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Aliases for PTGER4 Gene

Aliases for PTGER4 Gene

  • Prostaglandin E Receptor 4 2 3 5
  • Prostaglandin E Receptor 4 (Subtype EP4) 2 3
  • PGE2 Receptor EP4 Subtype 3 4
  • Prostanoid EP4 Receptor 3 4
  • Prostaglandin E2 Receptor EP4 Subtype 3
  • PGE Receptor, EP4 Subtype 3
  • PGE Receptor EP4 Subtype 4
  • PTGER2 4
  • EP4R 3
  • EP4 3

External Ids for PTGER4 Gene

Previous GeneCards Identifiers for PTGER4 Gene

  • GC05P040986
  • GC05P041772
  • GC05P040680
  • GC05P040725
  • GC05P040715
  • GC05P040632

Summaries for PTGER4 Gene

Entrez Gene Summary for PTGER4 Gene

  • The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGER4 Gene

PTGER4 (Prostaglandin E Receptor 4) is a Protein Coding gene. Diseases associated with PTGER4 include Malignant Epithelial Mesothelioma and Epididymis Cancer. Among its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is PTGIR.

UniProtKB/Swiss-Prot for PTGER4 Gene

  • Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

Tocris Summary for PTGER4 Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGER4 Gene

Additional gene information for PTGER4 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGER4 Gene

Genomics for PTGER4 Gene

GeneHancer (GH) Regulatory Elements for PTGER4 Gene

Promoters and enhancers for PTGER4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J040674 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 664.5 +2.9 2918 15.8 ATF1 PKNOX1 SIN3A FEZF1 ZNF2 BRCA1 YY1 GLIS2 ARID2 ZNF143 PTGER4 CARD6 TTC33 PRKAA1 GC05M040716
GH05J040404 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 31.7 -271.3 -271312 8 CTCF ELF3 MEIS2 JUN MAX ZBTB40 ZNF644 YY1 RELA HIC1 PTGER4 RPL37 CARD6 PRKAA1 GC05M039678 LOC105374736
GH05J040435 Enhancer 1.2 FANTOM5 Ensembl ENCODE 30.9 -242.3 -242300 2.6 PKNOX1 JUN RAD21 ZNF316 SMC3 RCOR1 ATF7 FOS FOSL2 MAFK PTGER4 RPL37 CARD6 ENSG00000283286 GC05P040507
GH05J040381 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 22.5 -295.5 -295508 5.6 CLOCK JUN MAX EBF1 RELA CTBP1 GATA3 RCOR1 FOSL2 FOS PTGER4 RPL37 CARD6 PRKAA1 GC05M039678 LOC105374736
GH05J040440 Enhancer 1.3 FANTOM5 Ensembl ENCODE 21.9 -237.3 -237288 2.6 ELF3 FOXA2 ZNF614 CREM IKZF2 THAP11 ELF1 ETV4 IKZF1 CEBPA PTGER4 CARD6 PRKAA1 ENSG00000283286 GC05P040507
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTGER4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTGER4 gene promoter:
  • AP-2alphaA
  • AP-2alpha isoform 4
  • AP-2alpha isoform 3
  • AP-2alpha isoform 2
  • AP-2alpha
  • C/EBPalpha
  • CREB
  • deltaCREB
  • PPAR-gamma2
  • PPAR-gamma1

Genomic Locations for PTGER4 Gene

Genomic Locations for PTGER4 Gene
chr5:40,679,498-40,741,764
(GRCh38/hg38)
Size:
62,267 bases
Orientation:
Plus strand
chr5:40,679,600-40,693,837
(GRCh37/hg19)
Size:
14,238 bases
Orientation:
Plus strand

Genomic View for PTGER4 Gene

Genes around PTGER4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGER4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGER4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGER4 Gene

Proteins for PTGER4 Gene

  • Protein details for PTGER4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35408-PE2R4_HUMAN
    Recommended name:
    Prostaglandin E2 receptor EP4 subtype
    Protein Accession:
    P35408
    Secondary Accessions:
    • Q3MJ87

