PTGR1 Gene (Protein Coding)

Prostaglandin Reductase 1

GC09M111549
GIFtS:
40
This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009] See more...

Aliases for PTGR1 Gene

Aliases for PTGR1 Gene

  • Prostaglandin Reductase 1 2 3 4 5
  • Zinc Binding Alcohol Dehydrogenase Domain Containing 3 2 3
  • NADP-Dependent Leukotriene B4 12-Hydroxydehydrogenase 3 4
  • Leukotriene B4 12-Hydroxydehydrogenase 2 3
  • 15-Oxoprostaglandin 13-Reductase 3 4
  • LTB4DH 3 4
  • ZADH3 2 3
  • PRG-1 3 4
  • EC 1.3.1.48 4
  • EC 1.3.1.74 4
  • EC 1.3.1.- 4
  • PTGR1 5
  • PGR1 3

External Ids for PTGR1 Gene

Previous HGNC Symbols for PTGR1 Gene

  • LTB4DH

Previous GeneCards Identifiers for PTGR1 Gene

  • GC09M113365
  • GC09M114324
  • GC09M083911

Summaries for PTGR1 Gene

Entrez Gene Summary for PTGR1 Gene

  • This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

GeneCards Summary for PTGR1 Gene

PTGR1 (Prostaglandin Reductase 1) is a Protein Coding gene. Among its related pathways are Arachidonic acid metabolism and Prostaglandin 2 biosynthesis and metabolism FM. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and 13-prostaglandin reductase activity. An important paralog of this gene is PTGR2.

UniProtKB/Swiss-Prot Summary for PTGR1 Gene

  • Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.

Additional gene information for PTGR1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTGR1 Gene

Genomics for PTGR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PTGR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTGR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTGR1

Top Transcription factor binding sites by QIAGEN in the PTGR1 gene promoter:
  • c-Myc
  • FOXD3
  • HSF1short
  • HSF2
  • Max1
  • Sox5
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT5B

Genomic Locations for PTGR1 Gene

Genomic Locations for PTGR1 Gene
chr9:111,549,722-111,599,893
(GRCh38/hg38)
Size:
50,172 bases
Orientation:
Minus strand
chr9:114,312,002-114,362,135
(GRCh37/hg19)
Size:
50,134 bases
Orientation:
Minus strand

Genomic View for PTGR1 Gene

Genes around PTGR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGR1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PTGR1 Gene

Proteins for PTGR1 Gene

Products:

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  2. Protein
  3. Assay

  • Protein details for PTGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14914-PTGR1_HUMAN
    Recommended name:
    Prostaglandin reductase 1
    Protein Accession:
    Q14914
    Secondary Accessions:
    • A8K0N2
    • B4DPK3
    • F5GY50
    • Q8IYQ0
    • Q9H1X6

    Protein attributes for PTGR1 Gene

    Size:
    329 amino acids
    Molecular mass:
    35870 Da
    Quaternary structure:
    • Monomer or homodimer.

    Three dimensional structures from OCA and Proteopedia for PTGR1 Gene

    Alternative splice isoforms for PTGR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTGR1 Gene

Protein Expression for PTGR1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PTGR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTGR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTGR1 Gene

Domains & Families for PTGR1 Gene

Gene Families for PTGR1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PTGR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PTGR1 Gene

GenScript: Design optimal peptide antigens:
  • NADP-dependent leukotriene B4 12-hydroxydehydrogenase (PTGR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14914

UniProtKB/Swiss-Prot:

PTGR1_HUMAN :
  • Belongs to the NADP-dependent oxidoreductase L4BD family.
Family:
  • Belongs to the NADP-dependent oxidoreductase L4BD family.
genes like me logo Genes that share domains with PTGR1: view

Function for PTGR1 Gene

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Molecular function for PTGR1 Gene

UniProtKB/Swiss-Prot Function:
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an n-alkanal + NAD(+) = an alk-2-enal + H(+) + NADH; Xref=Rhea:RHEA:13733, ChEBI:CHEBI:12834, ChEBI:CHEBI:13757, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.74;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:13737, ChEBI:CHEBI:12834, ChEBI:CHEBI:13757, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.74;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + H(+) + NADH; Xref=Rhea:RHEA:11916, ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57402, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.48;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + H(+) + NADPH; Xref=Rhea:RHEA:11912, ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57402, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.48;.

Enzyme Numbers (IUBMB) for PTGR1 Gene

Phenotypes From GWAS Catalog for PTGR1 Gene

Gene Ontology (GO) - Molecular Function for PTGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0032440 2-alkenal reductase [NAD(P)] activity IEA --
GO:0036132 13-prostaglandin reductase activity IEA --
GO:0047522 15-oxoprostaglandin 13-oxidase activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with PTGR1: view
genes like me logo Genes that share phenotypes with PTGR1: view

Animal Model Products

CRISPR Products

miRNA for PTGR1 Gene

miRTarBase miRNAs that target PTGR1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGR1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTGR1 Gene

Localization for PTGR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGR1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGR1 gene
Compartment Confidence
extracellular 4
cytosol 3
mitochondrion 2
nucleus 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PTGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with PTGR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGR1 Gene

Pathways & Interactions for PTGR1 Gene

genes like me logo Genes that share pathways with PTGR1: view

Pathways by source for PTGR1 Gene

1 GeneGo (Thomson Reuters) pathway for PTGR1 Gene
  • Prostaglandin 2 biosynthesis and metabolism FM

Gene Ontology (GO) - Biological Process for PTGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006691 leukotriene metabolic process NAS 8576264
GO:0006693 prostaglandin metabolic process IEA,IBA 21873635
GO:0055114 oxidation-reduction process IEA --
GO:0097327 response to antineoplastic agent IEA --
genes like me logo Genes that share ontologies with PTGR1: view

