The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to ... See more...

Aliases for PTGES Gene

Aliases for PTGES Gene

  • Prostaglandin E Synthase 2 3 4 5
  • Microsomal Glutathione S-Transferase 1-Like 1 2 3 4
  • MGST1-L1 2 3 4
  • PIG12 2 3 4
  • Tumor Protein P53 Inducible Protein 12 2 3
  • Microsomal Prostaglandin E Synthase-1 2 3
  • Glutathione S-Transferase 1-Like 1 2 3
  • Glutathione Transferase PTGES 3 4
  • Glutathione Peroxidase PTGES 3 4
  • P53-Induced Gene 12 Protein 3 4
  • MGST1-Like 1 2 3
  • MGST-IV 2 3
  • MGST1L1 3 4
  • TP53I12 2 3
  • MPGES-1 3 4
  • PGES 3 4
  • Microsomal Prostaglandin E Synthase 1 4
  • P53-Induced Apoptosis Protein 12 3
  • P53-Induced Gene 12 2
  • EC 5.3.99.3 4
  • EC 1.11.1.- 4
  • EC 2.5.1.18 4
  • PP1294 3
  • MPGES1 4
  • MPGES 3
  • PP102 3
  • PTGES 5

External Ids for PTGES Gene

Previous HGNC Symbols for PTGES Gene

  • MGST1L1

Previous GeneCards Identifiers for PTGES Gene

  • GC09M123615
  • GC09M124147
  • GC09M125954
  • GC09M127876
  • GC09M129580
  • GC09M131540
  • GC09M132500
  • GC09M102099

Summaries for PTGES Gene

Entrez Gene Summary for PTGES Gene

  • The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGES Gene

PTGES (Prostaglandin E Synthase) is a Protein Coding gene. Diseases associated with PTGES include Arthritis and Gastritis. Among its related pathways are PEDF Induced Signaling and Metabolism. Gene Ontology (GO) annotations related to this gene include glutathione binding and prostaglandin-E synthase activity. An important paralog of this gene is MGST1.

UniProtKB/Swiss-Prot Summary for PTGES Gene

  • Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:18682561, PubMed:10377395, PubMed:12672824, PubMed:12460774, PubMed:10869354, PubMed:12244105). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824).

Gene Wiki entry for PTGES Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTGES Gene

Genomics for PTGES Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTGES Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTGES on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTGES

Top Transcription factor binding sites by QIAGEN in the PTGES gene promoter:
  • AML1a
  • STAT3

Genomic Locations for PTGES Gene

Latest Assembly
chr9:129,738,331-129,753,042
(GRCh38/hg38)
Size:
14,712 bases
Orientation:
Minus strand

Previous Assembly
chr9:132,500,628-132,515,321
(GRCh37/hg19 by Entrez Gene)
Size:
14,694 bases
Orientation:
Minus strand

chr9:132,500,610-132,515,326
(GRCh37/hg19 by Ensembl)
Size:
14,717 bases
Orientation:
Minus strand

Genomic View for PTGES Gene

Genes around PTGES on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGES Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGES Gene

Proteins for PTGES Gene

  • Protein details for PTGES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14684-PTGES_HUMAN
    Recommended name:
    Prostaglandin E synthase
    Protein Accession:
    O14684
    Secondary Accessions:
    • O14900
    • Q5SZC0

    Protein attributes for PTGES Gene

    Size:
    152 amino acids
    Molecular mass:
    17102 Da
    Cofactor:
    Name=glutathione; Xref=ChEBI:CHEBI:57925;
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for PTGES Gene

neXtProt entry for PTGES Gene

Post-translational modifications for PTGES Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PTGES Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTGES Gene

Domains & Families for PTGES Gene

Gene Families for PTGES Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for PTGES Gene

InterPro:
Blocks:
  • Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)

Suggested Antigen Peptide Sequences for PTGES Gene

GenScript: Design optimal peptide antigens:
  • p53-induced gene 12 protein (PTGES_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14684

UniProtKB/Swiss-Prot:

PTGES_HUMAN :
  • Belongs to the MAPEG family.
Family:
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with PTGES: view

