The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this ... See more...

Aliases for PTGFR Gene

Aliases for PTGFR Gene

  • Prostaglandin F Receptor 2 3 5
  • Prostaglandin F2-Alpha Receptor 3 4
  • FP Prostanoid Receptor 2 3
  • Prostanoid FP Receptor 3 4
  • PGF Receptor 3 4
  • FP 2 3
  • Prostaglandin Receptor (2-Alpha) 3
  • Prostaglandin F Receptor (FP) 2
  • PGF2 Alpha Receptor 3
  • PGF2-Alpha Receptor 4
  • PTGFR 5

External Ids for PTGFR Gene

Previous GeneCards Identifiers for PTGFR Gene

  • GC01P079117
  • GC01P077856
  • GC01P078347
  • GC01P078379
  • GC01P078668
  • GC01P078542
  • GC01P078729
  • GC01P077088

Summaries for PTGFR Gene

Entrez Gene Summary for PTGFR Gene

  • The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGFR Gene

PTGFR (Prostaglandin F Receptor) is a Protein Coding gene. Diseases associated with PTGFR include Ocular Hyperemia and Ocular Hypertension. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and prostaglandin F receptor activity. An important paralog of this gene is PTGER1.

UniProtKB/Swiss-Prot Summary for PTGFR Gene

  • Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.

Tocris Summary for PTGFR Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGFR Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTGFR Gene

Genomics for PTGFR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTGFR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J078490 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 259.1 +187.4 187417 2.6 ZBTB10 ZBTB48 GLIS1 PKNOX1 ZNF366 L3MBTL2 ZBTB17 GLIS2 CEBPB ZBTB20 PTGFR piR-43106-007 HSALNG0004624 IFI44L
GH01J078229 Promoter/Enhancer 0.8 EPDnew Ensembl 250.2 -74.3 -74283 0.8 CEBPB EP300 STAT3 JUND FOS PTGFR GIPC2 piR-59490 MGC27382
GH01J078303 Enhancer 0.7 Ensembl ENCODE 263.4 -0.1 -80 1.2 CEBPB EP300 RAD21 RFX5 SMC3 STAT3 JUND FOS PTGFR HSALNG0004623 MGC27382 HSALNG0004624 GIPC2
GH01J078274 Enhancer 0.7 Ensembl ENCODE 15.5 -26.0 -25993 6.6 JUND BCL11A CEBPB CBFB BATF ATF2 JUNB BHLHE40 EP300 RUNX3 PTGFR FUBP1 HSALNG0004623 MGC27382 GIPC2
GH01J078286 Enhancer 0.6 Ensembl ENCODE 14.5 -17.0 -16983 1.4 CEBPB EP300 STAT3 POLR2A PTGFR HSALNG0004623 MGC27382 GIPC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTGFR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTGFR

Top Transcription factor binding sites by QIAGEN in the PTGFR gene promoter:
  • C/EBPalpha
  • CREB
  • deltaCREB
  • GATA-1
  • GATA-2
  • GATA-3
  • Lmo2
  • Pax-4a
  • S8

Genomic Locations for PTGFR Gene

Latest Assembly
chr1:78,303,884-78,540,701
(GRCh38/hg38)
Size:
236,818 bases
Orientation:
Plus strand

Previous Assembly
chr1:78,956,659-79,006,386
(GRCh37/hg19 by Entrez Gene)
Size:
49,728 bases
Orientation:
Plus strand

chr1:78,769,568-79,005,434
(GRCh37/hg19 by Ensembl)
Size:
235,867 bases
Orientation:
Plus strand

Genomic View for PTGFR Gene

Genes around PTGFR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGFR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGFR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGFR Gene

Proteins for PTGFR Gene

  • Protein details for PTGFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43088-PF2R_HUMAN
    Recommended name:
    Prostaglandin F2-alpha receptor
    Protein Accession:
    P43088
    Secondary Accessions:
    • A8K9Y0
    • Q2KHP3
    • Q6RYQ6
    • Q9P1X4

    Protein attributes for PTGFR Gene

    Size:
    359 amino acids
    Molecular mass:
    40055 Da
    Quaternary structure:
    • Isoform 1 can form heterodimers with isoform 5 (and probably other isoforms).

