The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. Th... See more...

Aliases for PTGDS Gene

Aliases for PTGDS Gene

  • Prostaglandin D2 Synthase 2 3 5
  • L-PGDS 2 3 4
  • PGDS 2 3 4
  • Lipocalin-Type Prostaglandin D Synthase 2 3
  • Prostaglandin D2 Synthase 21kDa (Brain) 2 3
  • Glutathione-Independent PGD Synthase 3 4
  • Prostaglandin-H2 D-Isomerase 3 4
  • Beta-Trace Protein 3 4
  • PGD2 Synthase 3 4
  • Cerebrin-28 3 4
  • EC 5.3.99.2 4 50
  • PGDS2 3 4
  • PDS 3 4
  • Testis Tissue Sperm-Binding Protein Li 63n 3
  • Prostaglandin D2 Synthase (21kD, Brain) 2
  • Lipocalin-Type Prostaglandin-D Synthase 4
  • Glutathione-Independent PGD Synthetase 3
  • Prostaglandin-D2 Synthase 4
  • Prostaglandin D Synthase 3
  • LPGDS 3
  • PTGDS 5
  • PGD2 3

External Ids for PTGDS Gene

Previous GeneCards Identifiers for PTGDS Gene

  • GC09M131178
  • GC09P131561
  • GC09P133310
  • GC09P135226
  • GC09P137145
  • GC09P138989
  • GC09P139871
  • GC09P109331
  • GC09P136977
  • GC09P136982
  • GC09P136987

Summaries for PTGDS Gene

Entrez Gene Summary for PTGDS Gene

  • The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

GeneCards Summary for PTGDS Gene

PTGDS (Prostaglandin D2 Synthase) is a Protein Coding gene. Diseases associated with PTGDS include Intracranial Hypotension and Normal Pressure Hydrocephalus. Among its related pathways are Prostaglandin Synthesis and Regulation and Metabolism. Gene Ontology (GO) annotations related to this gene include transporter activity and retinoid binding. An important paralog of this gene is ENSG00000284341.

UniProtKB/Swiss-Prot Summary for PTGDS Gene

  • Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation (PubMed:20667974). Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (PubMed:20667974, PubMed:9475419). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).

Tocris Summary for PTGDS Gene

Gene Wiki entry for PTGDS Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTGDS Gene

Genomics for PTGDS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PTGDS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J136981 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +3.1 3109 1.6 IKZF1 NFIC ZIC2 NONO KLF9 SKIL BCL11B SUPT5H SMARCA4 HDAC2 ENSG00000284341 PTGDS LCNL1 lnc-PTGDS-1 lnc-CLIC3-4
GH09J136973 Enhancer 0.7 ENCODE 250.7 +0.5 506 3.6 MYC ZNF600 ZNF223 ZIC2 REST MNT SIN3A SAP130 CTCF TBP ENSG00000284341 PTGDS lnc-PTGDS-1 LCNL1 lnc-CLIC3-4
GH09J136963 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 15.4 -10.6 -10600 1.1 MYC ZNF592 REST KLF7 MAX ZNF217 CTBP1 SMC3 TCF7L2 MYNN RF00017-7461 PTGDS HSALNG0075329 LCN12
GH09J136965 Enhancer 0.7 ENCODE 15.4 -9.1 -9096 1.2 IKZF1 REST MNT RAD51 ZBTB48 ZBTB33 NR2F1 ZBTB21 L3MBTL2 PKNOX1 KR153194-210 RF00017-7461 LCN12 PTGDS
GH09J136970 Enhancer 0.5 Ensembl 15.4 -4.0 -3991 3.4 NR2F6 GLIS1 KLF1 EGR2 KLF8 ZFHX2 LINC02692 LCN12 PTGDS lnc-PTGDS-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTGDS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTGDS

Top Transcription factor binding sites by QIAGEN in the PTGDS gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • CREB
  • deltaCREB

Genomic Locations for PTGDS Gene

Latest Assembly
chr9:136,975,092-136,981,742
(GRCh38/hg38)
Size:
6,651 bases
Orientation:
Plus strand

Previous Assembly
chr9:139,871,956-139,876,194
(GRCh37/hg19 by Entrez Gene)
Size:
4,239 bases
Orientation:
Plus strand

chr9:139,871,956-139,879,887
(GRCh37/hg19 by Ensembl)
Size:
7,932 bases
Orientation:
Plus strand

Genomic View for PTGDS Gene

Genes around PTGDS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTGDS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTGDS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTGDS Gene

