The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008] See more...

Aliases for PTGIR Gene

Aliases for PTGIR Gene

  • Prostaglandin I2 Receptor 2 3 4 5
  • Prostacyclin Receptor 2 3 4
  • Prostaglandin I2 (Prostacyclin) Receptor (IP) 2 3
  • Prostanoid IP Receptor 3 4
  • PGI2 Receptor 3 4
  • PGI Receptor 3 4
  • PRIPR 3 4
  • IP 2 3
  • PTGIR 5

External Ids for PTGIR Gene

Previous GeneCards Identifiers for PTGIR Gene

  • GC19M047767
  • GC19M047514
  • GC19M051799
  • GC19M051815
  • GC19M047123
  • GC19M043548

Summaries for PTGIR Gene

Entrez Gene Summary for PTGIR Gene

  • The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGIR Gene

PTGIR (Prostaglandin I2 Receptor) is a Protein Coding gene. Diseases associated with PTGIR include Acute Endometritis and Pulmonary Hypertension. Among its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is PTGER2.

UniProtKB/Swiss-Prot Summary for PTGIR Gene

  • Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

Tocris Summary for PTGIR Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGIR Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTGIR Gene

Genomics for PTGIR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTGIR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J046618 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 605.9 +2.5 2469 8.6 CEBPG SP1 CTCF HNRNPL ZNF512 LEF1 IKZF1 BACH1 FOXA1 LARP7 PTGIR ZC3H4 ENSG00000268810 BICRA ENSG00000268746 IRF2BP1 INAFM1 SYMPK CCDC61 FKRP
GH19J046024 Promoter 0.8 EPDnew Ensembl 4.9 +602.0 601993 0.6 SPI1 ZMYM3 LOC105372421 PGLYRP1 PTGIR IGFL4
GH19J047105 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.5 -485.3 -485259 9.3 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 TFE3 ZNF512 ZC3H4 ENSG00000268810 BICRA C5AR2 NOP53-AS1 DHX34 CCDC9 PRKD2 EHD2 ENSG00000268746
GH19J046627 Promoter 0.7 Ensembl 5.9 -3.0 -3004 1.4 ZIC2 HDAC2 PHB2 SMARCA4 ZMYM3 SMARCA5 ZNF121 lnc-PTGIR-1 PTGIR CALM3 GNG8 ENSG00000279161
GH19J046727 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE 2 -105.4 -105353 5.1 CTCF ZBTB33 PRDM10 IKZF1 ZNF692 POLR2A JUND ZNF143 ZIC2 PATZ1 ENSG00000269487 lnc-PRKD2-2 piR-34969 ZC3H4 ENSG00000268810 BICRA PRKD2 STRN4 IRF2BP1 CCDC61
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTGIR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTGIR

Top Transcription factor binding sites by QIAGEN in the PTGIR gene promoter:
  • aMEF-2
  • AP-4
  • MEF-2
  • MEF-2A
  • PPAR-gamma1
  • PPAR-gamma2
  • SEF-1 (1)
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for PTGIR Gene

Genomic Locations for PTGIR Gene
chr19:46,610,040-46,625,097
(GRCh38/hg38)
Size:
15,058 bases
Orientation:
Minus strand
chr19:47,123,725-47,128,375
(GRCh37/hg19)
Size:
4,651 bases
Orientation:
Minus strand

Genomic View for PTGIR Gene

Genes around PTGIR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGIR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGIR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGIR Gene

Proteins for PTGIR Gene

  • Protein details for PTGIR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43119-PI2R_HUMAN
    Recommended name:
    Prostacyclin receptor
    Protein Accession:
    P43119

    Protein attributes for PTGIR Gene

    Size:
    386 amino acids
    Molecular mass:
    40956 Da
    Quaternary structure:
    • Interacts (non-isoprenylated C-terminus) with PDZK1.

neXtProt entry for PTGIR Gene

Post-translational modifications for PTGIR Gene

  • Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling.
  • Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.
  • Glycosylation at Asn7
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGIR Gene

No data available for DME Specific Peptides for PTGIR Gene

Domains & Families for PTGIR Gene

Gene Families for PTGIR Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PTGIR Gene

