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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional simi... See more...
Aliases for PTGIS Gene
Aliases for PTGIS Gene
External Ids for PTGIS Gene
- HGNC: 9603
- Entrez Gene: 5740
- Ensembl: ENSG00000124212
- OMIM: 601699
- UniProtKB: Q16647
Previous GeneCards Identifiers for PTGIS Gene
- GC20M047848
- GC20M048758
- GC20M048805
- GC20M047553
- GC20M048120
- GC20M044868
Summaries for PTGIS Gene
-
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTGIS Gene
PTGIS (Prostaglandin I2 Synthase) is a Protein Coding gene. Diseases associated with PTGIS include Hypertension, Essential and Pulmonary Hypertension. Among its related pathways are Eicosanoid Synthesis and Synthesis of bile acids and bile salts. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP8B1.
UniProtKB/Swiss-Prot Summary for PTGIS Gene
-
Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:18032380, PubMed:25623425, PubMed:12372404, PubMed:15115769). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323).
Additional gene information for PTGIS Gene
- HGNC(9603)
- Entrez Gene(5740)
- Ensembl(ENSG00000124212)
- OMIM(601699)
- UniProtKB(Q16647)
- Open Targets Platform(ENSG00000124212)
- Monarch Initiative
- Search for PTGIS at DataMed
- Search for PTGIS at HumanCyc
No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for PTGIS Gene
Genomics for PTGIS Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PTGIS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PTGIS on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTGIS
- Top Transcription factor binding sites by QIAGEN in the PTGIS gene promoter:
-
- AP-1
- AREB6
- ATF-2
- c-Fos
- c-Jun
Genomic Locations for PTGIS Gene
Genomic Locations for PTGIS Gene
- chr20:49,503,874-49,568,137
- (GRCh38/hg38)
- Size:
- 64,264 bases
- Orientation:
- Minus strand
- chr20:48,120,411-48,184,707
- (GRCh37/hg19)
- Size:
- 64,297 bases
- Orientation:
- Minus strand
Genomic View for PTGIS Gene
Genes around PTGIS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.13 by HGNC
- 20q13.13 by Entrez Gene
- 20q13.13 by Ensembl
PTGIS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTGIS Gene
Proteins for PTGIS Gene
-
Protein details for PTGIS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16647-PTGIS_HUMAN
- Recommended name:
- Prostacyclin synthase
- Protein Accession:
- Q16647
- Q3MII8
- Q9HAX2
- Q9HAX3
- Q9HAX4
Protein attributes for PTGIS Gene
- Size:
- 500 amino acids
- Molecular mass:
- 57104 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
- No Data Available
Protein Expression for PTGIS Gene
Post-translational modifications for PTGIS Gene
Other Protein References for PTGIS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences PGIS / PTGIS Antibody (LS-B1505) and PGIS / PTGIS Antibody (LS-B2436)
- G Biosciences Immunotag™ PTGIS Antibody
-
Custom Antibody ServicesOriGene Antibodies for PTGIS
- Novus Biologicals Antibodies for PTGIS
-
Abcam antibodies for PTGIS
- Invitrogen Antibodies for PTGIS (AFLGC-PTGIS)
-
Boster Bio Antibodies for PTGIS
-
Santa Cruz Biotechnology (SCBT) Antibodies for PTGIS
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PTGIS
- Origene Custom Protein Services for PTGIS
- antibodies-online: Show 8 available PTGIS Proteins ranked by validation data
- Compare Top PTGIS Proteins
-
Quality Products:
-
Abcam proteins for PTGIS
Assay Products
- G Biosciences Immunotag™ Human PTGIS (Prostaglandin I Synthase) ELISA
- RayBiotech Custom Human PTGIS ELISA
No data available for DME Specific Peptides for PTGIS Gene
Domains & Families for PTGIS Gene
Gene Families for PTGIS Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted membrane proteins
Protein Domains for PTGIS Gene
- InterPro:
- Blocks:
-
- E-class P450 group IV signature
- ProtoNet:
Suggested Antigen Peptide Sequences for PTGIS Gene
- GenScript: Design optimal peptide antigens:
-
- Prostaglandin I2 synthase (PTGIS_HUMAN)
- Prostacyclin synthase (Q6LEN0_HUMAN)
- Prostacyclin synthase (Q6LEN2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q16647- Family:
-
- Belongs to the cytochrome P450 family.
