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Aliases for PTGER2 Gene

Aliases for PTGER2 Gene

  • Prostaglandin E Receptor 2 2 3 5
  • Prostaglandin E Receptor 2 (Subtype EP2), 53kDa 2 3
  • Prostaglandin E Receptor 2 (Subtype EP2), 53kD 2 3
  • PGE2 Receptor EP2 Subtype 3 4
  • PGE Receptor EP2 Subtype 3 4
  • Prostanoid EP2 Receptor 3 4
  • Prostaglandin E2 Receptor EP2 Subtype 3
  • EP2 3

External Ids for PTGER2 Gene

Previous GeneCards Identifiers for PTGER2 Gene

  • GC14P050103
  • GC14P046577
  • GC14P050771
  • GC14P051850
  • GC14P052781
  • GC14P032941

Summaries for PTGER2 Gene

Entrez Gene Summary for PTGER2 Gene

  • This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]

GeneCards Summary for PTGER2 Gene

PTGER2 (Prostaglandin E Receptor 2) is a Protein Coding gene. Diseases associated with PTGER2 include Asthma, Nasal Polyps, And Aspirin Intolerance and Deafness, Autosomal Dominant 17. Among its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is PTGDR.

UniProtKB/Swiss-Prot for PTGER2 Gene

  • Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

Tocris Summary for PTGER2 Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGER2 Gene

Additional gene information for PTGER2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGER2 Gene

Genomics for PTGER2 Gene

GeneHancer (GH) Regulatory Elements for PTGER2 Gene

Promoters and enhancers for PTGER2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J052311 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 672.6 +1.2 1164 8.7 PKNOX1 SIN3A ZNF2 IRF4 GLIS2 RUNX3 SP3 JUNB MAFF ZNF610 PTGER2 GNG2 TXNDC16 RTRAF GC14P052338 GC14M052143
GH14J052324 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 24 +12.3 12282 5 BACH1 STAT5A BATF IRF4 RELA ZNF316 NFATC1 EED ATF7 FOSL2 PTGER2 GNG2 TXNDC16 GC14P052338 GC14M052143
GH14J052353 Enhancer 1 Ensembl ENCODE dbSUPER 17.3 +40.9 40858 2.6 NFIB ZSCAN4 FOXA1 OSR2 SP1 ZNF217 CTBP1 JUND PRDM6 POLR2A PTGER2 GPR137C TXNDC16 GC14P052338 GC14M052426 GC14M052143
GH14J051865 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -446.5 -446492 4.7 STAT5A EBF1 EED ATF7 ETV6 IKZF2 CREM RUNX3 SMARCA5 ATF2 GNG2 RTRAF PTGER2 PTGDR LOC102723604
GH14J052349 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.3 +37.4 37376 4 PKNOX1 INSM2 MZF1 BMI1 FEZF1 BATF IRF4 ZSCAN5C IKZF2 RUNX3 PTGER2 GPR137C GC14P052338 GC14M052426 GC14M052143
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTGER2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTGER2 gene promoter:
  • Max
  • c-Myc
  • Sox9
  • ZIC2
  • Pax-2
  • Pax-2a
  • Pax-2b
  • TBP
  • Nkx2-2

Genomic Locations for PTGER2 Gene

Genomic Locations for PTGER2 Gene
14,309 bases
Plus strand
14,309 bases
Plus strand

Genomic View for PTGER2 Gene

Genes around PTGER2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGER2 Gene

Proteins for PTGER2 Gene

  • Protein details for PTGER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prostaglandin E2 receptor EP2 subtype
    Protein Accession:
    Secondary Accessions:
    • D3DSC0
    • Q52LG8

    Protein attributes for PTGER2 Gene

    358 amino acids
    Molecular mass:
    39761 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PTGER2 Gene

Post-translational modifications for PTGER2 Gene

  • Glycosylation at Asn287, Asn96, Asn6, and Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGER2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTGER2 Gene

Domains & Families for PTGER2 Gene

Gene Families for PTGER2 Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for PTGER2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGER2: view

Function for PTGER2 Gene

Molecular function for PTGER2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
GENATLAS Biochemistry:
prostaglandin E2 receptor,subtype EP2,G protein coupled receptor superfamily,expressed in peripheral leukocytes with alternatively transcripts in spleen and thymus

Phenotypes From GWAS Catalog for PTGER2 Gene

Gene Ontology (GO) - Molecular Function for PTGER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,IBA --
GO:0004957 prostaglandin E receptor activity IBA,TAS --
genes like me logo Genes that share ontologies with PTGER2: view
genes like me logo Genes that share phenotypes with PTGER2: view

Animal Models for PTGER2 Gene

MGI Knock Outs for PTGER2:

Animal Model Products

miRNA for PTGER2 Gene

miRTarBase miRNAs that target PTGER2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGER2 Gene

Localization for PTGER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGER2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGER2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for PTGER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10462542
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTGER2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGER2 Gene

