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This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009] See more...
Aliases for PTGR1 Gene
Aliases for PTGR1 Gene
- Prostaglandin Reductase 1 2 3 4 5
- Leukotriene B4 12-Hydroxydehydrogenase 2 3 4
- Zinc Binding Alcohol Dehydrogenase Domain Containing 3 2 3
- NAD(P)H-Dependent Alkenal/One Oxidoreductase 3 4
- Dithiolethione-Inducible Gene 1 Protein 3 4
- 15-Oxoprostaglandin 13-Reductase 3 4
- D3T-Inducible Gene 1 Protein 3 4
- LTB4DH 3 4
External Ids for PTGR1 Gene
- HGNC: 18429
- NCBI Entrez Gene: 22949
- Ensembl: ENSG00000106853
- OMIM®: 601274
- UniProtKB/Swiss-Prot: Q14914
Previous HGNC Symbols for PTGR1 Gene
- LTB4DH
Previous GeneCards Identifiers for PTGR1 Gene
- GC09M113365
- GC09M114324
- GC09M083911
Summaries for PTGR1 Gene
-
This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
GeneCards Summary for PTGR1 Gene
PTGR1 (Prostaglandin Reductase 1) is a Protein Coding gene. Diseases associated with PTGR1 include Enchondromatosis, Multiple, Ollier Type. Among its related pathways are Arachidonic acid metabolism and Prostaglandin 2 biosynthesis and metabolism FM. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and 13-prostaglandin reductase activity. An important paralog of this gene is PTGR2.
UniProtKB/Swiss-Prot Summary for PTGR1 Gene
-
NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:25619643). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:25619643). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (PubMed:25619643) (By similarity). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:25619643). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity).
Additional gene information for PTGR1 Gene
- HGNC (18429)
- NCBI Entrez Gene (22949)
- Ensembl (ENSG00000106853)
- OMIM® (601274)
- UniProtKB/Swiss-Prot (Q14914)
- Open Targets Platform(ENSG00000106853)
- Search for PTGR1 at DataMed
- Search for PTGR1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTGR1 Gene
Genomics for PTGR1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PTGR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PTGR1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTGR1
- Top Transcription factor binding sites by QIAGEN in the PTGR1 gene promoter:
-
- c-Myc
- FOXD3
- HSF1short
- HSF2
- Max1
- Sox5
- STAT1
- STAT1alpha
- STAT1beta
- STAT5B
Genomic Locations for PTGR1 Gene
Latest Assembly
- chr9:111,549,722-111,599,893
- (GRCh38/hg38)
- Size:
- 50,172 bases
- Orientation:
- Minus strand
Previous Assembly
- chr9:114,312,002-114,361,927
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 49,926 bases
- Orientation:
- Minus strand
- chr9:114,312,002-114,362,135
- (GRCh37/hg19 by Ensembl)
- Size:
- 50,134 bases
- Orientation:
- Minus strand
Genomic View for PTGR1 Gene
Genes around PTGR1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q31.3 by HGNC
- 9q31.3 by Entrez Gene
- 9q31.3 by Ensembl
PTGR1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTGR1 Gene
Proteins for PTGR1 Gene
-
Protein details for PTGR1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14914-PTGR1_HUMAN
- Recommended name:
- Prostaglandin reductase 1
- Protein Accession:
- Q14914
- A8K0N2
- B4DPK3
- F5GY50
- Q8IYQ0
- Q9H1X6
Protein attributes for PTGR1 Gene
- Size:
- 329 amino acids
- Molecular mass:
- 35870 Da
- Quaternary structure:
-
- Monomer or homodimer.
