The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blo... See more...

Aliases for PTGER1 Gene

Aliases for PTGER1 Gene

  • Prostaglandin E Receptor 1 2 3 5
  • Prostaglandin E Receptor 1 (Subtype EP1), 42kDa 2 3
  • Prostaglandin E Receptor 1 (Subtype EP1), 42kD 2 3
  • Prostaglandin E2 Receptor EP1 Subtype 3 4
  • PGE2 Receptor EP1 Subtype 3 4
  • Prostanoid EP1 Receptor 3 4
  • EP1 2 3
  • Prostaglandin E Receptor 1, Subtype EP1 3
  • PGE Receptor, EP1 Subtype 3
  • PGE Receptor EP1 Subtype 4
  • PTGER1 5

External Ids for PTGER1 Gene

Previous GeneCards Identifiers for PTGER1 Gene

  • GC19M014938
  • GC19M014428
  • GC19M014583
  • GC19M014153

Summaries for PTGER1 Gene

Entrez Gene Summary for PTGER1 Gene

  • The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGER1 Gene

PTGER1 (Prostaglandin E Receptor 1) is a Protein Coding gene. Diseases associated with PTGER1 include Tinea Barbae and Antenatal Bartter Syndrome. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and prostaglandin E receptor activity. An important paralog of this gene is PTGFR.

UniProtKB/Swiss-Prot Summary for PTGER1 Gene

  • Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

Tocris Summary for PTGER1 Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for PTGER1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTGER1 Gene

Genomics for PTGER1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTGER1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J014476 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 256.2 -1.4 -1391 4.8 MYC ZNF600 ATF2 NFIC ZIC2 ZBTB10 CEBPB ZNF639 ZNF341 CTCF PTGER1 YJU2B AKAP8 MRI1 ZNF333 BRD4 DCAF15 DDX39A ADGRL1 NANOS3
GH19J014473 Enhancer 0.4 ENCODE 250.7 +1.9 1930 0.2 HNRNPL PATZ1 CTCF PTGER1 HSALNG0124309 PKN1
GH19J014475 Enhancer 0.4 ENCODE 250.7 +1.3 1290 0.2 CTCF ZHX1 POLR2A PTGER1 HSALNG0124309 PKN1
GH19J014479 Promoter/Enhancer 1.2 Ensembl ENCODE 6.3 -4.7 -4733 1.3 ZNF654 ZNF10 NFIC ZBTB10 CTCF REST TRIM22 RAD21 SMC3 GABPB1 ENSG00000268189 AKAP8L ZNF333 PTGER1 HSALNG0124310 GIPC1
GH19J014471 Promoter/Enhancer 1.2 Ensembl ENCODE 0.7 +2.7 2653 1 MYC NFIC ZBTB10 CTCF REST TARDBP TRIM22 BHLHE40 MNT MAX AKAP8 YJU2B RFX1 ZNF333 BRD4 MRI1 DCAF15 PTGER1 HSALNG0124309 PKN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTGER1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTGER1

Top Transcription factor binding sites by QIAGEN in the PTGER1 gene promoter:
  • Egr-1
  • Elk-1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • SRF
  • SRF (504 AA)
  • STAT5A
  • ZID

Genomic Locations for PTGER1 Gene

Latest Assembly
chr19:14,472,466-14,475,354
(GRCh38/hg38)
Size:
2,889 bases
Orientation:
Minus strand

Previous Assembly
chr19:14,583,278-14,586,166
(GRCh37/hg19 by Entrez Gene)
Size:
2,889 bases
Orientation:
Minus strand

chr19:14,583,278-14,586,174
(GRCh37/hg19 by Ensembl)
Size:
2,897 bases
Orientation:
Minus strand

Genomic View for PTGER1 Gene

Genes around PTGER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGER1 Gene

Proteins for PTGER1 Gene

  • Protein details for PTGER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34995-PE2R1_HUMAN
    Recommended name:
    Prostaglandin E2 receptor EP1 subtype
    Protein Accession:
    P34995
    Secondary Accessions:
    • Q5U5U4
    • Q86UH3
    • Q86VB5
    • Q8NHB2

    Protein attributes for PTGER1 Gene

    Size:
    402 amino acids
    Molecular mass:
    41801 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05723.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PTGER1 Gene

Post-translational modifications for PTGER1 Gene

Other Protein References for PTGER1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PTGER1 Gene

Domains & Families for PTGER1 Gene

Gene Families for PTGER1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for PTGER1 Gene

InterPro:
Blocks:
  • Prostanoid EP1 receptor signature
  • Prostaglandin receptor signature

Suggested Antigen Peptide Sequences for PTGER1 Gene

GenScript: Design optimal peptide antigens:
  • Prostanoid EP1 receptor (PE2R1_HUMAN)
  • PTGER1 protein (Q05C32_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P34995

UniProtKB/Swiss-Prot:

PE2R1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PTGER1: view

Function for PTGER1 Gene

Molecular function for PTGER1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.
GENATLAS Biochemistry:
prostaglandin E2 receptor,subtype EP1 (42kDa),G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for PTGER1 Gene

