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This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]
PTGDR2 (Prostaglandin D2 Receptor 2) is a Protein Coding gene. Diseases associated with PTGDR2 include Eosinophilic Pustular Folliculitis and Folliculitis. Among its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and prostaglandin F receptor activity. An important paralog of this gene is LTB4R2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001785 | prostaglandin J receptor activity | IEA | -- |
GO:0004930 | G protein-coupled receptor activity | TAS,IDA | 11208866 |
GO:0004956 | prostaglandin D receptor activity | IEA,IDA | 11208866 |
GO:0004958 | prostaglandin F receptor activity | IEA | -- |
GO:0042277 | peptide binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS,IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0043005 | neuron projection | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | Eicosanoid ligand-binding receptors | ||
4 | Ibuprofen Pathway, Pharmacodynamics | ||
5 | Hematopoietic Stem Cells and Lineage-specific Markers |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006935 | chemotaxis | IEA,IDA | 11208866 |
GO:0006955 | immune response | TAS | 9973380 |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Indomethacin | Approved, Investigational | Pharma | Agonist, Partial agonist, Full agonist, Inhibitor, Inhibition, Target, other/unknown, inhibitor | Cox inhibitor | 150 | |
Sulindac | Approved, Investigational | Pharma | Target, antagonist | Anti-inflammatory agent;COX inhibitor | 37 | |
Istradefylline | Approved, Investigational | Pharma | Antagonist, antagonist | CRTh2 antagonist,potent and selective | 22 | |
Alprostadil | Approved, Investigational | Pharma | Target, agonist | 101 | ||
Dinoprost | Approved, Investigational | Pharma | Target, agonist | 15 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GPR44 30 |
|
||
PTGDR2 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | GPR44 30 |
|
||
CRTH2 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | GPR44 30 |
|
||
PTGDR2 31 |
|
OneToOne | |||
Mouse (Mus musculus) |
Mammalia | Gpr44 30 31 |
|
OneToOne | |
Ptgdr2 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Ptgdr2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | PTGDR2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PTGDR2 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | AL954173.1 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
eosinophilic pustular folliculitis |
|
|
folliculitis |
|
|
asthma |
|
|
allergic conjunctivitis |
|
|
apricot allergy |
|
|