Aliases for PSRC1 Gene
External Ids for PSRC1 Gene
Previous GeneCards Identifiers for PSRC1 Gene
This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]
GeneCards Summary for PSRC1 Gene
PSRC1 (Proline And Serine Rich Coiled-Coil 1) is a Protein Coding gene. Diseases associated with PSRC1 include Familial Hypercholesterolemia. Among its related pathways are Aryl Hydrocarbon Receptor. Gene Ontology (GO) annotations related to this gene include microtubule binding. An important paralog of this gene is GTSE1.
UniProtKB/Swiss-Prot Summary for PSRC1 Gene
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.