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Aliases for PTENP1 Gene

Subcategory (RNA class) for PTENP1 Gene


Aliases for PTENP1 Gene

  • Phosphatase And Tensin Homolog Pseudogene 1 2 3 5
  • Phosphatase And Tensin Homolog Pseudogene 1 (Functional) 2 3
  • Phosphatase And Tensin Homolog (Mutated In Multiple Advanced Cancers 1), Pseudogene 1 3
  • PTEN/MMAC1 Pseudogene 3
  • PTEN-Rs 3
  • PTENpg1 3
  • PsiPTEN 3
  • PTEN2 3
  • PTH2 3

External Ids for PTENP1 Gene

ORGUL Members for PTENP1 Gene

Previous GeneCards Identifiers for PTENP1 Gene

  • GC09M033987
  • GC09M033844

Summaries for PTENP1 Gene

Entrez Gene Summary for PTENP1 Gene

  • The phosphatase and tensin homolog (PTEN) gene encodes a tumor suppressor that functions by negatively regulating the AKT/PKB signaling pathway. A highly homologous processed pseudogene of PTEN is found on chromosome 9 and regulates PTEN by both sense and antisense RNAs (Gene ID: 101243555). This long-noncoding RNA (lncRNA) acts as a decoy for PTEN targeting microRNAs and also exerts a tumor suppressive activity. [provided by RefSeq, Apr 2013]

GeneCards Summary for PTENP1 Gene

PTENP1 (Phosphatase And Tensin Homolog Pseudogene 1) is a Pseudogene, and is affiliated with the lncRNA class. Diseases associated with PTENP1 include Prostate Disease and Endometrial Cancer.

Gene Wiki entry for PTENP1 Gene

fRNAdb sequence ontologies for PTENP1 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for PTENP1

Additional gene information for PTENP1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for PTENP1 Gene

Genomics for PTENP1 Gene

GeneHancer (GH) Regulatory Elements for PTENP1 Gene

Promoters and enhancers for PTENP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J033675 Promoter/Enhancer 1.3 Ensembl ENCODE 650.7 +0.7 683 1.9 RB1 SIN3A YY1 ZNF335 GLIS2 ATF7 ZNF280D YY2 CEBPB ZNF398 PTENP1 PTENP1-AS ENSG00000260947 LINC01251 NUDT2 TRBV25OR9-2
GH09J033813 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -139.2 -139213 6.9 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 UBE2R2 B4GALT1 UBAP1 ENSG00000228352 PTENP1 PRSS3 ENSG00000260947 ENSG00000230074 UBAP2 DCAF12
GH09J034177 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10.6 -501.9 -501924 3.2 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B UBAP1 ENSG00000228352 PTENP1 PIGO NUDT2 UBE2R2 LOC114224
GH09J033442 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.7 +232.1 232107 6.2 FOXA2 PKNOX1 MLX ARID4B SIN3A YY1 ZNF766 FOS DEK NFYC AQP3 AQP7 NOL6 PTENP1 NFX1 BAG1 SMU1 PIR43065
GH09J033940 Enhancer 0.9 ENCODE 10.6 -263.1 -263064 1.1 FOXA2 ARID4B DMAP1 ZNF48 TCF12 SLC30A9 NFKBIZ RXRA SP5 PPARG ENSG00000228352 B4GALT1 PTENP1 NUDT2 UBE2R2 KIF24 GC09M033934 SNORD121B GC09M033952 SNORD121A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PTENP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTENP1 gene promoter:
  • POU2F1
  • POU2F1a
  • Ik-3
  • FOXO3
  • FOXO3b
  • FOXO3a
  • ISGF-3
  • AP-1
  • Evi-1
  • Pbx1a

Genomic Locations for PTENP1 Gene

Genomic Locations for PTENP1 Gene
3,996 bases
Minus strand
3,996 bases
Minus strand

Genomic View for PTENP1 Gene

Genes around PTENP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTENP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTENP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTENP1 Gene

ORGUL Member Location for PTENP1 Gene

ORGUL Member Location for PTENP1 gene

Proteins for PTENP1 Gene

Post-translational modifications for PTENP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PTENP1 Gene