Protein Expression for PTGR1 Gene
Post-translational modifications for PTGR1 Gene
Other Protein References for PTGR1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences PTGR1 / LTB4DH Antibody
- G Biosciences Immunotag™ PTGR1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for PTGR1
- Novus Biologicals Antibodies for PTGR1
-
Abcam antibodies for PTGR1
- Invitrogen Antibodies for PTGR1 (AFLGC-PTGR1)
-
Biorbyt antibodies for PTGR1
-
Boster Bio Antibodies for PTGR1
-
Custom Antibody ServicesProSci Antibodies for PTGR1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for PTGR1
- Origene Custom Protein Services for PTGR1
- ProSpec Recombinant Proteins for PTGR1
-
Abcam proteins for PTGR1
Assay products for research
- antibodies-online: Show 6 available PTGR1 Elisa Kits ranked by validation data
- Compare Top PTGR1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for PTGR1 Gene
Domains & Families for PTGR1 Gene
Gene Families for PTGR1 Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PTGR1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PTGR1 Gene
- GenScript: Design optimal peptide antigens:
-
- NADP-dependent leukotriene B4 12-hydroxydehydrogenase (PTGR1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q14914- Family:
-
- Belongs to the NADP-dependent oxidoreductase L4BD family.
Function for PTGR1 Gene
Molecular function for PTGR1 Gene
- UniProtKB/Swiss-Prot Function:
- NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:25619643). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:25619643). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (PubMed:25619643) (By similarity). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:25619643). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + H(+) + NADPH; Xref=Rhea:RHEA:50584, ChEBI:CHEBI:15378, ChEBI:CHEBI:57401, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133408; Evidence={ECO:0000269|PubMed:25619643};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + H(+) + NADPH; Xref=Rhea:RHEA:11912, ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57402, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.48; Evidence={ECO:0000269|PubMed:25619643};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + H(+) + NADPH; Xref=Rhea:RHEA:50592, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:79072, ChEBI:CHEBI:133411; Evidence={ECO:0000269|PubMed:25619643};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + H(+) + NADPH; Xref=Rhea:RHEA:50588, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133374, ChEBI:CHEBI:133409; Evidence={ECO:0000269|PubMed:25619643};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + H(+) + NADPH; Xref=Rhea:RHEA:50608, ChEBI:CHEBI:15378, ChEBI:CHEBI:57461, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133309; Evidence={ECO:0000250|UniProtKB:Q29073, ECO:0000250|UniProtKB:Q9EQZ5};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH; Xref=Rhea:RHEA:51208, ChEBI:CHEBI:15378, ChEBI:CHEBI:57460, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133346; Evidence={ECO:0000250|UniProtKB:Q29073};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH; Xref=Rhea:RHEA:51204, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:90723, ChEBI:CHEBI:133974; Evidence={ECO:0000250|UniProtKB:Q29073};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH; Xref=Rhea:RHEA:51212, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133974, ChEBI:CHEBI:133975; Evidence={ECO:0000250|UniProtKB:Q29073};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:13737, ChEBI:CHEBI:12834, ChEBI:CHEBI:13757, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.74; Evidence={ECO:0000269|PubMed:25619643};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=hexanal + NADP(+) = (2E)-hexenal + H(+) + NADPH; Xref=Rhea:RHEA:50776, ChEBI:CHEBI:15378, ChEBI:CHEBI:28913, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:88528; Evidence={ECO:0000269|PubMed:25619643};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NADP(+) + octanal = (2E)-octenal + H(+) + NADPH; Xref=Rhea:RHEA:50780, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:61748; Evidence={ECO:0000269|PubMed:25619643};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=decanal + NADP(+) = (2E)-decenal + H(+) + NADPH; Xref=Rhea:RHEA:50612, ChEBI:CHEBI:15378, ChEBI:CHEBI:31457, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133455; Evidence={ECO:0000269|PubMed:25619643};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=dodecanal + NADP(+) = (2E)-dodecenal + H(+) + NADPH; Xref=Rhea:RHEA:50784, ChEBI:CHEBI:15378, ChEBI:CHEBI:27836, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133741; Evidence={ECO:0000269|PubMed:25619643};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:64736, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58968, ChEBI:CHEBI:156112; Evidence={ECO:0000250|UniProtKB:P97584};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NADP(+) + pentan-2-one = (3E)-penten-2-one + H(+) + NADPH; Xref=Rhea:RHEA:50788, ChEBI:CHEBI:15378, ChEBI:CHEBI:16472, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:145276; Evidence={ECO:0000269|PubMed:25619643};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NADP(+) + nonan-2-one = (3E)-nonen-2-one + H(+) + NADPH; Xref=Rhea:RHEA:50616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:77927, ChEBI:CHEBI:133457; Evidence={ECO:0000269|PubMed:25619643};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=33 uM for (2E)-hexenal {ECO:0000269|PubMed:25619643}; KM=14 uM for (2E)-octenal {ECO:0000269|PubMed:25619643}; KM=6 uM for (2E)-decenal {ECO:0000269|PubMed:25619643}; KM=12 uM for (2E)-dodecenal {ECO:0000269|PubMed:25619643}; KM=12 uM for (3E)-3-buten-2-one {ECO:0000269|PubMed:25619643}; KM=7.3 uM for (3E)-3-penten-2-one {ECO:0000269|PubMed:25619643}; KM=6.5 uM for (3E)-3-nonen-2-one {ECO:0000269|PubMed:25619643}; KM=1.4 uM for 15-oxoprostaglandin E1 {ECO:0000269|PubMed:25619643}; KM=0.6 uM for 15-oxoprostaglandin E2 {ECO:0000269|PubMed:25619643}; KM=1.1 uM for 15-oxoprostaglandin F1alpha {ECO:0000269|PubMed:25619643}; KM=3.2 uM for 15-oxoprostaglandin F2alpha {ECO:0000269|PubMed:25619643}; KM=5.2 uM for leukotriene B4 {ECO:0000269|PubMed:25619643}; KM=14 uM for NADPH {ECO:0000269|PubMed:25619643}; KM=200 uM for NADH {ECO:0000269|PubMed:25619643};
Enzyme Numbers (IUBMB) for PTGR1 Gene
Phenotypes From GWAS Catalog for PTGR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 32814053 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0032440 | 2-alkenal reductase [NAD(P)] activity | IEA | -- |
| GO:0035798 | 2-alkenal reductase (NADP+) activity | IDA | 25619643 |
| GO:0036132 | 13-prostaglandin reductase activity | IEA,IDA | 25619643 |
Phenotypes for PTGR1 Gene
- MGI mutant phenotypes for PTGR1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PTGR1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- shRNA abundance <= 50%
- Decreased viability
- Increased transferrin (TF) endocytosis
- Decreased viability in ovarian lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased replication of vaccinia virus (VACV)
- Decreased nuclei size in G2M
Animal Models for PTGR1 Gene
- MGI Knock Outs for PTGR1:
-
- Ptgr1 Ptgr1<tm1b(EUCOMM)Wtsi>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PTGR1 - Starting at $85 >
- * PTGR1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PTGR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTGR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGR1
miRNA for PTGR1 Gene
- miRTarBase miRNAs that target PTGR1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTGR1
- Browse OriGene Inhibitory RNA Products For PTGR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGR1
Clone products for research
- Applied Biological Materials (abm): Clones for PTGR1 - Starting at $45 >
- * PTGR1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG204840
- MR204840
- MR204840L3
- MR204840L4
- RC206692
- RC206692L1
- RC206692L2
- RC206692L3
- RC206692L4
- RC228235
- RC228235L3
- RC228235L4
- RC228825
- RC228825L3
- RC228825L4
- RG206692
- RG228235
- RG228825
- RR206688
- RR206688L3
- RR206688L4
- MR204840L3V
- MR204840L4V
- RC206692L1V
- RC206692L2V
- RC206692L3V
- RC206692L4V
- RC228235L3V
- RC228235L4V
- RC228825L3V
- RC228825L4V
