Aliases for PTGER2 Gene
Aliases for PTGER2 Gene
External Ids for PTGER2 Gene
- HGNC: 9594
- Entrez Gene: 5732
- Ensembl: ENSG00000125384
- OMIM: 176804
- UniProtKB: P43116
Previous GeneCards Identifiers for PTGER2 Gene
- GC14P050103
- GC14P046577
- GC14P050771
- GC14P051850
- GC14P052781
- GC14P032941
Summaries for PTGER2 Gene
-
This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]
GeneCards Summary for PTGER2 Gene
PTGER2 (Prostaglandin E Receptor 2) is a Protein Coding gene. Diseases associated with PTGER2 include Asthma, Nasal Polyps, And Aspirin Intolerance and Deafness, Autosomal Dominant 17. Among its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is PTGDR.
UniProtKB/Swiss-Prot for PTGER2 Gene
-
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
-
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.
Additional gene information for PTGER2 Gene
- Monarch Initiative
- Search for PTGER2 at DataMed
- Search for PTGER2 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTGER2 Gene
Genomics for PTGER2 Gene
GeneHancer (GH) Regulatory Elements for PTGER2 Gene
Promoters and enhancers for PTGER2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PTGER2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PTGER2 gene promoter:
-
- Max
- c-Myc
- Sox9
- ZIC2
- Pax-2
- Pax-2a
- Pax-2b
- TFIID
- TBP
- Nkx2-2
Regulatory Element Products
Genomic Locations for PTGER2 Gene
Genomic Locations for PTGER2 Gene
- chr14:52,314,298-52,328,606
- (GRCh38/hg38)
- Size:
- 14,309 bases
- Orientation:
- Plus strand
- chr14:52,781,016-52,795,324
- (GRCh37/hg19)
- Size:
- 14,309 bases
- Orientation:
- Plus strand
Genomic View for PTGER2 Gene
Genes around PTGER2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q22.1 by Entrez Gene
- 14q22.1 by HGNC
- 14q22.1 by Ensembl
PTGER2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTGER2 Gene
Proteins for PTGER2 Gene
-
Protein details for PTGER2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P43116-PE2R2_HUMAN
- Recommended name:
- Prostaglandin E2 receptor EP2 subtype
- Protein Accession:
- P43116
- D3DSC0
- Q52LG8
Protein attributes for PTGER2 Gene
- Size:
- 358 amino acids
- Molecular mass:
- 39761 Da
- Quaternary structure:
- No Data Available
Protein Expression for PTGER2 Gene
Post-translational modifications for PTGER2 Gene
Other Protein References for PTGER2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PTGER2 (PTGER2)
- Novus Biologicals Antibodies for PTGER2
-
Abcam antibodies for PTGER2
- Invitrogen Antibodies for PTGER2 (AFLGC-PTGER2)
- GeneTex PTGER2 Antibody for PTGER2
Protein Products
-
OriGene Purified Proteins for PTGER2
- Search Origene for MassSpec and Protein Over-expression Lysates for PTGER2
- Origene Custom Protein Services for PTGER2
- Search GeneTex for Proteins for PTGER2
-
Abcam proteins for PTGER2
Assay Products
No data available for DME Specific Peptides for PTGER2 Gene
Domains & Families for PTGER2 Gene
Gene Families for PTGER2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for PTGER2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PTGER2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P43116- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for PTGER2 Gene
Molecular function for PTGER2 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
- GENATLAS Biochemistry:
- prostaglandin E2 receptor,subtype EP2,G protein coupled receptor superfamily,expressed in peripheral leukocytes with alternatively transcripts in spleen and thymus
Phenotypes From GWAS Catalog for PTGER2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IEA,IBA | -- |
| GO:0004957 | prostaglandin E receptor activity | IBA,TAS | -- |
Phenotypes for PTGER2 Gene
- MGI mutant phenotypes for PTGER2:
-
inferred from 6 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- reproductive system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- GenomeRNAi human phenotypes for PTGER2:
-
- Decreased viability ratio
- Effect on mitosis
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Decreased shRNA abundance (Z-score < -2)
Animal Models for PTGER2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PTGER2
-
CRISPR Products
-
OriGene CRISPR knockouts for PTGER2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTGER2
- genomics-online: gRNA clones - Search results for 71 available PTGER2 gene related products
- Overview of 71 available PTGER2 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- Applied Biological Materials CRISPR for PTGER2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGER2
- GenScript: Design CRISPR guide RNA sequences for PTGER2
miRNA for PTGER2 Gene
- miRTarBase miRNAs that target PTGER2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTGER2
- Browse OriGene Inhibitory RNA Products For PTGER2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGER2
- genomics-online: shRNA clones - Search results for 71 available PTGER2 gene related products
- Overview of 71 available PTGER2 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
Clone Products
- GenScript: Custom all cDNA clones Services for PTGER2
- Sino Biological Human cDNA Clone for PTGER2
- Addgene plasmids for PTGER2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTGER2
