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Aliases for PTCRA Gene

Aliases for PTCRA Gene

  • Pre T Cell Antigen Receptor Alpha 2 3
  • Pre T-Cell Antigen Receptor Alpha 2 3 5
  • PT-Alpha-TCR 3 4
  • PT-ALPHA 3 4
  • PTA 3 4
  • Pre-T-Cell Receptor Alpha Chain 3

External Ids for PTCRA Gene

Previous GeneCards Identifiers for PTCRA Gene

  • GC06P042885
  • GC06P042931
  • GC06P042932
  • GC06P042992
  • GC06P042883
  • GC06P042601

Summaries for PTCRA Gene

Entrez Gene Summary for PTCRA Gene

  • The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for PTCRA Gene

PTCRA (Pre T Cell Antigen Receptor Alpha) is a Protein Coding gene. Diseases associated with PTCRA include Granulomatous Orchitis and Rumination Disorder. Among its related pathways are Notch signaling pathway (KEGG) and Transcriptional misregulation in cancer.

UniProtKB/Swiss-Prot for PTCRA Gene

  • The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.

Additional gene information for PTCRA Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTCRA Gene

Genomics for PTCRA Gene

GeneHancer (GH) Regulatory Elements for PTCRA Gene

Promoters and enhancers for PTCRA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I042916 Promoter/Enhancer 0.8 EPDnew dbSUPER 550.8 +0.2 227 0.1 RUNX3 PTCRA ENSG00000231113 PPP2R5D RPL7L1 C6orf226 PEX6 KLHDC3 MEA1 CUL9 RNU6-890P
GH06I042910 Enhancer 1 Ensembl ENCODE dbSUPER 0.8 -4.2 -4219 1.8 CTCF TFAP4 FOXA2 SAP130 BACH1 SIN3A POLR2A CTBP2 ZNF143 PEX6 RPL7L1 ENSG00000231113 PPP2R5D KLHDC3 MEA1 RNU6-890P PTCRA LOC105375063
GH06I042901 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.4 -12.8 -12756 3.3 FOXA2 ARNT ZFP64 ARID4B DMAP1 ZNF2 ZNF48 YY1 SLC30A9 TCF12 LOC105375063 RPL7L1 PEX6 CNPY3 ENSG00000231113 PPP2R5D KLC4 RN7SL403P CUL7 KLHDC3
GH06I042923 Enhancer 0.9 Ensembl ENCODE 0.4 +8.2 8194 1.2 BCOR ETV1 ZMYM3 CEBPG ZNF316 ZBTB48 ADNP PRDM10 MAFK SOX6 RPL7L1 RPL24P4 PEX6 PPP2R5D KLHDC3 MEA1 KLC4 CUL7 RN7SL403P DNPH1
GH06I042912 Enhancer 0.3 dbSUPER 0.8 -2.6 -2600 0.6 ZNF157 ENSG00000231113 PEX6 RPL7L1 PPP2R5D KLHDC3 MEA1 RNU6-890P PTCRA LOC105375063
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PTCRA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PTCRA gene promoter:

Genomic Locations for PTCRA Gene

Genomic Locations for PTCRA Gene
10,032 bases
Plus strand

Genomic View for PTCRA Gene

Genes around PTCRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PTCRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PTCRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PTCRA Gene

Proteins for PTCRA Gene

  • Protein details for PTCRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pre T-cell antigen receptor alpha
    Protein Accession:
    Secondary Accessions:
    • Q5TFZ7

    Protein attributes for PTCRA Gene

    281 amino acids
    Molecular mass:
    29266 Da
    Quaternary structure:
    • Heterodimer with TCRB; disulfide linked. This heterodimer assembles with CD3 proteins into a signaling-competent pre-T-cell receptor complex. Interacts with RHBDD1.

    Three dimensional structures from OCA and Proteopedia for PTCRA Gene

    Alternative splice isoforms for PTCRA Gene


neXtProt entry for PTCRA Gene

Post-translational modifications for PTCRA Gene

Other Protein References for PTCRA Gene

No data available for DME Specific Peptides for PTCRA Gene

Domains & Families for PTCRA Gene

Gene Families for PTCRA Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for PTCRA Gene

Suggested Antigen Peptide Sequences for PTCRA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PTCRA: view

No data available for UniProtKB/Swiss-Prot for PTCRA Gene

Function for PTCRA Gene

Molecular function for PTCRA Gene

GENATLAS Biochemistry:
pre-T-cell receptor alpha chain,invariant,heterodimerizing with TCRbeta chain receptor in immature thymocyte
UniProtKB/Swiss-Prot Function:
The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.

