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This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated wi... See more...
Aliases for PTGDR2 Gene
Aliases for PTGDR2 Gene
External Ids for PTGDR2 Gene
- HGNC: 4502
- Entrez Gene: 11251
- Ensembl: ENSG00000183134
- OMIM: 604837
- UniProtKB: Q9Y5Y4
Previous HGNC Symbols for PTGDR2 Gene
- GPR44
Previous GeneCards Identifiers for PTGDR2 Gene
- GC11M060619
Summaries for PTGDR2 Gene
-
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]
GeneCards Summary for PTGDR2 Gene
PTGDR2 (Prostaglandin D2 Receptor 2) is a Protein Coding gene. Diseases associated with PTGDR2 include Eosinophilic Pustular Folliculitis and Folliculitis. Among its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and prostaglandin F receptor activity. An important paralog of this gene is LTB4R2.
UniProtKB/Swiss-Prot Summary for PTGDR2 Gene
-
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
Additional gene information for PTGDR2 Gene
- HGNC(4502)
- Entrez Gene(11251)
- Ensembl(ENSG00000183134)
- OMIM(604837)
- UniProtKB(Q9Y5Y4)
- Open Targets Platform(ENSG00000183134)
- Search for PTGDR2 at DataMed
- Search for PTGDR2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PTGDR2 Gene
Genomics for PTGDR2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PTGDR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PTGDR2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PTGDR2
Genomic Locations for PTGDR2 Gene
Genomic Locations for PTGDR2 Gene
- chr11:60,850,933-60,855,950
- (GRCh38/hg38)
- Size:
- 5,018 bases
- Orientation:
- Minus strand
- chr11:60,618,398-60,623,444
- (GRCh37/hg19)
- Size:
- 5,047 bases
- Orientation:
- Minus strand
Genomic View for PTGDR2 Gene
Genes around PTGDR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.2 by HGNC
- 11q12.2 by Entrez Gene
- 11q12.2 by Ensembl
PTGDR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTGDR2 Gene
Proteins for PTGDR2 Gene
-
Protein details for PTGDR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y5Y4-PD2R2_HUMAN
- Recommended name:
- Prostaglandin D2 receptor 2
- Protein Accession:
- Q9Y5Y4
- O94765
- Q4QRI6
Protein attributes for PTGDR2 Gene
- Size:
- 395 amino acids
- Molecular mass:
- 43268 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAD21055.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAD21055.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for PTGDR2 Gene
Post-translational modifications for PTGDR2 Gene
- Phosphorylated.
-
Glycosylation at Asn4 and Asn25
- NX_Q9Y5Y4 (NX_Q9Y5Y4-1)
- Modification sites at PhosphoSitePlus
Other Protein References for PTGDR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences GPR44 / CRTH2 Antibody (LS-B3209) and GPR44 / CRTH2 Antibody (LS-A3528)
-
BioLegend
- CD294 (CRTH2) Antibody (350102)
- CD294 (CRTH2) Antibody (350103)
- CD294 (CRTH2) Antibody (350104)
- CD294 (CRTH2) Antibody (350106)
- CD294 (CRTH2) Antibody (350105)
- CD294 (CRTH2) Antibody (350109)
- CD294 (CRTH2) Antibody (350110)
- CD294 (CRTH2) Antibody (350108)
- CD294 (CRTH2) Antibody (350107)
- APC/Cyanine7 CD294 (CRTH2) Antibody (350114)
- APC/Cyanine7 CD294 (CRTH2) Antibody (350113)
- CD294 (CRTH2) Antibody (350112)
- PerCP/Cyanine5.5 CD294 (CRTH2) Antibody (350115)
- CD294 (CRTH2) Antibody (350118)
- CD294 (CRTH2) Antibody (350111)
- PerCP/Cyanine5.5 CD294 (CRTH2) Antibody (350116)
- CD294 (CRTH2) Antibody (350117)
- CD294 (CRTH2) Antibody (350120)
- CD294 (CRTH2) Antibody (350119)
- CD294 (CRTH2) Antibody (350121)
- CD294 (CRTH2) Antibody (350122)
- CD294 (CRTH2) Antibody (350124)
- CD294 (CRTH2) Antibody (350123)
- CD294 (CRTH2) Antibody (350126)
- CD294 (CRTH2) Antibody (350125)
- TotalSeq(TM)-A0102 CD294 (CRTH2) Antibody
- CD294 (CRTH2) Antibody (350129)
- CD294 (CRTH2) Antibody (350130)
-
Custom Antibody ServicesOriGene Antibodies for PTGDR2
- Novus Biologicals Antibodies for PTGDR2
-
Abcam antibodies for PTGDR2
- Invitrogen Antibodies for PTGDR2 (AFLGC-PTGDR2)
- antibodies-online: Show 34 available PTGDR2 Antibodies ranked by validation data
- Compare Top PTGDR2 Antibodies
-