    Protein attributes for PTGER4 Gene

    Size:
    488 amino acids
    Molecular mass:
    53119 Da
    Quaternary structure:
    • Interacts with FEM1A.

neXtProt entry for PTGER4 Gene

Post-translational modifications for PTGER4 Gene

  • Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention.
  • Glycosylation at Asn7
  • Ubiquitination at Lys468
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGER4 Gene

No data available for DME Specific Peptides for PTGER4 Gene

Domains & Families for PTGER4 Gene

Gene Families for PTGER4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for PTGER4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35408

UniProtKB/Swiss-Prot:

PE2R4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGER4: view

Function for PTGER4 Gene

Molecular function for PTGER4 Gene

UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
GENATLAS Biochemistry:
prostaglandin E4 receptor,subtype EP4,G protein coupled receptor superfamily,expressed in peripheral leukocytes with alternatively transcripts in spleen and thymus

Phenotypes From GWAS Catalog for PTGER4 Gene

Gene Ontology (GO) - Molecular Function for PTGER4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,IBA --
GO:0004955 prostaglandin receptor activity IEA --
GO:0004957 prostaglandin E receptor activity IDA 8163486
GO:0005515 protein binding IPI 16424369
genes like me logo Genes that share ontologies with PTGER4: view
genes like me logo Genes that share phenotypes with PTGER4: view

Animal Models for PTGER4 Gene

MGI Knock Outs for PTGER4:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGER4 Gene

Localization for PTGER4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGER4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGER4 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for PTGER4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 8163486
genes like me logo Genes that share ontologies with PTGER4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGER4 Gene

Pathways & Interactions for PTGER4 Gene

genes like me logo Genes that share pathways with PTGER4: view

Gene Ontology (GO) - Biological Process for PTGER4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IEP 8862514
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IDA 8163486
genes like me logo Genes that share ontologies with PTGER4: view

No data available for SIGNOR curated interactions for PTGER4 Gene

Drugs & Compounds for PTGER4 Gene

(59) Drugs for PTGER4 Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dinoprostone Approved Pharma antagonist, Target, agonist activates the PGE2 receptor, Major endogenous prostanoid 99
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist Others, Prostacyclin (PGI2) analog 83
Misoprostol Approved Pharma Target, agonist 323
Treprostinil Approved, Investigational Pharma Full agonist, Agonist, agonist 92
Limaprost Approved, Investigational Pharma Target 0

(21) Additional Compounds for PTGER4 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PGF<sub>2alpha</sub>
Full agonist, Agonist
(+-)-Cloprostenol sodium salt
55028-72-3

(5) Tocris Compounds for PTGER4 Gene

Compound Action Cas Number
(+-)-Cloprostenol sodium salt Water-soluble PGF2alpha analog and potent FP receptor agonist 55028-72-3
BMY 45778 Non-prostanoid prostacyclin IP receptor partial agonist 152575-66-1
Iloprost Prostacyclin (PGI2) analog 78919-13-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1
genes like me logo Genes that share compounds with PTGER4: view

Transcripts for PTGER4 Gene

Unigene Clusters for PTGER4 Gene

Prostaglandin E receptor 4 (subtype EP4):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGER4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for PTGER4 Gene

GeneLoc Exon Structure for
PTGER4
ECgene alternative splicing isoforms for
PTGER4

Expression for PTGER4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTGER4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGER4 Gene

This gene is overexpressed in Whole Blood (x4.8) and Pancreas (x4.5).

Protein differential expression in normal tissues from HIPED for PTGER4 Gene

This gene is overexpressed in Vitreous humor (38.1), Cardia (22.7), and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTGER4 Gene



Protein tissue co-expression partners for PTGER4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PTGER4 Gene:

PTGER4

SOURCE GeneReport for Unigene cluster for PTGER4 Gene:

Hs.199248

mRNA Expression by UniProt/SwissProt for PTGER4 Gene:

P35408-PE2R4_HUMAN
Tissue specificity: High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.

