Aliases for PTGER4 Gene
Aliases for PTGER4 Gene
External Ids for PTGER4 Gene
- HGNC: 9596
- Entrez Gene: 5734
- Ensembl: ENSG00000171522
- OMIM: 601586
- UniProtKB: P35408
Previous GeneCards Identifiers for PTGER4 Gene
- GC05P040986
- GC05P041772
- GC05P040680
- GC05P040725
- GC05P040715
- GC05P040632
Summaries for PTGER4 Gene
-
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
GeneCards Summary for PTGER4 Gene
PTGER4 (Prostaglandin E Receptor 4) is a Protein Coding gene. Diseases associated with PTGER4 include Malignant Epithelial Mesothelioma and Epididymis Cancer. Among its related pathways are PI3K-Akt signaling pathway and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is PTGIR.
UniProtKB/Swiss-Prot for PTGER4 Gene
-
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
-
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.
Additional gene information for PTGER4 Gene
- Monarch Initiative
- Search for PTGER4 at DataMed
- Search for PTGER4 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGER4 Gene
Genomics for PTGER4 Gene
GeneHancer (GH) Regulatory Elements for PTGER4 Gene
Promoters and enhancers for PTGER4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PTGER4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PTGER4 gene promoter:
Regulatory Element Products
Genomic Locations for PTGER4 Gene
Genomic Locations for PTGER4 Gene
- chr5:40,679,498-40,741,764
- (GRCh38/hg38)
- Size:
- 62,267 bases
- Orientation:
- Plus strand
- chr5:40,679,600-40,693,837
- (GRCh37/hg19)
Genomic View for PTGER4 Gene
Genes around PTGER4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p13.1 by Ensembl
- 5p13.1 by Entrez Gene
- 5p13.1 by HGNC
PTGER4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTGER4 Gene
Proteins for PTGER4 Gene
-
Protein details for PTGER4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35408-PE2R4_HUMAN
- Recommended name:
- Prostaglandin E2 receptor EP4 subtype
- Protein Accession:
- P35408
- Q3MJ87
Protein attributes for PTGER4 Gene
- Size:
- 488 amino acids
- Molecular mass:
- 53119 Da
- Quaternary structure:
-
- Interacts with FEM1A.
Protein Expression for PTGER4 Gene
Post-translational modifications for PTGER4 Gene
- Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention.
- Ubiquitination at isoforms=468
- Glycosylation at isoforms=7
- Modification sites at PhosphoSitePlus
Other Protein References for PTGER4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PTGER4
-
Abcam antibodies for PTGER4
- Invitrogen Antibodies for PTGER4
- GeneTex PTGER4 antibody for PTGER4
-
Santa Cruz Biotechnology (SCBT) Antibodies for PTGER4
Protein Products
-
OriGene Purified Proteins for PTGER4
- Search Origene for MassSpec and Protein Over-expression Lysates for PTGER4
- Origene Custom Protein Services for PTGER4
- Search GeneTex for Proteins for PTGER4
-
Abcam proteins for PTGER4
Assay Products
No data available for DME Specific Peptides for PTGER4 Gene
Domains & Families for PTGER4 Gene
Gene Families for PTGER4 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for PTGER4 Gene
Suggested Antigen Peptide Sequences for PTGER4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P35408- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for PTGER4 Gene
Molecular function for PTGER4 Gene
- GENATLAS Biochemistry:
- prostaglandin E4 receptor,subtype EP4,G protein coupled receptor superfamily,expressed in peripheral leukocytes with alternatively transcripts in spleen and thymus
- UniProtKB/Swiss-Prot Function:
- Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
Phenotypes From GWAS Catalog for PTGER4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
| GO:0004955 | prostaglandin receptor activity | IEA | -- |
| GO:0004957 | prostaglandin E receptor activity | IDA | 8163486 |
| GO:0005515 | protein binding | IPI | 16424369 |
Phenotypes for PTGER4 Gene
- MGI mutant phenotypes for PTGER4:
-
inferred from 5 alleles
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- neoplasm
- integument phenotype
- hematopoietic system phenotype
- skeleton phenotype
- liver/biliary system phenotype
- GenomeRNAi human phenotypes for PTGER4:
Animal Models for PTGER4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PTGER4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PTGER4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGER4 gene
- Search ViGene Biosciences for PTGER4
CRISPR Products
-
OriGene CRISPR knockouts for PTGER4
- genomics-online: gRNA clones - Search results for 110 available PTGER4 gene related products
- Overview of 110 available PTGER4 gene related products
- Applied Biological Materials CRISPR for PTGER4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGER4
- GenScript: Design CRISPR guide RNA sequences for PTGER4
miRNA for PTGER4 Gene
- miRTarBase miRNAs that target PTGER4
miRNA Products
- Search ViGene Biosciences for PTGER4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PTGER4
- Browse OriGene Inhibitory RNA Products For PTGER4
- genomics-online: shRNA clones - Search results for 110 available PTGER4 gene related products
