cluster for PTGS1 Gene:

Hs.201978

Evidence on tissue expression from TISSUES for PTGS1 Gene

  • Nervous system(4.7)
  • Blood(4.7)
  • Lung(4.5)
  • Skin(3.3)
  • Intestine(2.9)
  • Stomach(2.8)
  • Heart(2.6)
  • Kidney(2.6)
  • Muscle(2.5)
  • Liver(2.3)
  • Bone marrow(2.3)
  • Lymph node(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with PTGS1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGS1 Gene

Orthologs for PTGS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGS1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PTGS1 29 30
  • 99.12 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PTGS1 29 30
  • 89.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PTGS1 29 30
  • 89.35 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ptgs1 29 16 30
  • 85.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ptgs1 29
  • 84.32 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 78 (a)
OneToMany
-- 30
  • 73 (a)
OneToMany
-- 30
  • 71 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia PTGS1 30
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PTGS1 29 30
  • 75.97 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PTGS1 30
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ptgs1 29
  • 69.08 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6116 29
Zebrafish
(Danio rerio)
Actinopterygii ptgs1 29 30
  • 67.5 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11882 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 46 (a)
ManyToMany
CSA.3689 30
  • 43 (a)
ManyToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1052 29
Species where no ortholog for PTGS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PTGS1 Gene

ENSEMBL:
Gene Tree for PTGS1 (if available)
TreeFam:
Gene Tree for PTGS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTGS1: view image
Alliance of Genome Resources:
Additional Orthologs for PTGS1

Paralogs for PTGS1 Gene

Paralogs for PTGS1 Gene

(1) SIMAP similar genes for PTGS1 Gene using alignment to 1 proteins:

  • PGH1_HUMAN
genes like me logo Genes that share paralogs with PTGS1: view

Variants for PTGS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTGS1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs10306114 Drug Response: aspirin response - Efficacy 122,370,243(+) A/G
NM_000962.3(PTGS1):c.-842A>G
GENIC_UPSTREAM_TRANSCRIPT
rs192430192 Benign: not provided 122,381,757(+) G/A
NM_000962.4(PTGS1):c.762+10G>A
INTRON
rs199769305 Likely Benign: not provided 122,383,652(+) G/A
NM_000962.4(PTGS1):c.906G>A (p.Thr302=)
SYNONYMOUS
rs201018159 Likely Benign: not provided 122,386,534(+) C/T
NM_000962.4(PTGS1):c.1098C>T (p.Phe366=)
SYNONYMOUS
rs3842790 Benign: not provided 122,378,008(+) C/T
NM_000962.4(PTGS1):c.204C>T (p.Cys68=)
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PTGS1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PTGS1 Gene

Variant ID Type Subtype PubMed ID
esv2417467 CNV deletion 18987734
esv3452014 CNV insertion 20981092
nsv1115230 CNV deletion 24896259
nsv416964 CNV deletion 16902084
nsv831716 CNV gain 17160897

Variation tolerance for PTGS1 Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTGS1 Gene

Human Gene Mutation Database (HGMD)
PTGS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGS1
Leiden Open Variation Database (LOVD)
PTGS1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGS1 Gene

Disorders for PTGS1 Gene

MalaCards: The human disease database

(50) MalaCards diseases for PTGS1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
gastric ulcer
  • acute gastric ulcer with haemorrhage and perforation
aspirin resistance
  • aspirin antithrombotic effect of
chronic urticaria
  • urticaria chronic
urticaria
chronic cystitis
- elite association - COSMIC cancer census association via MalaCards
Search PTGS1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PTGS1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PTGS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGS1 Gene

Publications for PTGS1 Gene

  1. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PMID: 19046748) Lemaitre RN … Psaty BM (Atherosclerosis 2009) 3 22 40
  2. A polymorphism in the cyclooxygenase 1 gene is associated with decreased inflammatory prostaglandin F2alpha formation and lower risk of cardiovascular disease. (PMID: 19091535) Helmersson J … Basu S (Prostaglandins, leukotrienes, and essential fatty acids 2009) 3 22 40
  3. Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. (PMID: 19276290) Abraham JE … Pharoah PD (Clinical cancer research : an official journal of the American Association for Cancer Research 2009) 3 22 40
  4. Cyclooxygenase-1 haplotype C50T/A-842G does not affect platelet response to aspirin. (PMID: 19350112) Pettinella C … Davì G (Thrombosis and haemostasis 2009) 3 22 40
  5. Influence of cyclooxygenase-1 genotype on ex vivo aspirin response in patients at risk for stroke. (PMID: 19390185) Momary KM … Cavallari LH (Cerebrovascular diseases (Basel, Switzerland) 2009) 3 22 40

Products for PTGS1 Gene

Sources for PTGS1 Gene