Domains & Families for PTENP1 Gene

Gene Families for PTENP1 Gene

Suggested Antigen Peptide Sequences for PTENP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PTENP1: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for PTENP1 Gene

Function for PTENP1 Gene

Molecular function for PTENP1 Gene

GENATLAS Biochemistry:
phosphatase and tensin homolog 2,pseudogene 1,playing a role in small cell lung cancer tumorigenesis (see TSG9A)

Phenotypes From GWAS Catalog for PTENP1 Gene

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PTENP1 Gene

Localization for PTENP1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PTENP1 Gene

Pathways & Interactions for PTENP1 Gene

SuperPathways for PTENP1 Gene

No Data Available

Interacting Proteins for PTENP1 Gene

Gene Ontology (GO) - Biological Process for PTENP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for PTENP1 Gene

Drugs & Compounds for PTENP1 Gene

No Compound Related Data Available

Transcripts for PTENP1 Gene

fRNAdb Secondary structures for PTENP1 Gene

  • FR279969
  • FR272101

mRNA/cDNA for PTENP1 Gene

(5) Additional mRNA sequences :
(41) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PTENP1 Gene

Phosphatase and tensin homolog pseudogene 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PTENP1 Gene

No ASD Table

Relevant External Links for PTENP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTENP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTENP1 Gene

mRNA differential expression in normal tissues according to GTEx for PTENP1 Gene

This gene is overexpressed in Whole Blood (x7.0).

NURSA nuclear receptor signaling pathways regulating expression of PTENP1 Gene:


SOURCE GeneReport for Unigene cluster for PTENP1 Gene:

genes like me logo Genes that share expression patterns with PTENP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTENP1 Gene

Orthologs for PTENP1 Gene

Evolution for PTENP1 Gene

Gene Tree for PTENP1 (if available)
Gene Tree for PTENP1 (if available)

No data available for Orthologs for PTENP1 Gene

Paralogs for PTENP1 Gene

(4) SIMAP similar genes for PTENP1 Gene using alignment to 1 proteins:

  • O43460_HUMAN
genes like me logo Genes that share paralogs with PTENP1: view

No data available for Paralogs for PTENP1 Gene

Variants for PTENP1 Gene

Sequence variations from dbSNP and Humsavar for PTENP1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000341772 -- 33,673,715(-) A/C non_coding_transcript_variant
rs1000491893 -- 33,673,373(-) T/C downstream_transcript_variant
rs1002108603 -- 33,675,186(-) T/C non_coding_transcript_variant
rs1002564227 -- 33,674,876(-) C/T non_coding_transcript_variant
rs1002776203 -- 33,677,417(-) A/G non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PTENP1 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv471653 CNV gain 15918152
nsv518977 CNV gain 19592680
nsv614150 CNV gain 21841781
nsv968605 CNV duplication 23825009

Additional Variant Information for PTENP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PTENP1 Gene

Disorders for PTENP1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for PTENP1 Gene - From: LncRNADisease and GeneCards

Disorder Aliases PubMed IDs
prostate disease
  • prostate diseases
endometrial cancer
  • endometrial cancer, familial
renal cell carcinoma, nonpapillary
  • rcc
prostate cancer
  • prostate cancer, susceptibility to
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PTENP1

genes like me logo Genes that share disorders with PTENP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTENP1 Gene

Publications for PTENP1 Gene

  1. A highly conserved processed PTEN pseudogene is located on chromosome band 9p21. (PMID: 9620558) Dahia PL … Eng C (Oncogene 1998) 2 3 22 58
  2. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. (PMID: 20577206) Poliseno L … Pandolfi PP (Nature 2010) 2 3 58
  3. Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN. (PMID: 10208437) Fujii GH … Bolen JB (Oncogene 1999) 3 22 58
  4. Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines. (PMID: 9467947) Kim SK … Mao L (Oncogene 1998) 3 22 58
  5. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. (PMID: 9393738) Teng DH … Steck PA (Cancer research 1997) 2 3 58

Products for PTENP1 Gene

Sources for PTENP1 Gene

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