Function for PTGES Gene

Molecular function for PTGES Gene

UniProtKB/Swiss-Prot Function:
Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:18682561, PubMed:10377395, PubMed:12672824, PubMed:12460774, PubMed:10869354, PubMed:12244105). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=prostaglandin H2 = prostaglandin E2; Xref=Rhea:RHEA:12893, ChEBI:CHEBI:57405, ChEBI:CHEBI:606564; EC=5.3.99.3; Evidence={ECO:0000269|PubMed:10377395, ECO:0000269|PubMed:10869354, ECO:0000269|PubMed:12244105, ECO:0000269|PubMed:12460774, ECO:0000269|PubMed:12672824, ECO:0000269|PubMed:16439136, ECO:0000269|PubMed:18682561, ECO:0000269|PubMed:26755582, ECO:0000269|PubMed:27684486};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin E2; Xref=Rhea:RHEA:53324, ChEBI:CHEBI:85166, ChEBI:CHEBI:137172; Evidence={ECO:0000269|PubMed:12244105};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2; Xref=Rhea:RHEA:64364, ChEBI:CHEBI:82629, ChEBI:CHEBI:152564; Evidence={ECO:0000269|PubMed:12672824};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+); Xref=Rhea:RHEA:51220, ChEBI:CHEBI:15378, ChEBI:CHEBI:17996, ChEBI:CHEBI:34718, ChEBI:CHEBI:57925, ChEBI:CHEBI:133977; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:12672824, ECO:0000269|PubMed:27684486};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:48620, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90632; Evidence={ECO:0000269|PubMed:12244105};.
UniProtKB/Swiss-Prot Induction:
Induced by the interleukin IL1B (PubMed:10377395, PubMed:10760517). Induced By p53/TP53 (PubMed:9305847).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=75 uM for glutathione {ECO:0000269|PubMed:12460774}; KM=160 uM for prostaglandin H2 (at 37 degrees) {ECO:0000269|PubMed:12672824}; KM=71 uM for glutathione (at 37 degrees) {ECO:0000269|PubMed:12672824}; KM=160 uM for prostaglandin G2 (at 37 degrees) {ECO:0000269|PubMed:12672824}; KM=14 uM for prostaglandin H2 {ECO:0000269|PubMed:12460774}; KM=130 uM for prostaglandin H2 {ECO:0000269|PubMed:16439136}; Vmax=170 umol/min/mg enzyme with prostaglandin H2 as substrate {ECO:0000269|PubMed:12672824}; Note=kcat is 50 sec(-1) for prostaglandin H2 as substrate (PubMed:12672824). kcat is 75 sec(-1) for prostaglandin H2 as substrate (PubMed:12672824). kcat is 21 sec(-1) for glutathione as substrate (PubMed:12672824). {ECO:0000269|PubMed:12672824};
UniProtKB/Swiss-Prot EnzymeRegulation:
Induced by interleukin IL1B.

Enzyme Numbers (IUBMB) for PTGES Gene

Phenotypes From GWAS Catalog for PTGES Gene

Gene Ontology (GO) - Molecular Function for PTGES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IEA,IDA 12672824
GO:0004602 glutathione peroxidase activity IDA 12244105
GO:0004667 prostaglandin-D synthase activity IEA --
GO:0005515 protein binding IPI 32296183
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with PTGES: view
genes like me logo Genes that share phenotypes with PTGES: view

Animal Models for PTGES Gene

MGI Knock Outs for PTGES:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGES

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGES Gene

Localization for PTGES Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGES Gene

Membrane. Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment. {ECO:0000269 PubMed:10869354}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGES gene
Compartment Confidence
extracellular 3
nucleus 3
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PTGES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005641 nuclear envelope lumen IEA --
GO:0005737 cytoplasm IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane TAS 10377395
GO:0016021 integral component of membrane IBA,IDA 18682561
genes like me logo Genes that share ontologies with PTGES: view

Pathways & Interactions for PTGES Gene

genes like me logo Genes that share pathways with PTGES: view

Pathways by source for PTGES Gene

2 KEGG pathways for PTGES Gene
2 GeneGo (Thomson Reuters) pathways for PTGES Gene
  • Neurophysiological process PGE2-induced pain processing
  • Prostaglandin 2 biosynthesis and metabolism FM
1 Qiagen pathway for PTGES Gene
  • all-trans-Retinoic Acid Signaling in Brain

UniProtKB/Swiss-Prot O14684-PTGES_HUMAN

  • Pathway: Lipid metabolism; prostaglandin biosynthesis.

SIGNOR curated interactions for PTGES Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PTGES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IBA,IDA 18682561
GO:0002526 acute inflammatory response IEA --
GO:0002544 chronic inflammatory response IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
genes like me logo Genes that share ontologies with PTGES: view

Drugs & Compounds for PTGES Gene

(13) Drugs for PTGES Gene - From: PharmGKB, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Celecoxib Approved, Investigational Pharma Selective cyclooxygenase-2 (COX-2) inhibitor 561
Flurbiprofen Approved, Investigational Pharma 78
Suprofen Approved, Withdrawn Pharma 0
Dinoprostone Approved Pharma activates the PGE2 receptor, Major endogenous prostanoid 150
Glutathione Approved, Investigational Nutra 0

(15) Additional Compounds for PTGES Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Prostaglandin H2
  • (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate
  • (5Z,13E,15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate
  • (5Z,9alpha,11alpha,13E,15S)-9,11-Epidioxy-15-hydroxyprosta-5,13-dien-1-Oic acid
  • 9,11-Epoxymethano-PGH2
  • PGH2
42935-17-1

(3) ApexBio Compounds for PTGES Gene

Compound Action Cas Number
Flurbiprofen 5104-49-4
Mesalamine 89-57-6
Suprofen 40828-46-4
genes like me logo Genes that share compounds with PTGES: view

Drug products for research

Transcripts for PTGES Gene

mRNA/cDNA for PTGES Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGES

Alternative Splicing Database (ASD) splice patterns (SP) for PTGES Gene

No ASD Table

Relevant External Links for PTGES Gene

GeneLoc Exon Structure for
PTGES

Expression for PTGES Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTGES Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGES Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.6) and Skin - Sun Exposed (Lower leg) (x4.4).

