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Aliases for PTGES3L Gene

Aliases for PTGES3L Gene

  • Prostaglandin E Synthase 3 Like 2 3 5
  • Prostaglandin E Synthase 3 (Cytosolic)-Like 2
  • Prostaglandin E Synthase 3-Like 4

External Ids for PTGES3L Gene

Previous GeneCards Identifiers for PTGES3L Gene

  • GC00U934051
  • GC17M041120

Summaries for PTGES3L Gene

GeneCards Summary for PTGES3L Gene

PTGES3L (Prostaglandin E Synthase 3 Like) is a Protein Coding gene. An important paralog of this gene is PTGES3L-AARSD1.

Additional gene information for PTGES3L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGES3L Gene

Genomics for PTGES3L Gene

GeneHancer (GH) Regulatory Elements for PTGES3L Gene

Promoters and enhancers for PTGES3L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I042979 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 555.4 0.0 -34 2.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 SP3 PTGES3L PTGES3L-AARSD1 RUNDC1 HMGN2P15 RPL27 IFI35 AARSD1 PIR51537
GH17I042982 Enhancer 0.5 ENCODE 550.8 -1.8 -1755 0.4 GATA3 ZNF189 DPF2 FOXA1 PTGES3L-AARSD1 RUNDC1 PTGES3L NBR2 IFI35 PIR51537
GH17I043210 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 5.4 -232.1 -232070 4.4 HDGF ELF3 PKNOX1 FOXA2 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 TMEM106A NBR2 RND2 VAT1 PTGES3L PSMC3IP RNU2-1 NBR1
GH17I043024 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 4.6 -44.5 -44511 2 HDGF CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF766 RND2 VAT1 NBR2 HMGN1P29 CCR10 ENSG00000267758 ENSG00000267002 LINC00910 DHX8 HSD17B1P1
GH17I043314 Enhancer 1.5 Ensembl ENCODE dbSUPER 5.8 -335.4 -335385 2.6 HNRNPUL1 PKNOX1 SMAD1 ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF213 NBR2 ASB16-AS1 DHX8 HMGN1P29 LINC00910 TMUB2 UBTF NAGLU PLEKHH3 RPL27
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PTGES3L on UCSC Golden Path with GeneCards custom track

Genomic Locations for PTGES3L Gene

Genomic Locations for PTGES3L Gene
chr17:42,968,088-42,980,528
(GRCh38/hg38)
Size:
12,441 bases
Orientation:
Minus strand
chr17:41,120,105-41,132,545
(GRCh37/hg19)

Genomic View for PTGES3L Gene

Genes around PTGES3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGES3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGES3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGES3L Gene

Proteins for PTGES3L Gene

  • Protein details for PTGES3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E9PB15-PTG3L_HUMAN
    Recommended name:
    Putative protein PTGES3L
    Protein Accession:
    E9PB15

    Protein attributes for PTGES3L Gene

    Size:
    166 amino acids
    Molecular mass:
    19074 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PTGES3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PTGES3L Gene

Post-translational modifications for PTGES3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTGES3L Gene

No data available for DME Specific Peptides for PTGES3L Gene

Domains & Families for PTGES3L Gene

Gene Families for PTGES3L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PTGES3L Gene

Graphical View of Domain Structure for InterPro Entry

E9PB15

UniProtKB/Swiss-Prot:

PTG3L_HUMAN :
  • Belongs to the p23/wos2 family.
Family:
  • Belongs to the p23/wos2 family.
genes like me logo Genes that share domains with PTGES3L: view

No data available for Suggested Antigen Peptide Sequences for PTGES3L Gene

Function for PTGES3L Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTGES3L Gene

Localization for PTGES3L Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PTGES3L Gene

Pathways & Interactions for PTGES3L Gene

SuperPathways for PTGES3L Gene

No Data Available

Interacting Proteins for PTGES3L Gene

Gene Ontology (GO) - Biological Process for PTGES3L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PTGES3L Gene

Drugs & Compounds for PTGES3L Gene

No Compound Related Data Available

Transcripts for PTGES3L Gene

mRNA/cDNA for PTGES3L Gene

(3) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PTGES3L Gene

No ASD Table

Relevant External Links for PTGES3L Gene

GeneLoc Exon Structure for
PTGES3L
ECgene alternative splicing isoforms for
PTGES3L

Expression for PTGES3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTGES3L Gene

mRNA differential expression in normal tissues according to GTEx for PTGES3L Gene

This gene is overexpressed in Muscle - Skeletal (x11.8), Heart - Left Ventricle (x7.5), and Heart - Atrial Appendage (x5.4).

Protein differential expression in normal tissues from HIPED for PTGES3L Gene

This gene is overexpressed in Platelet (62.3) and Fetal heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTGES3L Gene



Protein tissue co-expression partners for PTGES3L Gene

NURSA nuclear receptor signaling pathways regulating expression of PTGES3L Gene:

PTGES3L
genes like me logo Genes that share expression patterns with PTGES3L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGES3L Gene

Orthologs for PTGES3L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PTGES3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGES3L 33
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia PTGES3L 33
  • 89.76 (n)
mouse
(Mus musculus)
Mammalia Ptges3l 33 16
  • 87.57 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 15 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 12 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-131k2.3 33
  • 58.39 (n)
PTGES3L 34
  • 31 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10802 34
  • 2 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC395.10 34
  • 14 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 4 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10501 34
  • 17 (a)
ManyToMany
Species where no ortholog for PTGES3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PTGES3L Gene

ENSEMBL:
Gene Tree for PTGES3L (if available)
TreeFam:
Gene Tree for PTGES3L (if available)

Paralogs for PTGES3L Gene

Paralogs for PTGES3L Gene

(2) SIMAP similar genes for PTGES3L Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PTGES3L: view

Variants for PTGES3L Gene

Sequence variations from dbSNP and Humsavar for PTGES3L Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs200141347 benign, not specified 42,969,193(-) GCG/G/GCGCG intron_variant
rs1000486057 -- 42,969,096(-) G/A/C 3_prime_UTR_variant
rs1000800008 -- 42,978,547(-) G/C intron_variant
rs1000912538 -- 42,969,350(-) T/G intron_variant
rs1001207723 -- 42,974,655(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PTGES3L Gene

Variant ID Type Subtype PubMed ID
esv2672913 CNV deletion 23128226
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv2057 CNV insertion 18451855
nsv457742 CNV loss 19166990
nsv483009 CNV gain 15286789
nsv575052 CNV loss 21841781

Variation tolerance for PTGES3L Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTGES3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGES3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGES3L Gene

Disorders for PTGES3L Gene

Additional Disease Information for PTGES3L

No disorders were found for PTGES3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PTGES3L Gene

Publications for PTGES3L Gene

  1. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 58

Products for PTGES3L Gene

Sources for PTGES3L Gene

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