- Overview of 110 available PTGER4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGER4 gene
Clone Products
- Sino Biological Human cDNA Clone for PTGER4
- VectorBuilder custom plasmid, inducible vectors for PTGER4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTGER4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PTGER4
- Applied Biological Materials Clones for PTGER4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for PTGER4 (PTGER4/EP4)
Cell Line Products
-
Horizon Cell Lines for PTGER4
-
ViGene Biosciences adenoviral particle packaged cDNA for PTGER4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PTGER4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGER4 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGER4 Gene
Localization for PTGER4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTGER4 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | NAS | 8163486 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGER4 Gene
Pathways & Interactions for PTGER4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Eicosanoid ligand-binding receptors | ||
| 3 | Signaling by GPCR | ||
| 4 | PI3K-Akt signaling pathway | ||
| 5 | Development Endothelin-1/EDNRA signaling | ||
Pathways by source for PTGER4 Gene
3 BioSystems pathways for PTGER4 Gene
8 Reactome pathways for PTGER4 Gene
2 PharmGKB pathways for PTGER4 Gene
5 KEGG pathways for PTGER4 Gene
1 GeneGo (Thomson Reuters) pathway for PTGER4 Gene
1 Qiagen pathway for PTGER4 Gene
Interacting Proteins for PTGER4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006955 | immune response | IEP | 8862514 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
| GO:0007188 | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | IDA | 8163486 |
| GO:0007254 | JNK cascade | ISS | -- |
No data available for SIGNOR curated interactions for PTGER4 Gene
Drugs & Compounds for PTGER4 Gene
(60) Drugs for PTGER4 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Iloprost | Approved, Investigational | Pharma | Full agonist, Agonist, agonist | Prostacyclin (PGI2) analog, Others | 83 | |
| Misoprostol | Approved | Pharma | Target, agonist | 323 | ||
| Dinoprostone | Approved | Pharma | Target, agonist, antagonist | 99 | ||
| Treprostinil | Approved, Investigational | Pharma | Full agonist, Agonist, agonist | 92 | ||
| Limaprost | Approved, Investigational | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| PGF<sub>2alpha</sub> |
|
Full agonist, Agonist |
|
(5) Tocris Compounds for PTGER4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| (+-)-Cloprostenol sodium salt | Water-soluble PGF2alpha analog and potent FP receptor agonist | 55028-72-3 |
| BMY 45778 | Non-prostanoid prostacyclin IP receptor partial agonist | 152575-66-1 |
| Iloprost | Prostacyclin (PGI2) analog | 78919-13-8 |
| Prostaglandin E2 | Major endogenous prostanoid | 363-24-6 |
| U 46619 | Potent, stable thromboxane A2 (TP) receptor agonist | 56985-40-1 |
(3) ApexBio Compounds for PTGER4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| MK-2894 | EP4 receptor inhibitor | 1006036-87-8 |
| MK-2894 sodium salt | EP4 antagonist | 1006036-88-9 |
| ONO-AE3-208 | EP4 receptor inhibitor,high affinity and selective | 402473-54-5 |
Transcripts for PTGER4 Gene
mRNA/cDNA for PTGER4 Gene
- (5) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (95) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PTGER4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PTGER4
- genomics-online: gRNA clones - Search results for 110 available PTGER4 gene related products
- Overview of 110 available PTGER4 gene related products
- Applied Biological Materials CRISPR for PTGER4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGER4
- GenScript: Design CRISPR guide RNA sequences for PTGER4
miRNA Products
- Search ViGene Biosciences for PTGER4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PTGER4
- Browse OriGene Inhibitory RNA Products For PTGER4
- genomics-online: shRNA clones - Search results for 110 available PTGER4 gene related products
- Overview of 110 available PTGER4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PTGER4 gene
Clone Products
- Sino Biological Human cDNA Clone for PTGER4
- VectorBuilder custom plasmid, inducible vectors for PTGER4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTGER4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PTGER4
- Applied Biological Materials Clones for PTGER4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for PTGER4 (PTGER4/EP4)
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||
| SP2: |
Expression for PTGER4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
- Inner Cell Mass (Early Embryonic Tissues)
- Endothelium (Cardiovascular System)
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
-
Epithelial Cells
- Duct Cells Pancreatic Ducts
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Eye (Sensory Organs)
- Umbilical Cord (Extraembryonic Tissues)
- NULL (Uncategorized)
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for PTGER4 Gene
This gene is overexpressed in Whole Blood (x4.8) and Pancreas (x4.5).
