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Aliases for PTGER3 Gene

Aliases for PTGER3 Gene

  • Prostaglandin E Receptor 3 2 3 5
  • Prostaglandin E Receptor 3 (Subtype EP3) 2 3
  • PGE2 Receptor EP3 Subtype 3 4
  • Prostanoid EP3 Receptor 3 4
  • PGE2-R 3 4
  • Prostaglandin E Receotor EP3 Subtype 3 Isoform 3
  • Prostaglandin E2 Receptor EP3 Subtype 3
  • Prostaglandin Receptor (PGE-2) 3
  • PGE Receptor, EP3 Subtype 3
  • PGE Receptor EP3 Subtype 4
  • EP3-III 3
  • EP3-II 3
  • EP3-IV 3
  • EP3-VI 3
  • EP3-I 3
  • EP3e 3
  • EP3 3

External Ids for PTGER3 Gene

Previous GeneCards Identifiers for PTGER3 Gene

  • GC01M071442
  • GC01M070241
  • GC01M070702
  • GC01M070688
  • GC01M070687
  • GC01M071030
  • GC01M071318
  • GC01M069428

Summaries for PTGER3 Gene

Entrez Gene Summary for PTGER3 Gene

  • The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for PTGER3 Gene

PTGER3 (Prostaglandin E Receptor 3) is a Protein Coding gene. Diseases associated with PTGER3 include Mast Cell Neoplasm and Antenatal Bartter Syndrome. Among its related pathways are Eicosanoid ligand-binding receptors and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is PTGER1.

UniProtKB/Swiss-Prot for PTGER3 Gene

  • Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).

Tocris Summary for PTGER3 Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGER3 Gene

Additional gene information for PTGER3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGER3 Gene

Genomics for PTGER3 Gene

GeneHancer (GH) Regulatory Elements for PTGER3 Gene

Promoters and enhancers for PTGER3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J071046 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 655.6 +0.5 532 1.9 ATF1 POLR2B ZNF766 ATF7 SP3 GTF2B ZNF592 CBX8 GLIS1 MEIS2 PTGER3 ZRANB2-AS1 SRSF11
GH01J071016 Enhancer 0.4 dbSUPER 47.4 +27.8 27754 7.1 ZNF184 ZSCAN4 RCOR1 PTGER3 ZRANB2-AS1 ENSG00000235782 MIR186 ZRANB2 GC01M071006
GH01J070674 Enhancer 1 ENCODE 18 +372.1 372063 1.7 PKNOX1 SMAD1 ATF1 ARNT NCOA2 TCF12 CBX5 GATA2 ATF7 RUNX3 PTGER3 ZRANB2-AS1 MIR186 ZRANB2 CASP3P1 LINC01788
GH01J071037 Enhancer 0.5 dbSUPER 35.3 +9.5 9513 2.6 PKNOX1 CEBPB CBFA2T3 CEBPG PTGER3 ZRANB2-AS1 GC01M071006
GH01J071026 Enhancer 0.5 dbSUPER 34.9 +19.6 19593 3 MITF USF1 ATF7 ATF2 PTGER3 ENSG00000235782 MIR186 ZRANB2 ZRANB2-AS1 GC01M071006
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTGER3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTGER3 gene promoter:
  • TBP

Genomic Locations for PTGER3 Gene

Genomic Locations for PTGER3 Gene
chr1:70,852,353-71,047,814
(GRCh38/hg38)
Size:
195,462 bases
Orientation:
Minus strand
chr1:71,318,036-71,513,491
(GRCh37/hg19)
Size:
195,456 bases
Orientation:
Minus strand

Genomic View for PTGER3 Gene

Genes around PTGER3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGER3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGER3 Gene

Proteins for PTGER3 Gene

  • Protein details for PTGER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43115-PE2R3_HUMAN
    Recommended name:
    Prostaglandin E2 receptor EP3 subtype
    Protein Accession:
    P43115
    Secondary Accessions:
    • B0AZN4
    • B1AK19
    • B5BUP5
    • O00326
    • Q12943
    • Q12944
    • Q12945
    • Q147X8
    • Q16546
    • Q5CZ59
    • Q5CZ61
    • Q5CZ62
    • Q5CZ63
    • Q5CZ64

