Aliases for PTGR1 Gene
External Ids for PTGR1 Gene
Previous HGNC Symbols for PTGR1 Gene
Previous GeneCards Identifiers for PTGR1 Gene
This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
GeneCards Summary for PTGR1 Gene
PTGR1 (Prostaglandin Reductase 1) is a Protein Coding gene. Among its related pathways are Arachidonic acid metabolism and NRF2 pathway. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and 13-prostaglandin reductase activity. An important paralog of this gene is PTGR2.
UniProtKB/Swiss-Prot Summary for PTGR1 Gene
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.