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This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
PTGR1 (Prostaglandin Reductase 1) is a Protein Coding gene. Diseases associated with PTGR1 include Enchondromatosis, Multiple, Ollier Type. Among its related pathways are Arachidonic acid metabolism and Prostaglandin 2 biosynthesis and metabolism FM. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and 13-prostaglandin reductase activity. An important paralog of this gene is PTGR2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 32814053 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0032440 | 2-alkenal reductase [NAD(P)] activity | IEA | -- |
GO:0035798 | 2-alkenal reductase (NADP+) activity | IDA | 25619643 |
GO:0036132 | 13-prostaglandin reductase activity | IEA,IDA | 25619643 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | ISS | -- |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Arachidonic acid metabolism | ||
2 | Metabolism |
.40
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3 | Prostaglandin 2 biosynthesis and metabolism FM |
Prostaglandin 2 biosynthesis and metabolism FM
-
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|
4 | NRF2 pathway | ||
5 | sphingosine and sphingosine-1-phosphate metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006631 | fatty acid metabolic process | IEA | -- |
GO:0006691 | leukotriene metabolic process | NAS | 8576264 |
GO:0006693 | prostaglandin metabolic process | IBA,IDA | 25619643 |
GO:0036102 | leukotriene B4 metabolic process | ISS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PTGR1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PTGR1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PTGR1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ptgr1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ptgr1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | PTGR1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PTGR1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PTGR1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PTGR1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100485344 30 |
|
||
Str.10740 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.23763 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ptgr1 30 31 |
|
OneToMany | |
PTGR1 (2 of 2) 31 |
|
OneToMany | |||
Dr.880 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000288 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 31 |
|
OneToMany | |
-- 33 |
|
|
|||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT3G03080 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os04g0497000 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU09040 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAPB24D3.08c 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4563 31 |
|
OneToMany | |
-- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs115758301 | Likely Benign: not provided | 111,570,132(-) |
G/A NM_001146108.2(PTGR1):c.838C>T (p.Arg280Cys) |
MISSENSE_VARIANT,INTRON | |
rs74633160 | Benign: not provided | 111,578,960(-) |
A/G NM_001146108.2(PTGR1):c.496-9T>C |
INTRON | |
rs1053959 | - |
p.Ala27Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1372e199 | CNV | deletion | 23128226 |
esv2665450 | CNV | deletion | 23128226 |
esv2678607 | CNV | deletion | 23128226 |
esv2738936 | CNV | deletion | 23290073 |
esv275316 | CNV | gain+loss | 21479260 |
esv3545319 | CNV | deletion | 23714750 |
esv3621491 | CNV | loss | 21293372 |
esv3621492 | CNV | loss | 21293372 |
esv3621494 | CNV | loss | 21293372 |
esv4254 | CNV | loss | 18987735 |
esv5602 | CNV | loss | 19470904 |
nsv1054737 | CNV | gain | 25217958 |
nsv478735 | CNV | novel sequence insertion | 20440878 |
Disorder | Aliases | PubMed IDs |
---|---|---|
enchondromatosis, multiple, ollier type |
|
|