    Alternative splice isoforms for PTGFR Gene

neXtProt entry for PTGFR Gene

Post-translational modifications for PTGFR Gene

  • Glycosylation at Asn4 and Asn19
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGFR Gene

No data available for DME Specific Peptides for PTGFR Gene

Domains & Families for PTGFR Gene

Gene Families for PTGFR Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for PTGFR Gene

InterPro:
Blocks:
  • Prostaglandin F receptor signature

Suggested Antigen Peptide Sequences for PTGFR Gene

GenScript: Design optimal peptide antigens:
  • Prostanoid FP receptor (PF2R_HUMAN)
  • Prostanoid FP receptor (Q4LEK1_HUMAN)
  • Prostanoid FP receptor (Q71UN9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P43088

UniProtKB/Swiss-Prot:

PF2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGFR: view

Function for PTGFR Gene

Molecular function for PTGFR Gene

UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
GENATLAS Biochemistry:
prostaglandin F2 alpha receptor,subtype FP,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for PTGFR Gene

Gene Ontology (GO) - Molecular Function for PTGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004958 prostaglandin F receptor activity TAS,IDA 18587449
genes like me logo Genes that share ontologies with PTGFR: view
genes like me logo Genes that share phenotypes with PTGFR: view

Animal Models for PTGFR Gene

MGI Knock Outs for PTGFR:

miRNA for PTGFR Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGFR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGFR Gene

Localization for PTGFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGFR Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGFR gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PTGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 10575000
GO:0005737 cytoplasm IDA 18508192
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8300593
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PTGFR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGFR Gene

Pathways & Interactions for PTGFR Gene

genes like me logo Genes that share pathways with PTGFR: view

SIGNOR curated interactions for PTGFR Gene

Activates:

Gene Ontology (GO) - Biological Process for PTGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA 21873635
GO:0007204 positive regulation of cytosolic calcium ion concentration IBA 21873635
genes like me logo Genes that share ontologies with PTGFR: view

Drugs & Compounds for PTGFR Gene

(38) Drugs for PTGFR Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bimatoprost Approved, Investigational Pharma Agonist, Full agonist, Target 150
Latanoprost Approved, Investigational Pharma Target, agonist 232
Travoprost Approved Pharma Target, agonist 142
Iloprost Approved, Investigational Pharma Agonist, Full agonist Prostacyclin (PGI2) analog, Others 97
Tafluprost Approved Pharma Target, agonist 0

(16) Additional Compounds for PTGFR Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Tafluprost free acid
  • (5Z)-7-{2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl}hept-5-enoate
(+-)-Cloprostenol sodium salt
55028-72-3

(5) Tocris Compounds for PTGFR Gene

Compound Action Cas Number
(+-)-Cloprostenol sodium salt Water-soluble PGF2alpha analog and potent FP receptor agonist 55028-72-3
BMY 45778 Non-prostanoid prostacyclin IP receptor partial agonist 152575-66-1
Iloprost Prostacyclin (PGI2) analog 78919-13-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1

(3) ApexBio Compounds for PTGFR Gene

Compound Action Cas Number
AL 8810 Antagonist of prostaglandin F2α (FP) receptor. 246246-19-5
Alprostadil 745-65-3
Bimatoprost 155206-00-1
genes like me logo Genes that share compounds with PTGFR: view

Drug products for research

Transcripts for PTGFR Gene

mRNA/cDNA for PTGFR Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGFR

Alternative Splicing Database (ASD) splice patterns (SP) for PTGFR Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - -
SP3: -
SP4: - - - -
SP5: - -

Relevant External Links for PTGFR Gene

GeneLoc Exon Structure for
PTGFR

Expression for PTGFR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTGFR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGFR Gene

This gene is overexpressed in Nerve - Tibial (x7.1).

Protein differential expression in normal tissues from HIPED for PTGFR Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTGFR Gene



Protein tissue co-expression partners for PTGFR Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTGFR

SOURCE GeneReport for Unigene cluster for PTGFR Gene:

Hs.654365

mRNA Expression by UniProt/SwissProt for PTGFR Gene:

P43088-PF2R_HUMAN
Tissue specificity: Eye.

