Aliases for PTAFR Gene
Aliases for PTAFR Gene
External Ids for PTAFR Gene
- HGNC: 9582
- Entrez Gene: 5724
- Ensembl: ENSG00000169403
- OMIM: 173393
- UniProtKB: P25105
Previous GeneCards Identifiers for PTAFR Gene
- GC01P026956
- GC01M027486
- GC01M027708
- GC01M028080
- GC01M028346
- GC01M028473
- GC01M026730
Summaries for PTAFR Gene
-
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
GeneCards Summary for PTAFR Gene
PTAFR (Platelet Activating Factor Receptor) is a Protein Coding gene. Diseases associated with PTAFR include Melanoma Metastasis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and lipopolysaccharide binding. An important paralog of this gene is LPAR4.
UniProtKB/Swiss-Prot for PTAFR Gene
-
Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
-
Platelet-activating factor receptor (PAF-R) is a Gq/G11-coupled-protein receptor that has a role in a wide range of biological processes such as vasodilation, superoxide formation, cell proliferation, angiogenesis and regulation of the inflammatory response.
Additional gene information for PTAFR Gene
- Monarch Initiative
- Search for PTAFR at DataMed
- Search for PTAFR at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PTAFR Gene
Genomics for PTAFR Gene
GeneHancer (GH) Regulatory Elements for PTAFR Gene
Promoters and enhancers for PTAFR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PTAFR on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PTAFR gene promoter:
-
- C/EBPalpha
- Pax-4a
- IRF-1
- XBP-1
- Nkx5-1
- HTF
- IRF-2
- LyF-1
- Roaz
Regulatory Element Products
Genomic Locations for PTAFR Gene
Genomic Locations for PTAFR Gene
- chr1:28,147,166-28,193,936
- (GRCh38/hg38)
- Size:
- 46,771 bases
- Orientation:
- Minus strand
- chr1:28,473,677-28,520,447
- (GRCh37/hg19)
- Size:
- 46,771 bases
- Orientation:
- Minus strand
Genomic View for PTAFR Gene
Genes around PTAFR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p35.3 by Entrez Gene
- 1p35.3 by HGNC
- 1p35.3 by Ensembl
PTAFR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PTAFR Gene
Proteins for PTAFR Gene
-
Protein details for PTAFR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25105-PTAFR_HUMAN
- Recommended name:
- Platelet-activating factor receptor
- Protein Accession:
- P25105
- A3KMC8
- A8K2H5
Protein attributes for PTAFR Gene
- Size:
- 342 amino acids
- Molecular mass:
- 39203 Da
- Quaternary structure:
-
- Interacts with ARRB1.
Post-translational modifications for PTAFR Gene
Other Protein References for PTAFR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PTAFR
- Novus Biologicals Antibodies for PTAFR
-
Abcam antibodies for PTAFR
- Invitrogen Antibodies for PTAFR
- antibodies-online: Search results for 43 available PTAFR Antibodies ranked by validation data
- Compare Top PTAFR Antibodies
-
Recommended
- GeneTex PTAFR Antibody for PTAFR
Protein Products
-
OriGene Purified Proteins for PTAFR
- Search Origene for MassSpec and Protein Over-expression Lysates for PTAFR
- Origene Custom Protein Services for PTAFR
- Search GeneTex for Proteins for PTAFR
-
Abcam proteins for PTAFR
Assay Products
No data available for DME Specific Peptides for PTAFR Gene
Domains & Families for PTAFR Gene
Gene Families for PTAFR Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
- Transporters
Protein Domains for PTAFR Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PTAFR Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P25105- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for PTAFR Gene
Molecular function for PTAFR Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
- UniProtKB/Swiss-Prot Induction:
- By CSF2/GM-CSF, IL5/interleukin-5 and n-butyrate.
