Aliases for PTGER2 Gene
External Ids for PTGER2 Gene
Previous GeneCards Identifiers for PTGER2 Gene
This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]
GeneCards Summary for PTGER2 Gene
PTGER2 (Prostaglandin E Receptor 2) is a Protein Coding gene. Diseases associated with PTGER2 include Asthma, Nasal Polyps, And Aspirin Intolerance and Asthma. Among its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is PTGDR.
UniProtKB/Swiss-Prot Summary for PTGER2 Gene
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.