Proteins for PTGDS Gene

  • Protein details for PTGDS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41222-PTGDS_HUMAN
    Recommended name:
    Prostaglandin-H2 D-isomerase
    Protein Accession:
    P41222
    Secondary Accessions:
    • B2R727
    • Q5SQ10
    • Q7M4P3
    • Q9UC22
    • Q9UCC9
    • Q9UCD9

    Protein attributes for PTGDS Gene

    Size:
    190 amino acids
    Molecular mass:
    21029 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • It has been proposed that the urinary and serum levels may provide a sensitive indicator of renal damage in diabetes mellitus and hypertension. Elevated levels in the coronary circulation may also be associated with angina. Changes in charge and molecular weight microheterogeneity, due to modification of the N-linked oligosaccharides, may be associated with neurodegenerative disease and multiple sclerosis. Detected in meningioma but not in other brain tumors and may be considered a specific cell marker for meningioma. Expression levels in amniotic fluid are altered in abnormal pregnancies. Levels are lower in pregnancies with trisomic fetuses and fetuses with renal abnormalities.

    Three dimensional structures from OCA and Proteopedia for PTGDS Gene

neXtProt entry for PTGDS Gene

Selected DME Specific Peptides for PTGDS Gene

P41222:
  • SPHWGSTYSVSVVETDYD
  • IVFLPQTDKC
  • GGLNLTSTFLRKNQCET
  • DKFLGRWFSAGLASNSSWL
  • SLGSYSY
  • HTLWMGL
  • MATLYSR
  • QPNFQQDKFLGRW

Post-translational modifications for PTGDS Gene

  • N- and O-glycosylated. Both N-glycosylation recognition sites are almost quantitatively occupied by N-glycans of the biantennary complex type, with a considerable proportion of structures bearing a bisecting GlcNAc. N-glycan at Asn-78: dHex1Hex5HexNAc4. Agalacto structure as well as sialylated and nonsialylated oligosaccharides bearing alpha2-3- and/or alpha2-6-linked NeuNAc are present.
  • Glycosylation at Ser29, Asn51, Ser67, Thr73, Asn78, Thr80, Ser81, and Asn87
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PTGDS_HUMAN (685)

Other Protein References for PTGDS Gene

Domains & Families for PTGDS Gene

Gene Families for PTGDS Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PTGDS Gene

InterPro:
Blocks:
  • Lipocalin signature
  • Prostaglandin D synthase signature

Suggested Antigen Peptide Sequences for PTGDS Gene

GenScript: Design optimal peptide antigens:
  • Prostaglandin-D2 synthase (PTGDS_HUMAN)
  • Prostaglandin D2 synthase 21kDa (Brain) (Q5SQ09_HUMAN)
  • Prostaglandin D2 synthase 21kDa (Brain) (Q5SQ19_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P41222

UniProtKB/Swiss-Prot:

PTGDS_HUMAN :
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Lipocalin family.
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with PTGDS: view

Function for PTGDS Gene

Molecular function for PTGDS Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation (PubMed:20667974). Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (PubMed:20667974, PubMed:9475419). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=prostaglandin H2 = prostaglandin D2; Xref=Rhea:RHEA:10600, ChEBI:CHEBI:57405, ChEBI:CHEBI:57406; EC=5.3.99.2; Evidence={ECO:0000269|PubMed:20667974};.
UniProtKB/Swiss-Prot Induction:
By IL1B/interleukin-1 beta and thyroid hormone. Probably induced by dexamethasone, dihydrotestosterone (DHT), progesterone, retinoic acid and retinal. Repressed by the Notch-Hes signaling pathway.
GENATLAS Biochemistry:
prostaglandin D2 synthase,glutathione independent,21kDa,brain-specific,membrane associated lipocalcin family

Enzyme Numbers (IUBMB) for PTGDS Gene

Phenotypes From GWAS Catalog for PTGDS Gene

Gene Ontology (GO) - Molecular Function for PTGDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004667 prostaglandin-D synthase activity TAS --
GO:0005501 retinoid binding ISS --
GO:0005504 fatty acid binding IDA 20667974
GO:0005515 protein binding IPI 16713569
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with PTGDS: view
genes like me logo Genes that share phenotypes with PTGDS: view

Animal Models for PTGDS Gene

MGI Knock Outs for PTGDS:

miRNA for PTGDS Gene

miRTarBase miRNAs that target PTGDS

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGDS

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGDS Gene

Localization for PTGDS Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTGDS Gene

Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear region. Secreted. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTGDS gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
nucleus 4
golgi apparatus 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
cytosol 2
lysosome 2
endosome 1