Function for PTGIS Gene
Molecular function for PTGIS Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:18032380, PubMed:25623425, PubMed:12372404, PubMed:15115769). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=prostaglandin H2 = prostaglandin I2; Xref=Rhea:RHEA:23580, ChEBI:CHEBI:57403, ChEBI:CHEBI:57405; EC=5.3.99.4; Evidence={ECO:0000269|PubMed:15115769, ECO:0000269|PubMed:18032380, ECO:0000269|PubMed:25623425};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O; Xref=Rhea:RHEA:55556, ChEBI:CHEBI:15377, ChEBI:CHEBI:59720, ChEBI:CHEBI:131859; EC=4.2.1.152; Evidence={ECO:0000269|PubMed:17459323};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48636, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:57446; Evidence={ECO:0000269|PubMed:17459323};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O; Xref=Rhea:RHEA:48856, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:57409, ChEBI:CHEBI:57446; Evidence={ECO:0000269|PubMed:17459323};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=9.55 uM for 6-keto-PGF1alpha {ECO:0000269|PubMed:25623425}; KM=30 uM for prostaglandin H2 {ECO:0000269|PubMed:15115769}; KM=60 uM for (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate {ECO:0000269|PubMed:17459323}; KM=13 uM for prostaglandin H2 (at 23 degrees Celsius) {ECO:0000269|PubMed:18032380}; Vmax=534 mmol/min/pg enzyme with prostaglandin H2 as substrate {ECO:0000269|PubMed:25623425}; Vmax=15 umol/min/mg enzyme with prostaglandin H2 as substrate {ECO:0000269|PubMed:15115769}; Vmax=980 mol/min/mol enzyme with prostaglandin H2 as substrate {ECO:0000269|PubMed:18032380};
- GENATLAS Biochemistry:
- prostaglandin 12 synthase
Enzyme Numbers (IUBMB) for PTGIS Gene
Phenotypes From GWAS Catalog for PTGIS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004497 | monooxygenase activity | IEA | -- |
| GO:0005506 | iron ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 20122998 |
| GO:0008116 | prostaglandin-I synthase activity | IBA,IDA | 15115769 |
| GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEA | -- |
Phenotypes for PTGIS Gene
- MGI mutant phenotypes for PTGIS:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PTGIS:
Animal Models for PTGIS Gene
- MGI Knock Outs for PTGIS:
-
- Ptgis Ptgis<tm1Tada>
Animal Model Products
-
Taconic Biosciences Mouse Models for PTGIS
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PTGIS - Select products 50% OFF >
- * PTGIS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PTGIS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTGIS
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGIS
miRNA for PTGIS Gene
- miRTarBase miRNAs that target PTGIS
-
- hsa-miR-496 (MIRT532291)
- hsa-miR-6867-3p (MIRT650379)
- hsa-miR-6845-3p (MIRT650381)
- hsa-miR-4685-3p (MIRT650382)
- hsa-miR-4287 (MIRT650383)
- hsa-miR-7113-3p (MIRT650384)
- hsa-miR-4469 (MIRT650385)
- hsa-miR-2276-5p (MIRT650386)
- hsa-miR-6892-3p (MIRT650387)
- hsa-miR-1273d (MIRT650388)
- hsa-miR-642a-5p (MIRT666770)
- hsa-miR-627-3p (MIRT666771)
- hsa-miR-4508 (MIRT670987)
- hsa-miR-6842-3p (MIRT670988)
- hsa-miR-647 (MIRT670989)
- hsa-miR-7977 (MIRT670990)
- hsa-miR-3178 (MIRT670991)
- hsa-miR-5787 (MIRT670992)
- hsa-miR-4505 (MIRT670993)
- hsa-miR-4430 (MIRT670994)
- hsa-miR-3652 (MIRT670995)
- hsa-miR-24-3p (MIRT670996)
- hsa-miR-4284 (MIRT670997)
- hsa-miR-4486 (MIRT670998)
- hsa-miR-342-3p (MIRT670999)
- hsa-miR-383-3p (MIRT671000)
- hsa-miR-1228-3p (MIRT671001)
- hsa-miR-5089-5p (MIRT685933)
- hsa-miR-7151-3p (MIRT685934)
- hsa-miR-5095 (MIRT685935)
- hsa-miR-5589-5p (MIRT685936)
- hsa-miR-4731-5p (MIRT685937)
- hsa-miR-6778-3p (MIRT685938)
- hsa-miR-6506-5p (MIRT685939)
- hsa-miR-619-5p (MIRT685940)
- hsa-miR-150-5p (MIRT685941)
- hsa-miR-6775-5p (MIRT685942)
- hsa-miR-5090 (MIRT685943)
- hsa-miR-7107-5p (MIRT685944)
- hsa-miR-1234-3p (MIRT685945)
- hsa-miR-6784-5p (MIRT685946)
- hsa-miR-1224-3p (MIRT685947)
- hsa-miR-186-3p (MIRT685948)
- hsa-miR-4742-5p (MIRT685949)
- hsa-miR-520h (MIRT685950)
- hsa-miR-520g-3p (MIRT685951)
- hsa-miR-6504-3p (MIRT685952)
- hsa-miR-512-3p (MIRT685953)
- hsa-miR-4438 (MIRT685954)
- hsa-miR-520e (MIRT685955)
- hsa-miR-520d-3p (MIRT685956)
- hsa-miR-520c-3p (MIRT685957)
- hsa-miR-520b (MIRT685958)
- hsa-miR-520a-3p (MIRT685959)
- hsa-miR-373-3p (MIRT685960)
- hsa-miR-372-3p (MIRT685961)
- hsa-miR-302e (MIRT685962)
- hsa-miR-302d-3p (MIRT685963)
- hsa-miR-302c-3p (MIRT685964)
- hsa-miR-302b-3p (MIRT685965)
- hsa-miR-302a-3p (MIRT685966)
