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The protein encoded by this gene binds RNA and is a regulator of cell differentiation. The encoded protein preferentially binds to poly(G) and poly(U) sequences in vitro. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PTBP3 (Polypyrimidine Tract Binding Protein 3) is a Protein Coding gene. Diseases associated with PTBP3 include Fanconi Anemia, Complementation Group A. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PTBP1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | TAS,HDA | 22658674 |
GO:0003729 | mRNA binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006397 | mRNA processing | IEA | -- |
GO:0006417 | regulation of translation | IBA | -- |
GO:0008380 | RNA splicing | IEA | -- |
GO:0009653 | anatomical structure morphogenesis | TAS | 10207106 |
GO:0030154 | cell differentiation | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
ExUns: | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||
SP2: | |||||||||||
SP3: | |||||||||||
SP4: | |||||||||||
SP5: | |||||||||||
SP6: | |||||||||||
SP7: | |||||||||||
SP8: | |||||||||||
SP9: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ROD1 30 |
|
||
PTBP3 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | PTBP3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Ptbp3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ptbp3 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PTBP3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PTBP3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ROD1 30 |
|
||
PTBP3 31 |
|
OneToOne | |||
Lizard (Anolis carolinensis) |
Reptilia | PTBP3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ptbp3 30 |
|
||
Str.13021 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | ptbp3 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | heph 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | ptb-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2279381 | CNV | deletion | 18987734 |
esv2461102 | CNV | deletion | 19546169 |
esv2662225 | CNV | deletion | 23128226 |
esv2672483 | CNV | deletion | 23128226 |
esv2738946 | CNV | deletion | 23290073 |
esv3621510 | CNV | loss | 21293372 |
esv3621511 | CNV | gain | 21293372 |
esv3621512 | CNV | loss | 21293372 |
nsv1035315 | CNV | gain | 25217958 |
nsv1053706 | CNV | loss | 25217958 |
nsv1124464 | CNV | deletion | 24896259 |
nsv1129305 | CNV | insertion | 24896259 |
nsv466487 | CNV | loss | 19166990 |
nsv511430 | CNV | loss | 21212237 |
nsv518422 | CNV | gain | 19592680 |
nsv615196 | CNV | loss | 21841781 |
nsv825045 | CNV | loss | 20364138 |
nsv950926 | CNV | duplication | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
fanconi anemia, complementation group a |
|
|