The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may als... See more...

Aliases for PTGER3 Gene

Aliases for PTGER3 Gene

  • Prostaglandin E Receptor 3 2 3 5
  • Prostaglandin E Receptor 3 (Subtype EP3) 2 3
  • Prostaglandin E2 Receptor EP3 Subtype 3 4
  • PGE2 Receptor EP3 Subtype 3 4
  • Prostanoid EP3 Receptor 3 4
  • PGE2-R 3 4
  • Prostaglandin E Receotor EP3 Subtype 3 Isoform 3
  • Prostaglandin Receptor (PGE-2) 3
  • PGE Receptor, EP3 Subtype 3
  • PGE Receptor EP3 Subtype 4
  • EP3-III 3
  • EP3-II 3
  • EP3-IV 3
  • EP3-VI 3
  • EP3-I 3
  • EP3e 3
  • EP3 3

External Ids for PTGER3 Gene

Previous GeneCards Identifiers for PTGER3 Gene

  • GC01M071442
  • GC01M070241
  • GC01M070702
  • GC01M070688
  • GC01M070687
  • GC01M071030
  • GC01M071318
  • GC01M069428

Summaries for PTGER3 Gene

Entrez Gene Summary for PTGER3 Gene

  • The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for PTGER3 Gene

PTGER3 (Prostaglandin E Receptor 3) is a Protein Coding gene. Diseases associated with PTGER3 include Ocular Hyperemia and Antenatal Bartter Syndrome. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is PTGER1.

UniProtKB/Swiss-Prot Summary for PTGER3 Gene

  • Receptor for prostaglandin E2 (PGE2) (PubMed:8307176, PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium (PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity).

Tocris Summary for PTGER3 Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGER3 Gene

Additional gene information for PTGER3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTGER3 Gene

Genomics for PTGER3 Gene

GeneHancer (GH) Regulatory Elements for PTGER3 Gene

Promoters and enhancers for PTGER3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J071044 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 533.3 +1.2 1165 3.5 NRF1 ZIC2 ZNF423 ZBTB26 TARDBP MYC TOE1 CTBP1 JUN PRPF4 PTGER3 ZRANB2-AS1 SRSF11 ZRANB2 ENSG00000269933
GH01J070674 Enhancer 1.1 Ensembl ENCODE 18 +372.1 372093 1.8 SIX5 PHB2 ZBTB11 TARDBP HES1 MYC RUNX1 CTBP1 HDAC3 NCOR1 PTGER3 ZRANB2-AS1 MIR186 ZRANB2 lnc-PTGER3-9 CASP3P1 LINC01788
GH01J071037 Enhancer 0.4 dbSUPER 35.3 +9.5 9513 2.6 CEBPG CEBPB PKNOX1 CBFA2T3 IKZF1 PTGER3 ZRANB2-AS1 lnc-CTH-13
GH01J071026 Enhancer 0.4 dbSUPER 34.9 +19.6 19593 3 USF1 MITF ATF2 USF2 ATF7 PTGER3 ENSG00000235782 MIR186 ZRANB2 lnc-CTH-13 ZRANB2-AS1 lnc-CTH-14
GH01J070978 Enhancer 0.6 Ensembl 24.3 +67.9 67913 3 TEAD4 ZNF316 MAFF CEBPG MAFK SPI1 MAFG GATA2 ATF4 ATF2 PTGER3 ENSG00000235782 lnc-CTH-12 ENSG00000269933 lnc-CTH-14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTGER3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTGER3

Top Transcription factor binding sites by QIAGEN in the PTGER3 gene promoter:
  • TBP

Genomic Locations for PTGER3 Gene

Genomic Locations for PTGER3 Gene
chr1:70,852,353-71,047,814
(GRCh38/hg38)
Size:
195,462 bases
Orientation:
Minus strand
chr1:71,318,036-71,513,491
(GRCh37/hg19)
Size:
195,456 bases
Orientation:
Minus strand

Genomic View for PTGER3 Gene

Genes around PTGER3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGER3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGER3 Gene

Proteins for PTGER3 Gene

  • Protein details for PTGER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43115-PE2R3_HUMAN
    Recommended name:
    Prostaglandin E2 receptor EP3 subtype
    Protein Accession:
    P43115
    Secondary Accessions:
    • B0AZN4
    • B1AK19
    • B5BUP5
    • O00326
    • Q12943
    • Q12944
    • Q12945
    • Q147X8
    • Q16546
    • Q5CZ59
    • Q5CZ61
    • Q5CZ62
    • Q5CZ63
    • Q5CZ64

