This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009] See more...

Aliases for PTGER2 Gene

Aliases for PTGER2 Gene

  • Prostaglandin E Receptor 2 2 3 5
  • Prostaglandin E Receptor 2 (Subtype EP2), 53kDa 2 3
  • Prostaglandin E Receptor 2 (Subtype EP2), 53kD 2 3
  • Prostaglandin E2 Receptor EP2 Subtype 3 4
  • PGE2 Receptor EP2 Subtype 3 4
  • PGE Receptor EP2 Subtype 3 4
  • Prostanoid EP2 Receptor 3 4
  • EP2 2 3
  • PTGER2 5

External Ids for PTGER2 Gene

Previous GeneCards Identifiers for PTGER2 Gene

  • GC14P050103
  • GC14P046577
  • GC14P050771
  • GC14P051850
  • GC14P052781
  • GC14P032941

Summaries for PTGER2 Gene

Entrez Gene Summary for PTGER2 Gene

  • This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]

GeneCards Summary for PTGER2 Gene

PTGER2 (Prostaglandin E Receptor 2) is a Protein Coding gene. Diseases associated with PTGER2 include Asthma, Nasal Polyps, And Aspirin Intolerance and Asthma. Among its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is PTGDR.

UniProtKB/Swiss-Prot Summary for PTGER2 Gene

  • Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

Tocris Summary for PTGER2 Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGER2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTGER2 Gene

Genomics for PTGER2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTGER2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J052311 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 622.5 +1.2 1157 8.7 CREB1 PRDM10 ZNF629 RELA ZIC2 POLR2A PATZ1 IKZF2 ZNF501 EZH2 PTGER2 GNG2 TXNDC16 RTRAF piR-46847-086
GH14J052324 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 24 +12.3 12275 5 BACH1 RELA IKZF2 TRIM22 EED ARID3A RFX1 DPF2 RELB RUNX3 lnc-TXNDC16-4 PTGER2 GNG2 TXNDC16 piR-46847-086
GH14J052347 Enhancer 1.2 Ensembl ENCODE dbSUPER 17.3 +37.8 37826 8.9 ZNF629 ZNF692 FOXA1 RELA ZSCAN4 IKZF2 PKNOX1 ZBTB44 CEBPB ARID3A piR-48759-087 PTGER2 GPR137C TXNDC16 RF00017-1551
GH14J052399 Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas 21 +87.3 87296 4.8 CTCF ZBTB20 RUNX3 ZSCAN5C ZNF580 ZBTB17 SPI1 PRDM4 PRDM6 ZBTB12 PTGER2 piR-56883-063 lnc-TXNDC16-1 TXNDC16
GH14J052368 Enhancer 0.9 Ensembl ENCODE dbSUPER 17.3 +55.6 55593 2.3 YBX1 RFX1 CTBP1 PKNOX1 ZNF217 GATAD2B KLF9 RCOR1 ZNF687 TCF7L2 PTGER2 piR-56883-063 piR-48759-087 TXNDC16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTGER2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTGER2

Top Transcription factor binding sites by QIAGEN in the PTGER2 gene promoter:
  • c-Myc
  • Max
  • Nkx2-2
  • Pax-2
  • Pax-2a
  • Pax-2b
  • Sox9
  • TBP
  • TFIID
  • ZIC2

Genomic Locations for PTGER2 Gene

Genomic Locations for PTGER2 Gene
chr14:52,314,305-52,328,598
(GRCh38/hg38)
Size:
14,294 bases
Orientation:
Plus strand
chr14:52,781,016-52,795,324
(GRCh37/hg19)
Size:
14,309 bases
Orientation:
Plus strand

Genomic View for PTGER2 Gene

Genes around PTGER2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGER2 Gene

Proteins for PTGER2 Gene

  • Protein details for PTGER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43116-PE2R2_HUMAN
    Recommended name:
    Prostaglandin E2 receptor EP2 subtype
    Protein Accession:
    P43116
    Secondary Accessions:
    • D3DSC0
    • Q52LG8