Recommended
- 91 WB Antibodies (anti-human)
- 27 FACS Antibodies (anti-human)
- 26 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 34 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 25 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Biorbyt antibodies for PTGDR2
-
Santa Cruz Biotechnology (SCBT) Antibodies for PTGDR2
- Sino Biological Antibodies for PTGDR2
Protein Products
-
OriGene Purified Proteins for PTGDR2
- Search Origene for MassSpec and Protein Over-expression Lysates for PTGDR2
- Origene Custom Protein Services for PTGDR2
-
Abcam proteins for PTGDR2
No data available for DME Specific Peptides for PTGDR2 Gene
Domains & Families for PTGDR2 Gene
Gene Families for PTGDR2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- CD markers
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for PTGDR2 Gene
- InterPro:
- Blocks:
-
- Formyl-methionyl peptide receptor signature
- ProtoNet:
Suggested Antigen Peptide Sequences for PTGDR2 Gene
- GenScript: Design optimal peptide antigens:
-
- Chemoattractant receptor-homologous molecule expressed on Th2 cells (GPR44_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y5Y4UniProtKB/Swiss-Prot:
PD2R2_HUMAN :- The 330-DSEL-333 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for GRK2 and GPRK5/GRK5 to promote agonist-induced internalization. Thr-347 is a major site for PKC-induced internalization of the receptor.
- Belongs to the G-protein coupled receptor 1 family.
- Domain:
-
- The 330-DSEL-333 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for GRK2 and GPRK5/GRK5 to promote agonist-induced internalization. Thr-347 is a major site for PKC-induced internalization of the receptor.
- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for PTGDR2 Gene
Molecular function for PTGDR2 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
Phenotypes From GWAS Catalog for PTGDR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001785 | prostaglandin J receptor activity | IEA | -- |
| GO:0004930 | G protein-coupled receptor activity | TAS,IDA | 11208866 |
| GO:0004956 | prostaglandin D receptor activity | IEA,IDA | 11208866 |
| GO:0004958 | prostaglandin F receptor activity | IEA | -- |
| GO:0042277 | peptide binding | IBA | 21873635 |
Phenotypes for PTGDR2 Gene
- MGI mutant phenotypes for PTGDR2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PTGDR2:
-
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- shRNA abundance <= 50%
- Decreased viability
- shRNA abundance <= 25%
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased Nanog expression
- Increased epidermal growth factor (EGF) endocytosis, increased transferrin (TF) endocytosis
- Decreased viability in non-small-cell lung cancer (NSCLC) lineage; decreased viability in ovarian lineage
Animal Models for PTGDR2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for PTGDR2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PTGDR2 - Select products 50% OFF >
- * PTGDR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PTGDR2
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-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGDR2
miRNA for PTGDR2 Gene
- miRTarBase miRNAs that target PTGDR2
-
- hsa-miR-1238-3p (MIRT647239)
- hsa-miR-670-3p (MIRT647240)
- hsa-miR-6873-3p (MIRT647241)
- hsa-miR-519e-5p (MIRT647242)
- hsa-miR-515-5p (MIRT647243)
- hsa-miR-514b-5p (MIRT647244)
- hsa-miR-513c-5p (MIRT647245)
- hsa-miR-6881-3p (MIRT647246)
- hsa-miR-6780a-3p (MIRT647247)
- hsa-miR-7111-3p (MIRT647248)
- hsa-miR-6715b-3p (MIRT647249)
- hsa-miR-103a-2-5p (MIRT647250)
- hsa-miR-3124-3p (MIRT647251)
- hsa-miR-942-5p (MIRT647252)
- hsa-miR-1236-3p (MIRT647253)
- hsa-miR-6515-3p (MIRT647254)
- hsa-miR-6817-3p (MIRT647255)
- hsa-miR-7110-3p (MIRT647256)
- hsa-miR-5695 (MIRT647257)
- hsa-miR-519d-5p (MIRT647258)
- hsa-miR-372-5p (MIRT647259)
- hsa-miR-616-5p (MIRT647260)
- hsa-miR-373-5p (MIRT647261)
- hsa-miR-371b-5p (MIRT647262)
- hsa-miR-6769b-3p (MIRT647263)
- hsa-miR-4723-3p (MIRT647264)
- hsa-miR-3183 (MIRT647265)
- hsa-miR-6715a-3p (MIRT647266)
- hsa-miR-520f-3p (MIRT647267)
