Aliases for PTCRA Gene
External Ids for PTCRA Gene
Previous GeneCards Identifiers for PTCRA Gene
The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
GeneCards Summary for PTCRA Gene
PTCRA (Pre T Cell Antigen Receptor Alpha) is a Protein Coding gene. Diseases associated with PTCRA include Palmoplantar Keratoderma And Congenital Alopecia 2 and Coronary Aneurysm. Among its related pathways are Transcriptional misregulation in cancer and C-MYB transcription factor network.
UniProtKB/Swiss-Prot Summary for PTCRA Gene
The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.