InterPro:
Blocks:
  • Prostacyclin (prostanoid IP) receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for PTGIR Gene

GenScript: Design optimal peptide antigens:
  • Prostanoid IP receptor (PI2R_HUMAN)
  • Prostaglandin I2 (Prostacyclin) receptor (IP) (Q2YD89_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P43119

UniProtKB/Swiss-Prot:

PI2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGIR: view

Function for PTGIR Gene

Molecular function for PTGIR Gene

UniProtKB/Swiss-Prot Function:
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
GENATLAS Biochemistry:
protaglandin 12 (prostacyclin) receptor,subtype IP,expressed in the cardiovascular system,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for PTGIR Gene

Gene Ontology (GO) - Molecular Function for PTGIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0016501 prostacyclin receptor activity IBA 21873635
genes like me logo Genes that share ontologies with PTGIR: view
genes like me logo Genes that share phenotypes with PTGIR: view

Animal Models for PTGIR Gene

MGI Knock Outs for PTGIR:

Animal Model Products

  • Taconic Biosciences Mouse Models for PTGIR

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGIR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PTGIR Gene

Localization for PTGIR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGIR Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGIR gene
Compartment Confidence
plasma membrane 5
cytosol 4
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PTGIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005829 cytosol IDA 20622039
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane TAS 7512962
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PTGIR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGIR Gene

Pathways & Interactions for PTGIR Gene

genes like me logo Genes that share pathways with PTGIR: view

Pathways by source for PTGIR Gene

SIGNOR curated interactions for PTGIR Gene

Activates:
Other effect:

Gene Ontology (GO) - Biological Process for PTGIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 7512962
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA,IMP 20622039
genes like me logo Genes that share ontologies with PTGIR: view

Drugs & Compounds for PTGIR Gene

(55) Drugs for PTGIR Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iloprost Approved, Investigational Pharma Agonist, Full agonist, Target, agonist Prostacyclin (PGI2) analog, Others 93
Epoprostenol Approved Pharma Target, agonist 89
Treprostinil Approved, Investigational Pharma Agonist, Full agonist, Target, agonist 109
Dinoprost tromethamine Approved, Vet_approved Pharma Target, antagonist 15
Selexipag Approved Pharma Target, agonist 26

(15) Additional Compounds for PTGIR Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Cloprostenol sodium salt
55028-72-3

(5) Tocris Compounds for PTGIR Gene

Compound Action Cas Number
(+-)-Cloprostenol sodium salt Water-soluble PGF2alpha analog and potent FP receptor agonist 55028-72-3
BMY 45778 Non-prostanoid prostacyclin IP receptor partial agonist 152575-66-1
Iloprost Prostacyclin (PGI2) analog 78919-13-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1

(21) ApexBio Compounds for PTGIR Gene

Compound Action Cas Number
(+)-Fluprostenol 54276-17-4
(±)-Cloprostenol sodium salt 55028-72-3
Alprostadil 745-65-3
Bimatoprost 155206-00-1
BMY 45778 Type I IL-1 receptor antagonist 152575-66-1
Epoprostenol 61849-14-7
GW 627368 439288-66-1
Iloprost 78919-13-8
L-161,982 147776-06-5
L-655,240 103253-15-2
L-670,596 121083-05-4
L-798,106 244101-02-8
Misoprostol 59122-46-2
NS 304 475086-01-2
PF 04418948 1078166-57-0
Prostaglandin F2α 38562-01-5
SC 51089 146033-02-5
SC 51322 146032-79-3
Sulprostone 60325-46-4
TCS 2510 346673-06-1
U 46619 selective agonist of prostaglandin H2 (PGH2)/thromboxane A2 (TxA2) (TP) receptor 56985-40-1
genes like me logo Genes that share compounds with PTGIR: view

Drug Products

Transcripts for PTGIR Gene

mRNA/cDNA for PTGIR Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGIR

Alternative Splicing Database (ASD) splice patterns (SP) for PTGIR Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -

Relevant External Links for PTGIR Gene

GeneLoc Exon Structure for
PTGIR

Expression for PTGIR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTGIR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGIR Gene

This gene is overexpressed in Artery - Aorta (x10.1) and Artery - Coronary (x5.0).