- RR206688L3V
- RR206688L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PTGR1
- Addgene plasmids for PTGR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTGR1
Cell Lines for research
-
Horizon Cell Lines for PTGR1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGR1 Gene
Localization for PTGR1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTGR1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| cytosol | 3 |
| mitochondrion | 2 |
| nucleus | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGR1 Gene
Pathways & Interactions for PTGR1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Arachidonic acid metabolism | ||
| 2 | Metabolism |
.40
|
|
| 3 | Prostaglandin 2 biosynthesis and metabolism FM |
Prostaglandin 2 biosynthesis and metabolism FM
-
|
|
| 4 | NRF2 pathway | ||
| 5 | sphingosine and sphingosine-1-phosphate metabolism | ||
Pathways by source for PTGR1 Gene
2 BioSystems pathways for PTGR1 Gene
5 Reactome pathways for PTGR1 Gene
1 GeneGo (Thomson Reuters) pathway for PTGR1 Gene
- Prostaglandin 2 biosynthesis and metabolism FM
Interacting Proteins for PTGR1 Gene
Selected Interacting proteins:
ENSP00000385763
Q14914-PTGR1_HUMAN
for PTGR1 Gene via
STRING
UniProtKB
IID
GPS-Prot Interaction Network for PTGR1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006631 | fatty acid metabolic process | IEA | -- |
| GO:0006691 | leukotriene metabolic process | NAS | 8576264 |
| GO:0006693 | prostaglandin metabolic process | IBA,IDA | 25619643 |
| GO:0036102 | leukotriene B4 metabolic process | ISS | -- |
No data available for SIGNOR curated interactions for PTGR1 Gene
Drugs & Compounds for PTGR1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for PTGR1 Gene
mRNA/cDNA for PTGR1 Gene
- 3 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000309195 1223 nts (view in UCSC)
- ENST00000374308 847 nts (view in UCSC)
- ENST00000374313 1061 nts (view in UCSC)
- ENST00000374324 2298 nts (view in UCSC)
- ENST00000407693 1599 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PTGR1 - Starting at $85 >
- * PTGR1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PTGR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTGR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGR1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTGR1
- Browse OriGene Inhibitory RNA Products For PTGR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGR1
Clone products for research
- Applied Biological Materials (abm): Clones for PTGR1 - Starting at $45 >
- * PTGR1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG204840
- MR204840
- MR204840L3
- MR204840L4
- RC206692
- RC206692L1
- RC206692L2
- RC206692L3
- RC206692L4
- RC228235
- RC228235L3
- RC228235L4
- RC228825
- RC228825L3
- RC228825L4
- RG206692
- RG228235
- RG228825
- RR206688
- RR206688L3
- RR206688L4
- MR204840L3V
- MR204840L4V
- RC206692L1V
- RC206692L2V
- RC206692L3V
- RC206692L4V
- RC228235L3V
- RC228235L4V
- RC228825L3V
- RC228825L4V
- RR206688L3V
- RR206688L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PTGR1
- Addgene plasmids for PTGR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTGR1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for PTGR1 Gene
- GeneLoc Exon Structure for
- PTGR1
Expression for PTGR1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
- Renal Collecting Duct System
-
Ovary (Reproductive System)
- Primary Oocyte Primary Follicle
-
Gonad
- Primary Oocyte Primary Follicle
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Endoderm (Gastrulation Derivatives)
- Primitive Streak (Early Embryonic Tissues)
-
Prostate (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for PTGR1 Gene
This gene is overexpressed in Liver (x11.3).
This gene is overexpressed in Liver, secretome (17.2) and Liver (8.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTGR1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTGR1
SOURCE GeneReport for Unigene cluster for PTGR1 Gene:
Hs.584864mRNA Expression by UniProt/SwissProt for PTGR1 Gene:
Q14914-PTGR1_HUMAN
Tissue specificity:
High expression in the kidney, liver, and intestine but not in leukocytes.
