Aliases for PTGES3 Gene
External Ids for PTGES3 Gene
Previous GeneCards Identifiers for PTGES3 Gene
This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]
GeneCards Summary for PTGES3 Gene
PTGES3 (Prostaglandin E Synthase 3) is a Protein Coding gene. Diseases associated with PTGES3 include Primary Hypertrophic Osteoarthropathy. Among its related pathways are Cytochrome P450 - arranged by substrate type and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and prostaglandin-E synthase activity. An important paralog of this gene is PTGES3L.
UniProtKB/Swiss-Prot Summary for PTGES3 Gene
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).