- GENATLAS Biochemistry:
- platelet activating factor,receptor,G protein coupled receptor superfamilu
Phenotypes From GWAS Catalog for PTAFR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001530 | lipopolysaccharide binding | IEA | -- |
| GO:0001875 | lipopolysaccharide receptor activity | IEA | -- |
| GO:0004871 | obsolete signal transducer activity | IEA | -- |
| GO:0004930 | G-protein coupled receptor activity | TAS | 1322356 |
| GO:0004992 | platelet activating factor receptor activity | IDA | 1281995 |
Phenotypes for PTAFR Gene
- MGI mutant phenotypes for PTAFR:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PTAFR:
-
- Increased shRNA abundance (Z-score > 2)
- Increased transcriptional activity
- Dynamic nuclei (hole, folded or small irregular)
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased gamma-H2AX phosphorylation
- Mildly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PTAFR
-
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-
OriGene CRISPR knockouts for PTAFR
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- Overview of 131 available PTAFR gene related products
-
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-
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miRNA for PTAFR Gene
- miRTarBase miRNAs that target PTAFR
-
- hsa-mir-335-5p (MIRT017043)
- hsa-mir-6788-3p (MIRT516031)
- hsa-mir-4635 (MIRT516032)
- hsa-mir-3663-5p (MIRT516033)
- hsa-mir-4716-5p (MIRT516034)
- hsa-mir-4494 (MIRT516035)
- hsa-mir-4463 (MIRT516036)
- hsa-mir-6829-3p (MIRT632517)
- hsa-mir-6791-3p (MIRT632518)
- hsa-mir-2276-3p (MIRT632519)
- hsa-mir-1281 (MIRT632520)
- hsa-mir-4485-5p (MIRT632521)
- hsa-mir-186-3p (MIRT639948)
- hsa-mir-208b-5p (MIRT639949)
- hsa-mir-208a-5p (MIRT639950)
- hsa-mir-6749-3p (MIRT654638)
- hsa-mir-3156-3p (MIRT654639)
- hsa-mir-188-3p (MIRT654640)
- hsa-mir-3157-5p (MIRT654641)
- hsa-mir-24-3p (MIRT654642)
- hsa-mir-4284 (MIRT654643)
- hsa-mir-6778-3p (MIRT654644)
- hsa-mir-149-5p (MIRT654645)
- hsa-mir-532-3p (MIRT654646)
- hsa-mir-8073 (MIRT654647)
- hsa-mir-221-5p (MIRT654648)
- hsa-mir-4301 (MIRT654649)
- hsa-mir-660-3p (MIRT654650)
- hsa-mir-125b-2-3p (MIRT654651)
- hsa-mir-5697 (MIRT654652)
- hsa-mir-562 (MIRT654653)
- hsa-mir-1307-3p (MIRT666784)
- hsa-mir-5193 (MIRT666785)
miRNA Products
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 131 available PTAFR gene related products
- Overview of 131 available PTAFR gene related products
-
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PTAFR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTAFR
- genomics-online: cdna clones - Search results for 131 available PTAFR gene related products
- Overview of 131 available PTAFR gene related products
-
Recommended
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- Overview of 131 available PTAFR gene related products
-
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for PTAFR (PAFR)
Cell Line Products
-
Horizon Cell Lines for PTAFR
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PTAFR Gene
Localization for PTAFR Gene
Subcellular locations from UniProtKB/Swiss-Prot for PTAFR Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 2 |
| extracellular | 1 |
- Nucleoplasm (3)
- Plasma membrane (3)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8168510 |
| GO:0016020 | membrane | IEA,IDA | 1374385 |
| GO:0016021 | integral component of membrane | NAS | 1281995 |
| GO:0030667 | secretory granule membrane | TAS | -- |
Pathways & Interactions for PTAFR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Innate Immune System |
.61
|
|
| 4 | Cytokine Signaling in Immune system | ||
| 5 | RET signaling | ||
Pathways by source for PTAFR Gene
2 BioSystems pathways for PTAFR Gene
3 KEGG pathways for PTAFR Gene
Interacting Proteins for PTAFR Gene
GPS-Prot Interaction Network for PTAFR