    Protein attributes for PTGER3 Gene

    Size:
    390 amino acids
    Molecular mass:
    43310 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA58742.1; Type=Frameshift; Positions=374; Evidence={ECO:0000305};

    Alternative splice isoforms for PTGER3 Gene

neXtProt entry for PTGER3 Gene

Post-translational modifications for PTGER3 Gene

  • Glycosylation at Asn36 and Asn18
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PTGER3 Gene

Domains & Families for PTGER3 Gene

Gene Families for PTGER3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

P43115

UniProtKB/Swiss-Prot:

PE2R3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGER3: view

Function for PTGER3 Gene

Molecular function for PTGER3 Gene

UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).
GENATLAS Biochemistry:
prostaglandin E2 receptor,subtype EP3,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for PTGER3 Gene

Gene Ontology (GO) - Molecular Function for PTGER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA,IEA --
GO:0004955 prostaglandin receptor activity IEA --
GO:0004957 prostaglandin E receptor activity NAS,TAS 9073510
genes like me logo Genes that share ontologies with PTGER3: view
genes like me logo Genes that share phenotypes with PTGER3: view

Animal Models for PTGER3 Gene

MGI Knock Outs for PTGER3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGER3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGER3 Gene

Localization for PTGER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGER3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGER3 gene
Compartment Confidence
plasma membrane 5
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for PTGER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS 10336471
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8307176
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9073510
genes like me logo Genes that share ontologies with PTGER3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGER3 Gene

Pathways & Interactions for PTGER3 Gene

genes like me logo Genes that share pathways with PTGER3: view

SIGNOR curated interactions for PTGER3 Gene

Activates:

Gene Ontology (GO) - Biological Process for PTGER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007189 NOT adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with PTGER3: view

Drugs & Compounds for PTGER3 Gene

(46) Drugs for PTGER3 Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bimatoprost Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 136
Dinoprostone Approved Pharma antagonist, Target, agonist activates the PGE2 receptor, Major endogenous prostanoid 99
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist Others, Prostacyclin (PGI2) analog 83
Misoprostol Approved Pharma Target, agonist 323
Treprostinil Approved, Investigational Pharma Full agonist, Agonist, agonist 92

(18) Additional Compounds for PTGER3 Gene - From: Novoseek, IUPHAR, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
L-826266 (sodium salt)
Antagonist
PGF<sub>2alpha</sub>
Full agonist, Agonist
sodium
  • Na(+)
  • Na+
  • SODIUM ion
7440-23-5
(+-)-Cloprostenol sodium salt
55028-72-3

(5) Tocris Compounds for PTGER3 Gene

Compound Action Cas Number
(+-)-Cloprostenol sodium salt Water-soluble PGF2alpha analog and potent FP receptor agonist 55028-72-3
BMY 45778 Non-prostanoid prostacyclin IP receptor partial agonist 152575-66-1
Iloprost Prostacyclin (PGI2) analog 78919-13-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1
genes like me logo Genes that share compounds with PTGER3: view

Transcripts for PTGER3 Gene

mRNA/cDNA for PTGER3 Gene

Unigene Clusters for PTGER3 Gene

Prostaglandin E receptor 3 (subtype EP3):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGER3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGER3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: -
SP6: - - - - - - - - -
SP7:

Relevant External Links for PTGER3 Gene

GeneLoc Exon Structure for
PTGER3
ECgene alternative splicing isoforms for
PTGER3

Expression for PTGER3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTGER3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGER3 Gene

This gene is overexpressed in Uterus (x8.2), Adipose - Visceral (Omentum) (x5.2), Adipose - Subcutaneous (x5.1), and Kidney - Cortex (x5.0).

Protein differential expression in normal tissues from HIPED for PTGER3 Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTGER3 Gene



Protein tissue co-expression partners for PTGER3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PTGER3 Gene:

PTGER3

SOURCE GeneReport for Unigene cluster for PTGER3 Gene:

Hs.445000

mRNA Expression by UniProt/SwissProt for PTGER3 Gene:

P43115-PE2R3_HUMAN
Tissue specificity: Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels.