Evidence on tissue expression from TISSUES for PTGER4 Gene

  • Lung(4.6)
  • Nervous system(4.4)
  • Blood(2.7)
  • Bone marrow(2.6)
  • Intestine(2.6)
  • Kidney(2.4)
  • Lymph node(2.4)
  • Stomach(2.2)
  • Muscle(2.1)
  • Heart(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with PTGER4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGER4 Gene

Orthologs for PTGER4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGER4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGER4 34 33
  • 99.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PTGER4 34 33
  • 90.1 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PTGER4 34 33
  • 88.73 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptger4 33
  • 86.6 (n)
mouse
(Mus musculus)
Mammalia Ptger4 16 34 33
  • 86.46 (n)
oppossum
(Monodelphis domestica)
Mammalia PTGER4 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTGER4 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves EP4 34
  • 76 (a)
OneToOne
PTGER4 33
  • 74.59 (n)
lizard
(Anolis carolinensis)
Reptilia PTGER4 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptger4 33
  • 68.47 (n)
zebrafish
(Danio rerio)
Actinopterygii ptger4a 34
  • 67 (a)
OneToMany
ptger4b 34 33
  • 63.35 (n)
OneToMany
Species where no ortholog for PTGER4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGER4 Gene

ENSEMBL:
Gene Tree for PTGER4 (if available)
TreeFam:
Gene Tree for PTGER4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTGER4: view image

Paralogs for PTGER4 Gene

Paralogs for PTGER4 Gene

(4) SIMAP similar genes for PTGER4 Gene using alignment to 2 proteins:

  • PE2R4_HUMAN
  • A0PJF5_HUMAN

Pseudogenes.org Pseudogenes for PTGER4 Gene

genes like me logo Genes that share paralogs with PTGER4: view

Variants for PTGER4 Gene

Sequence variations from dbSNP and Humsavar for PTGER4 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs111866313 benign, not specified 40,691,791(+) G/A 3_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant, synonymous_variant
rs1000074054 -- 40,695,014(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000102264 -- 40,679,929(+) G/A upstream_transcript_variant
rs1000154750 -- 40,741,137(+) T/A downstream_transcript_variant
rs1000176147 -- 40,694,561(+) T/G genic_downstream_transcript_variant, intron_variant

Variation tolerance for PTGER4 Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTGER4 Gene

Human Gene Mutation Database (HGMD)
PTGER4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGER4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PTGER4 Gene

Disorders for PTGER4 Gene

MalaCards: The human disease database

(31) MalaCards diseases for PTGER4 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malignant epithelial mesothelioma
  • epithelioid mesothelioma, malignant
epididymis cancer
  • malignant epididymal tumor
epididymis adenocarcinoma
  • adenocarcinoma of the epididymis
papillary thymic adenocarcinoma
  • papillary carcinoma of the thymus
lymphocytic colitis
  • colitis, lymphocytic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PTGER4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PTGER4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGER4 Gene

Publications for PTGER4 Gene

  1. The structure of the prostaglandin EP4 receptor gene and related pseudogenes. (PMID: 8661119) Foord SM … Lee MG (Genomics 1996) 2 3 4 22 58
  2. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PMID: 20086108) Poole EM … Ulrich CM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 22 44 58
  3. Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma. (PMID: 17496729) Kim SH … Min KU (Pharmacogenetics and genomics 2007) 3 22 44 58
  4. Identification of a Ser/Thr cluster in the C-terminal domain of the human prostaglandin receptor EP4 that is essential for agonist-induced beta-arrestin1 recruitment but differs from the apparent principal phosphorylation site. (PMID: 14709160) Neuschäfer-Rube F … Püschel GP (The Biochemical journal 2004) 3 4 22 58
  5. Sequestration and phosphorylation of the prostaglandin E2 EP4 receptor: dependence on the C-terminal tail. (PMID: 11597569) Slipetz D … Metters KM (Biochemical pharmacology 2001) 3 4 22 58

Products for PTGER4 Gene

Sources for PTGER4 Gene

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