This gene is overexpressed in Vitreous humor (38.1), Cardia (22.7), and Lung (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTGER4 Gene
NURSA nuclear receptor signaling pathways regulating expression of PTGER4 Gene:
PTGER4SOURCE GeneReport for Unigene cluster for PTGER4 Gene:
Hs.199248mRNA Expression by UniProt/SwissProt for PTGER4 Gene:
P35408-PE2R4_HUMAN
Tissue specificity:
High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.
Evidence on tissue expression from TISSUES for PTGER4 Gene
- Lung(4.6)
- Nervous system(4.4)
- Blood(2.7)
- Bone marrow(2.6)
- Intestine(2.6)
- Kidney(2.4)
- Lymph node(2.3)
- Stomach(2.2)
- Muscle(2.1)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for PTGER4
-
OriGene qPCR primer pairs and template standards for PTGER4
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGER4 Gene
Orthologs for PTGER4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PTGER4 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PTGER4 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PTGER4 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ptger4 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ptger4 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PTGER4 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PTGER4 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | EP4 34 |
|
OneToOne | |
| PTGER4 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | PTGER4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ptger4 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ptger4a 34 |
|
OneToMany | |
| ptger4b 33 34 |
|
- Species where no ortholog for PTGER4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PTGER4 Gene
(4) SIMAP similar genes for PTGER4 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for PTGER4 Gene
Variants for PTGER4 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs111866313 | benign, not specified | 40,691,791(+) | G/A | 3_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant, synonymous_variant | |
| rs1000074054 | -- | 40,695,014(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000102264 | -- | 40,679,929(+) | G/A | upstream_transcript_variant | |
| rs1000154750 | -- | 40,741,137(+) | T/A | downstream_transcript_variant | |
| rs1000176147 | -- | 40,694,561(+) | T/G | genic_downstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.00;
20.61% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PTGER4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PTGER4 Gene
Disorders for PTGER4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| malignant epithelial mesothelioma |
|
|
| epididymis cancer |
|
|
| epididymis adenocarcinoma |
|
|
| papillary thymic adenocarcinoma |
|
|
| lymphocytic colitis |
|
|
Search PTGER4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PTGER4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PTGER4 Gene
Publications for PTGER4 Gene
- The structure of the prostaglandin EP4 receptor gene and related pseudogenes. (PMID: 8661119) Foord SM … Lee MG (Genomics 1996) 2 3 4 22 58
- Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PMID: 20086108) Poole EM … Ulrich CM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 22 44 58
- Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma. (PMID: 17496729) Kim SH … Min KU (Pharmacogenetics and genomics 2007) 3 22 44 58
- Identification of a Ser/Thr cluster in the C-terminal domain of the human prostaglandin receptor EP4 that is essential for agonist-induced beta-arrestin1 recruitment but differs from the apparent principal phosphorylation site. (PMID: 14709160) Neuschäfer-Rube F … Püschel GP (The Biochemical journal 2004) 3 4 22 58
- Sequestration and phosphorylation of the prostaglandin E2 EP4 receptor: dependence on the C-terminal tail. (PMID: 11597569) Slipetz D … Metters KM (Biochemical pharmacology 2001) 3 4 22 58
Products for PTGER4 Gene
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTGER4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PTGER4
- antibodies-online: Search results for 80 available PTGER4 Antibodies ranked by validation data
- Compare Top PTGER4 Antibodies
- antibodies-online: Search results for available PTGER4 related products ranked by validation data
- antibodies-online: Search results for 8 available PTGER4 Proteins ranked by validation data
- Compare Top PTGER4 Proteins
- Quality Products:
- GeneTex PTGER4 antibody for PTGER4
- Search GeneTex for Proteins for PTGER4
- ViGene Biosciences adenoviral particle packaged cDNA for PTGER4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PTGER4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PTGER4 gene
- Search ViGene Biosciences for PTGER4
- Santa Cruz Biotechnology (SCBT) Antibodies for PTGER4
- Search Santa Cruz Biotechnology (SCBT) for PTGER4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PTGER4
- Horizon Cell Lines for PTGER4
- genomics-online: cdna clones - Search results for 110 available PTGER4 gene related products
- Overview of 110 available PTGER4 gene related products
- orf clones - Search results for 110 available PTGER4 gene related products
- Overview of 110 available PTGER4 gene related products
- genomics-online: gRNA clones - Search results for 110 available PTGER4 gene related products
- Overview of 110 available PTGER4 gene related products
- genomics-online: primer clones - Search results for 110 available PTGER4 gene related products
- Overview of 110 available PTGER4 gene related products
- genomics-online: shRNA clones - Search results for 110 available PTGER4 gene related products
- Overview of 110 available PTGER4 gene related products
Sources for PTGER4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