- hsa-miR-302c-3p (MIRT647268)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTGDR2
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Clone Products
- Applied Biological Materials (abm): Clones for PTGDR2 - Select products 50% OFF >
- * PTGDR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PTGDR2
- Addgene plasmids for PTGDR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTGDR2
Cell Line Products
-
Horizon Cell Lines for PTGDR2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTGDR2 Gene
Localization for PTGDR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTGDR2 Gene
- Cell membrane. Multi-pass membrane protein. Note=Internalized receptors colocalized with RAB11A. {ECO:0000269 PubMed:17207480}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| nucleus | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS,IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0043005 | neuron projection | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTGDR2 Gene
Pathways & Interactions for PTGDR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Eicosanoid ligand-binding receptors | ||
| 4 | Ibuprofen Pathway, Pharmacodynamics | ||
| 5 | Hematopoietic Stem Cells and Lineage-specific Markers | ||
Pathways by source for PTGDR2 Gene
1 BioSystems pathway for PTGDR2 Gene
8 Reactome pathways for PTGDR2 Gene
1 PharmGKB pathway for PTGDR2 Gene
2 R&D Systems pathways for PTGDR2 Gene
Interacting Proteins for PTGDR2 Gene
GPS-Prot Interaction Network for PTGDR2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006935 | chemotaxis | IEA,IDA | 11208866 |
| GO:0006955 | immune response | TAS | 9973380 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | IEA | -- |
No data available for SIGNOR curated interactions for PTGDR2 Gene
Drugs & Compounds for PTGDR2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Indomethacin | Approved, Investigational | Pharma | Agonist, Partial agonist, Full agonist, Inhibitor, Inhibition, Target, other/unknown, inhibitor | Cox inhibitor | 150 | |
| Sulindac | Approved, Investigational | Pharma | Target, antagonist | Anti-inflammatory agent;COX inhibitor | 37 | |
| Istradefylline | Approved, Investigational | Pharma | Antagonist, antagonist | CRTh2 antagonist,potent and selective | 22 | |
| Alprostadil | Approved, Investigational | Pharma | Target, agonist | 101 | ||
| Dinoprost | Approved, Investigational | Pharma | Target, agonist | 15 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(2) ApexBio Compounds for PTGDR2 Gene
Transcripts for PTGDR2 Gene
mRNA/cDNA for PTGDR2 Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000332539 2881 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PTGDR2 - Select products 50% OFF >
- * PTGDR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for PTGDR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTGDR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTGDR2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTGDR2
- Browse OriGene Inhibitory RNA Products For PTGDR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGDR2
Clone Products
- Applied Biological Materials (abm): Clones for PTGDR2 - Select products 50% OFF >
- * PTGDR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PTGDR2
- Addgene plasmids for PTGDR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTGDR2
Relevant External Links for PTGDR2 Gene
- GeneLoc Exon Structure for
- PTGDR2
Expression for PTGDR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Positive Thymocytes Thymus
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for PTGDR2 Gene
This gene is overexpressed in Colon - Transverse (x7.2), Stomach (x5.9), Heart - Left Ventricle (x4.5), and Brain - Putamen (basal ganglia) (x4.0).
This gene is overexpressed in Adipocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PTGDR2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PTGDR2
SOURCE GeneReport for Unigene cluster for PTGDR2 Gene:
Hs.299567mRNA Expression by UniProt/SwissProt for PTGDR2 Gene:
Q9Y5Y4-PD2R2_HUMAN
Tissue specificity:
Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils.