Protein differential expression in normal tissues from HIPED for PTGIR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (55.5) and Adipocyte (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTGIR Gene



Protein tissue co-expression partners for PTGIR Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTGIR

SOURCE GeneReport for Unigene cluster for PTGIR Gene:

Hs.458324

Evidence on tissue expression from TISSUES for PTGIR Gene

  • Lung(4.4)
  • Pancreas(4.2)
  • Nervous system(3.9)
  • Muscle(3.7)
  • Heart(3.6)
  • Kidney(3.3)
  • Liver(3.1)
  • Intestine(3.1)
  • Stomach(2.7)
  • Blood(2.5)
genes like me logo Genes that share expression patterns with PTGIR: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGIR Gene

Orthologs for PTGIR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGIR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PTGIR 30 31
  • 98.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PTGIR 30 31
  • 86.89 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PTGIR 30 31
  • 86.37 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ptgir 30 17 31
  • 80.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ptgir 30
  • 78.61 (n)
Oppossum
(Monodelphis domestica)
Mammalia PTGIR 31
  • 74 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PTGIR 31
  • 50 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ptgir 30
  • 55.81 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC561406 30
  • 59.43 (n)
ptgir 31
  • 48 (a)
OneToOne
Species where no ortholog for PTGIR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PTGIR Gene

ENSEMBL:
Gene Tree for PTGIR (if available)
TreeFam:
Gene Tree for PTGIR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTGIR: view image

Paralogs for PTGIR Gene

Paralogs for PTGIR Gene

(4) SIMAP similar genes for PTGIR Gene using alignment to 5 proteins:

  • PI2R_HUMAN
  • M0QXV5_HUMAN
  • M0QZI2_HUMAN
  • M0QZW0_HUMAN
  • Q2YD89_HUMAN

Pseudogenes.org Pseudogenes for PTGIR Gene

genes like me logo Genes that share paralogs with PTGIR: view

Variants for PTGIR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTGIR Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
742244 Likely Benign: not provided 46,621,403(-) G/A SYNONYMOUS_VARIANT
781491 Benign: not provided 46,621,322(-) C/T SYNONYMOUS_VARIANT
781492 Benign: not provided 46,621,485(-) G/C MISSENSE_VARIANT
rs2229127 - p.Val25Met
rs28590598 - p.Ser319Trp

Additional dbSNP identifiers (rs#s) for PTGIR Gene

Structural Variations from Database of Genomic Variants (DGV) for PTGIR Gene

Variant ID Type Subtype PubMed ID
nsv833849 CNV loss 17160897
nsv953589 CNV deletion 24416366

Variation tolerance for PTGIR Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTGIR Gene

Human Gene Mutation Database (HGMD)
PTGIR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGIR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGIR Gene

Disorders for PTGIR Gene

MalaCards: The human disease database

(4) MalaCards diseases for PTGIR Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute endometritis
pulmonary hypertension
  • primary pulmonary hypertension
chronic pulmonary heart disease
pulmonary valve insufficiency
  • pulmonary incompetence
- elite association - COSMIC cancer census association via MalaCards
Search PTGIR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PTGIR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PTGIR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGIR Gene

Publications for PTGIR Gene

  1. Role of extracellular cysteine residues in dimerization/oligomerization of the human prostacyclin receptor. (PMID: 15194446) Giguère V … Parent JL (European journal of pharmacology 2004) 3 4 23
  2. Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor. (PMID: 11895442) Miggin SM … Kinsella BT (European journal of biochemistry 2002) 3 4 23
  3. Structural organization and chromosomal assignment of the human prostacyclin receptor gene. (PMID: 7665161) Ogawa Y … Narumiya S (Genomics 1995) 3 4 23
  4. Chromosomal localization of the human prostanoid receptor gene family. (PMID: 7759114) Duncan AM … Adam M (Genomics 1995) 2 3 23
  5. Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system. (PMID: 7923647) Nakagawa O … Nakao K (Circulation 1994) 3 4 23

Products for PTGIR Gene

  • Addgene plasmids for PTGIR
  • Signalway ELISA kits for PTGIR

Sources for PTGIR Gene