    Protein attributes for PTGER3 Gene

    Size:
    390 amino acids
    Molecular mass:
    43310 Da
    Quaternary structure:
    • Interacts (via C-terminus) with MKLN1.
    Miscellaneous:
    • [Isoform EP3C]: Known as EP3D in Ref.7.
    • [Isoform EP3B]: Known as EP3E in Ref.7.
    • [Isoform EP3D]: Known as EP3F in Ref.7.
    SequenceCaution:
    • Sequence=CAA58742.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PTGER3 Gene

    Alternative splice isoforms for PTGER3 Gene

neXtProt entry for PTGER3 Gene

Post-translational modifications for PTGER3 Gene

  • Glycosylation at Asn18 and Asn36
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PTGER3 Gene

Domains & Families for PTGER3 Gene

Gene Families for PTGER3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for PTGER3 Gene

Blocks:
  • Prostaglandin receptor signature
  • Prostanoid EP3 receptor signature
  • Prostanoid EP3 receptor type 2 signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PTGER3 Gene

GenScript: Design optimal peptide antigens:
  • Prostaglandin E receptor 3 subtype EP3 isoform 4 (B2KKV4_HUMAN)
  • Prostanoid EP3 receptor (PE2R3_HUMAN)
  • PTGER3 protein (Q147U0_HUMAN)
  • EP3e protein (Q5CZ59_HUMAN)
  • EP3-VI protein (Q5CZ61_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P43115

UniProtKB/Swiss-Prot:

PE2R3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGER3: view

Function for PTGER3 Gene

Molecular function for PTGER3 Gene

UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin E2 (PGE2) (PubMed:8307176, PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium (PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity).
GENATLAS Biochemistry:
prostaglandin E2 receptor,subtype EP3,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for PTGER3 Gene

Gene Ontology (GO) - Molecular Function for PTGER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004955 prostaglandin receptor activity IEA --
GO:0004957 prostaglandin E receptor activity NAS,TAS 9073510
genes like me logo Genes that share ontologies with PTGER3: view
genes like me logo Genes that share phenotypes with PTGER3: view

Animal Models for PTGER3 Gene

MGI Knock Outs for PTGER3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGER3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGER3 Gene

Localization for PTGER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGER3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGER3 gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PTGER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005635 nuclear envelope TAS 10336471
GO:0005886 plasma membrane IBA,TAS --
GO:0005887 integral component of plasma membrane TAS 8307176
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PTGER3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGER3 Gene

Pathways & Interactions for PTGER3 Gene

genes like me logo Genes that share pathways with PTGER3: view

Pathways by source for PTGER3 Gene

SIGNOR curated interactions for PTGER3 Gene

Gene Ontology (GO) - Biological Process for PTGER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA 21873635
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with PTGER3: view

Drugs & Compounds for PTGER3 Gene

(46) Drugs for PTGER3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bimatoprost Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 143
Dinoprostone Approved Pharma antagonist, Target, agonist activates the PGE2 receptor, Major endogenous prostanoid 128
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist Prostacyclin (PGI2) analog, Others 92
Misoprostol Approved Pharma Target, agonist 402
Treprostinil Approved, Investigational Pharma Full agonist, Agonist, agonist 108

(18) Additional Compounds for PTGER3 Gene - From: IUPHAR, Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
L-826266 (sodium salt)
Antagonist
PGF<sub>2alpha</sub>
Full agonist, Agonist
sodium
  • Na(+)
  • Na+
  • SODIUM ion
7440-23-5
(+-)-Cloprostenol sodium salt
55028-72-3

(5) Tocris Compounds for PTGER3 Gene

Compound Action Cas Number
(+-)-Cloprostenol sodium salt Water-soluble PGF2alpha analog and potent FP receptor agonist 55028-72-3
BMY 45778 Non-prostanoid prostacyclin IP receptor partial agonist 152575-66-1
Iloprost Prostacyclin (PGI2) analog 78919-13-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1

(3) ApexBio Compounds for PTGER3 Gene

Compound Action Cas Number
Alprostadil 745-65-3
Bimatoprost 155206-00-1
BMY 45778 Type I IL-1 receptor antagonist 152575-66-1
genes like me logo Genes that share compounds with PTGER3: view

Drug Products

Transcripts for PTGER3 Gene

mRNA/cDNA for PTGER3 Gene

11 REFSEQ mRNAs :
42 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGER3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGER3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: -
SP6: - - - - - - - - -
SP7:

Relevant External Links for PTGER3 Gene

GeneLoc Exon Structure for
PTGER3

Expression for PTGER3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTGER3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGER3 Gene

This gene is overexpressed in Uterus (x8.2), Adipose - Visceral (Omentum) (x5.2), Adipose - Subcutaneous (x5.1), and Kidney - Cortex (x5.0).