- hsa-miR-93-5p (MIRT685967)
- hsa-miR-526b-3p (MIRT685968)
- hsa-miR-519d-3p (MIRT685969)
- hsa-miR-20b-5p (MIRT685970)
- hsa-miR-20a-5p (MIRT685971)
- hsa-miR-17-5p (MIRT685972)
- hsa-miR-106b-5p (MIRT685973)
- hsa-miR-106a-5p (MIRT685974)
- hsa-miR-4684-5p (MIRT719895)
- hsa-miR-3675-3p (MIRT719896)
- hsa-miR-605-5p (MIRT719897)
- hsa-miR-4668-3p (MIRT719898)
- hsa-miR-548c-3p (MIRT719899)
- hsa-miR-2110 (MIRT763784)
- hsa-miR-340-3p (MIRT765733)
- hsa-miR-4271 (MIRT768258)
- hsa-miR-4293 (MIRT768439)
- hsa-miR-4725-3p (MIRT771628)
- hsa-miR-4786-5p (MIRT772321)
- hsa-miR-6771-3p (MIRT778647)
- hsa-miR-6780b-5p (MIRT779049)
- hsa-miR-6827-3p (MIRT779931)
- hsa-miR-6849-3p (MIRT780326)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTGIS
- Browse OriGene Inhibitory RNA Products For PTGIS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGIS
Clone Products
- Applied Biological Materials (abm): Clones for PTGIS - Select products 50% OFF >
- * PTGIS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PTGIS
- Addgene plasmids for PTGIS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTGIS
Cell Line Products
-
Horizon Cell Lines for PTGIS
No data available for Transcription Factor Targets and HOMER Transcription for PTGIS Gene
Localization for PTGIS Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTGIS Gene
- Endoplasmic reticulum membrane. Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| extracellular | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| cytosol | 2 |
| golgi apparatus | 2 |
| endosome | 1 |
| lysosome | 1 |
- Endoplasmic reticulum (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | ISS | -- |
| GO:0005634 | nucleus | IEA,IDA | 21035466 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IBA,IDA | 21035466 |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
Pathways & Interactions for PTGIS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type |
.01
|
|
| 2 | Synthesis of bile acids and bile salts | ||
| 3 | Metabolism |
.40
|
|
| 4 | Arachidonic acid metabolism | ||
| 5 | Metabolism of water-soluble vitamins and cofactors | ||
Pathways by source for PTGIS Gene
3 BioSystems pathways for PTGIS Gene
19 Reactome pathways for PTGIS Gene
3 PharmGKB pathways for PTGIS Gene
2 KEGG pathways for PTGIS Gene
3 GeneGo (Thomson Reuters) pathways for PTGIS Gene
- HETE and HPETE biosynthesis and metabolism
- Prostaglandin 2 biosynthesis and metabolism FM
- Transcription PPAR Pathway
Interacting Proteins for PTGIS Gene
GPS-Prot Interaction Network for PTGIS
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001516 | prostaglandin biosynthetic process | IBA,IDA | 15115769 |
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006631 | fatty acid metabolic process | IEA | -- |
| GO:0006633 | fatty acid biosynthetic process | IEA | -- |
| GO:0006690 | icosanoid metabolic process | TAS | -- |
No data available for SIGNOR curated interactions for PTGIS Gene
Drugs & Compounds for PTGIS Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Phenylbutazone | Approved, Vet_approved | Pharma | Target, inhibitor | 0 | ||
| Epoprostenol | Approved | Pharma | Target, inducer | 89 | ||
| (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acid | Experimental | Pharma | Target | 0 | ||
| heme | Pharma | Agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Prostaglandin H2 |
|
42935-17-1 |
|
Transcripts for PTGIS Gene
mRNA/cDNA for PTGIS Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000244043 5570 nts (view in UCSC)
- ENST00000478971 1343 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PTGIS - Select products 50% OFF >
- * PTGIS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PTGIS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTGIS
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGIS
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTGIS
- Browse OriGene Inhibitory RNA Products For PTGIS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGIS
Clone Products
- Applied Biological Materials (abm): Clones for PTGIS - Select products 50% OFF >
- * PTGIS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PTGIS
- Addgene plasmids for PTGIS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTGIS
Relevant External Links for PTGIS Gene
- GeneLoc Exon Structure for
- PTGIS
Expression for PTGIS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for PTGIS Gene
This gene is overexpressed in Artery - Coronary (x5.8), Artery - Aorta (x5.8), and Artery - Tibial (x4.0).