Evidence on tissue expression from TISSUES for PTGER3 Gene

  • Kidney(4.7)
  • Intestine(4.4)
  • Lung(4.4)
  • Stomach(2.2)
  • Nervous system(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with PTGER3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGER3 Gene

Orthologs for PTGER3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGER3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTGER3 34 33
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PTGER3 33
  • 88.95 (n)
cow
(Bos Taurus)
Mammalia PTGER3 34 33
  • 86.43 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ptger3 16 34 33
  • 83.93 (n)
rat
(Rattus norvegicus)
Mammalia Ptger3 33
  • 83.38 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
OneToMany
-- 34
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves PTGER3 33
  • 77.11 (n)
EP3 34
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTGER3 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptger3 33
  • 68.66 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100000544 33
  • 61.69 (n)
ptger3 34
  • 53 (a)
OneToOne
Species where no ortholog for PTGER3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGER3 Gene

ENSEMBL:
Gene Tree for PTGER3 (if available)
TreeFam:
Gene Tree for PTGER3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTGER3: view image

Paralogs for PTGER3 Gene

Paralogs for PTGER3 Gene

(6) SIMAP similar genes for PTGER3 Gene using alignment to 7 proteins:

  • PE2R3_HUMAN
  • B1AK19_HUMAN
  • B2KKV4_HUMAN
  • O00325_HUMAN
  • Q147U0_HUMAN
  • Q147X8_HUMAN
  • Q6TTN3_HUMAN
genes like me logo Genes that share paralogs with PTGER3: view

Variants for PTGER3 Gene

Sequence variations from dbSNP and Humsavar for PTGER3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000031976 -- 70,950,671(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000034830 -- 71,008,387(-) T/A 3_prime_UTR_variant, intron_variant
rs1000042859 -- 71,016,244(-) C/T intron_variant
rs1000087594 -- 70,936,616(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000089240 -- 70,944,824(-) G/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PTGER3 Gene

Variant ID Type Subtype PubMed ID
dgv177n100 CNV loss 25217958
dgv22e214 CNV loss 21293372
esv2138101 CNV deletion 18987734
esv2672048 CNV deletion 23128226
esv2762149 CNV loss 21179565
esv3342245 CNV insertion 20981092
esv3577913 CNV loss 25503493
esv3577914 CNV loss 25503493
esv3586370 CNV loss 21293372
esv3586371 CNV loss 21293372
esv3893657 CNV loss 25118596
esv994407 CNV insertion 20482838
nsv461851 CNV gain 19166990
nsv516212 CNV loss 19592680
nsv546471 CNV loss 21841781
nsv546472 CNV gain 21841781
nsv546473 CNV gain 21841781
nsv830148 CNV gain 17160897

Variation tolerance for PTGER3 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTGER3 Gene

Human Gene Mutation Database (HGMD)
PTGER3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGER3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGER3 Gene

Disorders for PTGER3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PTGER3 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mast cell neoplasm
  • mast cell proliferative disease
antenatal bartter syndrome
  • bartter syndrome, furosemide type
chronic conjunctivitis
severe cutaneous adverse reaction
  • sjs
ocular hyperemia
  • hyperemia eye
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PTGER3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PTGER3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGER3 Gene

Publications for PTGER3 Gene

  1. Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). (PMID: 9073510) Kotani M … Nakao K (Genomics 1997) 2 3 4 22 58
  2. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman KK … Jacobsson B (PloS one 2010) 3 22 44 58
  3. Association between genetic variations in prostaglandin E2 receptor subtype EP3 gene (Ptger3) and asthma in the Korean population. (PMID: 17877755) Park HW … Cho SH (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007) 3 22 44 58
  4. A new mRNA splice variant coding for the human EP3-I receptor isoform. (PMID: 18023986) Kotelevets L … Norel X (Prostaglandins, leukotrienes, and essential fatty acids 2007) 3 4 22 58
  5. Chromosomal localization of the human prostanoid receptor gene family. (PMID: 7759114) Duncan AM … Adam M (Genomics 1995) 2 3 22 58

Products for PTGER3 Gene

Sources for PTGER3 Gene

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