Protein differential expression in normal tissues from HIPED for PTGER3 Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTGER3 Gene



Protein tissue co-expression partners for PTGER3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTGER3

SOURCE GeneReport for Unigene cluster for PTGER3 Gene:

Hs.445000

mRNA Expression by UniProt/SwissProt for PTGER3 Gene:

P43115-PE2R3_HUMAN
Tissue specificity: Detected in kidney (PubMed:8117308, PubMed:8135729). Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels.

Evidence on tissue expression from TISSUES for PTGER3 Gene

  • Kidney(4.7)
  • Intestine(4.4)
  • Lung(4.4)
  • Stomach(2.2)
  • Nervous system(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with PTGER3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGER3 Gene

Orthologs for PTGER3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGER3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGER3 31 30
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PTGER3 30
  • 88.95 (n)
cow
(Bos Taurus)
Mammalia PTGER3 31 30
  • 86.43 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ptger3 17 31 30
  • 83.93 (n)
rat
(Rattus norvegicus)
Mammalia Ptger3 30
  • 83.38 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 68 (a)
OneToMany
-- 31
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves PTGER3 30
  • 77.11 (n)
EP3 31
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGER3 31
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptger3 30
  • 68.66 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100000544 30
  • 61.69 (n)
ptger3 31
  • 53 (a)
OneToOne
Species where no ortholog for PTGER3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGER3 Gene

ENSEMBL:
Gene Tree for PTGER3 (if available)
TreeFam:
Gene Tree for PTGER3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTGER3: view image

Paralogs for PTGER3 Gene

Paralogs for PTGER3 Gene

(6) SIMAP similar genes for PTGER3 Gene using alignment to 7 proteins:

  • PE2R3_HUMAN
  • B1AK19_HUMAN
  • B2KKV4_HUMAN
  • O00325_HUMAN
  • Q147U0_HUMAN
  • Q147X8_HUMAN
  • Q6TTN3_HUMAN
genes like me logo Genes that share paralogs with PTGER3: view

Variants for PTGER3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTGER3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs13306014 - p.Asn366Ser
rs13306020 - p.Thr319Met
rs5670 - p.Met169Leu
rs5694 - p.Pro375Leu

Additional dbSNP identifiers (rs#s) for PTGER3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PTGER3 Gene

Variant ID Type Subtype PubMed ID
dgv177n100 CNV loss 25217958
dgv22e214 CNV loss 21293372
esv2138101 CNV deletion 18987734
esv2672048 CNV deletion 23128226
esv2762149 CNV loss 21179565
esv3342245 CNV insertion 20981092
esv3577913 CNV loss 25503493
esv3577914 CNV loss 25503493
esv3586370 CNV loss 21293372
esv3586371 CNV loss 21293372
esv3893657 CNV loss 25118596
esv994407 CNV insertion 20482838
nsv461851 CNV gain 19166990
nsv516212 CNV loss 19592680
nsv546471 CNV loss 21841781
nsv546472 CNV gain 21841781
nsv546473 CNV gain 21841781
nsv830148 CNV gain 17160897

Variation tolerance for PTGER3 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTGER3 Gene

Human Gene Mutation Database (HGMD)
PTGER3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGER3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGER3 Gene

Disorders for PTGER3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PTGER3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ocular hyperemia
  • hyperemia eye
antenatal bartter syndrome
  • bartter syndrome, furosemide type
severe cutaneous adverse reaction
  • sjs
lung cancer susceptibility 3
  • lncr3
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PTGER3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PTGER3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGER3 Gene

Publications for PTGER3 Gene

  1. Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). (PMID: 9073510) Kotani M … Nakao K (Genomics 1997) 2 3 4 23 54
  2. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman KK … Jacobsson B (PloS one 2010) 3 23 41 54
  3. Association between genetic variations in prostaglandin E2 receptor subtype EP3 gene (Ptger3) and asthma in the Korean population. (PMID: 17877755) Park HW … Cho SH (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007) 3 23 41 54
  4. A new mRNA splice variant coding for the human EP3-I receptor isoform. (PMID: 18023986) Kotelevets L … Norel X (Prostaglandins, leukotrienes, and essential fatty acids 2007) 3 4 23 54
  5. Chromosomal localization of the human prostanoid receptor gene family. (PMID: 7759114) Duncan AM … Adam M (Genomics 1995) 2 3 23 54

Products for PTGER3 Gene

Sources for PTGER3 Gene