Aliases for PTGR2 Gene
External Ids for PTGR2 Gene
Previous HGNC Symbols for PTGR2 Gene
Previous GeneCards Identifiers for PTGR2 Gene
This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
GeneCards Summary for PTGR2 Gene
PTGR2 (Prostaglandin Reductase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and 15-oxoprostaglandin 13-oxidase activity. An important paralog of this gene is ENSG00000258653.
UniProtKB/Swiss-Prot Summary for PTGR2 Gene
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2 (PubMed:19000823). Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).