Evidence on tissue expression from TISSUES for PTGFR Gene

  • Eye(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with PTGFR: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGFR Gene

Orthologs for PTGFR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGFR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PTGFR 29 30
  • 99.72 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PTGFR 29 30
  • 92.02 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PTGFR 29
  • 86.85 (n)
FP 30
  • 82 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Ptgfr 29 16 30
  • 85.25 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PTGFR 30
  • 84 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ptgfr 29
  • 81.6 (n)
Chicken
(Gallus gallus)
Aves PTGFR 29 30
  • 79.26 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PTGFR 30
  • 77 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ptgfr 29
  • 71.35 (n)
Zebrafish
(Danio rerio)
Actinopterygii ptgfr 29 30
  • 56.34 (n)
OneToMany
PTGFR (2 of 2) 30
  • 48 (a)
OneToMany
Species where no ortholog for PTGFR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PTGFR Gene

ENSEMBL:
Gene Tree for PTGFR (if available)
TreeFam:
Gene Tree for PTGFR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTGFR: view image
Alliance of Genome Resources:
Additional Orthologs for PTGFR

Paralogs for PTGFR Gene

Paralogs for PTGFR Gene

(7) SIMAP similar genes for PTGFR Gene using alignment to 4 proteins:

  • PF2R_HUMAN
  • F2Z2Z6_HUMAN
  • Q4LEK1_HUMAN
  • Q71UN9_HUMAN
genes like me logo Genes that share paralogs with PTGFR: view

Variants for PTGFR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTGFR Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs115994459 Benign: not provided 78,493,396(+) T/C
NM_000959.4(PTGFR):c.653T>C (p.Leu218Ser)
MISSENSE
rs3753380 Drug Response: latanoprost response - Efficacy 78,490,747(+) T/C
NM_000959.3(PTGFR):c.-562T>C
rs41292960 Benign: not provided 78,492,766(+) A/T
NM_000959.4(PTGFR):c.23A>T (p.Gln8Leu)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PTGFR Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PTGFR Gene

Variant ID Type Subtype PubMed ID
esv1614956 CNV deletion 17803354
esv2376136 CNV deletion 18987734
esv2660451 CNV deletion 23128226
esv2750185 CNV deletion 23290073
esv2750196 CNV deletion 23290073
esv3586546 CNV loss 21293372
nsv1566 CNV insertion 18451855

Variation tolerance for PTGFR Gene

Residual Variation Intolerance Score: 60.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTGFR Gene

Human Gene Mutation Database (HGMD)
PTGFR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGFR
Leiden Open Variation Database (LOVD)
PTGFR

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGFR Gene

Disorders for PTGFR Gene

MalaCards: The human disease database

(8) MalaCards diseases for PTGFR Gene - From: COP and GCD

Disorder Aliases PubMed IDs
ocular hyperemia
  • hyperemia eye
ocular hypertension
  • hypertension, ocular
intraocular pressure quantitative trait locus
  • iopqtl
punctate epithelial keratoconjunctivitis
  • punctate keratitis
open-angle glaucoma
  • glaucoma simplex
- elite association - COSMIC cancer census association via MalaCards
Search PTGFR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PTGFR

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PTGFR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGFR Gene

Publications for PTGFR Gene

  1. Cloning and expression of a cDNA for the human prostanoid FP receptor. (PMID: 8300593) Abramovitz M … Grygorczyk R (The Journal of biological chemistry 1994) 2 3 4 22
  2. Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes. (PMID: 18587449) Liang Y … Fliri H (British journal of pharmacology 2008) 3 4 22
  3. Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor. (PMID: 14984197) Vielhauer GA … Regan JW (Archives of biochemistry and biophysics 2004) 3 4 22
  4. Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha. (PMID: 9341156) Kunapuli P … FitzGerald GA (The Journal of biological chemistry 1997) 3 4 22
  5. Chromosomal localization of the human prostanoid receptor gene family. (PMID: 7759114) Duncan AM … Adam M (Genomics 1995) 2 3 22

Products for PTGFR Gene

Sources for PTGFR Gene