Aliases for PTGES2 Gene
External Ids for PTGES2 Gene
Previous HGNC Symbols for PTGES2 Gene
Previous GeneCards Identifiers for PTGES2 Gene
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]
GeneCards Summary for PTGES2 Gene
PTGES2 (Prostaglandin E Synthase 2) is a Protein Coding gene. Diseases associated with PTGES2 include Colorectal Cancer. Among its related pathways are Immune response IFN gamma signaling pathway and Metabolism. Gene Ontology (GO) annotations related to this gene include heme binding and lyase activity.
UniProtKB/Swiss-Prot Summary for PTGES2 Gene
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:18198127, PubMed:17585783). The biological function and the GSH-dependent property of PTGES2 is still under debate (PubMed:18198127, PubMed:17585783). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (PubMed:17585783) (By similarity).