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001816 | cytokine production | IEA | -- |
| GO:0002693 | positive regulation of cellular extravasation | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006935 | chemotaxis | TAS,IEA | -- |
| GO:0006954 | inflammatory response | IEA,TAS | -- |
No data available for SIGNOR curated interactions for PTAFR Gene
Drugs & Compounds for PTAFR Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Etizolam | Approved | Pharma | Target, antagonist | 0 | ||
| Rupatadine | Approved | Pharma | Target, antagonist | 0 | ||
| calcium | Approved | Nutra | 0 | |||
| Platelet Activating Factor | Experimental | Pharma | Target | 0 | ||
| PCA 4248 | Pharma | Antagonist | PAF receptor antagonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 52770 RP |
|
Antagonist |
|
|||
| SR 27417 |
|
Antagonist |
|
|||
| Y-24180 |
|
Antagonist |
|
(4) Tocris Compounds for PTAFR Gene
| Compound | Action | Cas Number |
|---|---|---|
| Ginkgolide B | PAF receptor antagonist | 15291-77-7 |
| PAF (C16) | Endogenous platelet-activating factor (PAF) | 74389-68-7 |
| PCA 4248 | PAF receptor antagonist | 123875-01-4 |
| WEB 2086 | Potent PAF receptor antagonist | 105219-56-5 |
(4) ApexBio Compounds for PTAFR Gene
| Compound | Action | Cas Number |
|---|---|---|
| Ginkgolide B | PAF receptor antagonist | 15291-77-7 |
| PAF (C16) | ligand for PAF receptors | 74389-68-7 |
| PCA 4248 | 123875-01-4 | |
| WEB 2086 | 105219-56-5 |
Transcripts for PTAFR Gene
mRNA/cDNA for PTAFR Gene
- (4) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (61) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000373857 4491 bps (uc001bpl.4)
- ENST00000305392 1539 bps (uc001bpm.5)
- ENST00000539896 4191 bps (uc009vte.3)
Unigene Clusters for PTAFR Gene
- Platelet-activating factor receptor:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PTAFR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTAFR
- genomics-online: gRNA clones - Search results for 131 available PTAFR gene related products
- Overview of 131 available PTAFR gene related products
-
Recommended
- Applied Biological Materials CRISPR for PTAFR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PTAFR
- GenScript: Design CRISPR guide RNA sequences for PTAFR
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTAFR
- Browse OriGene Inhibitory RNA Products For PTAFR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTAFR
- genomics-online: shRNA clones - Search results for 131 available PTAFR gene related products
- Overview of 131 available PTAFR gene related products
-
Recommended
Clone Products
- Sino Biological Human cDNA Clone for PTAFR
- VectorBuilder custom plasmid, inducible vectors for PTAFR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTAFR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PTAFR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTAFR
- genomics-online: cdna clones - Search results for 131 available PTAFR gene related products
- Overview of 131 available PTAFR gene related products
-
Recommended
- orf clones - Search results for 131 available PTAFR gene related products
- Overview of 131 available PTAFR gene related products
-
Recommended
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for PTAFR (PAFR)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||
| SP2: | - | - | |||||||||||||||||
| SP3: | - | ||||||||||||||||||
| SP4: | - | - | - |
Expression for PTAFR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
mRNA differential expression in normal tissues according to GTEx for PTAFR Gene
This gene is overexpressed in Whole Blood (x30.8).
NURSA nuclear receptor signaling pathways regulating expression of PTAFR Gene:
PTAFRSOURCE GeneReport for Unigene cluster for PTAFR Gene:
Hs.77542mRNA Expression by UniProt/SwissProt for PTAFR Gene:
P25105-PTAFR_HUMAN
Tissue specificity:
Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.
Evidence on tissue expression from TISSUES for PTAFR Gene
- Blood(4.7)
- Heart(4.3)
- Nervous system(4.3)
- Lung(2.4)
Primer Products
-
OriGene qPCR primer pairs and template standards for PTAFR
-
OriGene qPCR primer pairs for PTAFR
- genomics-online: primer clones - Search results for 131 available PTAFR gene related products
- Overview of 131 available PTAFR gene related products
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Recommended
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PTAFR Gene
Orthologs for PTAFR Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PTAFR 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PTAFR 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PTAFR 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ptafr 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ptafr 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PTAFR 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PTAFR 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PTAFR 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PTAFR 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ptafr 33 |
|
||
| Str.5217 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC52896 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100002627 33 |
|
||
| PTAFR 34 |
|
OneToOne |
- Species where no ortholog for PTAFR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PTAFR Gene
- ENSEMBL:
- Gene Tree for PTAFR (if available)
- TreeFam:
- Gene Tree for PTAFR (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PTAFR: view image
Paralogs for PTAFR Gene
Paralogs for PTAFR Gene
(20) SIMAP similar genes for PTAFR Gene using alignment to 1 proteins:
- PTAFR_HUMAN
Variants for PTAFR Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000027735 | -- | 28,187,815(-) | A/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000056383 | -- | 28,163,939(-) | G/A | intron_variant | |
| rs1000088372 | -- | 28,181,392(-) | G/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000108889 | -- | 28,175,158(-) | C/T | intron_variant | |
| rs1000170168 | -- | 28,192,145(-) | C/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2678105 | CNV | deletion | 23128226 |
| esv3359002 | CNV | duplication | 20981092 |
| esv3370107 | CNV | insertion | 20981092 |
| esv3585573 | CNV | loss | 21293372 |
| esv3585574 | CNV | loss | 21293372 |
| nsv473375 | CNV | novel sequence insertion | 20440878 |
| nsv7546 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.49;
55.19% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PTAFR Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PTAFR Gene
Disorders for PTAFR Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| melanoma metastasis |
|
|
Search PTAFR in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PTAFR
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PTAFR Gene
Publications for PTAFR Gene
- The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1. (PMID: 1322356) Seyfried CE … Gray PW (Genomics 1992) 2 3 4 22 58
- Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. (PMID: 16709866) McLaughlin NJ … Silliman CC (Journal of immunology (Baltimore, Md. : 1950) 2006) 3 4 22 58
- Platelet-activating factor receptor gene polymorphism in Japanese patients with multiple sclerosis. (PMID: 15748960) Osoegawa M … Kira J (Journal of neuroimmunology 2005) 3 22 44 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor. (PMID: 20007715) Hirota N … Nakamura M (The Journal of biological chemistry 2010) 3 22 58
Products for PTAFR Gene
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- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PTAFR
- Search Origene for MassSpec and Protein Over-expression Lysates for PTAFR
- Origene Custom Protein Services for PTAFR
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PTAFR
- Browse OriGene Inhibitory RNA Products For PTAFR
- OriGene qPCR primer pairs and template standards for PTAFR
- OriGene qPCR primer pairs for PTAFR
- OriGene CRISPR knockouts for PTAFR
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PTAFR
- GenScript: Next-day shipping of latest version cDNA ORF clones for PTAFR in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PTAFR
- GenScript Activity-based Kinase Assay for Compound Screening for PTAFR
- GenScript Custom Assay Services for PTAFR
- GenScript PTAFR - overexpressing Cell Line for Assay
- GenScript Custom overexpressing Cell Line Services for PTAFR
- GenScript: Design CRISPR guide RNA sequences for PTAFR
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PTAFR
- Sino Biological Human cDNA Clone for PTAFR
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PTAFR
- Novus Biologicals proteins and lysates for PTAFR
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PTAFR
- Abcam proteins for PTAFR
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cyagen custom Knockout/knockin (KOKI) mouse models for PTAFR
- VectorBuilder custom plasmid, inducible vectors for PTAFR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PTAFR
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PTAFR
- antibodies-online: Search results for 43 available PTAFR Antibodies ranked by validation data
- Compare Top PTAFR Antibodies
- Recommended
- antibodies-online: Search results for 18 available PTAFR Elisa Kits ranked by validation data
- Compare Top PTAFR Elisa Kits
- antibodies-online: Search results for 3 available PTAFR Proteins ranked by validation data
- Compare Top PTAFR Proteins
- genomics-online: cdna clones - Search results for 131 available PTAFR gene related products
- Overview of 131 available PTAFR gene related products
- Recommended
- orf clones - Search results for 131 available PTAFR gene related products
- Overview of 131 available PTAFR gene related products
- Recommended
- genomics-online: gRNA clones - Search results for 131 available PTAFR gene related products
- Overview of 131 available PTAFR gene related products
- Recommended
- genomics-online: primer clones - Search results for 131 available PTAFR gene related products
- Overview of 131 available PTAFR gene related products
- Recommended
- genomics-online: shRNA clones - Search results for 131 available PTAFR gene related products
- Overview of 131 available PTAFR gene related products
- Recommended
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PTAFR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PTAFR
- GeneCopoeia miRNA 3'UTR Target clone products for PTAFR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PTAFR
Sources for PTAFR Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt