Aliases for PSTK Gene

Aliases for PSTK Gene

  • Phosphoseryl-TRNA Kinase 2 3 5
  • O-Phosphoseryl-TRNA(Sec) Kinase 2 3 4
  • L-Seryl-TRNA(Sec) Kinase 2 3 4
  • C10orf89 3 4
  • Chromosome 10 Open Reading Frame 89 2
  • EC 2.7.1.164 4

External Ids for PSTK Gene

Previous HGNC Symbols for PSTK Gene

  • C10orf89

Previous GeneCards Identifiers for PSTK Gene

  • GC10P124730
  • GC10P118357

Summaries for PSTK Gene

GeneCards Summary for PSTK Gene

PSTK (Phosphoseryl-TRNA Kinase) is a Protein Coding gene. Diseases associated with PSTK include Hemochromatosis, Type 5. Among its related pathways are Viral mRNA Translation and Metabolism. Gene Ontology (GO) annotations related to this gene include kinase activity and tRNA binding.

UniProtKB/Swiss-Prot Summary for PSTK Gene

  • Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.

Additional gene information for PSTK Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PSTK Gene

Genomics for PSTK Gene

GeneHancer (GH) Regulatory Elements for PSTK Gene

Promoters and enhancers for PSTK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J122952 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 -0.5 -535 3 ZBTB40 ZNF217 EP300 ZSCAN5C TCF12 SIN3A NRF1 USF1 POLR2G SP1 C10orf88 PSTK lnc-IKZF5-2 BUB3 NSMCE4A IKZF5
GH10J122979 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.3 +26.4 26366 2 ZBTB40 ZNF217 EP300 CTCF MYC NRF1 POLR2G SP1 JUND PHF8 PSTK ACADSB IKZF5 BTBD16 C10orf88 lnc-IKZF5-1
GH10J122957 Enhancer 0.6 Ensembl 0.7 +3.5 3466 0.2 FOXA2 NFIL3 NFIA HLF CEBPG CEBPB FOS ZNF652 FOXA1 RCOR2 C10orf88 PSTK lnc-IKZF5-1 IKZF5
GH10J122990 Enhancer 0.5 Ensembl 0.3 +36.2 36166 0.4 ZNF639 PRDM6 FOS PKNOX1 SP7 TSHZ1 ZNF600 ACADSB IKZF5 lnc-IKZF5-1 PSTK C10orf88
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PSTK on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PSTK

Top Transcription factor binding sites by QIAGEN in the PSTK gene promoter:
  • C/EBPalpha
  • HNF-1
  • HOXA9
  • HOXA9B
  • LCR-F1
  • Lhx3a
  • LHX3b
  • Meis-1
  • Meis-1b
  • MRF-2

Genomic Locations for PSTK Gene

Genomic Locations for PSTK Gene
chr10:122,954,235-122,997,519
(GRCh38/hg38)
Size:
43,285 bases
Orientation:
Plus strand
chr10:124,713,897-124,757,029
(GRCh37/hg19)
Size:
43,133 bases
Orientation:
Plus strand

Genomic View for PSTK Gene

Genes around PSTK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSTK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSTK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSTK Gene

Proteins for PSTK Gene

  • Protein details for PSTK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV42-PSTK_HUMAN
    Recommended name:
    L-seryl-tRNA(Sec) kinase
    Protein Accession:
    Q8IV42
    Secondary Accessions:
    • Q6ZSS9

    Protein attributes for PSTK Gene

    Size:
    348 amino acids
    Molecular mass:
    39527 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PSTK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSTK Gene

Post-translational modifications for PSTK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PSTK Gene

No data available for DME Specific Peptides for PSTK Gene

Domains & Families for PSTK Gene

Gene Families for PSTK Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PSTK Gene

Blocks:
  • Chromatin associated protein KTI12
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PSTK Gene

GenScript: Design optimal peptide antigens:
  • O-phosphoseryl-tRNA(Sec) kinase (PSTK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IV42

UniProtKB/Swiss-Prot:

PSTK_HUMAN :
  • Belongs to the L-seryl-tRNA(Sec) kinase family.
Family:
  • Belongs to the L-seryl-tRNA(Sec) kinase family.
genes like me logo Genes that share domains with PSTK: view

Function for PSTK Gene

Molecular function for PSTK Gene

UniProtKB/Swiss-Prot Function:
Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec); Xref=Rhea:RHEA:25037, Rhea:RHEA-COMP:9742, Rhea:RHEA-COMP:9947, ChEBI:CHEBI:30616, ChEBI:CHEBI:78533, ChEBI:CHEBI:78551, ChEBI:CHEBI:456216; EC=2.7.1.164;.

Enzyme Numbers (IUBMB) for PSTK Gene

Phenotypes From GWAS Catalog for PSTK Gene

Gene Ontology (GO) - Molecular Function for PSTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IBA 21873635
GO:0000166 nucleotide binding IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IBA 21873635
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PSTK: view
genes like me logo Genes that share phenotypes with PSTK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PSTK

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSTK Gene

Localization for PSTK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSTK gene
Compartment Confidence
nucleus 3
cytoskeleton 2
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Nuclear bodies (2)
  • Nucleoli (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PSTK Gene

Pathways & Interactions for PSTK Gene

genes like me logo Genes that share pathways with PSTK: view

Pathways by source for PSTK Gene

UniProtKB/Swiss-Prot Q8IV42-PSTK_HUMAN

  • Pathway: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 1/2.

Gene Ontology (GO) - Biological Process for PSTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001514 selenocysteine incorporation IEA --
GO:0006412 translation IEA --
GO:0016310 phosphorylation IEA --
GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process IEA --
genes like me logo Genes that share ontologies with PSTK: view

No data available for SIGNOR curated interactions for PSTK Gene

Drugs & Compounds for PSTK Gene

(1) Drugs for PSTK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
genes like me logo Genes that share compounds with PSTK: view

Transcripts for PSTK Gene

mRNA/cDNA for PSTK Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSTK Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2:
SP3: - - - -
SP4: - -
SP5:

Relevant External Links for PSTK Gene

GeneLoc Exon Structure for
PSTK

Expression for PSTK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PSTK Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PSTK

SOURCE GeneReport for Unigene cluster for PSTK Gene:

Hs.281004

Evidence on tissue expression from TISSUES for PSTK Gene

  • Intestine(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PSTK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSTK Gene

Orthologs for PSTK Gene

This gene was present in the common ancestor of animals.

Orthologs for PSTK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSTK 31 30
  • 98.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PSTK 31 30
  • 85.31 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PSTK 31 30
  • 84.6 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pstk 17 31 30
  • 80.68 (n)
rat
(Rattus norvegicus)
Mammalia Pstk 30
  • 79.77 (n)
oppossum
(Monodelphis domestica)
Mammalia PSTK 31
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSTK 31
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSTK 31 30
  • 59.8 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSTK 31
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pstk 30
  • 54.3 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101884223 30
  • 48.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12788 31
  • 23 (a)
OneToOne
Species where no ortholog for PSTK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PSTK Gene

ENSEMBL:
Gene Tree for PSTK (if available)
TreeFam:
Gene Tree for PSTK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PSTK: view image

Paralogs for PSTK Gene

No data available for Paralogs for PSTK Gene

Variants for PSTK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PSTK Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs3736582 - p.Gly206Arg

Additional dbSNP identifiers (rs#s) for PSTK Gene

Structural Variations from Database of Genomic Variants (DGV) for PSTK Gene

Variant ID Type Subtype PubMed ID
nsv7586 CNV insertion 18451855
nsv832010 CNV gain 17160897

Variation tolerance for PSTK Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSTK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PSTK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSTK Gene

Disorders for PSTK Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSTK Gene - From: DISEASES

Disorder Aliases PubMed IDs
hemochromatosis, type 5
  • hfe5
- elite association - COSMIC cancer census association via MalaCards
Search PSTK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PSTK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PSTK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSTK Gene

Publications for PSTK Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase. (PMID: 15317934) Carlson BA … Hatfield DL (Proceedings of the National Academy of Sciences of the United States of America 2004) 2 3 54
  5. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 54

Products for PSTK Gene

Sources for PSTK Gene