Aliases for PTGFR Gene
External Ids for PTGFR Gene
Previous GeneCards Identifiers for PTGFR Gene
The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTGFR Gene
PTGFR (Prostaglandin F Receptor) is a Protein Coding gene. Diseases associated with PTGFR include Ocular Hypertension and Open-Angle Glaucoma. Among its related pathways are GPCRs, Other and Eicosanoid ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and prostaglandin F receptor activity. An important paralog of this gene is PTGER1.
UniProtKB/Swiss-Prot for PTGFR Gene
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.