- genomics-online: cdna clones - Search results for 71 available PTGER2 gene related products
- Overview of 71 available PTGER2 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- orf clones - Search results for 71 available PTGER2 gene related products
- Overview of 71 available PTGER2 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- Applied Biological Materials Clones for PTGER2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for PTGER2
Cell Line Products
-
Horizon Cell Lines for PTGER2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGER2 Gene
Localization for PTGER2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTGER2 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 10462542 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGER2 Gene
Pathways & Interactions for PTGER2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Eicosanoid ligand-binding receptors | ||
| 3 | Signaling by GPCR | ||
| 4 | cAMP signaling pathway | ||
| 5 | Development Endothelin-1/EDNRA signaling | ||
Pathways by source for PTGER2 Gene
4 BioSystems pathways for PTGER2 Gene
8 Reactome pathways for PTGER2 Gene
3 PharmGKB pathways for PTGER2 Gene
5 KEGG pathways for PTGER2 Gene
1 GeneGo (Thomson Reuters) pathway for PTGER2 Gene
1 Qiagen pathway for PTGER2 Gene
Interacting Proteins for PTGER2 Gene
GPS-Prot Interaction Network for PTGER2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006954 | inflammatory response | IBA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
| GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway | ISS,IEA | -- |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | IBA | -- |
Drugs & Compounds for PTGER2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dinoprostone | Approved | Pharma | antagonist, Target, agonist | activates the PGE2 receptor, Major endogenous prostanoid | 99 | |
| Misoprostol | Approved | Pharma | Target, agonist | 323 | ||
| Iloprost | Approved, Investigational | Pharma | Full agonist, Agonist, agonist | Others, Prostacyclin (PGI2) analog | 83 | |
| Alprostadil | Approved, Investigational | Pharma | antagonist, Target, agonist | 71 | ||
| Aspirin | Approved, Vet_approved | Pharma | Channel blocker | 1232 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| CP-544326 |
|
Full agonist, Agonist |
|
|||
| PGF<sub>2alpha</sub> |
|
Full agonist, Agonist |
|
|||
| (+-)-Cloprostenol sodium salt |
|
55028-72-3 |
|
|
(5) Tocris Compounds for PTGER2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| (+-)-Cloprostenol sodium salt | Water-soluble PGF2alpha analog and potent FP receptor agonist | 55028-72-3 |
| BMY 45778 | Non-prostanoid prostacyclin IP receptor partial agonist | 152575-66-1 |
| Iloprost | Prostacyclin (PGI2) analog | 78919-13-8 |
| Prostaglandin E2 | Major endogenous prostanoid | 363-24-6 |
| U 46619 | Potent, stable thromboxane A2 (TP) receptor agonist | 56985-40-1 |
Drug Products
Transcripts for PTGER2 Gene
mRNA/cDNA for PTGER2 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (25) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000557436 643 bps (uc059bns.1)
- ENST00000245457 2383 bps (uc001wzr.4)
Unigene Clusters for PTGER2 Gene
- Prostaglandin E receptor 2 (subtype EP2), 53kDa:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PTGER2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTGER2
- genomics-online: gRNA clones - Search results for 71 available PTGER2 gene related products
- Overview of 71 available PTGER2 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- Applied Biological Materials CRISPR for PTGER2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGER2
- GenScript: Design CRISPR guide RNA sequences for PTGER2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTGER2
- Browse OriGene Inhibitory RNA Products For PTGER2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGER2
- genomics-online: shRNA clones - Search results for 71 available PTGER2 gene related products
- Overview of 71 available PTGER2 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
Clone Products
- GenScript: Custom all cDNA clones Services for PTGER2
- Sino Biological Human cDNA Clone for PTGER2
- Addgene plasmids for PTGER2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTGER2
- genomics-online: cdna clones - Search results for 71 available PTGER2 gene related products
- Overview of 71 available PTGER2 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- orf clones - Search results for 71 available PTGER2 gene related products
- Overview of 71 available PTGER2 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- Applied Biological Materials Clones for PTGER2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for PTGER2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: |
Expression for PTGER2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Crest (Gastrulation Derivatives)
- Bone (Muscoskeletal System)
- NULL (Uncategorized)
- Spleen (Hematopoietic System)
- Blood (Cardiovascular System)
- Paraxial Mesoderm (Gastrulation Derivatives)
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
- Cartilage (Muscoskeletal System)
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for PTGER2 Gene
This gene is overexpressed in Whole Blood (x12.4).