No data available for SIGNOR curated interactions for PTGR1 Gene

Drugs & Compounds for PTGR1 Gene

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  1. Drug

(5) Drugs for PTGR1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADP Experimental Pharma Target 0
(5E,13E)-11-HYDROXY-9,15-DIOXOPROSTA-5,13-DIEN-1-OIC ACID Experimental Pharma Target 0
p-coumaric acid Experimental Pharma Target 0
NAD Experimental Pharma Agonist, Full agonist, Activator 0

(1) Additional Compounds for PTGR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PTGR1: view

Transcripts for PTGR1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for PTGR1 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGR1

Alternative Splicing Database (ASD) splice patterns (SP) for PTGR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - -
SP6:
SP7:

Relevant External Links for PTGR1 Gene

GeneLoc Exon Structure for
PTGR1

Expression for PTGR1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTGR1 Gene

mRNA expression in normal human tissues for PTGR1 Gene
mRNA expression by BioGPS for PTGR1 GenemRNA expression by GTEx for PTGR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGR1 Gene

This gene is overexpressed in Liver (x11.3).

Protein differential expression in normal tissues from HIPED for PTGR1 Gene

This gene is overexpressed in Liver, secretome (17.2) and Liver (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTGR1 Gene



Protein tissue co-expression partners for PTGR1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTGR1

SOURCE GeneReport for Unigene cluster for PTGR1 Gene:

Hs.584864

mRNA Expression by UniProt/SwissProt for PTGR1 Gene:

Q14914-PTGR1_HUMAN
Tissue specificity: High expression in the kidney, liver, and intestine but not in leukocytes.

Evidence on tissue expression from TISSUES for PTGR1 Gene

  • Liver(4.6)
  • Kidney(4.6)
  • Nervous system(4.4)
  • Stomach(2.4)
  • Intestine(2.3)
  • Skin(2.3)
  • Heart(2.2)
  • Lung(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with PTGR1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGR1 Gene

Orthologs for PTGR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PTGR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PTGR1 30 31
  • 99.49 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia PTGR1 30 31
  • 88.55 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia PTGR1 30 31
  • 84.6 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Ptgr1 30 17 31
  • 83.18 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ptgr1 30
  • 82.98 (n)
Oppossum
(Monodelphis domestica)
 Mammalia PTGR1 31
  • 74 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia PTGR1 31
  • 70 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves PTGR1 30 31
  • 67.58 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia PTGR1 31
  • 62 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC100485344 30
  • 64.23 (n)
Str.10740 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.23763 30
Zebrafish
(Danio rerio)
 Actinopterygii ptgr1 30 31
  • 62.08 (n)
 OneToMany
PTGR1 (2 of 2) 31
  • 52 (a)
 OneToMany
Dr.880 30
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP000288 30
  • 52.75 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes -- 31
  • 24 (a)
 OneToMany
-- 33
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT3G03080 30
  • 49.17 (n)
Rice
(Oryza sativa)
 Liliopsida Os04g0497000 30
  • 47.59 (n)
Bread mold
(Neurospora crassa)
 Ascomycetes NCU09040 30
  • 47.6 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes SPAPB24D3.08c 30
  • 47.43 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.4563 31
  • 45 (a)
 OneToMany
-- 31
  • 43 (a)
 OneToMany
Species where no ortholog for PTGR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PTGR1 Gene

ENSEMBL:
Gene Tree for PTGR1 (if available)
TreeFam:
Gene Tree for PTGR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTGR1: view image

Paralogs for PTGR1 Gene

Paralogs for PTGR1 Gene

(2) SIMAP similar genes for PTGR1 Gene using alignment to 5 proteins:

  • PTGR1_HUMAN
  • F2Z3J9_HUMAN
  • F6XGT7_HUMAN
  • Q5JVP2_HUMAN
  • Q5JVP3_HUMAN

Pseudogenes.org Pseudogenes for PTGR1 Gene

genes like me logo Genes that share paralogs with PTGR1: view

Variants for PTGR1 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTGR1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
745658 Likely Benign: not provided 111,570,132(-) G/A MISSENSE_VARIANT,INTRON_VARIANT
769755 Benign: not provided 111,578,960(-) A/G INTRON_VARIANT
rs1053959 - p.Ala27Ser

Additional dbSNP identifiers (rs#s) for PTGR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for PTGR1 Gene

Variant ID Type Subtype PubMed ID
dgv1372e199 CNV deletion 23128226
esv2665450 CNV deletion 23128226
esv2678607 CNV deletion 23128226
esv2738936 CNV deletion 23290073
esv275316 CNV gain+loss 21479260
esv3545319 CNV deletion 23714750
esv3621491 CNV loss 21293372
esv3621492 CNV loss 21293372
esv3621494 CNV loss 21293372
esv4254 CNV loss 18987735
esv5602 CNV loss 19470904
nsv1054737 CNV gain 25217958
nsv478735 CNV novel sequence insertion 20440878

Variation tolerance for PTGR1 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTGR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGR1 Gene

Disorders for PTGR1 Gene

Additional Disease Information for PTGR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for PTGR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTGR1 Gene

Publications for PTGR1 Gene

  1. cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase. (PMID: 8576264) Yokomizo T … Shimizu T (The Journal of biological chemistry 1996) 2 3 4 23
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  3. Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. (PMID: 17449869) Chou WL … Chang ZF (The Journal of biological chemistry 2007) 2 3
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

ExternalLinks

View latest publications for PTGR1 gene in Mastermind

Products for PTGR1 Gene

  • Addgene plasmids for PTGR1
  • Signalway ELISA kits for PTGR1

Sources for PTGR1 Gene