Evidence on tissue expression from TISSUES for PTGR1 Gene
- Liver(4.6)
- Kidney(4.5)
- Nervous system(4.4)
- Stomach(2.3)
- Skin(2.2)
- Intestine(2.2)
- Heart(2.1)
- Lung(2)
Primer products for research
-
OriGene qPCR primer pairs for PTGR1
-
OriGene qPCR primer pairs and template standards for PTGR1
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGR1 Gene
Orthologs for PTGR1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PTGR1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PTGR1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PTGR1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ptgr1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ptgr1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PTGR1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PTGR1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PTGR1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PTGR1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100485344 30 |
|
||
| Str.10740 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23763 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ptgr1 30 31 |
|
OneToMany | |
| PTGR1 (2 of 2) 31 |
|
OneToMany | |||
| Dr.880 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000288 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 31 |
|
OneToMany | |
| -- 33 |
|
|
|||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT3G03080 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os04g0497000 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU09040 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAPB24D3.08c 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4563 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany |
- Species where no ortholog for PTGR1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PTGR1 Gene
- ENSEMBL:
- Gene Tree for PTGR1 (if available)
- TreeFam:
- Gene Tree for PTGR1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PTGR1: view image
Paralogs for PTGR1 Gene
Paralogs for PTGR1 Gene
(2) SIMAP similar genes for PTGR1 Gene using alignment to 5 proteins:
- PTGR1_HUMAN
- F2Z3J9_HUMAN
- F6XGT7_HUMAN
- Q5JVP2_HUMAN
- Q5JVP3_HUMAN
Pseudogenes.org Pseudogenes for PTGR1 Gene
Variants for PTGR1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTGR1 Gene
| SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs115758301 | Likely Benign: not provided | 111,570,132(-) |
G/A NM_001146108.2(PTGR1):c.838C>T (p.Arg280Cys) |
MISSENSE_VARIANT,INTRON | |
| rs74633160 | Benign: not provided | 111,578,960(-) |
A/G NM_001146108.2(PTGR1):c.496-9T>C |
INTRON | |
| rs1053959 | - |
p.Ala27Ser |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1372e199 | CNV | deletion | 23128226 |
| esv2665450 | CNV | deletion | 23128226 |
| esv2678607 | CNV | deletion | 23128226 |
| esv2738936 | CNV | deletion | 23290073 |
| esv275316 | CNV | gain+loss | 21479260 |
| esv3545319 | CNV | deletion | 23714750 |
| esv3621491 | CNV | loss | 21293372 |
| esv3621492 | CNV | loss | 21293372 |
| esv3621494 | CNV | loss | 21293372 |
| esv4254 | CNV | loss | 18987735 |
| esv5602 | CNV | loss | 19470904 |
| nsv1054737 | CNV | gain | 25217958 |
| nsv478735 | CNV | novel sequence insertion | 20440878 |
Residual Variation Intolerance Score:
54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.74;
33.01% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PTGR1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PTGR1
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGR1 Gene
Disorders for PTGR1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| enchondromatosis, multiple, ollier type |
|
|
Search PTGR1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PTGR1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PTGR1 Gene
Publications for PTGR1 Gene
- cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase. (PMID: 8576264) Yokomizo T … Shimizu T (The Journal of biological chemistry 1996) 2 3 4 23
- Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis. (PMID: 25619643) Mesa J … Porté S (Chemico-biological interactions 2015) 3 4
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. (PMID: 17449869) Chou WL … Chang ZF (The Journal of biological chemistry 2007) 2 3
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
ExternalLinks
Products for PTGR1 Gene
- Custom Antibody ServicesOriGene Antibodies for PTGR1
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Origene Custom Protein Services for PTGR1
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- Browse OriGene Inhibitory RNA Products For PTGR1
- OriGene qPCR primer pairs for PTGR1
- OriGene qPCR primer pairs and template standards for PTGR1
- OriGene CRISPR knockouts for PTGR1
- MG204840
- MR204840
- MR204840L3
- MR204840L4
- RC206692
- RC206692L1
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- RG206692
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- RC228825L3V
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- RR206688L3V
- RR206688L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Novus Biologicals proteins and lysates for PTGR1
- Browse Antibodies
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- Abcam antibodies for PTGR1
- Abcam proteins for PTGR1
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- Browse Primary Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for PTGR1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PTGR1 (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Virus packaging for PTGR1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PTGR1
- Addgene plasmids for PTGR1
- antibodies-online: Show 17 available PTGR1 Antibodies ranked by validation data
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- antibodies-online: Show 13 available PTGR1 Proteins ranked by validation data
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- Custom Antibody ServicesProSci Antibodies for PTGR1
- Search for PTGR1 Proteins at ProSci
- Horizon Cell Lines for PTGR1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTGR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTGR1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PTGR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGR1
- Boster Bio Antibodies for PTGR1
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for PTGR1
Sources for PTGR1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB