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Aliases for PSORS1C2 Gene

Aliases for PSORS1C2 Gene

  • Psoriasis Susceptibility 1 Candidate 2 2 3 5
  • C6orf17 3 4
  • SPR1 3 4
  • Psoriasis Susceptibility 1 Candidate Gene 2 Protein 3
  • Chromosome 6 Open Reading Frame 17 2
  • Protein SPR1 4

External Ids for PSORS1C2 Gene

Previous HGNC Symbols for PSORS1C2 Gene

  • C6orf17

Previous GeneCards Identifiers for PSORS1C2 Gene

  • GC00U991168
  • GC06U900362
  • GC06M031211
  • GC06M031213
  • GC06M030907

Summaries for PSORS1C2 Gene

GeneCards Summary for PSORS1C2 Gene

PSORS1C2 (Psoriasis Susceptibility 1 Candidate 2) is a Protein Coding gene. Diseases associated with PSORS1C2 include Psoriasis.

Additional gene information for PSORS1C2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSORS1C2 Gene

Genomics for PSORS1C2 Gene

GeneHancer (GH) Regulatory Elements for PSORS1C2 Gene

Promoters and enhancers for PSORS1C2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I031137 Enhancer 1.2 Ensembl ENCODE 579.2 +1.6 1649 0.6 HDGF PKNOX1 ATF1 ARNT ARID4B DMAP1 ZNF2 ZNF48 GLIS2 ARID2 PSORS1C2 PSORS1C1 HCG18 HCG27 ZBTB12 RPP21 PRR3 GTF2H4 DXO HLA-C
GH06I031139 Promoter 0.6 EPDnew 550.8 +0.3 264 0.1 FOS PSORS1C2 POLR2LP1 CDSN PSORS1C1
GH06I031140 Enhancer 0.5 ENCODE 571.7 -0.5 -479 0.8 MAZ ZBTB6 HLF FOS ZBTB17 PSORS1C2 POLR2LP1 CCHCR1 HCG22 MICA-AS1 PSORS1C1
GH06I031196 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 32.1 -58.5 -58548 3.1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC ZNF610 ENSG00000272501 GC06M031194 HCG27 PSORS1C3 POU5F1 PSORS1C2 PRRT1 CCHCR1 HLA-C GNL1
GH06I030715 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 21.1 +419.8 419824 7.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 MDC1 TUBB DDX39B TRIM39 DHX16 LY6G5B PPP1R10 ZNRD1 PAIP1P1 NRM
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PSORS1C2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PSORS1C2 gene promoter:

Genomic Locations for PSORS1C2 Gene

Genomic Locations for PSORS1C2 Gene
1,817 bases
Minus strand

Genomic View for PSORS1C2 Gene

Genes around PSORS1C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSORS1C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSORS1C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for PSORS1C2 Gene

  • Protein details for PSORS1C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Psoriasis susceptibility 1 candidate gene 2 protein
    Protein Accession:
    Secondary Accessions:
    • Q5STD0

    Protein attributes for PSORS1C2 Gene

    136 amino acids
    Molecular mass:
    15101 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PSORS1C2 Gene

Post-translational modifications for PSORS1C2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PSORS1C2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PSORS1C2 Gene

Domains & Families for PSORS1C2 Gene

Gene Families for PSORS1C2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PSORS1C2 Gene


Suggested Antigen Peptide Sequences for PSORS1C2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PSORS1C2: view

No data available for UniProtKB/Swiss-Prot for PSORS1C2 Gene

Function for PSORS1C2 Gene

Phenotypes From GWAS Catalog for PSORS1C2 Gene

Gene Ontology (GO) - Molecular Function for PSORS1C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with PSORS1C2: view
genes like me logo Genes that share phenotypes with PSORS1C2: view

Animal Model Products

CRISPR Products

miRNA for PSORS1C2 Gene

miRTarBase miRNAs that target PSORS1C2

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSORS1C2 Gene

Localization for PSORS1C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSORS1C2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PSORS1C2 gene
Compartment Confidence
extracellular 5
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PSORS1C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PSORS1C2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PSORS1C2 Gene

Pathways & Interactions for PSORS1C2 Gene

SuperPathways for PSORS1C2 Gene

No Data Available

Interacting Proteins for PSORS1C2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000259845 Q9UIG4-PS1C2_HUMAN for PSORS1C2 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for PSORS1C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PSORS1C2: view

No data available for Pathways by source and SIGNOR curated interactions for PSORS1C2 Gene

Drugs & Compounds for PSORS1C2 Gene

No Compound Related Data Available

Transcripts for PSORS1C2 Gene

mRNA/cDNA for PSORS1C2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSORS1C2 Gene

Psoriasis susceptibility 1 candidate 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSORS1C2 Gene

No ASD Table

Relevant External Links for PSORS1C2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSORS1C2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PSORS1C2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSORS1C2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x30.0) and Skin - Sun Exposed (Lower leg) (x12.0).

NURSA nuclear receptor signaling pathways regulating expression of PSORS1C2 Gene:


SOURCE GeneReport for Unigene cluster for PSORS1C2 Gene:


mRNA Expression by UniProt/SwissProt for PSORS1C2 Gene:

Tissue specificity: Expressed in skin. Also expressed in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for PSORS1C2 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with PSORS1C2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PSORS1C2 Gene

Orthologs for PSORS1C2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSORS1C2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PSORS1C2 33 34
  • 98.28 (n)
(Canis familiaris)
Mammalia PSORS1C2 33 34
  • 85.54 (n)
(Bos Taurus)
Mammalia PSORS1C2 34
  • 80 (a)
(Mus musculus)
Mammalia Psors1c2 33 16 34
  • 79.26 (n)
(Rattus norvegicus)
Mammalia Psors1c2 33
  • 77.11 (n)
(Monodelphis domestica)
Mammalia PSORS1C2 34
  • 70 (a)
Species where no ortholog for PSORS1C2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSORS1C2 Gene

Gene Tree for PSORS1C2 (if available)
Gene Tree for PSORS1C2 (if available)

Paralogs for PSORS1C2 Gene

(1) SIMAP similar genes for PSORS1C2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PSORS1C2: view

No data available for Paralogs for PSORS1C2 Gene

Variants for PSORS1C2 Gene

Sequence variations from dbSNP and Humsavar for PSORS1C2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000289720 -- 31,139,431(-) C/T upstream_transcript_variant
rs1002599159 -- 31,137,039(-) T/G downstream_transcript_variant
rs1002935858 -- 31,137,417(-) G/A/C downstream_transcript_variant
rs1006840016 -- 31,137,759(-) A/T 3_prime_UTR_variant
rs1006856372 -- 31,137,462(-) AAAAAAA/AAAAAA/AAAAAAAA downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PSORS1C2 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV deletion 23290073
esv2759414 CNV gain+loss 17122850
esv33699 CNV loss 17666407
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv428140 CNV gain+loss 18775914
nsv524061 CNV loss 19592680
nsv525933 CNV loss 19592680
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781

Variation tolerance for PSORS1C2 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.23; 76.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PSORS1C2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSORS1C2 Gene

Disorders for PSORS1C2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PSORS1C2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PSORS1C2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PSORS1C2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSORS1C2 Gene

Publications for PSORS1C2 Gene

  1. Polymorphisms in the SEEK1 and SPR1 genes on 6p21.3 associate with psoriasis in the Swedish population. (PMID: 12930300) Holm SJ … O'Brien KP (Experimental dermatology 2003) 3 4 22 58
  2. Phylogenetic profiling and gene expression studies implicate a primary role of PSORS1C2 in terminal differentiation of keratinocytes. (PMID: 27943452) Abbas Zadeh S … Eckhart L (Experimental dermatology 2017) 2 3 58
  3. Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis. (PMID: 21750679) Allanore Y … Martinez M (PLoS genetics 2011) 3 44 58
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  5. SPR1 gene near HLA-C is unlikely to be a psoriasis susceptibility gene. (PMID: 12823445) Chang YT … Wang WJ (Experimental dermatology 2003) 3 22 58

Products for PSORS1C2 Gene

Sources for PSORS1C2 Gene

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