Gene Ontology (GO) - Molecular Function for PTGER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004955 prostaglandin receptor activity IEA --
GO:0004957 prostaglandin E receptor activity TAS,IBA 21873635
GO:0031748 D1 dopamine receptor binding IEA --
genes like me logo Genes that share ontologies with PTGER1: view
genes like me logo Genes that share phenotypes with PTGER1: view

Animal Models for PTGER1 Gene

MGI Knock Outs for PTGER1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGER1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PTGER1 Gene

Localization for PTGER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGER1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGER1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PTGER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8253813
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTGER1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGER1 Gene

Pathways & Interactions for PTGER1 Gene

genes like me logo Genes that share pathways with PTGER1: view

SIGNOR curated interactions for PTGER1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PTGER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA 21873635
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with PTGER1: view

Drugs & Compounds for PTGER1 Gene

(48) Drugs for PTGER1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iloprost Approved, Investigational Pharma Agonist, Full agonist, Target Prostacyclin (PGI2) analog, Others 97
Bimatoprost Approved, Investigational Pharma Target, agonist 150
Dinoprostone Approved Pharma Target, agonist, antagonist activates the PGE2 receptor, Major endogenous prostanoid 150
Carboprost tromethamine Approved Pharma Target, agonist, binder 8
Alprostadil Approved, Investigational Pharma Target, agonist, antagonist 113

(21) Additional Compounds for PTGER1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Cloprostenol sodium salt
55028-72-3

(5) Tocris Compounds for PTGER1 Gene

Compound Action Cas Number
(+-)-Cloprostenol sodium salt Water-soluble PGF2alpha analog and potent FP receptor agonist 55028-72-3
BMY 45778 Non-prostanoid prostacyclin IP receptor partial agonist 152575-66-1
Iloprost Prostacyclin (PGI2) analog 78919-13-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1

(4) ApexBio Compounds for PTGER1 Gene

Compound Action Cas Number
AH 6809 EP and DP receptor antagonist 33458-93-4
Alprostadil 745-65-3
Bimatoprost 155206-00-1
SC 19220 19395-87-0
genes like me logo Genes that share compounds with PTGER1: view

Drug products for research

Transcripts for PTGER1 Gene

mRNA/cDNA for PTGER1 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGER1

Alternative Splicing Database (ASD) splice patterns (SP) for PTGER1 Gene

No ASD Table

Relevant External Links for PTGER1 Gene

GeneLoc Exon Structure for
PTGER1

Expression for PTGER1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTGER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTGER1 Gene

This gene is overexpressed in Kidney - Cortex (x11.5) and Spleen (x8.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTGER1

SOURCE GeneReport for Unigene cluster for PTGER1 Gene:

Hs.159360

mRNA Expression by UniProt/SwissProt for PTGER1 Gene:

P34995-PE2R1_HUMAN
Tissue specificity: Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.

Evidence on tissue expression from TISSUES for PTGER1 Gene

  • Kidney(4.6)
  • Pancreas(4.2)
  • Muscle(2.4)
  • Nervous system(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with PTGER1: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGER1 Gene

Orthologs for PTGER1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGER1 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia EP1 30
  • 88 (a)
OneToOne
PTGER1 29
  • 87.15 (n)
Dog
(Canis familiaris)
Mammalia PTGER1 29 30
  • 87.53 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ptger1 29 16 30
  • 81.8 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ptger1 29
  • 81.46 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia PTGER1 30
  • 64 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PTGER1 30
  • 63 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PTGER1 30
  • 55 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii ptger1a 29 30
  • 53.46 (n)
OneToMany
ptger1b 30
  • 45 (a)
OneToMany
Species where no ortholog for PTGER1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PTGER1 Gene

ENSEMBL:
Gene Tree for PTGER1 (if available)
TreeFam:
Gene Tree for PTGER1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTGER1: view image
Alliance of Genome Resources:
Additional Orthologs for PTGER1

Paralogs for PTGER1 Gene

Paralogs for PTGER1 Gene

(1) SIMAP similar genes for PTGER1 Gene using alignment to 2 proteins:

  • PE2R1_HUMAN
  • Q05C32_HUMAN
genes like me logo Genes that share paralogs with PTGER1: view

Variants for PTGER1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTGER1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1057362 -- p.Ala71Thr
rs28364042 -- p.Thr223Met
rs7249305 -- p.His256Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PTGER1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PTGER1 Gene

Variant ID Type Subtype PubMed ID
nsv470127 CNV loss 18288195
nsv527867 CNV loss 19592680
nsv817814 CNV loss 17921354
nsv833764 CNV loss 17160897

Variation tolerance for PTGER1 Gene

Gene Damage Index Score: 5.25; 70.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTGER1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGER1
Leiden Open Variation Database (LOVD)
PTGER1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGER1 Gene

Disorders for PTGER1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PTGER1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
tinea barbae
  • dermatophytosis of beard
antenatal bartter syndrome
  • bartter syndrome, furosemide type
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PTGER1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PTGER1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGER1 Gene

Publications for PTGER1 Gene

  1. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. (PMID: 8253813) Funk CD … Metters KM (The Journal of biological chemistry 1993) 2 3 4 22
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  3. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PMID: 20673868) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 40
  4. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 40
  5. Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmatics. (PMID: 20587336) Park BL … Shin HD (BMB reports 2010) 3 40

Products for PTGER1 Gene

Sources for PTGER1 Gene