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Aliases for PTGFRN Gene

Aliases for PTGFRN Gene

  • Prostaglandin F2 Receptor Inhibitor 2 3 5
  • Prostaglandin F2-Alpha Receptor Regulatory Protein 3 4
  • Prostaglandin F2-Alpha Receptor-Associated Protein 3 4
  • Prostaglandin F2 Receptor Negative Regulator 2 3
  • Glu-Trp-Ile EWI Motif-Containing Protein F 3 4
  • CD9 Partner 1 3 4
  • CD9P-1 3 4
  • EWI-F 3 4
  • FPRP 3 4
  • CD315 Antigen 4
  • KIAA1436 4
  • SMAP-6 3
  • CD315 3
  • CD9P1 4
  • EWIF 4

External Ids for PTGFRN Gene

Previous GeneCards Identifiers for PTGFRN Gene

  • GC01P117943
  • GC01P116322
  • GC01P116600
  • GC01P116796
  • GC01P116799
  • GC01P117164
  • GC01P117254
  • GC01P117452
  • GC01P115311

Summaries for PTGFRN Gene

GeneCards Summary for PTGFRN Gene

PTGFRN (Prostaglandin F2 Receptor Inhibitor) is a Protein Coding gene. Diseases associated with PTGFRN include Exudative Vitreoretinopathy. An important paralog of this gene is CD101.

UniProtKB/Swiss-Prot for PTGFRN Gene

  • Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).

Gene Wiki entry for PTGFRN Gene

Additional gene information for PTGFRN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGFRN Gene

Genomics for PTGFRN Gene

GeneHancer (GH) Regulatory Elements for PTGFRN Gene

Promoters and enhancers for PTGFRN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I116908 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.8 839 3.6 HDGF ARNT SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF121 ARID2 ATF7 ENSG00000272715 PTGFRN MAN1A2 CD2 PIR48772
GH01I117007 Enhancer 1 Ensembl ENCODE dbSUPER 18.9 +97.7 97656 0.9 RXRA HLF CEBPB ZNF384 CEBPG ATF2 IRF9 ATF4 ATF3 IKZF1 PTGFRN CD101 PIR49222
GH01I116880 Enhancer 1.4 FANTOM5 Ensembl ENCODE 13 -28.1 -28116 2.5 HDGF PKNOX1 ATF1 ARNT IRF4 TCF12 ZNF766 ARID2 ZNF143 FOS LOC105378927 PTGFRN IGSF3 MIR320B1 CD101 FTH1P22
GH01I116877 Enhancer 1.5 FANTOM5 Ensembl ENCODE 11.4 -31.2 -31216 3.1 HDGF PKNOX1 ARNT SIN3A YBX1 FEZF1 ZNF2 ZNF213 ZNF302 ZNF416 MAN1A2 ATP1A1-AS1 PTGFRN CD2 CD101 TRIM45 TTF2 LOC105378927 FTH1P22
GH01I116852 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.9 -55.2 -55233 5 PKNOX1 CLOCK FOXA2 NEUROD1 SIN3A FEZF1 ZNF2 ZNF213 ZNF207 FOS PTGFRN CD2 MIR320B1 IGSF3 CD101 LOC105378927 FTH1P22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PTGFRN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTGFRN gene promoter:

Genomic Locations for PTGFRN Gene

Genomic Locations for PTGFRN Gene
80,436 bases
Plus strand

Genomic View for PTGFRN Gene

Genes around PTGFRN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGFRN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGFRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGFRN Gene

Proteins for PTGFRN Gene

  • Protein details for PTGFRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prostaglandin F2 receptor negative regulator
    Protein Accession:
    Secondary Accessions:
    • Q5VVU9
    • Q8N2K6

    Protein attributes for PTGFRN Gene

    879 amino acids
    Molecular mass:
    98556 Da
    Quaternary structure:
    • Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151.
    • Sequence=BAA92674.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11104.1; Type=Erroneous termination; Positions=864; Note=Translated as Gln.; Evidence={ECO:0000305};

neXtProt entry for PTGFRN Gene

Post-translational modifications for PTGFRN Gene

  • Glycosylation at Asn44, isoforms=150, isoforms=286, isoforms=300, isoforms=383, Asn413, isoforms=525, Asn600, Asn618, and isoforms=691
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGFRN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTGFRN Gene

Domains & Families for PTGFRN Gene

Gene Families for PTGFRN Gene

Suggested Antigen Peptide Sequences for PTGFRN Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PTGFRN: view

No data available for UniProtKB/Swiss-Prot for PTGFRN Gene

Function for PTGFRN Gene

Molecular function for PTGFRN Gene

GENATLAS Biochemistry:
prostaglandin F2 alpha receptor (FP),negative receptor
UniProtKB/Swiss-Prot Function:
Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).

Phenotypes From GWAS Catalog for PTGFRN Gene

Gene Ontology (GO) - Molecular Function for PTGFRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11278880
genes like me logo Genes that share ontologies with PTGFRN: view

Phenotypes for PTGFRN Gene

genes like me logo Genes that share phenotypes with PTGFRN: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PTGFRN

CRISPR Products

miRNA for PTGFRN Gene

miRTarBase miRNAs that target PTGFRN

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTGFRN Gene

Localization for PTGFRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGFRN Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGFRN gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
endoplasmic reticulum 3
extracellular 2
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PTGFRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IBA --
GO:0009986 cell surface HDA,IDA 19581412
genes like me logo Genes that share ontologies with PTGFRN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGFRN Gene

Pathways & Interactions for PTGFRN Gene

SuperPathways for PTGFRN Gene

No Data Available

Gene Ontology (GO) - Biological Process for PTGFRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034389 lipid particle organization IEA --
genes like me logo Genes that share ontologies with PTGFRN: view

No data available for Pathways by source and SIGNOR curated interactions for PTGFRN Gene

Drugs & Compounds for PTGFRN Gene

No Compound Related Data Available

Transcripts for PTGFRN Gene

Unigene Clusters for PTGFRN Gene

Prostaglandin F2 receptor inhibitor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGFRN Gene

No ASD Table

Relevant External Links for PTGFRN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTGFRN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTGFRN Gene

Protein differential expression in normal tissues from HIPED for PTGFRN Gene

This gene is overexpressed in Uterus (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PTGFRN Gene

Protein tissue co-expression partners for PTGFRN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTGFRN Gene:


SOURCE GeneReport for Unigene cluster for PTGFRN Gene:


Evidence on tissue expression from TISSUES for PTGFRN Gene

  • Stomach(4.8)
  • Nervous system(4.5)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with PTGFRN: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGFRN Gene

Orthologs for PTGFRN Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGFRN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTGFRN 33 34
  • 99.35 (n)
(Bos Taurus)
Mammalia PTGFRN 33 34
  • 87.84 (n)
(Canis familiaris)
Mammalia PTGFRN 33 34
  • 86.49 (n)
(Mus musculus)
Mammalia Ptgfrn 33 16 34
  • 86.35 (n)
(Rattus norvegicus)
Mammalia Ptgfrn 33
  • 85.59 (n)
(Monodelphis domestica)
Mammalia PTGFRN 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia PTGFRN 34
  • 58 (a)
(Gallus gallus)
Aves PTGFRN 33 34
  • 66.74 (n)
(Anolis carolinensis)
Reptilia PTGFRN 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493252 33
  • 53.7 (n)
(Danio rerio)
Actinopterygii si:ch211-132g1.7 33
  • 48.39 (n)
PTGFRN (2 of 2) 34
  • 38 (a)
PTGFRN (1 of 2) 34
  • 34 (a)
Species where no ortholog for PTGFRN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGFRN Gene

Gene Tree for PTGFRN (if available)
Gene Tree for PTGFRN (if available)

Paralogs for PTGFRN Gene

Paralogs for PTGFRN Gene

(1) SIMAP similar genes for PTGFRN Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PTGFRN: view

Variants for PTGFRN Gene

Sequence variations from dbSNP and Humsavar for PTGFRN Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000004302 -- 116,939,177(+) T/C intron_variant
rs1000026186 -- 116,964,695(+) C/T intron_variant
rs1000047226 -- 116,941,260(+) G/A intron_variant
rs1000101120 -- 116,912,539(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000183212 -- 116,915,739(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PTGFRN Gene

Variant ID Type Subtype PubMed ID
nsv2566 CNV deletion 18451855
nsv519074 CNV loss 19592680
nsv547586 CNV loss 21841781
nsv831159 CNV loss 17160897

Variation tolerance for PTGFRN Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.36; 95.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTGFRN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGFRN Gene

Disorders for PTGFRN Gene

MalaCards: The human disease database

(1) MalaCards diseases for PTGFRN Gene - From: DISEASES

Disorder Aliases PubMed IDs
exudative vitreoretinopathy
  • exudative vitreoretinopathy 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PTGFRN

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PTGFRN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGFRN Gene

Publications for PTGFRN Gene

  1. Glycosylation status of the membrane protein CD9P-1. (PMID: 17960739) André M … Le Naour F (Proteomics 2007) 3 4 22 58
  2. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. (PMID: 11278880) Charrin S … Rubinstein E (The Journal of biological chemistry 2001) 3 4 22 58
  3. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PMID: 19850283) Ikeda M … Iwata N (Biological psychiatry 2010) 3 44 58
  4. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PMID: 20932654) Kerns SL … Rosenstein BS (International journal of radiation oncology, biology, physics 2010) 3 44 58
  5. The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells. (PMID: 17407154) Abache T … Rubinstein E (Journal of cellular biochemistry 2007) 3 22 58

Products for PTGFRN Gene

Sources for PTGFRN Gene

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