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This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]
PTGER2 (Prostaglandin E Receptor 2) is a Protein Coding gene. Diseases associated with PTGER2 include Asthma, Nasal Polyps, And Aspirin Intolerance and Asthma. Among its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is PTGDR.
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004957 | prostaglandin E receptor activity | TAS,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 10462542 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Eicosanoid ligand-binding receptors | ||
3 | Signaling by GPCR | ||
4 | cAMP signaling pathway | ||
5 | Human cytomegalovirus infection |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006954 | inflammatory response | IBA | 21873635 |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | IEA,ISS | -- |
GO:0007204 | positive regulation of cytosolic calcium ion concentration | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Dinoprostone | Approved | Pharma | Target, agonist, antagonist | activates the PGE2 receptor, Major endogenous prostanoid | 137 | |
Iloprost | Approved, Investigational | Pharma | Agonist, Full agonist, agonist | Prostacyclin (PGI2) analog, Others | 93 | |
Misoprostol | Approved | Pharma | Target, agonist | 412 | ||
Alprostadil | Approved, Investigational | Pharma | Target, agonist, antagonist | 101 | ||
Aspirin | Approved, Vet_approved | Pharma | Channel blocker | 1512 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
CP-544326 |
|
Agonist, Full agonist |
|
|||
(+-)-Cloprostenol sodium salt |
|
55028-72-3 |
|
|
Compound | Action | Cas Number |
---|---|---|
(+-)-Cloprostenol sodium salt | Water-soluble PGF2alpha analog and potent FP receptor agonist | 55028-72-3 |
BMY 45778 | Non-prostanoid prostacyclin IP receptor partial agonist | 152575-66-1 |
Iloprost | Prostacyclin (PGI2) analog | 78919-13-8 |
Prostaglandin E2 | Major endogenous prostanoid | 363-24-6 |
U 46619 | Potent, stable thromboxane A2 (TP) receptor agonist | 56985-40-1 |
Compound | Action | Cas Number |
---|---|---|
(+)-Fluprostenol | 54276-17-4 | |
(±)-Cloprostenol sodium salt | 55028-72-3 | |
16,16-Dimethyl Prostaglandin E2 | derivative of prostaglandin E2 | 39746-25-3 |
GW 627368 | 439288-66-1 | |
L-161,982 | 147776-06-5 | |
L-655,240 | 103253-15-2 | |
L-670,596 | 121083-05-4 | |
L-798,106 | 244101-02-8 | |
Misoprostol | 59122-46-2 | |
NS 304 | 475086-01-2 | |
PF 04418948 | 1078166-57-0 | |
Pranoprofen | 52549-17-4 | |
Prostaglandin E2 | activates the PGE2 receptor | 363-24-6 |
Prostaglandin F2α | 38562-01-5 | |
SC 51089 | 146033-02-5 | |
SC 51322 | 146032-79-3 | |
Sulprostone | 60325-46-4 | |
TCS 2510 | 346673-06-1 | |
U 46619 | selective agonist of prostaglandin H2 (PGH2)/thromboxane A2 (TxA2) (TP) receptor | 56985-40-1 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||
SP2: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PTGER2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PTGER2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PTGER2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ptger2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ptger2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | PTGER2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PTGER2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PTGER2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PTGER2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ptger2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ptger2b 30 31 |
|
OneToMany | |
ptger2a 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3634521 | CNV | gain | 21293372 |
nsv832795 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
asthma, nasal polyps, and aspirin intolerance |
|
|
asthma |
|
|
colorectal cancer |
|