This gene is overexpressed in Lung (55.8) and Peripheral blood mononuclear cells (11.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTGER2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PTGER2 Gene:
PTGER2SOURCE GeneReport for Unigene cluster for PTGER2 Gene:
Hs.2090mRNA Expression by UniProt/SwissProt for PTGER2 Gene:
P43116-PE2R2_HUMAN
Tissue specificity:
Placenta and lung.
Primer Products
-
OriGene qPCR primer pairs for PTGER2
-
OriGene qPCR primer pairs and template standards for PTGER2
- genomics-online: primer clones - Search results for 71 available PTGER2 gene related products
- Overview of 71 available PTGER2 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
Gene Expression Assay Products
No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGER2 Gene
Orthologs for PTGER2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PTGER2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PTGER2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PTGER2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ptger2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ptger2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PTGER2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PTGER2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PTGER2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PTGER2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ptger2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ptger2b 34 33 |
|
OneToMany | |
| ptger2a 34 |
|
OneToMany |
- Species where no ortholog for PTGER2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PTGER2 Gene
- ENSEMBL:
- Gene Tree for PTGER2 (if available)
- TreeFam:
- Gene Tree for PTGER2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PTGER2: view image
Paralogs for PTGER2 Gene
Variants for PTGER2 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000084931 | -- | 52,314,287(+) | G/C | upstream_transcript_variant | |
| rs1000481160 | -- | 52,322,574(+) | T/C | intron_variant | |
| rs1000698474 | -- | 52,324,159(+) | A/C | intron_variant | |
| rs1000703813 | -- | 52,323,910(+) | T/C | intron_variant | |
| rs1000918468 | -- | 52,317,647(+) | G/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3634521 | CNV | gain | 21293372 |
| nsv832795 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.20;
24.10% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PTGER2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGER2 Gene
Disorders for PTGER2 Gene
(3) MalaCards diseases for PTGER2 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| asthma, nasal polyps, and aspirin intolerance |
|
|
| deafness, autosomal dominant 17 |
|
|
| colorectal cancer |
|
Search PTGER2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PTGER2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PTGER2 Gene
Publications for PTGER2 Gene
- Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PMID: 20086108) Poole EM … Ulrich CM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 22 44 58
- Chromosomal localization of the human prostanoid receptor gene family. (PMID: 7759114) Duncan AM … Adam M (Genomics 1995) 2 3 22 58
- Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. (PMID: 8078484) Regan JW … Gil DW (Molecular pharmacology 1994) 3 4 22 58
- Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2. (PMID: 8250933) An S … Goetzl EJ (Biochemical and biophysical research communications 1993) 2 3 22 58
- Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 44 58
Products for PTGER2 Gene
- R&D Systems Antibodies for PTGER2 (PTGER2)
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- R&D Systems cDNA Clones for PTGER2
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- antibodies-online: Search results for 107 available PTGER2 Antibodies ranked by validation data
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- GeneTex PTGER2 Antibody for PTGER2
- Search GeneTex for Proteins for PTGER2
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- Horizon Cell Lines for PTGER2
- genomics-online: cdna clones - Search results for 71 available PTGER2 gene related products
- Overview of 71 available PTGER2 gene related products
- Recommended
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- genomics-online: gRNA clones - Search results for 71 available PTGER2 gene related products
- Overview of 71 available PTGER2 gene related products
- Recommended
- pCMV6-Entry
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- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- genomics-online: primer clones - Search results for 71 available PTGER2 gene related products
- Overview of 71 available PTGER2 gene related products
- Recommended
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- genomics-online: shRNA clones - Search results for 71 available PTGER2 gene related products
- Overview of 71 available PTGER2 gene related products
- Recommended
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-His-GST
- pPB-C-His
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTGER2
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- GeneCopoeia miRNA 3'UTR Target clone products for PTGER2
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Sources for PTGER2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
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- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
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- (41) dbSNP
- (42) GenAtlas
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- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
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- (50) H-invDB
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- (52) HUGE
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- (54) Leiden
- (55) miRBase
- (56) DME
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- (58) PubMed
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- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
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- (148) abm
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- (155) genomics-online
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- (160) Aminode
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- (163) RNACentral
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- (169) Biorbyt