Aliases for PTGIR Gene
External Ids for PTGIR Gene
Previous GeneCards Identifiers for PTGIR Gene
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTGIR Gene
PTGIR (Prostaglandin I2 Receptor) is a Protein Coding gene. Diseases associated with PTGIR include Acute Endometritis and Pulmonary Hypertension. Among its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is PTGER2.
UniProtKB/Swiss-Prot Summary for PTGIR Gene
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.