Protein differential expression in normal tissues from HIPED for PTGES Gene

This gene is overexpressed in Nasal epithelium (60.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PTGES Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTGES

SOURCE GeneReport for Unigene cluster for PTGES Gene:

Hs.146688

Evidence on tissue expression from TISSUES for PTGES Gene

  • Pancreas(4.3)
  • Intestine(2.7)
  • Lung(2.7)
  • Nervous system(2.5)
  • Heart(2.5)
  • Skin(2.4)
  • Kidney(2.3)
  • Blood(2.2)
  • Muscle(2.2)
  • Lymph node(2)
  • Spleen(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with PTGES: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGES Gene

Orthologs for PTGES Gene

This gene was present in the common ancestor of animals.

Orthologs for PTGES Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PTGES 29 30
  • 99.12 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PTGES 29 30
  • 88.81 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PTGES 29 30
  • 88.38 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ptges 29 16 30
  • 83.33 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ptges 29
  • 82.46 (n)
Oppossum
(Monodelphis domestica)
Mammalia PTGES 30
  • 67 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PTGES 30
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PTGES 29 30
  • 74.13 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PTGES 30
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ptges 29
  • 69.01 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19439 29
Zebrafish
(Danio rerio)
Actinopterygii ptges 29 30
  • 66.17 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Mgstl 30
  • 34 (a)
ManyToMany
CG33178 30
  • 30 (a)
ManyToMany
CG33177 30
  • 28 (a)
ManyToMany
Species where no ortholog for PTGES was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PTGES Gene

ENSEMBL:
Gene Tree for PTGES (if available)
TreeFam:
Gene Tree for PTGES (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTGES: view image
Alliance of Genome Resources:
Additional Orthologs for PTGES

Paralogs for PTGES Gene

Paralogs for PTGES Gene

(1) SIMAP similar genes for PTGES Gene using alignment to 1 proteins:

  • PTGES_HUMAN
genes like me logo Genes that share paralogs with PTGES: view

Variants for PTGES Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTGES Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs142287855 Benign: not provided 129,748,684(-) C/T
NM_004878.5(PTGES):c.180G>A (p.Arg60=)
SYNONYMOUS
rs146562511 Likely Benign: not provided 129,752,999(-) C/T
NM_004878.5(PTGES):c.14G>A (p.Ser5Asn)
MISSENSE
rs1588184967 Uncertain Significance: not provided 129,739,766(-) G/A
NM_004878.5(PTGES):c.304C>T (p.His102Tyr)
MISSENSE
rs3205181 Benign: not provided 129,748,681(-) G/A
NM_004878.5(PTGES):c.183C>T (p.Ser61=)
SYNONYMOUS
rs45499692 Benign: not provided 129,752,993(-) A/T
NM_004878.5(PTGES):c.20T>A (p.Val7Glu)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PTGES Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PTGES Gene

Variant ID Type Subtype PubMed ID
dgv1511e214 CNV gain 21293372
esv3621839 CNV loss 21293372
nsv1046477 CNV gain 25217958
nsv6728 CNV deletion 18451855

Variation tolerance for PTGES Gene

Gene Damage Index Score: 1.35; 26.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTGES Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGES
Leiden Open Variation Database (LOVD)
PTGES

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGES Gene

Disorders for PTGES Gene

MalaCards: The human disease database

(8) MalaCards diseases for PTGES Gene - From: COP and GCD

Disorder Aliases PubMed IDs
arthritis
  • inflammatory disorder of joint
gastritis
  • acute gastric mucosal erosion
endometrial disease
  • endometrial disorder
primary hypertrophic osteoarthropathy
  • pachydermoperiostosis of nail
gastroesophageal reflux
  • ger
- elite association - COSMIC cancer census association via MalaCards
Search PTGES in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PTGES

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PTGES: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGES Gene

Publications for PTGES Gene

  1. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PMID: 20086108) Poole EM … Ulrich CM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 22 40
  2. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PMID: 19046748) Lemaitre RN … Psaty BM (Atherosclerosis 2009) 3 22 40
  3. Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. (PMID: 19276290) Abraham JE … Pharoah PD (Clinical cancer research : an official journal of the American Association for Cancer Research 2009) 3 22 40
  4. Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphoma. (PMID: 18038187) Hoeft B … Nieters A (Cancer causes & control : CCC 2008) 3 22 40
  5. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. (PMID: 15167446) Iwai N … Shioji K (Journal of hypertension 2004) 3 22 40

Products for PTGES Gene

Sources for PTGES Gene