Phenotypes From GWAS Catalog for PTCRA Gene

Gene Ontology (GO) - Molecular Function for PTCRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22795130
genes like me logo Genes that share ontologies with PTCRA: view
genes like me logo Genes that share phenotypes with PTCRA: view

Animal Models for PTCRA Gene

MGI Knock Outs for PTCRA:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTCRA Gene

Localization for PTCRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PTCRA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PTCRA gene
Compartment Confidence
plasma membrane 4
extracellular 3
nucleus 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PTCRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PTCRA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PTCRA Gene

Pathways & Interactions for PTCRA Gene

genes like me logo Genes that share pathways with PTCRA: view

SIGNOR curated interactions for PTCRA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PTCRA Gene


Drugs & Compounds for PTCRA Gene

(2) Drugs for PTCRA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PTCRA: view

Transcripts for PTCRA Gene

Unigene Clusters for PTCRA Gene

Pre T-cell antigen receptor alpha:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PTCRA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - -
SP3: -
SP4: - -
SP5: - - - -

Relevant External Links for PTCRA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PTCRA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PTCRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PTCRA Gene

This gene is overexpressed in Whole Blood (x34.1) and Spleen (x8.4).

Protein differential expression in normal tissues from HIPED for PTCRA Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PTCRA Gene

Protein tissue co-expression partners for PTCRA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PTCRA Gene:


SOURCE GeneReport for Unigene cluster for PTCRA Gene:


mRNA Expression by UniProt/SwissProt for PTCRA Gene:

Tissue specificity: Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

Evidence on tissue expression from TISSUES for PTCRA Gene

  • Blood(4.5)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with PTCRA: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PTCRA Gene

Orthologs for PTCRA Gene

This gene was present in the common ancestor of mammals.

Orthologs for PTCRA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PTCRA 33 34
  • 98.7 (n)
(Bos Taurus)
Mammalia PTCRA 33 34
  • 85.78 (n)
(Canis familiaris)
Mammalia PTCRA 33 34
  • 84.14 (n)
(Mus musculus)
Mammalia Ptcra 33 16 34
  • 81.35 (n)
(Rattus norvegicus)
Mammalia Ptcra 33
  • 78.91 (n)
Species where no ortholog for PTCRA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PTCRA Gene

Gene Tree for PTCRA (if available)
Gene Tree for PTCRA (if available)

Paralogs for PTCRA Gene

No data available for Paralogs for PTCRA Gene

Variants for PTCRA Gene

Sequence variations from dbSNP and Humsavar for PTCRA Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000414551 -- 42,918,405(+) T/C intron_variant
rs1000475886 -- 42,922,596(+) C/T intron_variant
rs1000529191 -- 42,922,382(+) A/G intron_variant
rs1000851346 -- 42,916,569(+) A/G intron_variant
rs1001046764 -- 42,915,839(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PTCRA Gene

Variant ID Type Subtype PubMed ID
nsv830651 CNV loss 17160897
nsv1017398 CNV gain 25217958
esv3608807 CNV loss 21293372
esv3576145 CNV gain 25503493
esv1622905 CNV insertion 17803354

Variation tolerance for PTCRA Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.99; 89.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PTCRA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTCRA Gene

Disorders for PTCRA Gene

MalaCards: The human disease database

(23) MalaCards diseases for PTCRA Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
granulomatous orchitis
  • non-specific granulomatous orchitis
rumination disorder
  • psychogenic rumination
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
cavernous sinus thrombosis
  • thrombosis of cavernous venous sinus
marantic endocarditis
  • non-bacterial thrombotic endocarditis
- elite association - COSMIC cancer census association via MalaCards
Search PTCRA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PTCRA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PTCRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PTCRA Gene

Publications for PTCRA Gene

  1. Genomic structure of the human pre-T cell receptor alpha chain and expression of two mRNA isoforms. (PMID: 9842925) Saint-Ruf C … von Boehmer H (European journal of immunology 1998) 2 3 4 22 58
  2. Cloning and comparative analysis of the human pre-T-cell receptor alpha-chain gene. (PMID: 8618853) Del Porto P … Saint-Ruf C (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 22 58
  3. Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins. (PMID: 22795130) Fleig L … Lemberg MK (Molecular cell 2012) 3 4 58
  4. Differential subcellular localization regulates c-Cbl E3 ligase activity upon Notch3 protein in T-cell leukemia. (PMID: 19966856) Checquolo S … Screpanti I (Oncogene 2010) 3 22 58
  5. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PMID: 19019335) Velez DR … Menon R (American journal of obstetrics and gynecology 2009) 3 44 58

Products for PTCRA Gene

Sources for PTCRA Gene

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