Gene Ontology (GO) - Cellular Components for PTGDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,IDA 7692978
GO:0005615 extracellular space IBA,IDA 19878301
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with PTGDS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGDS Gene

Pathways & Interactions for PTGDS Gene

genes like me logo Genes that share pathways with PTGDS: view

Pathways by source for PTGDS Gene

2 KEGG pathways for PTGDS Gene
1 GeneGo (Thomson Reuters) pathway for PTGDS Gene
  • Prostaglandin 2 biosynthesis and metabolism FM

SIGNOR curated interactions for PTGDS Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PTGDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process ISS --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006693 prostaglandin metabolic process IEA --
genes like me logo Genes that share ontologies with PTGDS: view

Drugs & Compounds for PTGDS Gene

(15) Drugs for PTGDS Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved, Vet_approved Nutra Target, ligand 747
Floxuridine Approved Pharma Antineoplastic antimetabolite, Inhibitor of thymidylate synthetase; anticancer agent, RNA and DNA synthesis inhibitor 59
Zoledronic Acid Approved Pharma Potent nitrogen-containing bisphosphonates, Potent farnesyl diphosphate (FPP) synthase inhibitor, Osteoclast function modifiers (important in bone metastasis) 344
Prostaglandin D2 Investigational Pharma 0
AT 56 Pharma L-PGDS inhibitor 0

(15) Additional Compounds for PTGDS Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Prostaglandin H2
  • (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate
  • (5Z,13E,15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate
  • (5Z,9alpha,11alpha,13E,15S)-9,11-Epidioxy-15-hydroxyprosta-5,13-dien-1-Oic acid
  • 9,11-Epoxymethano-PGH2
  • PGH2
42935-17-1
Bz 423
216691-95-1
Trifluorothymidine
70-00-8

(5) Tocris Compounds for PTGDS Gene

Compound Action Cas Number
Borrelidin Antiangiogenic; inhibits threonyl-tRNA synthetase 7184-60-3
Bz 423 ATP synthase inhibitor; proapoptotic 216691-95-1
Floxuridine Inhibitor of thymidylate synthetase; anticancer agent 50-91-9
Trifluorothymidine Thymidylate synthase inhibitor; induces DNA fragmentation 70-00-8
Zoledronic Acid Potent farnesyl diphosphate (FPP) synthase inhibitor 118072-93-8

(1) ApexBio Compounds for PTGDS Gene

Compound Action Cas Number
AT 56 L-PGDS inhibitor 162640-98-4
genes like me logo Genes that share compounds with PTGDS: view

Drug products for research

Transcripts for PTGDS Gene

mRNA/cDNA for PTGDS Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGDS

Alternative Splicing Database (ASD) splice patterns (SP) for PTGDS Gene

No ASD Table

Relevant External Links for PTGDS Gene

GeneLoc Exon Structure for
PTGDS

Expression for PTGDS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PTGDS Gene

mRNA differential expression in normal tissues according to GTEx for PTGDS Gene

This gene is overexpressed in Heart - Atrial Appendage (x5.0) and Heart - Left Ventricle (x5.0).

Protein differential expression in normal tissues from HIPED for PTGDS Gene

This gene is overexpressed in Cerebrospinal fluid (39.8), Vitreous humor (17.5), and Urine (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTGDS Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTGDS

SOURCE GeneReport for Unigene cluster for PTGDS Gene:

Hs.446429

mRNA Expression by UniProt/SwissProt for PTGDS Gene:

P41222-PTGDS_HUMAN
Tissue specificity: Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, epididymis and prostate, and is secreted into the seminal fluid. Expressed in the eye and secreted into the aqueous humor. Lower levels detected in various tissue fluids such as serum, normal urine, ascitic fluid and tear fluid. Also found in a number of other organs including ovary, fimbriae of the fallopian tubes, kidney, leukocytes.

Evidence on tissue expression from TISSUES for PTGDS Gene

  • Nervous system(5)
  • Eye(4.8)
  • Liver(4.5)
  • Bone marrow(4.3)
  • Heart(3.9)
  • Muscle(3.6)
  • Kidney(3.2)
  • Lymph node(3.2)
  • Intestine(3)
  • Spleen(3)
  • Lung(2.9)
  • Skin(2.9)
  • Stomach(2.6)
  • Adrenal gland(2.6)
  • Gall bladder(2.4)
  • Blood(2.3)
  • Pancreas(2.3)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with PTGDS: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGDS Gene

Orthologs for PTGDS Gene

This gene was present in the common ancestor of chordates.