Pathways & Interactions for PTGER2 Gene

genes like me logo Genes that share pathways with PTGER2: view

SIGNOR curated interactions for PTGER2 Gene


Gene Ontology (GO) - Biological Process for PTGER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway ISS,IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IBA --
genes like me logo Genes that share ontologies with PTGER2: view

Drugs & Compounds for PTGER2 Gene

(62) Drugs for PTGER2 Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dinoprostone Approved Pharma antagonist, Target, agonist activates the PGE2 receptor, Major endogenous prostanoid 99
Misoprostol Approved Pharma Target, agonist 323
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist Others, Prostacyclin (PGI2) analog 83
Alprostadil Approved, Investigational Pharma antagonist, Target, agonist 71
Aspirin Approved, Vet_approved Pharma Channel blocker 1232

(29) Additional Compounds for PTGER2 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist
Full agonist, Agonist
(+-)-Cloprostenol sodium salt

(5) Tocris Compounds for PTGER2 Gene

Compound Action Cas Number
(+-)-Cloprostenol sodium salt Water-soluble PGF2alpha analog and potent FP receptor agonist 55028-72-3
BMY 45778 Non-prostanoid prostacyclin IP receptor partial agonist 152575-66-1
Iloprost Prostacyclin (PGI2) analog 78919-13-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1
genes like me logo Genes that share compounds with PTGER2: view

Transcripts for PTGER2 Gene

mRNA/cDNA for PTGER2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTGER2 Gene

Prostaglandin E receptor 2 (subtype EP2), 53kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTGER2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b

Relevant External Links for PTGER2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTGER2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTGER2 Gene

mRNA differential expression in normal tissues according to GTEx for PTGER2 Gene

This gene is overexpressed in Whole Blood (x12.4).

Protein differential expression in normal tissues from HIPED for PTGER2 Gene

This gene is overexpressed in Lung (55.8) and Peripheral blood mononuclear cells (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTGER2 Gene

Protein tissue co-expression partners for PTGER2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTGER2 Gene:


SOURCE GeneReport for Unigene cluster for PTGER2 Gene:


mRNA Expression by UniProt/SwissProt for PTGER2 Gene:

Tissue specificity: Placenta and lung.
genes like me logo Genes that share expression patterns with PTGER2: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGER2 Gene

Orthologs for PTGER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGER2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTGER2 34 33
  • 99.35 (n)
(Canis familiaris)
Mammalia PTGER2 34 33
  • 90.4 (n)
(Bos Taurus)
Mammalia PTGER2 34 33
  • 87.22 (n)
(Mus musculus)
Mammalia Ptger2 16 34 33
  • 83.94 (n)
(Rattus norvegicus)
Mammalia Ptger2 33
  • 83.9 (n)
(Monodelphis domestica)
Mammalia PTGER2 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia PTGER2 34
  • 63 (a)
(Gallus gallus)
Aves PTGER2 34 33
  • 65.5 (n)
(Anolis carolinensis)
Reptilia PTGER2 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ptger2 33
  • 62.92 (n)
(Danio rerio)
Actinopterygii ptger2b 34 33
  • 51.85 (n)
ptger2a 34
  • 41 (a)
Species where no ortholog for PTGER2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PTGER2 Gene

Gene Tree for PTGER2 (if available)
Gene Tree for PTGER2 (if available)
Evolutionary constrained regions (ECRs) for PTGER2: view image

Paralogs for PTGER2 Gene

Paralogs for PTGER2 Gene

(3) SIMAP similar genes for PTGER2 Gene using alignment to 2 proteins:

  • G3V2Y6_HUMAN
genes like me logo Genes that share paralogs with PTGER2: view

Variants for PTGER2 Gene

Sequence variations from dbSNP and Humsavar for PTGER2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000084931 -- 52,314,287(+) G/C upstream_transcript_variant
rs1000481160 -- 52,322,574(+) T/C intron_variant
rs1000698474 -- 52,324,159(+) A/C intron_variant
rs1000703813 -- 52,323,910(+) T/C intron_variant
rs1000918468 -- 52,317,647(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PTGER2 Gene

Variant ID Type Subtype PubMed ID
esv3634521 CNV gain 21293372
nsv832795 CNV gain 17160897

Variation tolerance for PTGER2 Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTGER2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGER2 Gene

Disorders for PTGER2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PTGER2 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PTGER2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PTGER2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGER2 Gene

Publications for PTGER2 Gene

  1. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PMID: 20086108) Poole EM … Ulrich CM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 22 44 58
  2. Chromosomal localization of the human prostanoid receptor gene family. (PMID: 7759114) Duncan AM … Adam M (Genomics 1995) 2 3 22 58
  3. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. (PMID: 8078484) Regan JW … Gil DW (Molecular pharmacology 1994) 3 4 22 58
  4. Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2. (PMID: 8250933) An S … Goetzl EJ (Biochemical and biophysical research communications 1993) 2 3 22 58
  5. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 44 58

Products for PTGER2 Gene

Sources for PTGER2 Gene

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