    Protein attributes for PTGER2 Gene

    Size:
    358 amino acids
    Molecular mass:
    39761 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PTGER2 Gene

Post-translational modifications for PTGER2 Gene

  • Glycosylation at Asn3, Asn6, Asn96, and Asn287
  • Modification sites at PhosphoSitePlus

Other Protein References for PTGER2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTGER2 Gene

Domains & Families for PTGER2 Gene

Gene Families for PTGER2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for PTGER2 Gene

InterPro:
Blocks:
  • Prostanoid EP2 receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for PTGER2 Gene

GenScript: Design optimal peptide antigens:
  • Prostanoid EP2 receptor (PE2R2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P43116

UniProtKB/Swiss-Prot:

PE2R2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGER2: view

Function for PTGER2 Gene

Molecular function for PTGER2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
GENATLAS Biochemistry:
prostaglandin E2 receptor,subtype EP2,G protein coupled receptor superfamily,expressed in peripheral leukocytes with alternatively transcripts in spleen and thymus

Phenotypes From GWAS Catalog for PTGER2 Gene

Gene Ontology (GO) - Molecular Function for PTGER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004957 prostaglandin E receptor activity TAS,IBA 21873635
genes like me logo Genes that share ontologies with PTGER2: view
genes like me logo Genes that share phenotypes with PTGER2: view

Human Phenotype Ontology for PTGER2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PTGER2 Gene

MGI Knock Outs for PTGER2:

Animal Model Products

CRISPR Products

miRNA for PTGER2 Gene

miRTarBase miRNAs that target PTGER2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGER2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PTGER2 Gene

Localization for PTGER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGER2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGER2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PTGER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10462542
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTGER2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGER2 Gene

Pathways & Interactions for PTGER2 Gene

genes like me logo Genes that share pathways with PTGER2: view

Pathways by source for PTGER2 Gene

SIGNOR curated interactions for PTGER2 Gene

Activates:

Gene Ontology (GO) - Biological Process for PTGER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA,ISS --
GO:0007204 positive regulation of cytosolic calcium ion concentration IBA 21873635
genes like me logo Genes that share ontologies with PTGER2: view

Drugs & Compounds for PTGER2 Gene

(62) Drugs for PTGER2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dinoprostone Approved Pharma Target, agonist, antagonist activates the PGE2 receptor, Major endogenous prostanoid 137
Iloprost Approved, Investigational Pharma Agonist, Full agonist, agonist Prostacyclin (PGI2) analog, Others 93
Misoprostol Approved Pharma Target, agonist 412
Alprostadil Approved, Investigational Pharma Target, agonist, antagonist 101
Aspirin Approved, Vet_approved Pharma Channel blocker 1512

(28) Additional Compounds for PTGER2 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CP-544326
Agonist, Full agonist
(+-)-Cloprostenol sodium salt
55028-72-3

(5) Tocris Compounds for PTGER2 Gene

Compound Action Cas Number
(+-)-Cloprostenol sodium salt Water-soluble PGF2alpha analog and potent FP receptor agonist 55028-72-3
BMY 45778 Non-prostanoid prostacyclin IP receptor partial agonist 152575-66-1
Iloprost Prostacyclin (PGI2) analog 78919-13-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1

(19) ApexBio Compounds for PTGER2 Gene

Compound Action Cas Number
(+)-Fluprostenol 54276-17-4
(±)-Cloprostenol sodium salt 55028-72-3
16,16-Dimethyl Prostaglandin E2 derivative of prostaglandin E2 39746-25-3
GW 627368 439288-66-1
L-161,982 147776-06-5
L-655,240 103253-15-2
L-670,596 121083-05-4
L-798,106 244101-02-8
Misoprostol 59122-46-2
NS 304 475086-01-2
PF 04418948 1078166-57-0
Pranoprofen 52549-17-4
Prostaglandin E2 activates the PGE2 receptor 363-24-6
Prostaglandin F2α 38562-01-5
SC 51089 146033-02-5
SC 51322 146032-79-3
Sulprostone 60325-46-4
TCS 2510 346673-06-1
U 46619 selective agonist of prostaglandin H2 (PGH2)/thromboxane A2 (TxA2) (TP) receptor 56985-40-1
genes like me logo Genes that share compounds with PTGER2: view

Drug Products

Transcripts for PTGER2 Gene

mRNA/cDNA for PTGER2 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGER2

Alternative Splicing Database (ASD) splice patterns (SP) for PTGER2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for PTGER2 Gene

GeneLoc Exon Structure for
PTGER2

Expression for PTGER2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTGER2 Gene

mRNA differential expression in normal tissues according to GTEx for PTGER2 Gene

This gene is overexpressed in Whole Blood (x12.4).

Protein differential expression in normal tissues from HIPED for PTGER2 Gene

This gene is overexpressed in Lung (55.8) and Peripheral blood mononuclear cells (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTGER2 Gene



Protein tissue co-expression partners for PTGER2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTGER2

SOURCE GeneReport for Unigene cluster for PTGER2 Gene:

Hs.2090

mRNA Expression by UniProt/SwissProt for PTGER2 Gene:

P43116-PE2R2_HUMAN
Tissue specificity: Placenta and lung.

Evidence on tissue expression from TISSUES for PTGER2 Gene

  • Blood(2.2)
  • Bone marrow(2.2)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with PTGER2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGER2 Gene

Orthologs for PTGER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGER2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PTGER2 30 31
  • 99.35 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PTGER2 30 31
  • 90.4 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PTGER2 30 31
  • 87.22 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ptger2 30 17 31
  • 83.94 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ptger2 30
  • 83.9 (n)
Oppossum
(Monodelphis domestica)
Mammalia PTGER2 31
  • 67 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PTGER2 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PTGER2 30 31
  • 65.5 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PTGER2 31
  • 49 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ptger2 30
  • 62.92 (n)
Zebrafish
(Danio rerio)
Actinopterygii ptger2b 30 31
  • 51.85 (n)
OneToMany
ptger2a 31
  • 41 (a)
OneToMany
Species where no ortholog for PTGER2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PTGER2 Gene

ENSEMBL:
Gene Tree for PTGER2 (if available)
TreeFam:
Gene Tree for PTGER2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTGER2: view image

Paralogs for PTGER2 Gene

Paralogs for PTGER2 Gene

(3) SIMAP similar genes for PTGER2 Gene using alignment to 2 proteins:

  • PE2R2_HUMAN
  • G3V2Y6_HUMAN
genes like me logo Genes that share paralogs with PTGER2: view

Variants for PTGER2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTGER2 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
710814 Benign: not provided 52,314,795(+) T/G MISSENSE_VARIANT
719357 Likely Benign: not provided 52,327,231(+) A/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for PTGER2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PTGER2 Gene

Variant ID Type Subtype PubMed ID
esv3634521 CNV gain 21293372
nsv832795 CNV gain 17160897

Variation tolerance for PTGER2 Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTGER2 Gene

Human Gene Mutation Database (HGMD)
PTGER2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGER2 Gene

Disorders for PTGER2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PTGER2 Gene - From: OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma, nasal polyps, and aspirin intolerance
  • asa triad
asthma
  • asthma, susceptibility to
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PTGER2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PTGER2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGER2 Gene

Publications for PTGER2 Gene

  1. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PMID: 20086108) Poole EM … Ulrich CM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 23 41
  2. Chromosomal localization of the human prostanoid receptor gene family. (PMID: 7759114) Duncan AM … Adam M (Genomics 1995) 2 3 23
  3. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. (PMID: 8078484) Regan JW … Gil DW (Molecular pharmacology 1994) 3 4 23
  4. Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2. (PMID: 8250933) An S … Goetzl EJ (Biochemical and biophysical research communications 1993) 2 3 23
  5. EP2 receptor mediated cAMP release is augmented by PGF 2 alpha activation of the FP receptor via the calcium-calmodulin pathway. (PMID: 19782748) Abera AB … Jabbour HN (Cellular signalling 2010) 3 23

Products for PTGER2 Gene

Sources for PTGER2 Gene