Orthologs for PTGDS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PTGDS 29 30
  • 97.97 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PTGDS 29 30
  • 82.75 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ptgds 29 16 30
  • 80.78 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PTGDS 29 30
  • 78.77 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ptgds 29
  • 77.25 (n)
Oppossum
(Monodelphis domestica)
Mammalia PTGDS 30
  • 43 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PTGDS 30
  • 33 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PTGDS 29 30
  • 60.38 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PTGDS 30
  • 41 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii ptgdsb 30
  • 29 (a)
OneToMany
PTGDS (2 of 3) 30
  • 24 (a)
OneToMany
PTGDS (3 of 3) 30
  • 22 (a)
OneToMany
Species where no ortholog for PTGDS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PTGDS Gene

ENSEMBL:
Gene Tree for PTGDS (if available)
TreeFam:
Gene Tree for PTGDS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PTGDS: view image
Alliance of Genome Resources:
Additional Orthologs for PTGDS

Paralogs for PTGDS Gene

(2) SIMAP similar genes for PTGDS Gene using alignment to 6 proteins:

  • PTGDS_HUMAN
  • F8W7I2_HUMAN
  • H0Y4L4_HUMAN
  • H0Y5A1_HUMAN
  • Q5SQ11_HUMAN
  • Q5SQ12_HUMAN
genes like me logo Genes that share paralogs with PTGDS: view

Variants for PTGDS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PTGDS Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs147964178 Benign: not provided 136,980,066(+) C/T
NM_000954.6(PTGDS):c.448+4C>T
INTRON
rs34184410 Benign: not provided 136,978,985(+) C/T
NM_000954.6(PTGDS):c.115-8C>T
INTRON
rs35556170 Benign: not provided 136,978,984(+) T/C
NM_000954.6(PTGDS):c.115-9T>C
INTRON
rs8192610 Benign: not provided 136,980,846(+) G/A
NM_000954.6(PTGDS):c.564G>A (p.Thr188=)
SYNONYMOUS
rs11552179 -- p.Arg56Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PTGDS Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PTGDS Gene

Variant ID Type Subtype PubMed ID
dgv13007n54 CNV loss 21841781
dgv13008n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
nsv469918 CNV loss 18288195
nsv524322 CNV loss 19592680
nsv615991 CNV loss 21841781
nsv615992 CNV loss 21841781
nsv615993 CNV gain 21841781
nsv615994 CNV gain 21841781
nsv615995 CNV loss 21841781
nsv615997 CNV loss 21841781
nsv616002 CNV loss 21841781
nsv818738 CNV gain 17921354
nsv951206 CNV deletion 24416366

Variation tolerance for PTGDS Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTGDS Gene

Human Gene Mutation Database (HGMD)
PTGDS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PTGDS
Leiden Open Variation Database (LOVD)
PTGDS

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGDS Gene

Disorders for PTGDS Gene

MalaCards: The human disease database

(26) MalaCards diseases for PTGDS Gene - From: COP and GCD

Disorder Aliases PubMed IDs
intracranial hypotension
normal pressure hydrocephalus
  • low pressure hydrocephalus
cerebrospinal fluid leak
  • csf leak
spontaneous intracranial hypotension
  • spontaneous cerebrospinal fluid leak
macular holes
  • macular hole
- elite association - COSMIC cancer census association via MalaCards
Search PTGDS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PTGDS

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PTGDS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTGDS Gene

Publications for PTGDS Gene

  1. Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. (PMID: 19276290) Abraham JE … Pharoah PD (Clinical cancer research : an official journal of the American Association for Cancer Research 2009) 3 22 40
  2. Family-based and case-control studies reveal no association of lipocalin-type prostaglandin D2 synthase with schizophrenia. (PMID: 17230501) Ruano D … Palha JA (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 22 40
  3. Identification of gene polymorphism in lipocalin-type prostaglandin D synthase and its association with carotid atherosclerosis in Japanese hypertensive patients. (PMID: 15325247) Miwa Y … Kawano Y (Biochemical and biophysical research communications 2004) 3 22 40
  4. Lipocalin-type prostaglandin d synthase in essential hypertension. (PMID: 11882588) Hirawa N … Umemura S (Hypertension (Dallas, Tex. : 1979) 2002) 3 4 22
  5. Charge microheterogeneity of the beta-trace proteins (lipocalin-type prostaglandin D synthase) in the cerebrospinal fluid of patients with neurological disorders analyzed by capillary isoelectrofocusing. (PMID: 11669522) Hiraoka A … Baba K (Electrophoresis 2001) 3 4 22

Products for PTGDS Gene

Sources for PTGDS Gene