Evidence on tissue expression from TISSUES for PTGDR2 Gene
- Blood(4.5)
- Intestine(2.3)
- Lymph node(2.2)
- Spleen(2.2)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for PTGDR2
-
OriGene qPCR primer pairs and template standards for PTGDR2
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTGDR2 Gene
Orthologs for PTGDR2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GPR44 30 |
|
||
| PTGDR2 31 |
|
OneToOne | |||
| Dog (Canis familiaris) |
Mammalia | GPR44 30 |
|
||
| CRTH2 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | GPR44 30 |
|
||
| PTGDR2 31 |
|
OneToOne | |||
| Mouse (Mus musculus) |
Mammalia | Gpr44 30 31 |
|
OneToOne | |
| Ptgdr2 17 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | Ptgdr2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PTGDR2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PTGDR2 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | AL954173.1 31 |
|
ManyToMany |
- Species where no ortholog for PTGDR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PTGDR2 Gene
- ENSEMBL:
- Gene Tree for PTGDR2 (if available)
- TreeFam:
- Gene Tree for PTGDR2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PTGDR2: view image
Paralogs for PTGDR2 Gene
Paralogs for PTGDR2 Gene
(12) SIMAP similar genes for PTGDR2 Gene using alignment to 1 proteins:
- PD2R2_HUMAN
Variants for PTGDR2 Gene
Gene Damage Index Score:
2.81;
47.67% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PTGDR2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTGDR2 Gene
Disorders for PTGDR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| eosinophilic pustular folliculitis |
|
|
| folliculitis |
|
|
| asthma |
|
|
| allergic conjunctivitis |
|
|
| apricot allergy |
|
|
Search PTGDR2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PTGDR2
No data available for UniProtKB/Swiss-Prot and Genatlas for PTGDR2 Gene
Publications for PTGDR2 Gene
- Discovery of three novel orphan G-protein-coupled receptors. (PMID: 10036181) Marchese A … O'dowd BF (Genomics 1999) 2 3 4
- Selective expression of a novel surface molecule by human Th2 cells in vivo. (PMID: 9973380) Nagata K … Takano S (Journal of immunology (Baltimore, Md. : 1950) 1999) 3 4 23
- Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif. (PMID: 20035740) Roy SJ … Parent JL (European journal of pharmacology 2010) 3 4
- Indomethacin-induced reduction in CRTH2 in eosinophilic pustular folliculitis (Ofuji's disease): a proposed mechanism of action. (PMID: 20107720) Satoh T … Yokozeki H (Acta dermato-venereologica 2010) 3 23
- Expression and characterization of PGD2 receptors in chronic rhinosinusitis: modulation of DP and CRTH2 by PGD2. (PMID: 18802357) Yamamoto M … Nishizaki K (International archives of allergy and immunology 2009) 3 23
ExternalLinks
Products for PTGDR2 Gene
- Custom Antibody ServicesOriGene Antibodies for PTGDR2
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- Custom Assay Services
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- Search Origene for MassSpec and Protein Over-expression Lysates for PTGDR2
- Origene Custom Protein Services for PTGDR2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTGDR2
- Browse OriGene Inhibitory RNA Products For PTGDR2
- OriGene qPCR primer pairs for PTGDR2
- OriGene qPCR primer pairs and template standards for PTGDR2
- OriGene CRISPR knockouts for PTGDR2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PTGDR2
- Sino Biological Human cDNA Clone for PTGDR2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for PTGDR2
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PTGDR2
- Novus Biologicals proteins and lysates for PTGDR2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PTGDR2
- Abcam proteins for PTGDR2
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- Taconic Biosciences Mouse Models for PTGDR2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PTGDR2 (AFLGC-PTGDR2)
- ApexBio compounds for PTGDR2
- VectorBuilder Custom and pre-made DNA vectors for PTGDR2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PTGDR2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PTGDR2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PTGDR2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PTGDR2
- Addgene plasmids for PTGDR2
- antibodies-online: Show 34 available PTGDR2 Antibodies ranked by validation data
- Compare Top PTGDR2 Antibodies
- Recommended
- 91 WB Antibodies (anti-human)
- 27 FACS Antibodies (anti-human)
- 26 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 34 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 25 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for available PTGDR2 related products ranked by validation data
- antibodies-online: Search results for available PTGDR2 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for PTGDR2
- Search Santa Cruz Biotechnology (SCBT) for PTGDR2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PTGDR2
- Horizon Cell Lines for PTGDR2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTGDR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTGDR2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PTGDR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTGDR2
- Biorbyt antibodies for PTGDR2
Sources for PTGDR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB