Aliases for PTGFRN Gene

Aliases for PTGFRN Gene

  • Prostaglandin F2 Receptor Inhibitor 2 3 5
  • Prostaglandin F2 Receptor Negative Regulator 2 3 4
  • Prostaglandin F2-Alpha Receptor Regulatory Protein 3 4
  • Prostaglandin F2-Alpha Receptor-Associated Protein 3 4
  • Glu-Trp-Ile EWI Motif-Containing Protein F 3 4
  • CD9 Partner 1 3 4
  • CD9P-1 3 4
  • EWI-F 3 4
  • FPRP 3 4
  • CD315 Antigen 4
  • KIAA1436 4
  • SMAP-6 3
  • CD315 3
  • CD9P1 4
  • EWIF 4

External Ids for PTGFRN Gene

Previous GeneCards Identifiers for PTGFRN Gene

  • GC01P117943
  • GC01P116322
  • GC01P116600
  • GC01P116796
  • GC01P116799
  • GC01P117164
  • GC01P117254
  • GC01P117452
  • GC01P115311

Summaries for PTGFRN Gene

GeneCards Summary for PTGFRN Gene

PTGFRN (Prostaglandin F2 Receptor Inhibitor) is a Protein Coding gene. An important paralog of this gene is IGSF3.

UniProtKB/Swiss-Prot Summary for PTGFRN Gene

  • Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity).

Gene Wiki entry for PTGFRN Gene

Additional gene information for PTGFRN Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTGFRN Gene

Genomics for PTGFRN Gene

GeneHancer (GH) Regulatory Elements for PTGFRN Gene

Promoters and enhancers for PTGFRN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTGFRN on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTGFRN

Top Transcription factor binding sites by QIAGEN in the PTGFRN gene promoter:
  • COMP1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GATA-1
  • RORalpha1
  • S8

Genomic Locations for PTGFRN Gene

Genomic Locations for PTGFRN Gene
chr1:116,909,916-116,990,358
(GRCh38/hg38)
Size:
80,443 bases
Orientation:
Plus strand
chr1:117,452,679-117,532,980
(GRCh37/hg19)
Size:
80,302 bases
Orientation:
Plus strand

Genomic View for PTGFRN Gene

Genes around PTGFRN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGFRN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGFRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGFRN Gene

Proteins for PTGFRN Gene

  • Protein details for PTGFRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2B2-FPRP_HUMAN
    Recommended name:
    Prostaglandin F2 receptor negative regulator
    Protein Accession:
    Q9P2B2
    Secondary Accessions:
    • Q5VVU9
    • Q8N2K6

    Protein attributes for PTGFRN Gene

    Size:
    879 amino acids
    Molecular mass:
    98556 Da
    Quaternary structure:
    • Interacts with CD9 and CD81 (PubMed:11278880). Part of a complex composed of CD9, CD81 and IGSF8 (By similarity). Also seems to interact with CD63, CD82 and CD151 (PubMed:11278880).
    SequenceCaution:
    • Sequence=BAA92674.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11104.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

neXtProt entry for PTGFRN Gene

Post-translational modifications for PTGFRN Gene

  • Glycosylation at Asn44, Ser150, Asn286, Asn300, Asn383, Asn413, Asn525, Asn600, Asn618, and Asn691
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for PTGFRN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTGFRN Gene

Domains & Families for PTGFRN Gene

Gene Families for PTGFRN Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins

Protein Domains for PTGFRN Gene

Blocks:
  • Immunoglobulin subtype
  • Immunoglobulin V-set
  • Immunoglobulin V-type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PTGFRN Gene

GenScript: Design optimal peptide antigens:
  • PTGFRN protein (A4QPA1_HUMAN)
  • Prostaglandin F2-alpha receptor-associated protein (FPRP_HUMAN)
  • PTGFRN protein (Q1WWL2_HUMAN)
  • PTGFRN protein (Q4QQP8_HUMAN)
  • SMAP-6 (Q9H3U3_HUMAN)
genes like me logo Genes that share domains with PTGFRN: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PTGFRN Gene

Function for PTGFRN Gene

Molecular function for PTGFRN Gene

UniProtKB/Swiss-Prot Function:
Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity).
GENATLAS Biochemistry:
prostaglandin F2 alpha receptor (FP),negative receptor

Phenotypes From GWAS Catalog for PTGFRN Gene

Gene Ontology (GO) - Molecular Function for PTGFRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11278880
genes like me logo Genes that share ontologies with PTGFRN: view
genes like me logo Genes that share phenotypes with PTGFRN: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PTGFRN

CRISPR Products

miRNA for PTGFRN Gene

miRTarBase miRNAs that target PTGFRN

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGFRN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTGFRN Gene

Localization for PTGFRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGFRN Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGFRN gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
golgi apparatus 3
extracellular 2
cytoskeleton 1
nucleus 1
endosome 1
cytosol 1
lysosome 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for PTGFRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0009986 cell surface HDA 19581412
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PTGFRN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGFRN Gene

Pathways & Interactions for PTGFRN Gene

PathCards logo

SuperPathways for PTGFRN Gene

No Data Available

Gene Ontology (GO) - Biological Process for PTGFRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014905 myoblast fusion involved in skeletal muscle regeneration IEA,ISS --
GO:0034389 lipid droplet organization IEA --
genes like me logo Genes that share ontologies with PTGFRN: view

No data available for Pathways by source and SIGNOR curated interactions for PTGFRN Gene

Drugs & Compounds for PTGFRN Gene

No Compound Related Data Available

Transcripts for PTGFRN Gene

mRNA/cDNA for PTGFRN Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGFRN

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGFRN Gene

No ASD Table

Relevant External Links for PTGFRN Gene

GeneLoc Exon Structure for
PTGFRN

Expression for PTGFRN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTGFRN Gene

Protein differential expression in normal tissues from HIPED for PTGFRN Gene

This gene is overexpressed in Uterus (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTGFRN Gene



Protein tissue co-expression partners for PTGFRN Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTGFRN

SOURCE GeneReport for Unigene cluster for PTGFRN Gene:

Hs.418093

Evidence on tissue expression from TISSUES for PTGFRN Gene

  • Stomach(4.8)
  • Nervous system(4.5)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with PTGFRN: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGFRN Gene

Orthologs for PTGFRN Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGFRN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGFRN 31 30
  • 99.35 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PTGFRN 31 30
  • 87.84 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PTGFRN 31 30
  • 86.49 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ptgfrn 17 31 30
  • 86.35 (n)
rat
(Rattus norvegicus)
Mammalia Ptgfrn 30
  • 85.59 (n)
oppossum
(Monodelphis domestica)
Mammalia PTGFRN 31
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGFRN 31
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTGFRN 31 30
  • 66.74 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGFRN 31
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493252 30
  • 53.7 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-132g1.7 30
  • 48.39 (n)
PTGFRN (2 of 2) 31
  • 38 (a)
OneToMany
PTGFRN (1 of 2) 31
  • 34 (a)
OneToMany
Species where no ortholog for PTGFRN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGFRN Gene

ENSEMBL:
Gene Tree for PTGFRN (if available)
TreeFam:
Gene Tree for PTGFRN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTGFRN: view image

Paralogs for PTGFRN Gene

Paralogs for PTGFRN Gene

(1) SIMAP similar genes for PTGFRN Gene using alignment to 4 proteins:

  • FPRP_HUMAN
  • A4QPA1_HUMAN
  • Q1WWL2_HUMAN
  • Q4QQP8_HUMAN
genes like me logo Genes that share paralogs with PTGFRN: view

Variants for PTGFRN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTGFRN Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
710498 Likely Benign: not provided 116,944,985(+) A/G MISSENSE_VARIANT
726015 Likely Benign: not provided 116,944,945(+) G/A MISSENSE_VARIANT
733804 Benign: not provided 116,941,959(+) C/T SYNONYMOUS_VARIANT
733805 Benign: not provided 116,984,822(+) C/T SYNONYMOUS_VARIANT
738559 Likely Benign: not provided 116,967,110(+) G/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PTGFRN Gene

Structural Variations from Database of Genomic Variants (DGV) for PTGFRN Gene

Variant ID Type Subtype PubMed ID
nsv2566 CNV deletion 18451855
nsv519074 CNV loss 19592680
nsv547586 CNV loss 21841781
nsv831159 CNV loss 17160897

Variation tolerance for PTGFRN Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.36; 95.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTGFRN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGFRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGFRN Gene

Disorders for PTGFRN Gene

Additional Disease Information for PTGFRN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PTGFRN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTGFRN Gene

Publications for PTGFRN Gene

  1. Glycosylation status of the membrane protein CD9P-1. (PMID: 17960739) André M … Le Naour F (Proteomics 2007) 3 4 23 54
  2. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. (PMID: 11278880) Charrin S … Rubinstein E (The Journal of biological chemistry 2001) 3 4 23 54
  3. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PMID: 20932654) Kerns SL … Rosenstein BS (International journal of radiation oncology, biology, physics 2010) 3 41 54
  4. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PMID: 19850283) Ikeda M … Iwata N (Biological psychiatry 2010) 3 41 54
  5. The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells. (PMID: 17407154) Abache T … Rubinstein E (Journal of cellular biochemistry 2007) 3 23 54

Products for PTGFRN Gene

Sources for PTGFRN Gene