This gene is overexpressed in Urinary Bladder (12.9), Testis (11.5), and Uterus (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTGIS Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTGIS
SOURCE GeneReport for Unigene cluster for PTGIS Gene:
Hs.302085mRNA Expression by UniProt/SwissProt for PTGIS Gene:
Q16647-PTGIS_HUMAN
Tissue specificity:
Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.
Evidence on tissue expression from TISSUES for PTGIS Gene
- Nervous system(4.5)
- Heart(3.2)
- Muscle(3)
- Skin(2.6)
- Intestine(2.5)
- Lung(2.4)
- Kidney(2.3)
- Liver(2.2)
- Blood(2.2)
- Pancreas(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGIS Gene
Germ Layers:
- mesoderm
Systems:
- cardiovascular
Regions:
Head and neck:
- ear
Thorax:
- heart
General:
- blood
- blood vessel
Primer Products
-
OriGene qPCR primer pairs for PTGIS
-
OriGene qPCR primer pairs and template standards for PTGIS
Gene Expression Assay Products
Orthologs for PTGIS Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PTGIS 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PTGIS 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PTGIS 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ptgis 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ptgis 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PTGIS 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PTGIS 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PTGIS 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ptgis 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ptgis 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4049 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for PTGIS was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PTGIS Gene
- ENSEMBL:
- Gene Tree for PTGIS (if available)
- TreeFam:
- Gene Tree for PTGIS (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PTGIS: view image
Paralogs for PTGIS Gene
Variants for PTGIS Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTGIS Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 781903 | Benign: not provided | 49,524,207(-) | G/A | MISSENSE_VARIANT | |
| 786681 | Likely Benign: not provided | 49,508,045(-) | C/T | MISSENSE_VARIANT | |
| rs13306026 | Pathogenic: Essential hypertension | 49,511,026(-) | A/G | SPLICE_DONOR_VARIANT | |
| rs61734270 | Likely Pathogenic: Childhood-Onset Schizophrenia | 49,524,089(-) | C/T | MISSENSE_VARIANT | |
| rs1173082660 | - | p.Pro38Leu |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4323n100 | CNV | loss | 25217958 |
| esv2762080 | CNV | loss | 21179565 |
| esv3568005 | CNV | loss | 25503493 |
| esv3646015 | CNV | loss | 21293372 |
| nsv1065852 | CNV | loss | 25217958 |
| nsv586173 | CNV | loss | 21841781 |
| nsv586174 | CNV | loss | 21841781 |
| nsv586175 | CNV | loss | 21841781 |
| nsv586176 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.95;
49.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PTGIS Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGIS Gene
Disorders for PTGIS Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypertension, essential |
|
|
| pulmonary hypertension |
|
|
| female stress incontinence |
|
|
| myocardial infarction |
|
|
| stroke, ischemic |
|
Search PTGIS in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PTGIS_HUMAN- Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher than normal with no identifiable cause. {ECO:0000269 PubMed:12372404}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
Additional Disease Information for PTGIS
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for PTGIS Gene
Publications for PTGIS Gene
- Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. (PMID: 12372404) Nakayama T … Oates JA (Biochemical and biophysical research communications 2002) 3 4 23 41
- Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PMID: 19046748) Lemaitre RN … Psaty BM (Atherosclerosis 2009) 3 23 41
- Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. (PMID: 19276290) Abraham JE … Pharoah PD (Clinical cancer research : an official journal of the American Association for Cancer Research 2009) 3 23 41
- Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction. (PMID: 19327107) Xie X … Liu F (Clinical chemistry and laboratory medicine 2009) 3 23 41
- A quantitative trait locus for SBP maps near KCNB1 and PTGIS in a population isolate. (PMID: 19265782) Barbalić M … Rudan P (American journal of hypertension 2009) 3 23 41
ExternalLinks
Products for PTGIS Gene
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Sources for PTGIS Gene
- (1) GeneCards
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